Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂,对 α4β2 亚型有高度选择性(Ki= 26 nM),比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 18,698 | 10-14周 |
Rivanicline hemioxalate 的其他形式现货产品:
产品描述 | Rivanicline hemioxalate, also known as RJR-2403 hemioxalate or (E)-Metanicotine hemioxalate, is a chemical compound acting as a neuronal nicotinic receptor agonist with pronounced selectivity for the α4β2 receptor subtype, showing over 1,000-fold greater selectivity for this subtype (Ki=26 nM) compared to α7 receptors (Ki=3.6 μM). Its in vitro studies demonstrate no significant activation of nAChRs in PC12 cells, muscle type nAChRs, or muscarinic receptors at concentrations up to 1 mM. Furthermore, Rivanicline displayed less than one-tenth the potency of nicotine in inducing ileum contraction, with substantially lower efficacy, and failed to antagonize nicotine-induced stimulation of muscle or ganglionic nAChR functions, with an IC50 value greater than 1 mM. Chronic exposure to Rivanicline at 10 microM led to up-regulation of high-affinity nAChRs in M10 cells, mimicking effects observed with nicotine. In vivo studies revealed that Rivanicline significantly reversed scopolamine-induced amnesia and improved working and reference memory in a rat model, while being 15 to 30 times less potent than nicotine in affecting body temperature, respiration, and other physiological responses. Metanicitone’s potency was approximately five times lower than nicotine in tail-flick tests following subcutaneous administration, yet slightly more potent upon central administration. |
别名 | RJR-2403 hemioxalate, (E)-Metanicotine hemioxalate |
分子量 | 207.23 |
分子式 | C12H16N2O4 |
CAS No. | T12738 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (241.28 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.8256 mL | 24.1278 mL | 48.2556 mL | 120.6389 mL |
5 mM | 0.9651 mL | 4.8256 mL | 9.6511 mL | 24.1278 mL | |
10 mM | 0.4826 mL | 2.4128 mL | 4.8256 mL | 12.0639 mL | |
20 mM | 0.2413 mL | 1.2064 mL | 2.4128 mL | 6.0319 mL | |
50 mM | 0.0965 mL | 0.4826 mL | 0.9651 mL | 2.4128 mL | |
100 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 1.2064 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Rivanicline hemioxalate T12738 Others RJR2403 Hemioxalate Metanicotine Hemioxalate Metanicotine RJR-2403 RJR-2403 Hemioxalate RJR2403 RJR 2403 RJR-2403 hemioxalate Rivanicline Hemioxalate RJR 2403 Hemioxalate Rivanicline (E)-Metanicotine hemioxalate Inhibitor inhibitor inhibit