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19

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4512	Magnesium glycinate magnesium 2-aminoacetate,Magnesium diglycinate,甘氨酸镁	Others	Others
	Magnesium glycinate (magnesium 2-aminoacetate) 是一种营养补充剂，是甘氨酸的镁盐，具有良好的理化性质和生物活性。Magnesium 是人体必需的矿物质，参与能量代谢过程，协助维持正常的肌肉功能，对人体起着至关重要的作用。
T19663	Triheptanoin UX 007,IND106011,三庚酸甘油脂,UX007,UX-007,IND 106011,IND-106011	Others	Others
	Triheptanoin (IND 106011) 是合成的中链甘油三酯 (MCT)，由甘油主链上的三个奇数链 7-碳(庚酸)脂肪酸组成，可以用于研究遗传代谢紊乱。
T8734	Choline	Others	Others
	Choline hydroxide 是一种普遍存在的水溶性营养素，通常与 B 族维生素有关。
T11593	I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R; PI3K	PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	I-OMe-Tyrphostin AG 538是一种特异性 IGF-1R 抑制剂和 PI5P4Kα的 ATP 竞争性抑制剂（IC50：1 µM）。I-OMe-Tyrphostin AG 538可抑制 IGF-1R 介导的信号传导，并对营养缺乏的 PANC1细胞具有优先细胞毒性。
T3602	D-Pantothenic acid sodium 泛酸钠,D-Pantothenate Sodium,D-Pantothenic acid sodium salt,Sodium pantothenate,D-泛酸钠,vitamin B5 sodium	Apoptosis; Others	Apoptosis; Others
	D-Pantothenic acid sodium (vitamin B5 sodium) 是一种必需的微量营养素，作为辅酶 A 的前体，在调节碳水化合物，脂质，蛋白和核酸代谢中发挥关键作用。
T9308	AzoMethine-H Monosodium salt hydrate Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate,偶氮甲碱-H 单钠盐水合物	Others	Others
	AzoMethine-H Monosodium salt hydrate (Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate) 是一种试剂，用于比色测定土壤、植物、堆肥、肥料、水和营养液中的硼。
T37844	Kigamicin C
	Kigamicins are natural antitumor antibiotics that selectively kill pancreatic cancer PANC-1 cells only under nutrient-starved conditions. They also show antimicrobial activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Kigamicin C inhibits PANC-1 cell survival in nutrient-deprived media at a 100-fold lower concentration than that required for cells maintained in nutrient-rich media. A related compound, kigamicin D, is active in vivo, suppressing the tumor growth o...
T70991	Efrapeptin F
	Efrapeptin F is a metabolite of entomogenous fungi in the genus Tolypocladium that acts as a mitochondrial complex V inhibitor. It has been shown to express preferential cytotoxicity to nutrient-deprived tumor cells compared with nutrient-sufficient tumor cells.
T31838	Folic acid, methyl- x-Methylfolic acid,x-Methyl folic acid,x-Methylpteroylglutamic acid
	Folic acid, methyl- is a nutrient that belongs to the vitamin B family. Folate is significant for the easy conversion of carbohydrates into glucose and is essential in red blood cell formation, cell division, detoxification, and the production of some neu
T27107	CYM-5478 CYM 5478,CYM5478
	CYM-5478 is a potent and selective S1P2 agonist. Under nutrient-deprivation stress produced by serum-starvation, CYM-5478 induced a significant increase in the viability of C6 cells in a dose dependent manner at concentrations above 100 nM.
T68482	CE-326597
	CE-326597 is a potent and selective CCK1R agonist. The type 1 cholecystokinin receptor (CCK1R) has multiple physiologic roles relating to nutrient homeostasis,including mediation of postcibal satiety. The type 1 cholecystokinin (CCK) receptor (CCK1R) is a key mediator of postcibal satiety and a potential target for drugs that may be useful to prevent and/or treat obesity.
T11336	Fumarate hydratase-IN-2 sodium salt	Others	Others
	Fumarate hydratase-IN-2 sodium salt (compound 3) 是一种具有细胞渗透性和竞争性的富马酸水合酶(fumarate hydratase)抑制剂 (Ki=4.5 μM)，具有营养依赖性细胞毒性。
T83877	2-(cyclohexylmethyl)-Plumbagin
	2-(cyclohexylmethyl)-Plumbagin是naphthoquinone plumbagin的衍生物。在模拟胰腺癌肿瘤微环境的营养匮乏条件下，与营养丰富条件下的PANC-1细胞相比，对PANC-1人类胰腺癌细胞表现出选择性的细胞毒性，50%优选细胞毒性值(PC50s)分别为0.11和47.2 µM。1 µM浓度下，还可诱导PANC-1细胞发生凋亡。此外，2-(cyclohexylmethyl)-Plumbagin在营养匮乏条件下，而非营养丰富条件下，选择性降低PANC-1细胞中Akt和哺乳动物雷帕霉素靶蛋白(mTOR)的磷酸化。在以每周五次、每次50和250 µg/动物剂量给药的MiaPaCa-2胰腺癌小鼠异种移植模型中，能减少肿瘤体积和重量。
T39109	ML338 ML338
	ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 values of 1 μM and 4 μM, respectively, as determined by CFU. This compound, ML338, is an invaluable tool for identifying essential functions and vulnerabilities of M. tuberculosis bacilli under nutrient deprivation conditions. Additionally, ML338 is highly useful for studying M. tuber...
T75757	GIP, human TFA
	GIP, human TFA 是一种42个氨基酸构成的肽类激素，促进葡萄糖依赖性胰岛素释放，同时轻度抑制胃酸分泌。该激素由肠K细胞释放，响应营养摄入。
T3984	GLP-1(7-36), amide MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素，能够刺激胰岛素分泌。
T62910	Antibacterial agent 62
	Antibacterial agent 62 是一种新型氧化还原循环抗结核化合物，对生长和营养缺乏的表型耐药非生长细菌表现出显著的杀菌作用。
T68667	Oxanosine
	Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al...
T28157	Nephrin
	Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highl

