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82

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20350	Benzaldehyde, oxime	Others	Others
	Benzaldehyde, oxime 是合成色酮的中间体。
T9138	Indirubin-3′-oxime Indirubin-3'-monoxime	GSK-3; CDK; JNK	Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。
T1917	GSK 3 Inhibitor IX BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime	Apoptosis; GSK-3; Tyrosine Kinases; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	GSK 3 Inhibitor IX (6-BIO) 是一种选择性可逆的，ATP 竞争性的 GSK-3α/β和 CDK1-cyclinB 复合体抑制剂，能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性，IC50值分别为 5 nM/320 nM/83 nM。
T37039	Betulinic Aldehyde oxime
	Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2
T35902	Milbemycin A4 oxime
	Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, ...
T5200	Indirubin-3'-monoxime 靛玉红-3' -单肟,Indirubin-3'-oxime	GSK-3; Lipoxygenase; CDK	Cell Cycle/Checkpoint; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin-3'-monoxime (Indirubin-3'-oxime) 是一种有效的 GSK3β 抑制剂，IC50值为 22 nM。它对 CDK5/p25、CDK1/cyclin B 和CDk2/cyclin E 也有作用，IC50值分别为 100、180 和 250 nM。
T37271	9(E)-Erythromycin A oxime
	(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .
T35157	Xanthone oxime NSC-73162,NSC 73162,NSC73162
	Xanthone oxime is a biochemical.
T12734	Risperidone E-oxime	Others	Others
	Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin blocker of 5-HT2 receptor, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist(Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively ).
T10143	4-Hydroxyacetophenone oxime	Others	Others
	4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent COX-2 and hepatic NAT2 inhibitor and used antipyretic and analgesic drug.
T30949	Citral oxime AI3-12094,AI312094,AI3 12094
	Citral oxime is a biochemical.
T20409	Benzoin oxime NSC 659,NSC-659,NSC659
	Benzoin oxime is a compound that is used in the spectrophotometric determination of chromium(III) ion.
T19757	Oxamyl oxime A-2213,A 2213,A2213
	Oxamyl oxime is an agricultural chemical and pesticide.
T1592	Acetohydroxamic acid Methylhydroxamic acid,Acetic acid,Lithostat,AHA,oxime,N-Hydroxyacetamide,乙酰氧肟酸	MMP; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Acetohydroxamic acid (N-Hydroxyacetamide) 是一种不可逆的细菌和植物尿素酶抑制剂，可研究慢性尿路感染。
T29369	2-Phenylpropionaldehyde oxime AI313013,AI3-13013,AI3 13013
	2-Phenylpropionaldehyde oxime is a food-grade flavor ingredient.
T124516	Heptanal oxime
	Heptanal oxime 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124516。
T21219	Isatin-O Isatin-3-oxime
	Isatin-O acts as a neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon and is also an anticonvulsant.
T20580	Picolinamidoxime RA7,RA-7,RA 7,Picolinamide oxime
	Picolinamidoxime is a biochemical substance.
T7537	Norgestimate 炔诺肟酯,诺孕酯	Progesterone Receptor	Others
	Norgestimate 是一种具有口服活性、高度选择性的孕激素活性和较小雄激素作用的孕激素，是一种合成的孕激素类似物。它可用作口服的避孕药。
T4180	Adipamidoxime NSC70868	Others	Others
	Adipamidoxime (NSC-70868) 是一种肟类活性化合物，可以抑制某些细菌、真菌和病毒的生长，并具有一些抗炎和抗肿瘤活性。
T1111	Pralidoxime Chloride 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)	AChE	Neuroscience
	Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物，对中毒乙酰胆碱酯酶具有恢复作用，可用于有机磷中毒的研究。
T14333	Asoxime dichloride Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate,Asoxime (dichloride),HI-6	AChR	Neuroscience
	Asoxime dichloride (Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate) 是乙酰胆碱受体 (AChRs) 拮抗剂，包括烟碱受体，α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用，改善神经系统的免疫效果。
T2176	2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放，能够有效抑制骨骼肌和心肌收缩。
T4572	Desoximetasone 去羟米松,Desoximetasonum,Topicort,Desoxymethasone,Desoximetasona	Others	Others
	Desoximetasone (Desoximetasona) 是一种可缓解皮疹等多种皮肤疾病的皮质类固醇。
T1224	Cefuroxime sodium Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。
T4998	Cefpodoxime proxetil	Antibacterial; Antibiotic	Microbiology/Virology
