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Search Results for " nicotine "

45

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20533	NNK Nicotine-derived nitrosamine ketone	Lipoxygenase	Metabolism
	NNK (Nicotine-derived nitrosamine ketone) 是尼古丁亚硝化衍生物。它可以激活 ERK1/2和 PKCα，并在 Ser70 激活 Bcl2磷酸化，以及在 Thr58和 Ser62激活 c-Myc。它可用于构建肺癌小鼠模型，以及诱导人肺癌细胞的增殖和存活。
T68439	Nicotine dicitrate
	Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T23279	RuBi-Nicotine	Others	Others
	Nicotinic receptor agonist
T69804	Nicotine monomethiodide
	Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T69439	Nicotine tartrate
	Nicotine tartrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T70625	Nicotine lactate
	Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist.
T68289	Nicotine hemicitrate
	Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T10871	CP-809101 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	CP-809101 hydrochloride 是选择性 5-HT2C 受体激动剂，对于人类 5-HT2C/5-HT2B/5-HT2A 受体。
T4246	Varenicline dihydrochloride	AChR	Neuroscience
	Varenicline dihydrochloride是一种选择性 α4β2 烟碱乙酰胆碱受体部分激动剂。
T10432L	AZD-8529 mesylate	GluR	Neuroscience
	AZD-8529 mesylate 是高度选择性的可口服mGluR2正向调节剂，EC50值为 285 nM。它在 20-25 M 时，对 mGluR1、3、4、5、6、7 和 8 亚型没有显示正变构调节剂反应。
T8702	SKF-83566	Dopamine Receptor; 5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂，Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂，可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。
T69803	Pelanserin Free Base
	Pelanserin Free Base is an antagonist of the 5-HT2 and α1-adrenergic receptors.
T20366	beta-Nicotyrine bata-碱二烯,Nicotyrine,alpha-Nicotyrine	Others	Others
	beta-Nicotyrine 是一种 Nicotine 的代谢物。它是一种微量的烟草生物碱，提取自普通烟草植物的叶子和香烟烟雾冷凝物。
T77676	(Z)-Metanicotine 2HCl (Z)-Metanicotine 2HCl(1129-68-6 Free base)	Others	Others
	(Z)-Metanicotine 2HCl 具有镇痛活性，可用于治疗中枢系统疾病。
T36709	N’-Nitrosonornicotine
	N’-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N’-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N’-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S....
T69134	Metanicotine
	Metanicotine is a selective nicotinic agonist with antinociceptive properties.
T13241	UB 165 fumarate UB-165 fumarate,UB165 fumarate	AChR	Neuroscience
	UB 165 fumarate 是 nAChR 的激动剂，α4β2 亚型的部分激动剂，是 α3β2 亚型的全激动剂，其在大鼠脑中测得的结合到 [3H]-nicotine 的 Ki 值为 0.27 nM，可用于研究神经系统疾病。
T13080L	Taranabant MK-0364	Cannabinoid Receptor	GPCR/G Protein
	Taranabant (MK-0364) 是一种具有选择性和高效性的 cannabinoid 1 (CB1) 受体反向激动剂，可用于研究肥胖和尼古丁依赖。
T61562	CB1R Allosteric modulator 3	cAMP; Cannabinoid Receptor	GPCR/G Protein
	CB1R Allosteric modulator 3 是一种有效的 CB1R 调制剂。CB1R Allosteric modulator 3 抑制 cAMP 和 β-Arrestin ，可用于研究肥胖和尼古丁成瘾。
T4132	BPTU BMS-646786	P2Y Receptor	GPCR/G Protein; Neuroscience
	BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂，能够阻断位于胃肠道神经肌肉接头的 P2Y1受体，具有抗血栓活性。
T1366	3-Pyridylacetic acid hydrochloride	DPP-4	Proteases/Proteasome
	3-Pyridylacetic acid hydrochloride （3-PAA-HCl）尼克酸的高同系物，是尼古丁（和其它烟草生物碱）的分解产物，还可与胺、醇和羧酸等反应，也可在反应中作为酸催化剂。
T30640	Butyrylcholine BA 51 090059,BA-51-090059,BA 51090059,BA 51-090059
	Butyrylcholine is a novel colonic ion transport regulator produced by colonic epithelial cells that stimulates nicotine and muscarinic receptors.
T71262	AZD-8418
	AZD-8418 is an mGlu2 receptor positive allosteric modulators that attenuates nicotine-taking and nicotine-seeking behavior. Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, 17.5, and 58.3 mg/kg) deceased nicotine self-administration and had no effect on food-maintained responding. Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. The inhibition of nicotine self-administration by c...
T16563	Pozanicline ABT-089	AChR	Neuroscience
	Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a no
T26791	BHF-177
