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Search Results for " mutagenic "

23

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13457	(Z)-9-Propenyladenine (Z)-替诺福韦酯杂质,(Z)-Mutagenic Impurity of Tenofovir Disoproxil	Others	Others
	(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
T12127	9-Propenyladenine Mutagenic Impurity of Tenofovir Disoproxil,替诺福韦酯杂质,Tenofovir Impurity 2	Others	Others
	9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.
T5363	Tempo 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy	Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化，也可诱导DNA 链断裂。
T20760	Benzidine orange DCC-1802,颜料橙13,Polymo Orange GR,Oralith Orange PG,DCC 1802,DCC1802	Others	Others
	Benzidine orange (DCC-1802) 具有致突变和致癌活性。
T15611	JH-RE-06	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	JH-RE-06是一种REV1-REV7互作抑制剂，IC50为0.78 μM，Kd 为0.42 μM。它靶向与 POLζ 的 REV7 亚基相互作用的 REV1，可改善化疗效果。它通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成。
T68110	Moxnidazole
	Moxnidazole 是一种5-硝基咪唑，在微生物试验和果蝇中具有诱变性，诱导小鼠体细胞的遗传改变。
T4169	N-Nitroso-N-methylurea 1-甲基-1-亚硝基脲,1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	N-Nitroso-N-methylurea (Methylnitrosourea) 是一种具有烷基化、致癌和致突变特性的亚硝基脲化合物。它靶向多种动物器官，可引起各种癌症和变性疾病，可用于重氮甲烷合成。
T9049	Difurazon hydrochloride	Others	Others
	Difurazon hydrochloride 是一种致突变药物。它可能已用于治疗细菌性痢疾。它是动物饲料中的抗菌促生长剂。
T19859	Nicosulfuron Milagro,Accent,Motivell,烟嘧磺隆	Others	Others
	Nicosulfuron (Milagro) 是一种磺酰脲类的选择性除草剂，常用作出苗后的除草剂，保护玉米作物免受杂草的侵害。它也能够降低乙酰乳酸合酶的活性。
T1488	Procarbazine hydrochloride NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Procarbazine hydrochloride (NSC-77213 HCl) 是一种烷化剂，是甲基肼衍生物的盐酸盐，具有抗肿瘤和诱变活性。
T37514	Hydroxy Dimetridazole	Drug Metabolite	Metabolism
	Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物，可用于对抗原生动物感染。
T31601	Eclanamine maleate U-48753E,U48,753E,U-48,753E,U48753E,U 48,753E
	Eclanamine was discovered to be slightly mutagenic in the AS52 assay, and a potential agent which was subjected to a battery of short-term assays for genetic activity.
T33623	Necatorin Necatorine
	Necatorin is a mutagenic compound from edible mushroom Lactarius necator.
T71210	S7958
	S7958 is a is a TAS2R8 antagonist. It was found to be non-mutagenic in vitro.
T71422	S6821
	S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo.
T23797	Bis(diazoacetyl)butane 1,4-Bis-diazoacetylbutane,Supermutagen,1,4-Bis(diazoacetyl)butane,DAB (mutagen)
	Bis(diazoacetyl)butane is a mutagen and traditionally related to radio-mimetic chemical mutagens due to the similarity of appearance of mutagenic action of this mutagen and physical mutagens. It also has anti-tumor and carcinogenic activity.
T28894	SZV558 SZV 558,SZV-558
	SZV558 is a potent inhibitor of both human and rodent MAO-B. SZV558 is safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD.
T40933	Bromochloroacetonitrile
	Bromochloroacetonitrile is a chemical compound that is formed as a by-product during the chlorine disinfection process of water that contains natural organic material. This compound exhibits direct mutagenic activity and can induce DNA strand breakage.
T63236	AZD4625
	AZD4625 (Compound 21) 是选择性的、高效的、口服具有活力的、共价的和变构的突变 GTPaseKRASG12C 抑制剂。
T9233	Metronidazole acetic acid	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Metronidazole acetic acid 是 Metronidazole 的代谢产物，在细菌中具有诱变活性。Metronidazole 是硝基咪唑类抗生素，杀螨剂和抗原生动物剂。
T78460	1-Methylpyrene
	1-Methylpyrene是一种环境污染物和已知的啮齿动物致癌物，它的诱变活性依赖于CYP和磺酰转移酶（SULT）系列酶的连续活化。该化合物可诱导染色体缺失和有丝分裂障碍，可能机制为对有丝分裂纺锤体和中心粒的干扰。
T74622	Antibacterial agent 109
	Antibacterial agent 109 (Compound C-2) 是一种有效的抗细菌 (antibacterial) 剂，对革兰氏阳性和革兰氏阴性细菌均有效，且无诱变作用。Antibacterial agent 109 通过阻断新肽链的延伸抑制蛋白质合成。
T36235	5-Chlorouracil
	5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. ...

