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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6593	ML324	Histone Demethylase; Others; HSV	Chromatin/Epigenetic; Microbiology/Virology; Others
	ML324 是 jumonji 组蛋白去甲基化酶的特异性抑制剂，IC50值为920 nM。
T15779	LP-533401 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	LP-533401 hydrochloride 是不能穿过血脑屏障的外周 Tph 抑制剂，抑制5-羟色胺合成，可用于研究牙周病和肝脂肪变性。
T67915	Succinate/succinate receptor antagonist 1	Others	Others
	Succinate/succinate receptor antagonist 1 是一种有效的琥珀酸受体拮抗剂。Succinate/succinate receptor antagonist 1 中断牙龈组织中的琥珀酸信号，抑制琥珀酸受体 1 (SucnRl Antagonist 1) 的激活，对琥珀酸受体 1的 IC50 值为 20 μΜ。Succinate/succinate receptor antagonist 1 可用于治疗牙周病。
T0291	Flurbiprofen 氟比洛芬,dl-Flurbiprofen	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病的研究。它是一种非选择性的环氧合酶抑制剂，可研究结肠癌。
T69082	Flurbiprofen sodium
	Flurbiprofen sodium is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase.
T40274	XVA143 XVA143
	XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo. XVA143 is an antagonist of both mouse and human CR3, inhibits the ability of P. gingivalis to persist in the mouse host and cause periodontal bone loss.
T64692	AMY-101 acetate
	Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute...

化合物

ML324

Cat.No: T6593

Synonym:

Target: Histone Demethylase, Others, HSV

LP-533401 hydrochloride

Cat.No: T15779

Synonym:

Target: 5-HT Receptor

Succinate/succinate receptor antagonist 1

Synonym: 氟比洛芬,dl-Flurbiprofen

Target: Apoptosis, COX, MRP

Cat. No.	Product Name	Target	Signaling Pathways
T79993	Oleanolic aldehyde
	Oleanolic aldehyde 是一种具有抗菌性质的化合物，能够抑制口腔内细菌生长。该化合物对变形链球菌和牙龈卟啉单胞菌——与龋齿和牙周病有关的细菌——显示出显著的抑制效果，其最低抑菌浓度(MICs)分别为488 μg/mL和250 μg/mL。
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 檀木	ERK; IL Receptor; Antioxidant; TNF; NF-κB; MAPK; Prostaglandin Receptor; JNK; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; oxidation-reduction
	6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物，具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的研究。

天然产物

6,4'-Dihydroxy-7-methoxyflavanone

Cat.No: TN3144

Synonym: 檀木

Target: ERK, IL Receptor, Antioxidant, TNF, NF-κB, MAPK, Prostaglandin Receptor, JNK, Autophagy

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