	BHF-177 is a positive allosteric modulator of the GABAB receptor. BHF-177 reduces self-administration of nicotine in animal studies.
T41210	PA Nic
	PA Nic is a coumarin-caged nicotine. Releases nicotine when exposed to 390 ± 10 nm wavelength light (λmax = 404 nm). Suitable for two-photon uncaging at <900 nm (Maximum two-photon cross-section at 810 nm). Extinction coefficient (ε) 17,400 M-1cm-1. Evokes nicotinic currents in mouse brain slices under one and two-photon activation conditions.
T70987	AT-1001
	AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal prepar...
T10308	AMPD2 inhibitor 1	Others	Others
	AMPD2 inhibitor 1 is an inhibitor of adenosine monophosphate deaminase 2 (AMPD2), used in the research of salt craving, sugar craving, umami craving, and addictions including tobacco, drug, nicotine and alcohol addictions.
T26807	Bifeprunox Mesylate Bifeprunox,DU 127090,DU-127090,DU127090
	Bifeprunox is a partial dopamine and serotonin agonist potentially for the treatment of schizophrenia. Bifeprunox suppresses in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. Bifeprunox influences nicotine-seek
T32833	Lobeline, (+)- (+)-Lobeline
	Lobeline, (+)- is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, a
TP1490	Proadrenomedullin (1-20), human
	Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrena
T71398	RO5126946
	RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946's effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.
T12738	Rivanicline hemioxalate RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate	Others	Others
	Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂，对 α4β2 亚型有高度选择性(Ki= 26 nM)，比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。
T38903	(S)-UFR2709 (S)-UFR2709
	(S)-UFR2709 is a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting a greater affinity for α4β2 nAChRs compared to α7 nAChRs. It effectively reduces anxiety and ethanol consumption, as well as ethanol preference, in alcohol-preferring rats. Additionally, (S)-UFR2709 functions as an anxiolytic agent and holds the potential for investigating nicotine addiction.
T23228	(R,S)-Anatabine (tartrate) (2743-90-0 free base) (R,S)-Anatabine (tartrate)	Others	Others
	Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tart
T75309	R-(+)-Cotinine
	R-(+)-Cotinine ((+)-Cotinine) 是一种尼古丁代谢物，在广泛的药理靶标中缺乏显着活性。R-(+)-Cotinine 可以增强人 α7nAChR 中的 Ach 诱发电流。
T39771	nAChR agonist CMPI hydrochloride
	nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.
T37094	(S)-UFR2709 hydrochloride (S)-UFR2709 hydrochloride
	(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2]. Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, whi...
T76342	α-Conotoxin M I
	α-Conotoxin M I 是 mAChR 和α1β1γδnAChR 的选择性和有效的抑制剂，但对尼古丁刺激的多巴胺释放无影响。α-Conotoxin 毒素是一种小的、富含二硫的多肽，竞争性地抑制肌肉和神经元的尼古丁 AChR。
T35745	Marcfortine A
	Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subuni...
T37202	CC4 CC4
	High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats. Sala et al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 ...
T78135	Nicotelline Nicotellin
	Nicotelline（Nicotellin）是一种与尼古丁相关的生物碱，作为人类cDNA表达的细胞色素P-450 2A6（CYP2A6）的弱抑制剂，不显著抑制该酶介导的香豆素7-羟基化反应，在300 μM浓度下效果更是如此。此外，Nicotelline还被用作烟草烟雾中颗粒物（PM）的示踪剂和生物标记物。
T36554	TMB 8 (hydrochloride)
	TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration o...
T83665	α-Helical CRF (9-41) TFA α-Helical Corticotropin-Releasing Factor (9-41)
	α-Helical CRF (9-41) 是一种合成的皮质酮释放因子（CRF）拮抗剂。它在0.5至5 µM浓度范围内，能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素（ACTH）。在体内研究中，α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放，并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外，α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间，并减少小鼠的类似暴饮暴食的乙醇消费。
T36241	Arecaidine propargyl ester (hydrobromide)
	Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai...

