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Cat. No. | Product Name | Target | Signaling Pathways |
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T7769 |
Nonapeptide-1
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5 |
Others | Others |
Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成,这使得它对治疗某些皮肤病很感兴趣。 | |||
T34321 |
Rhododendrol, (+/-)-
AI3-31843 |
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Rhododendrol, (+/-)-, is an aromatic compound that may be useful in the treatment of hepatic diseases. However, this product is a known pro-oxidant which can be toxic to melanocytes. | |||
T39569 |
Gp100 (25-33), mouse
Mgp100 (25-33),Gp100 (25-33), mouse |
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Gp100 (25-33) corresponds to residues 25 to 33 of the mouse self/tumor antigen glycoprotein (mgp100), which is an enzyme responsible for pigment synthesis. This epitope fragment is found in both normal melanocytes and melanoma cells. | |||
T81563 |
Palmitoyl tetrapeptide-20
PTP20 |
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Palmitoyl tetrapeptide-20(PTP20)为具保护作用的生物活性肽,旨在维护滤泡黑素细胞,常用作化妆品配料。 | |||
T73598 | Tyrosinase | ||
Tyrosinase(Polyphenol oxidase) 是控制黑色素产生的限速酶,由 TYR 基因编码。Tyrosinase 主要存在于皮肤黑素细胞合成的黑素体中。 | |||
T79378 |
IIIM-8
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Melanocortin Receptor | GPCR/G Protein; Neuroscience |
IIIM-8作为一种黑色素生成抑制剂,在体外和体内均表现出显著地抑制色素生成的功效,同时对成人表皮黑色素细胞(HAEM)不表现出细胞毒性。IIIM-8适用于色素沉着症研究。 | |||
T60821 | ACA-28 | ||
ACA-28 (compound 2a) 是ERK MAPK 信号的有效调节剂,可通过过度激活 ERK 诱导细胞凋亡,从而选择性抑制癌细胞生长。ACA-28 对黑色素瘤细胞 (SK-MEL-28) 和正常黑色素细胞 (NHEM) 细胞生长的IC50值分别为 5.3 和 10.1 μM。 | |||
T75714 |
Decapeptide-12
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Decapeptide-12,一个小型寡肽,作为tyrosinase的抑制剂,通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM),Decapeptide-12有效上调SIRT的转录水平,并能减少黑色素细胞中的黑色素含量,适用于黑色素生成、衰老和炎症的研究。 | |||
T75715 |
Nonapeptide-1 acetate salt
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Nonapeptide-1 (Melanostatine-5) acetate salt,一种多肽类激素,是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂,可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成,可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。 | |||
TP1727 |
Gp100 (25-33), human
|
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Gp100 (25-33), human is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2Db and recognized by the T cells.This is amino acids 25 to 33 fragment of human melanoma antigen gp100. This H-2Db res | |||
T83765 |
Dendrogenin A
DDA |
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Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物,通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在,但在多种乳腺癌细胞或黑色素瘤细胞中未发现,且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM),但也是LXR的部分激动剂,在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ,而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外,DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平,并在2... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
T0501 |
Mequinol
4-Hydroxyanisole,Leucobasal,对苯二酚单甲醚,4-Methoxyphenol |
Others | Others |
Mequinol (Leucobasal) 是一种Mercurialis spp 的生物活性成分,常用于皮肤褪色。 | |||
T2S0633 |
Raspberry ketone
Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物,主要用作化妆品的香料和食品增味剂,也可作 PPAR-α激动剂。 | |||
T30048 |
Anemonin (6CI)
Pulsatilla camphor,Anemonin,Anemone camphor |
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Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis progression. | |||
TN1583 |
Dihydromorin
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicating that a non-tumor melanocyte system is more suitable for the screening o | |||
TN4489 | Manassantin A | ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act |