	Cefpodoxime Proxetil 是一种口服的广谱型抗生素。它与青霉素结合蛋白结合，抑制肽聚糖的合成，干扰细菌细胞壁的生物合成。
T4998L	Cefpodoxime (free acid)	Others	Others
	Cefpodoxime (free acid) 是一种口服的第三代头孢菌素抗生素。除铜绿假单胞菌、肠球菌和脆弱拟杆菌外，它对大多数革兰氏阳性和革兰氏阴性微生物均有效。
T1190	Cefmenoxime hydrochloride Cefmenoxime hemihydrochloride,SCE-1365 hemihydrochloride,盐酸头孢甲肟	Antibacterial; Antibiotic; Antifection	Microbiology/Virology
	Cefmenoxime hydrochloride (Cefmenoxime hemihydrochloride) 是一种头孢类抗生素，可通过静脉内或肌肉内给药。它对大多数常见的革兰氏阳性和革兰氏阴性微生物有活性，是一种肠杆菌科抑制剂，并且对 β-内酰胺酶的水解具有高度抗性。
T1227	Cefuroxime axetil Cepazine,头孢呋辛酯,Zinnat,Elobact,Ceftin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime axetil (Zinnat) 是头孢菌素头孢呋辛的前药和一种广谱抗生素，可抑制几种革兰氏阳性和革兰氏阴性生物。
T26631L	Anidoxime HCl USVP-E142,Anidoxime HCl( 34297-34-2 Free base)
	Anidoxime HCl (USVP-E142) 是一种新型可口服的具有抗镇痛活性的化合物。
T6787	BIO-acetoxime BIA,GSK-3 Inhibitor X	Apoptosis; GSK-3; HSV	Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	BIO-acetoxime (GSK-3 Inhibitor X) 是一种 GSK3α/β 抑制剂，IC50值均为 10 nM，具有抗惊厥和抗感染作用。
T8317	5'-Fluoroindirubinoxime 5'-FIO	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	5'-Fluoroindirubinoxime (5'-FIO) 是一种 Indirubin 的衍生物，是一种 FLT3 的抑制剂(IC50:15 nM)。
T20346	Salicylaldoxime	Others	Others
	Salicylaldoxime 是一种螯合剂，有时用于分析含有过渡金属离子的样品，它通常与过渡金属离子形成色彩鲜艳的配位络合物。
T7629	Olesoxime NSC 21311,TRO 19622,奥利索西	Mitochondrial Metabolism	Metabolism
	Olesoxime (TRO 19622) 是一种靶向线粒体的神经保护性试剂，能够促进细胞存活，其 EC50=3.2±0.2 µM。
T4271	Diroximel fumarate Diroximel Fumarete	Others	Others
	Diroximel fumarate (Diroximel Fumarete) 是一种控释制剂，是口服具有活力的富马酸单乙酯的前体药物。它被认为与其活性代谢物富马酸二甲酯的活性等效。它具有良好的安全性和有效性，具有研究多发性硬化的潜力。
T4501	Ceftizoxime 头孢唑肟,Epocelin	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftizoxime (Epocelin) 是一种强效抗菌剂，它通过干扰细菌细胞壁合成和抑制肽聚糖的交联起作用。它对广谱的 β-内酰胺酶具有高度抗性，并且对多种需氧和厌氧的革兰氏阳性和革兰氏阴性微生物均有效。
T68624	Asoxime chloride monohydrate
	Asoxime chloride monohydrate is an oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited by cytotoxic nerve agents such as sarin or soman.
T16372	Obidoxime dichloride	Others	Others
	Obidoxime dichloride, a selective oxime agent, effectively reactivates sarin-inhibited acetylcholinesterase (AChE) and mitigates the acute toxicity associated with sarin exposure. It is also utilized as an antidote for organophosphate nerve agent poisoning.
T70641	Asoxime dimethanesulfonate
	Asoxime dimethanesulfonate is an oxime reactivator used for counteracting intoxication by nerve agents. It is able to reactivate acetylcholinesterase (AChE) inhibited by cytotoxic nerve agents such as sarin or soman.
T73060	Pralidoxime
	Pralidoxime 是一种有效的乙酰胆碱酯酶 (AChE) 的再激活剂。Pralidoxime 通过肟部分对结合神经毒剂磷中心的亲核攻击，重新激活受神经毒剂抑制的 AChE。Pralidoxime 是一种有机磷中毒的解毒剂。
T34299	Retinaloxime trans-Retinaloxime
	Retinaloxime is a retinoid.
T65068	Cefuroxime
	Cefuroxime 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65068，CAS号为 55268-75-2。
T15600	Istaroxime PST2744	Others	Others
	Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).
T73198	Nifuroxime
	Nifuroxime 是一种抗感染剂，可用于真菌感染相关的研究。
T18877	β-Estradiol-6-one 6-(O-carboxymethyloxime)	Others	Others
	β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker utilized for PROTAC synthesis[1].
T22404	Pralidoxime Iodide 2-PAM,碘解磷定	Others	Others
	Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning.
T68938	Cefmenoxime sodium
	Cefmenoxime sodium is the ssalt form of Cefmenoxime (free base), a cephalosporin antibiotic administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms. It is a potent inhibitor of Enterobacteriaceae, and is resistant to beta-lactamase-initiated hydrolysis. The drug has a high success rate against many types of infection.
T68770	Obidoxime thiocyanate
	Obidoxime thiocyanate is an AChE reactivator.
T20408	Dimethylglyoxime AI314925,AI3 14925,AI3-14925
	Dimethylglyoxime is a compound that is used in the nickel spot test.
T69079	Trimedoxime bromide
	Trimedoxime bromide is a cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.