化合物

Cat.No: T20533

Synonym: Nicotine-derived nitrosamine ketone

Target: Lipoxygenase

Nicotine dicitrate

Cat.No: T68439

RuBi-Nicotine

Cat.No: T23279

Target: Others

Nicotine monomethiodide

Cat.No: T69804

Nicotine tartrate

Cat.No: T69439

Nicotine lactate

Cat.No: T70625

Nicotine hemicitrate

Cat.No: T68289

CP-809101 hydrochloride

Cat.No: T10871

Target: 5-HT Receptor

Varenicline dihydrochloride

Cat.No: T4246

Target: AChR

AZD-8529 mesylate

Cat.No: T10432L

Target: GluR

Cat.No: T8702

Target: Dopamine Receptor, 5-HT Receptor, AChR

Pelanserin Free Base

Cat.No: T69803

beta-Nicotyrine

Cat.No: T20366

Synonym: bata-碱二烯,Nicotyrine,alpha-Nicotyrine

Target: Others

(Z)-Metanicotine 2HCl

Cat.No: T77676

Synonym: (Z)-Metanicotine 2HCl(1129-68-6 Free base)

Target: Others

N’-Nitrosonornicotine

Cat.No: T36709

Cat.No: T69134

UB 165 fumarate

Cat.No: T13241

Synonym: UB-165 fumarate,UB165 fumarate

Target: AChR

Cat.No: T13080L

Synonym: MK-0364

Target: Cannabinoid Receptor

CB1R Allosteric modulator 3

Cat.No: T61562

Target: cAMP, Cannabinoid Receptor

Cat.No: T4132

Synonym: BMS-646786

Target: P2Y Receptor

3-Pyridylacetic acid hydrochloride

Cat.No: T1366

Target: DPP-4

Cat.No: T30640

Synonym: BA 51 090059,BA-51-090059,BA 51090059,BA 51-090059

Cat.No: T71262

Cat.No: T16563

Synonym: ABT-089

Target: AChR

Cat.No: T26791

Cat.No: T41210

Cat.No: T70987

AMPD2 inhibitor 1

Cat.No: T10308

Target: Others

Bifeprunox Mesylate

Cat.No: T26807

Synonym: Bifeprunox,DU 127090,DU-127090,DU127090

Cat.No: T32833

Synonym: (+)-Lobeline

Proadrenomedullin (1-20), human

Cat.No: TP1490

Cat.No: T71398

Rivanicline hemioxalate

Cat.No: T12738

Synonym: RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate

Target: Others

Cat.No: T38903

Synonym: (S)-UFR2709

(R,S)-Anatabine (tartrate) (2743-90-0 free base)

Cat.No: T23228

Synonym: (R,S)-Anatabine (tartrate)

Target: Others

Cat.No: T75309

nAChR agonist CMPI hydrochloride

Cat.No: T39771

(S)-UFR2709 hydrochloride

Cat.No: T37094

Synonym: (S)-UFR2709 hydrochloride

α-Conotoxin M I

Cat.No: T76342

Cat.No: T35745

Cat.No: T37202

Synonym: CC4

Cat.No: T78135

Synonym: Nicotellin

TMB 8 (hydrochloride)

