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35

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8461	SKI V	Apoptosis; PI3K; S1P Receptor	Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling
	SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂，对 GST-hSK 的IC50为 2 μM。它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成，可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K，对 hPI3k 的IC50为 6 μM。
T41324	L319 Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate	Others	Others
	L319 (Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate) 是一种脂质膜，是一种潜在的核酸载体。
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T37184	CX08005 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid	Phosphatase	Metabolism
	CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂，可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。
T22812	GRI977143 GRI 977143	LPA Receptor	GPCR/G Protein
	GRI977143 是 LPA2 的选择性非脂质激动剂 (EC50 = 3.3 μM)。 GRI977143 抑制半胱天冬酶 3、7、8 和 9 的激活，并减少 DNA 片段化。
T14933	Cetaben	Others	Others
	Cetaben 是不依赖 PPARα 的过氧化物酶体增殖物。它可有效降低胆固醇和甘油三酸酯的浓度，是一种非纤维化降血脂药。
T4313	Tinoridine hydrochloride 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride	COX; Glutathione Peroxidase	Immunology/Inflammation; Metabolism; Neuroscience
	Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药，具有显著的自由基清除和抗过氧化物特性。
T28978	Tirilazad mesylate U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate	Antiviral	Immunology/Inflammation
	Tirilazad mesylate (U 74006F) 是一种非糖皮质激素，是一种脂质过氧化抑制剂，具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化，可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤，抑制狗体内毒素的作用，降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。
T64297	Triton X-100
	Triton X-100 是一种溶解脂膜的非变性洗涤剂。Triton X-100 通常用于实验室，并在生产过程的不同阶段应用于疫苗。Triton X-100 被列为某些疫苗,包括裂解病毒流感疫苗的赋形剂。Triton X-100 是一种非离子表面活性剂。
T14775	Bragsin2 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2	Others	Others
	Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) 是非竞争性的核苷酸交换因子 BRAG2选择性抑制剂，其 IC50值为 3 μM。它能够结合到 BRAG2 的 PH 结构域和磷脂双分子层的界面处，使 BRAG2 无法激活磷脂化的 Arf GTPase。它能够影响乳腺癌干细胞。
T22070	DBIBB	LPA Receptor	GPCR/G Protein
	DBIBB 是一种特异性溶血磷脂酸 (LPA2) 的 2 型 G 蛋白偶联受体的非脂质激动剂，是一种能够治疗高强度γ 射线对造血和胃肠系统引起的急性放射综合征的潜在活性分子，是一种作未有机合成和药物研究中的中间体。 DBIBB 可用于制备各种化合物，可减轻胃肠道辐射综合征，增加肠隐窝存活率和肠细胞增殖，并减少细胞凋亡。
T8902	DOTMA Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium	Others	Others
	DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。
T25885	NSC12404 CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404
	NSC-12404 is a selective non-lipid LPA2/3 agonist.
T74238	BGTC
	BGTC 是一种非氨基酸阳离子脂质。BGTC 可用于核酸递送。
T74445	ZA3-Ep10
	ZA3-Ep10是一种两性离子的脂质，用于合成脂质纳米颗粒，用于体内 RNA 传递和非病毒 CRISPR/Cas 基因编辑。
T74313	MVL5
	MVL5 是一种不可降解的多价阳离子脂质。MVL5 是一种高效的 DNA 和 siRNA 载体。
T35801	ML-262
	ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM).
T62029	ML261
	ML261 是肝脂滴形成的抑制剂，IC50值为 69.7 nM。ML261 在非酒精性脂肪性肝病 (NAFLD) 和炎症中具有研究价值。
T35462	(±)11-HETE
	(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid . The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T36558	(±)9-HETE
	(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T37255	12-methyl Myristic Acid methyl ester
	12-methyl Myristic acid methyl ester is a methylated fatty acid methyl ester that has been found in vermicomposts of cattle manure, carica papaya leaves, and cuticular wax of K. africana. It is a volatile compound in lipid-lowering granulated tea. Levels of 12-methyl myristic acid methyl ester are decreased in T. cruzi treated with nifurtimox compared to non-treated controls.
T78658	Pemvidutide TFA
	Pemvidutide (TFA) 是一款针对GLP-1R/GCGR的双重激动剂，有助于显著降低体重、肝脏脂肪以及血清脂质水平。该化合物主要适用于非酒精性脂肪性肝炎（NASH）和肥胖症的研究领域。
T78071	3-Methylglutaconic acid β-Methylglutaconic acid	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	3-Methylglutaconic acid 是MGTA (3-甲基戊二酸尿症) 的主要积累代谢物，能够诱发脂质和蛋白质的氧化损伤，减弱大脑皮层上清液的非酶促抗氧化防御，导致氧化应激。此化合物适用于研究大脑损伤相关疾病。
T38296	Alamethicin F50 Alamethicin F50
	Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most abundant designated as alamethicin F50/5. Alamethicin F50 forms voltage-dependent ion channels in lipid membranes and acts as a lytic agent. It induces lysis of leukocytes (IC50 = 54 and 80 μM for rat mast cells and mouse spleen lymphocytes, respectively) and exhibits antibacteria...
T79783	NSC 48160	Apoptosis	Apoptosis
	NSC 48160对胰腺癌细胞具有抑制作用，IC50分别针对CPFAC-1为84.3μM，对BxPC-3为94.5μM。此外，NSC 48160能够诱导胰腺癌细胞(apoptosis)。该化合物亦能改善代谢综合征症状，包括NASH、肥胖及脂质代谢紊乱。
T68485	Apilimod HCl
	Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. It reduces the number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. It also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma ...
T74553	YSK 05
	YSK 05是一种对pH敏感的阳离子脂质，能够改善非病毒载体的胞内转运效率。YSK 05-MEND显示出显著的基因沉默活性和溶血性。通过聚乙二醇化处理，YSK 05有效克服了对内体逃逸的抑制，从而在体外和体内均显著增强了siRNA的传递效率。
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) 可降低 HepG2 和 3T3-L1 细胞中的脂质含量并激活AMPK 通路。AMPK activator 6 对血清中甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白-C (LDL-C) 和其他生化指标的增加有显著的抑制作用。AMPK activator 6 在非酒精性脂肪肝（NAFLD）和代谢综合征中有研究价值。
T37606	Resolvin D5 7(S),17(S)-diHDHA
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.[3] RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in...
T36166	8-iso-15-keto Prostaglandin F2α 8-iso-15-keto Prostaglandin F2α
	8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the in...
T36165	8-iso-13,14-dihydro-15-keto Prostaglandin F2α 8-iso-13,14-dihydro-15-keto Prostaglandin F2α
	8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into ra...
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin...
T37018	OH-Chol
	OH-Chol is a cationic cholesterol derivative.1 OH-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intrat...