化合物

(Z)-9-Propenyladenine

Cat.No: T13457

Synonym: (Z)-替诺福韦酯杂质,(Z)-Mutagenic Impurity of Tenofovir Disoproxil

Target: Others

9-Propenyladenine

Cat.No: T12127

Synonym: Mutagenic Impurity of Tenofovir Disoproxil,替诺福韦酯杂质,Tenofovir Impurity 2

Target: Others

Cat.No: T5363

Synonym: 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy

Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism

Benzidine orange

Cat.No: T20760

Synonym: DCC-1802,颜料橙13,Polymo Orange GR,Oralith Orange PG,DCC 1802,DCC1802

Target: Others

Cat.No: T15611

Target: DNA/RNA Synthesis

Cat.No: T68110

N-Nitroso-N-methylurea

Cat.No: T4169

Synonym: 1-甲基-1-亚硝基脲,1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea

Target: Others, DNA Alkylator/Crosslinker

Difurazon hydrochloride

Cat.No: T9049

Target: Others

Cat.No: T19859

Synonym: Milagro,Accent,Motivell,烟嘧磺隆

Target: Others

Procarbazine hydrochloride

Cat.No: T1488

Synonym: NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Hydroxy Dimetridazole

Cat.No: T37514

Target: Drug Metabolite

Eclanamine maleate

Cat.No: T31601

Synonym: U-48753E,U48,753E,U-48,753E,U48753E,U 48,753E

Cat.No: T33623

Synonym: Necatorine

Cat.No: T71210

Cat.No: T71422

Bis(diazoacetyl)butane

Cat.No: T23797

Synonym: 1,4-Bis-diazoacetylbutane,Supermutagen,1,4-Bis(diazoacetyl)butane,DAB (mutagen)

Cat.No: T28894

Synonym: SZV 558,SZV-558

Bromochloroacetonitrile

Cat.No: T40933

Cat.No: T63236

Metronidazole acetic acid

Cat.No: T9233

Target: Antibacterial, Antibiotic, Parasite

Cat.No: T78460

Antibacterial agent 109

Cat.No: T74622

Cat.No: T36235

Cat. No.	Product Name	Target	Signaling Pathways
T19412	Macrozamin 甲基氧化偶氮甲醇樱草糖苷,大泽明素	Others	Others
	Macrozamin 是苏铁的一种主要成分，表现出致癌，致畸，诱变和神经毒性作用。
T2895	Lupeol Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol	Apoptosis; Androgen Receptor; Akt	Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; PI3K/Akt/mTOR signaling
	Lupeol (Monogynol B) 是一个活跃的五环三萜，具有抗氧化剂、抗肿瘤和抗炎活性。它是一种雄激素受体抑制剂，可研究癌症，特别是雄激素依赖表型和去势抵抗表型的前列腺癌。
T2863	p-Coumaric acid para-Coumaric Acid,4-Hydroxycinnamic acid,trans-4-Hydroxycinnamic acid,对香豆酸,Trans-p-Coumaric acid,4-Coumaric acid,P-Hydroxycinnamic acid	Endogenous Metabolite; Antibiotic	Metabolism; Microbiology/Virology
	p-Coumaric acid (para-Coumaric Acid) 是肉桂酸的丰富异构体，具有抗诱变和抗肿瘤特性。
TJS0405	Lucidin NSC 30546,芦西定；卢西定,卢西定,亮黄素,Henine	Others	Others
	Lucidin (NSC-30546) 是茜草中的一种天然成分，可以诱导细菌和哺乳动物细胞的突变。
TN1683	Gentisin 龙胆根素,龍膽根素	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Gentisin 是一种提取于 Gentianae radix (Gentianaceae) 的天然化合物，具有诱变活性。
T19317	Ethyl phenylacetate	Others	Others
	Ethyl phenylacetate 是天然香料，其感官阈值接近 73 µg/L。它可使葡萄酒具有强烈的蜂蜜样特性。它是一种毒性较小且对环境更友好的溶剂，是非诱变性的，并且是犹太食品添加剂。
T5746	Dictamine Dictamnine,Dectamine,白鲜碱	Apoptosis; Anti-infection; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Dictamine (Dectamine) 显示抗胆碱酯酶、抗炎、致突变、抗菌和抗真菌活性。它具有在人子宫颈、结肠和口腔癌细胞中发挥细胞毒性的能力。
T2801	Aristolochic acid A 马兜铃酸,TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid	Others; NF-κB	NF-κB; Others
	Aristolochic acid A (TR 1736) 是植物提取物 Aristolochic acids 的主要成分，主要存在于 Aristolochia 和 Asarum 草本植物中。它降低人细胞中膀胱癌相关BLCAP 基因表达。它显著降低激活蛋白1 (AP-1) 和NF-κB 活性。
T4832	Cytosine 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine,胞嘧啶	Endogenous Metabolite	Metabolism
	Cytosine (6-Aminopyrimidin-2(1H)-one) 是 DNA 和 RNA 中发现的四个主要碱基之一。它修饰表现出与表观遗传多样性和衰老有关的昼夜节律振荡。
TN1078	Seneciphylline 千里光菲灵碱,千里光非灵	P450; GST	Metabolism; oxidation-reduction
	Seneciphylline 是一种有毒的吡咯烷核生物碱，存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性，但导致细胞色素 P-450 和相关单加氧酶特性的抑制。
T19165	8-Hydroxyguanine 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine	Endogenous Metabolite	Metabolism
	8-Hydroxyguanine (8 Hydroxyguanine)是由活性氧物质产生的主要诱变前损伤。它导致G-T和A-C置换。8-Hydroxyguanine 是一种 RNA 氧化和 DNA 氧化损伤的生物标记物。8-Hydroxyguanine 具有致突变性和致癌性，常用于癌症实验中。
TN1711	Gossypetin	Antioxidant; p38 MAPK; MAPK; Antibacterial	MAPK; Microbiology/Virology; oxidation-reduction
	Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮，是一种有效的 MKK3 和 MKK6 抑制剂，可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用，它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。
T7031	Aristolochic acid B 马兜铃酸B,Aristolochic Acid II,马兜铃酸 B	DNA	DNA Damage/DNA Repair
	Aristolochic acid B (Aristolochic Acid II) 是一种来自马兜铃科分类群的天然产物，是马兜铃酸的主要成分之一。已知马兜铃酸是诱变剂和致癌物质。它在体内表现出比 Aristolochic acid I 更大的致癌风险。
T4918	DL-Glyceraldehyde Glyceric aldehyde,DL-甘油醛晶体	Reductase	Endocrinology/Hormones; Metabolism
	DL-Glyceraldehyde (Glyceric aldehyde) 是由酶甘油醛脱氢酶的作用产生的，该酶使用 NADP 作为辅因子将甘油转化为甘油醛。它是一种高活性化合物，可以修饰和交联蛋白质。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
T13531	Aflatoxicol 黄曲霉毒醇,Aflatoxin R0	Others	Others
	Aflatoxin (Aflatoxin R0) is a mutagenic and carcinogenic mycotoxin derived from aflatoxin B1 through metabolic processes facilitated by Rhizopus spp.
T13544	Altertoxin I Dihydroalterperylenol	Others	Others
	Altertoxin I (Dihydroalterperylenol) is a quinone-type mycotoxin produced by Alternaria alternata fungi. It is mutagenic and cytotoxic and can weakly disrupt metabolic communication.
TN4346	Jaconine	Others	Others
	Jaconine, jacoline,jacobine, and jacozine, the hepatotoxic alkaloids, are potentially carcinogenic, mutagenic, and teratogenic and may pose health hazards to the human consumer.
TN3608	Catalpin	Others	Others
	Catalpin exhibited mutagenic activity towards Salmonella typhimurium strain TA100 in the presence and absence of rat liver homogenate (S9) mix in Ames' test.