Cat.No: T36554

α-Helical CRF (9-41) TFA

Cat.No: T83665

Synonym: α-Helical Corticotropin-Releasing Factor (9-41)

Arecaidine propargyl ester (hydrobromide)

Cat.No: T36241

Cat. No.	Product Name	Target	Signaling Pathways
TN4655	Nicotine 1'-N-oxide	Others	Others
	Nicotine 1'-N-oxide is a natural product from tobacco smoke.
T8044	Ajmalicine 阿吗里新,Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ajmalicine (Raubasine) 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂，IC50 为 72.3 μM。Ajmalicine 还可用于降压、蛇毒，具有镇静活性。
TN1081	Hirsuteine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物，非竞争性地拮抗烟碱介导的多巴胺释放。
T7671	Myosmine 麦司明,麦斯明	Others; AChR	Neuroscience; Others
	Myosmine 是存在于木贼中的一种烟草生物碱，对 a4b2 烟碱乙酰胆碱受体具有低亲和力，Ki 值为 3300 nM。
T1202	Cotinine (-)-Cotinine,S-(-)-Cotinine,(S)-Cotinine,NIH-10498,可替宁	Endogenous Metabolite; AChR	Metabolism; Neuroscience
	Cotinine (NIH-10498) 是烟草中的生物碱, 也是尼古丁的主要代谢物。Cotinine (NIH-10498) 是测量烟草烟雾成分的生物指标。
T68953	Arecoline	Reactive Oxygen Species; AChR	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Arecoline 是一种来自棕榈科植物槟榔的天然生物碱，是有效的烟碱和毒蕈碱乙酰胆碱受体的部分激动剂。Arecoline 具有抗焦虑和抗寄生虫活性，可诱导氧化应激，可用于研究阿尔茨海默病和老年性痴呆。
T19361	Hydroxycotinine	Others	Others
	Hydroxycotinine is the main nicotine metabolite detected in smokers' urine.
T72382	Dihydro-β-erythroidine
	Dihydro-β-erythroidine是竞争性nicotinic receptor拮抗剂，能阻断尼古丁的辨别刺激特性并抑制其诱导的抗焦虑作用。
T22357	Lobeline sulfate 硫酸山梗菜碱,Lobelin sulphate	Others	Others
	Lobelin sulphate is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in insomnia, and smoking cessation, peripheral vascular disorders, respiratory disor
T19128	3-Pyridineacetic acid	Others	Others
	3-Pyridineacetic acid is a homolog of nicotinic acid, a breakdown product of nicotine and other tobacco alkaloids.
T69254	Ajmalicine hydrochloride Raubasine hydrochloride
	Ajmalicine (Raubasine) hydrochloride 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine hydrochloride 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂，其 IC50为 72.3 μM。Ajmalicine hydrochloride 还可用于降压、蛇毒，具有镇静活性。

天然产物

Nicotine 1'-N-oxide

Cat.No: TN4655

Target: Others

Cat.No: T8044

Synonym: 阿吗里新,Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin

Target: Adrenergic Receptor

Cat.No: TN1081

Target: Dopamine Receptor

Cat.No: T7671

Synonym: 麦司明,麦斯明

Target: Others, AChR

Cat.No: T1202

Synonym: (-)-Cotinine,S-(-)-Cotinine,(S)-Cotinine,NIH-10498,可替宁

Target: Endogenous Metabolite, AChR

Cat.No: T68953

Target: Reactive Oxygen Species, AChR

Hydroxycotinine

Cat.No: T19361

Target: Others

Dihydro-β-erythroidine

Cat.No: T72382

Lobeline sulfate

Cat.No: T22357

Synonym: 硫酸山梗菜碱,Lobelin sulphate

Target: Others

3-Pyridineacetic acid

Cat.No: T19128

Target: Others

Ajmalicine hydrochloride

Cat.No: T69254

Synonym: Raubasine hydrochloride

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