化合物

Benzaldehyde, oxime

Cat.No: T20350

Target: Others

Indirubin-3′-oxime

Cat.No: T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

GSK 3 Inhibitor IX

Cat.No: T1917

Synonym: BIO,GSK 3 IX,6-BIO,6-Bromoindirubin-3'-oxime,MLS 2052,6-bromoindirubin-3-oxime

Target: Apoptosis, GSK-3, Tyrosine Kinases, CDK

Betulinic Aldehyde oxime

Cat.No: T37039

Milbemycin A4 oxime

Cat.No: T35902

Indirubin-3'-monoxime

Cat.No: T5200

Synonym: 靛玉红-3' -单肟,Indirubin-3'-oxime

Target: GSK-3, Lipoxygenase, CDK

9(E)-Erythromycin A oxime

Cat.No: T37271

Xanthone oxime

Cat.No: T35157

Synonym: NSC-73162,NSC 73162,NSC73162

Risperidone E-oxime

Cat.No: T12734

Target: Others

4-Hydroxyacetophenone oxime

Cat.No: T10143

Target: Others

Cat.No: T30949

Synonym: AI3-12094,AI312094,AI3 12094

Benzoin oxime

Cat.No: T20409

Synonym: NSC 659,NSC-659,NSC659

Cat.No: T19757

Synonym: A-2213,A 2213,A2213

Acetohydroxamic acid

Cat.No: T1592

Synonym: Methylhydroxamic acid,Acetic acid,Lithostat,AHA,oxime,N-Hydroxyacetamide,乙酰氧肟酸

Target: MMP, Antibacterial

2-Phenylpropionaldehyde oxime

Cat.No: T29369

Synonym: AI313013,AI3-13013,AI3 13013

Heptanal oxime

Cat.No: T124516

Cat.No: T21219

Synonym: Isatin-3-oxime

Picolinamidoxime

Cat.No: T20580

Synonym: RA7,RA-7,RA 7,Picolinamide oxime

Cat.No: T7537

Synonym: 炔诺肟酯,诺孕酯

Target: Progesterone Receptor

Cat.No: T4180

Synonym: NSC70868

Target: Others

Pralidoxime Chloride

Cat.No: T1111

Synonym: 2-PAM chloride,吡啶醛肟甲氯,2-Pyridinealdoxime methochloride,2-PAM (chloride)