化合物

Cat.No: T8461

Target: Apoptosis, PI3K, S1P Receptor

Cat.No: T41324

Synonym: Di((Z)-Non-2-en-1-yl) 9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate

Target: Others

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Cat.No: T37184

Synonym: 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid

Target: Phosphatase

Cat.No: T22812

Synonym: GRI 977143

Target: LPA Receptor

Cat.No: T14933

Target: Others

Tinoridine hydrochloride

Cat.No: T4313

Synonym: 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride

Target: COX, Glutathione Peroxidase

Tirilazad mesylate

Cat.No: T28978

Synonym: U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate

Target: Antiviral

Cat.No: T64297

Cat.No: T14775

Synonym: 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2

Target: Others

Cat.No: T22070

Target: LPA Receptor

Cat.No: T8902

Synonym: Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

Target: Others

Cat.No: T25885

Synonym: CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404

Cat.No: T74238

Cat.No: T74445

Cat.No: T74313

Cat.No: T35801

Cat.No: T62029

Cat.No: T35462

Cat.No: T36558

12-methyl Myristic Acid methyl ester

Cat.No: T37255

Pemvidutide TFA

Cat.No: T78658

3-Methylglutaconic acid

Cat.No: T78071

Synonym: β-Methylglutaconic acid

Target: GABA Receptor

Alamethicin F50

Cat.No: T38296

Synonym: Alamethicin F50

Cat.No: T79783

Target: Apoptosis

Cat.No: T68485

Cat.No: T74553

AMPK activator 6

Cat.No: T62052

Cat.No: T37606

Synonym: 7(S),17(S)-diHDHA

8-iso-15-keto Prostaglandin F2α

Cat.No: T36166

Synonym: 8-iso-15-keto Prostaglandin F2α

8-iso-13,14-dihydro-15-keto Prostaglandin F2α

Cat.No: T36165

Synonym: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Cat.No: T35881

MBX-8025 (sodium salt)

Cat.No: T35799

Cat.No: T37018

Cat. No.	Product Name	Target	Signaling Pathways
T19161	7α-Hydroxycholesterol	Others	Others
	7α-Hydroxycholesterol 是一种由酶促氧化和非酶促氧化形成的胆固醇氧化物，可用作脂质过氧化的生物标志物。
T37526	2-Oleoylglycerol 2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR	Endocrinology/Hormones; GPCR/G Protein
	2-Oleoylglycerol 是一种存在于棕榈仁、葵花籽和米糠中的脂质。2-Oleoylglycerol 可当作一种 GPR119 激动剂，具有神经保护作用，可诱导胰高血糖素样肽 1 (GLP-1) 分泌。2-Oleoylglycerol 可用于非酒精性脂肪性肝炎造模。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。

天然产物

7α-Hydroxycholesterol

Cat.No: T19161

Target: Others

2-Oleoylglycerol

Cat.No: T37526

Synonym: 2-Oleoyl Glycerol,2-OG,2-Monoolein

Target: GPR

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

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