化合物

Magnesium glycinate

Cat.No: T4512

Synonym: magnesium 2-aminoacetate,Magnesium diglycinate,甘氨酸镁

Target: Others

Cat.No: T19663

Synonym: UX 007,IND106011,三庚酸甘油脂,UX007,UX-007,IND 106011,IND-106011

Target: Others

Cat.No: T8734

Target: Others

I-OMe-Tyrphostin AG 538

Cat.No: T11593

Synonym: I-OMe-AG 538

Target: IGF-1R, PI3K

D-Pantothenic acid sodium

Cat.No: T3602

Synonym: 泛酸钠,D-Pantothenate Sodium,D-Pantothenic acid sodium salt,Sodium pantothenate,D-泛酸钠,vitamin B5 sodium

Target: Apoptosis, Others

AzoMethine-H Monosodium salt hydrate

Cat.No: T9308

Synonym: Sodium 5-hydroxy-4-((2-hydroxybenzylidene)amino)-7-sulfonaphthalene-2-sulfonate hydrate,偶氮甲碱-H 单钠盐水合物

Target: Others

Cat.No: T37844

Cat.No: T70991

Folic acid, methyl-

Cat.No: T31838

Synonym: x-Methylfolic acid,x-Methyl folic acid,x-Methylpteroylglutamic acid

Cat.No: T27107

Synonym: CYM 5478,CYM5478

Cat.No: T68482

Fumarate hydratase-IN-2 sodium salt

Cat.No: T11336

Target: Others

2-(cyclohexylmethyl)-Plumbagin

Cat.No: T83877

Cat.No: T39109

Synonym: ML338

Cat.No: T75757

GLP-1(7-36), amide

Cat.No: T3984

Synonym: MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide

Target: Glucagon Receptor

Antibacterial agent 62

Cat.No: T62910

Cat.No: T68667

Cat.No: T28157

Cat. No.	Product Name	Target	Signaling Pathways
T5692	Pyrroloquinoline quinone	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone 是氧化还原辅助因子，一种阴离子型氧化还原循环原醌。它是哺乳动物的必需营养素，对免疫功能很重要。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。
T5663	α-Lactose D-乳糖单水合物,Lactose	Others	Others
	α-Lactose 是牛奶中的主要的糖。它一般以 α 和 β 两个异构体的形式存在，其中α 形式通常以一水合物的形式结晶。
T0062	Folic acid Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Folic acid (Vitamin B9) 是维生素B9，是合成DNA/RNA，新细胞产生和维持的必要成分。
T4P2931	Linoleic acid 9,12-octadecadienoic acid,亚油酸,α-亚油酸,acidelinoleique,9,12-Linoleic acid	Others; Endogenous Metabolite	Metabolism; Others
	Linoleic acid (9,12-octadecadienoic acid) 是一种多不饱和脂肪酸，存在于坚果、种子和植物性油中。它是膜磷脂的一部分，作为膜流动性的结构成分来维持表皮透皮水屏障。它通过氧化作用引起血红蛋白和红细胞损伤。
T5693	Pyrroloquinoline quinone disodium salt 吡咯喹啉醌二钠盐,Methoxatin disodium salt	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone disodium salt (Methoxatin disodium salt) 一种阴离子型氧化还原循环原醌，作为氧化还原辅助因子。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。它是哺乳动物的必需营养素，对免疫功能很重要。
T1116	Biotin Vitamin B7,生物素,D-Biotin,Vitamin H,D-生物素（维生素H）
	Biotin (Vitamin H) 是一种水溶性B族维生素，是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢所必需的。
T1331	Riboflavin phosphate sodium Riboflavin 5'-phosphate sodium,核黄素磷酸钠(维生素B2),Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,核黄素磷酸钠,FMN-Na,riboflavin-5'-phosphate	Endogenous Metabolite	Metabolism