Target: AChE

Asoxime dichloride

Cat.No: T14333

Synonym: Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate,Asoxime (dichloride),HI-6

Target: AChR

2,3-Butanedione 2-Monoxime

Cat.No: T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Cat.No: T4572

Synonym: 去羟米松,Desoximetasonum,Topicort,Desoxymethasone,Desoximetasona

Target: Others

Cefuroxime sodium

Cat.No: T1224

Synonym: Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin

Target: Antibacterial, Antibiotic

Cefpodoxime proxetil

Cat.No: T4998

Target: Antibacterial, Antibiotic

Cefpodoxime (free acid)

Cat.No: T4998L

Target: Others

Cefmenoxime hydrochloride

Cat.No: T1190

Synonym: Cefmenoxime hemihydrochloride,SCE-1365 hemihydrochloride,盐酸头孢甲肟

Target: Antibacterial, Antibiotic, Antifection

Cefuroxime axetil

Cat.No: T1227

Synonym: Cepazine,头孢呋辛酯,Zinnat,Elobact,Ceftin

Target: Antibacterial, Antibiotic

Cat.No: T26631L

Synonym: USVP-E142,Anidoxime HCl( 34297-34-2 Free base)

Cat.No: T6787

Synonym: BIA,GSK-3 Inhibitor X

Target: Apoptosis, GSK-3, HSV

5'-Fluoroindirubinoxime

Cat.No: T8317

Synonym: 5'-FIO

Target: FLT

Salicylaldoxime

Cat.No: T20346

Target: Others

Cat.No: T7629

Synonym: NSC 21311,TRO 19622,奥利索西

Target: Mitochondrial Metabolism

Diroximel fumarate

Cat.No: T4271

Synonym: Diroximel Fumarete

Target: Others

Cat.No: T4501

Synonym: 头孢唑肟,Epocelin

Target: Antibacterial, Antibiotic

Asoxime chloride monohydrate

Cat.No: T68624

Obidoxime dichloride

Cat.No: T16372

Target: Others

Asoxime dimethanesulfonate

Cat.No: T70641

Cat.No: T73060

Cat.No: T34299

Synonym: trans-Retinaloxime

Cat.No: T65068

Cat.No: T15600

Synonym: PST2744

Target: Others

Cat.No: T73198

β-Estradiol-6-one 6-(O-carboxymethyloxime)

Cat.No: T18877

Target: Others

Pralidoxime Iodide

Cat.No: T22404

Synonym: 2-PAM,碘解磷定

Target: Others

Cefmenoxime sodium

Cat.No: T68938

Obidoxime thiocyanate

Cat.No: T68770

Dimethylglyoxime

Cat.No: T20408

Synonym: AI314925,AI3 14925,AI3-14925

Trimedoxime bromide

Cat.No: T69079

Cat. No.	Product Name	Target	Signaling Pathways
T1381	Milbemycin oxime	Others; Antibiotic; Parasite	Microbiology/Virology; Others
	Milbemycin oxime 是一种大环内酯，具有广谱抗寄生虫活性。它由 Milbemycin A4 和 A3 组成。它可结合谷氨酸门控的氯离子通道，可作用于肠道线虫，肺和心脏蠕虫。
T4930	ISOBUTYRALDEHYDE OXIME	Others	Others
	ISOBUTYRALDEHYDE OXIME 是衍生自 2-methylpropanal 的醛肟。它来源于异丁醛。
T1346	1-Phenyl-1,2-ethanediol	Others	Others
	1-Phenyl-1,2-ethanediol 是 O-benzyl oxime ether 衍生物，用作杀虫剂。

天然产物

Milbemycin oxime

Cat.No: T1381

Target: Others, Antibiotic, Parasite

ISOBUTYRALDEHYDE OXIME

Cat.No: T4930

Target: Others

1-Phenyl-1,2-ethanediol

Cat.No: T1346

Target: Others

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