天然产物

Cat.No: T19412

Synonym: 甲基氧化偶氮甲醇樱草糖苷,大泽明素

Target: Others

Cat.No: T2895

Synonym: Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol

Target: Apoptosis, Androgen Receptor, Akt

p-Coumaric acid

Cat.No: T2863

Synonym: para-Coumaric Acid,4-Hydroxycinnamic acid,trans-4-Hydroxycinnamic acid,对香豆酸,Trans-p-Coumaric acid,4-Coumaric acid,P-Hydroxycinnamic acid

Target: Endogenous Metabolite, Antibiotic

Cat.No: TJS0405

Synonym: NSC 30546,芦西定；卢西定,卢西定,亮黄素,Henine

Target: Others

Cat.No: TN1683

Synonym: 龙胆根素,龍膽根素

Target: DNA/RNA Synthesis

Ethyl phenylacetate

Cat.No: T19317

Target: Others

Cat.No: T5746

Synonym: Dictamnine,Dectamine,白鲜碱

Target: Apoptosis, Anti-infection, Antibacterial, Antifungal

Aristolochic acid A

Cat.No: T2801

Synonym: 马兜铃酸,TR 1736,Aristolochin,Aristolochine,Aristolochic Acid I,Aristolochic Acid

Target: Others, NF-κB

Cat.No: T4832

Synonym: 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine,胞嘧啶

Target: Endogenous Metabolite

Cat.No: TN1078

Synonym: 千里光菲灵碱,千里光非灵

Target: P450, GST

8-Hydroxyguanine

Cat.No: T19165

Synonym: 8 Hydroxyguanine,7,8-dihydro-8-oxoguanine,2-Amino-6,8-dihydroxypurine

Target: Endogenous Metabolite

Cat.No: TN1711

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

Aristolochic acid B

Cat.No: T7031

Synonym: 马兜铃酸B,Aristolochic Acid II,马兜铃酸 B

Target: DNA

DL-Glyceraldehyde

Cat.No: T4918

Synonym: Glyceric aldehyde,DL-甘油醛晶体

Target: Reductase

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Cat.No: T13531

Synonym: 黄曲霉毒醇,Aflatoxin R0

Target: Others

Cat.No: T13544

Synonym: Dihydroalterperylenol

Target: Others

Cat.No: TN4346

Target: Others

Cat.No: TN3608

Target: Others

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