	Riboflavin phosphate sodium (FMN) 是 riboflavin 的磷酸钠盐形式，riboflavin 是一种水溶性和必需的微量营养素，是自然产生的维生素B复合物的主要生长促进因子。Riboflavin phosphate sodium 转化为2种辅酶，黄素单核苷酸(FMN)和黄素腺嘌呤二核苷酸(FAD)，这两种辅酶通过帮助脂肪、碳水化合物和蛋白质的代谢来产生能量，并且是红细胞形成和呼吸、抗体产生以及调节人体生长和繁殖所必需的。
T19224	C-Phycocyanin C-PC,藻蓝蛋白,C-藻蓝蛋白	Others	Others
	C-Phycocyanin (C-PC) 是一种蛋白质色素，常作为人类的优良营养补充剂。
T2O2666	Methyl stearate Stearic Acid methyl ester,硬脂酸甲酯,Methyl Octadecanoate	Others	Others
	Methyl stearate (Methyl Octadecanoate) 是大豆和油菜籽生物柴油的组分，分离自 Rheum palmatumL 中。
T5812	Zinc Phytate	Others	Others
	Zinc Phytate 存在于食物中，对人类吸收营养有重要意义。
T4884	alpha-D-glucose α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose	Others; Endogenous Metabolite	Metabolism; Others
	alpha-D-glucose (α-Dextrose) 是内源性代谢产物的一种。
TMS2181	trans-Zeatin (E)-Zeatin,玉米素	ERK; MEK; Endogenous Metabolite	MAPK; Metabolism
	trans-Zeatin ((E)-Zeatin) 是植物细胞分裂素，可抑制紫外线诱导的MEK/ERK 的活化，在细胞生长、分化和分裂中起着重要的作用。
T3823	D-Pinitol Pinitol,Inzitol,D-(+)-Pinitol,D-松醇,Methylinositol,3-O-Methyl-D-chiro-inositol	Others; Influenza Virus	Microbiology/Virology; Others
	D-Pinitol (Methylinositol) 是一种存在于几种植物中，如松科和豆科植物的天然产物，具有抗病毒、杀幼虫、降血糖活性和心血管系统保护作用。
T6805	Choline bitartrate 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱	Others; AChR	Neuroscience; Others
	Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) 是一种存在于食物中的营养胆碱，可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。它是神经递质乙酰胆碱的前体，作为甲基供体参与各种代谢过程和脂质代谢。
T0887	D-Glucose Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose	Endogenous Metabolite	Metabolism
	D-Glucose (Glucopyranose) 是一种单糖。D-Glucose 是甜味剂，是一般代谢的关键组成部分，并作为与细胞代谢状态以及生物和非生物应激反应有关的关键信号分子。
T2O2728	glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸	MT Receptor; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	glycine (2-Aminoacetic acid) 是中枢神经系统的抑制性神经递质，也是谷氨酸的联合激动剂，有促进谷氨酸能NMDA 受体兴奋的潜力。它主要存在于明胶和丝素蛋白中，并在治疗上用作营养物质。
T3606	γ-Oryzanol 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza	DNA Methyltransferase	Chromatin/Epigenetic
	γ-Oryzanol (Gamma-Oryzanol) 是一种从米糠油中分离出来的营养提取物，是含有甾醇和阿魏酸的混合物，有助于破坏皮肤中的自由基。它有效抑制小鼠纹状体中的 DNA 甲基转移酶(DNMTs)。它抑制DNMT1和DNMT3a，IC50分别为 3.2 和 22.3 μM。
T4786	D-Ribose(mixture of isomers) D-Ribose,D-(-)-Ribose,D-(-)-核糖	Others; Endogenous Metabolite	Metabolism; Others
	D-Ribose(mixture of isomers) (D-(-)-Ribose) 是 ATP 的糖部分，可作为能量增强剂，被广泛用作慢性疲劳综合症和心肌能量代谢的代谢疗法补充剂。它在蛋白质糖化中具有特性，能够 RAGE 依赖的方式诱导 NF-Κb 炎症。
T2864	Lycopene 番茄红素,ψ,ψ-Carotene	Reactive Oxygen Species; ROS	Immunology/Inflammation; Metabolism; NF-κB
	Lycopene (ψ,ψ-Carotene) 是一种番茄及其产品和其他红色水果和蔬菜中天然存在的类胡萝卜素，具有抗氧化活性。
TN4822	Prehelminthosporol	Antifection	Microbiology/Virology
	Prehelminthosporol is a phytotoxin, it may play an important role in pathogenesis by killing or weakening plant cells in advance of the growing hyphae and facilitating nutrient uptake and further growth of the fungus in plant tissue.

天然产物

Pyrroloquinoline quinone

Cat.No: T5692

Target: Others, Endogenous Metabolite

Cat.No: T5663

Synonym: D-乳糖单水合物,Lactose

Target: Others

Cat.No: T0062

Synonym: Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T4P2931

Synonym: 9,12-octadecadienoic acid,亚油酸,α-亚油酸,acidelinoleique,9,12-Linoleic acid

Target: Others, Endogenous Metabolite

Pyrroloquinoline quinone disodium salt

Cat.No: T5693

Synonym: 吡咯喹啉醌二钠盐,Methoxatin disodium salt

Target: Others, Endogenous Metabolite

Cat.No: T1116

Synonym: Vitamin B7,生物素,D-Biotin,Vitamin H,D-生物素（维生素H）

Riboflavin phosphate sodium

Cat.No: T1331

Synonym: Riboflavin 5'-phosphate sodium,核黄素磷酸钠(维生素B2),Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,核黄素磷酸钠,FMN-Na,riboflavin-5'-phosphate

Target: Endogenous Metabolite

Cat.No: T19224

Synonym: C-PC,藻蓝蛋白,C-藻蓝蛋白

Target: Others

Methyl stearate

Cat.No: T2O2666

Synonym: Stearic Acid methyl ester,硬脂酸甲酯,Methyl Octadecanoate

Target: Others

Cat.No: T5812

Target: Others

alpha-D-glucose

Cat.No: T4884

Synonym: α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose

Target: Others, Endogenous Metabolite

Cat.No: TMS2181

Synonym: (E)-Zeatin,玉米素

Target: ERK, MEK, Endogenous Metabolite

Cat.No: T3823

Synonym: Pinitol,Inzitol,D-(+)-Pinitol,D-松醇,Methylinositol,3-O-Methyl-D-chiro-inositol

Target: Others, Influenza Virus

Choline bitartrate

Cat.No: T6805

Synonym: 2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱

Target: Others, AChR

Cat.No: T0887

Synonym: Dextrose,D-无水葡萄糖,Glucopyranose,Grape sugar,葡萄糖,D(+)-Glucose

Target: Endogenous Metabolite

Cat.No: T2O2728

Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸

Target: MT Receptor, Endogenous Metabolite, iGluR

Cat.No: T3606

Synonym: 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza

Target: DNA Methyltransferase

D-Ribose(mixture of isomers)

Cat.No: T4786

Synonym: D-Ribose,D-(-)-Ribose,D-(-)-核糖

Target: Others, Endogenous Metabolite

Cat.No: T2864

Synonym: 番茄红素,ψ,ψ-Carotene

Target: Reactive Oxygen Species, ROS

Prehelminthosporol

Cat.No: TN4822

Target: Antifection

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