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Search Results for " immunosuppressive effects "

22

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9744	MP07-66	Phosphatase	Metabolism
	MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
T20168	Aurothiomalate sodium 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂，可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂，也是一种抗风湿剂。
T37547	trans-Urocanic Acid
	trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic ...
T41303	Isoflupredone Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone	Others	Others
	Isoflupredone (Isoflupredonum) 是一种合成的皮质类固醇，通过与动物 (如马) 的糖皮质激素和矿皮质激素受体结合抑制炎症细胞和抑制炎症介质的表达在生物体内发挥作用。Isoflupredone 具有抗炎和免疫抑制作用，可应用于治疗各种肌肉骨骼、过敏性和全身炎症性疾病。
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T34952	Trinactin Akd1D,Akd 1D,Akd-1D
	Trinactin is a nonactin homolog that has Immunosuppressive effects.
T30136	Armepavine hydrochloride, (+/-)- DL-Armepavine hydrochloride
	Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice.
T33883	Paramethasone Acetate NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP	Others	Others
	Paramethasone Acetate 是一种合成的糖皮质激素，具有抗炎和免疫抑制作用，可用于治疗系统性红斑狼疮。
T13734	ILS-920	Others	Others
	ILS-920 is a Rapamycin analog characterized by diminished immunosuppressive effects but remarkable neuroprotective properties. It exhibits selective binding affinity towards the immunophilin FKBP52 as well as the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 displays a notable 200-fold preference for FKBP52 over FKBP12.
T61099	Mycophenolic acid sodium
	Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 of 0.24 μM. It has broad antiviral activity against RNA viruses, including influenza. Additionally, mycophenolic acid sodium possesses immunosuppressive properties and exerts antiangiogenic and antitumor effects [1][2].
T11701	J22352	Caspase	Apoptosis; Proteases/Proteasome
	J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.
T82142	Hymenistatin I
	Hymenistatin I，一种环八肽[c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-ile-Ile-)]，具有免疫抑制活性，影响体液和细胞免疫应答。
T78304	Bapotulimab BAY-1905254
	Bapotulimab (BAY-1905254)为一种全人IgG2型单克隆抗体，专一性靶向免疫球蛋白样结构域含受体2(ILDR2)。该抗体展现出抗肿瘤及免疫抑制功能。
T61090	CD73-IN-8
	CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosuppressive effects and facilitate tumor proliferation and/or metastasis. Therefore, CD73-IN-8 holds promise in the development of therapeutic interventions for tumor-related diseases[1].
T79791	Immunosuppressant-1	Apoptosis	Apoptosis
	Immunosuppressant-1（Compound 31）抑制抗-CD3/抗-CD28共刺激的T细胞增殖，具备免疫抑制活性。该化合物能激活活化的淋巴结细胞中的caspase-3和PARP，从而诱导细胞凋亡（apoptosis）。
T63856	M1069
	M1069 是一种选择性的、口服具有活力的 A2A/A2B 型双腺苷受体拮抗剂，选择性比 A1、 A3亚型高 100 多倍。M1069 可拮抗腺苷引起的免疫抑制机制，表现出抗肿瘤作用。
T60844	CD73-IN-9
	CD73-IN-9 是 CD73 的有效抑制剂，可用于制备治疗肿瘤相关疾病的药物。CD73 可以催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷。腺苷能够诱导免疫抑制作用，并且促进肿瘤增殖和/或转移。
T83136	alpha-Cobratoxin
	alpha-Cobratoxin 是从泰国眼镜蛇的毒液中提取的神经毒素，具有调节神经系统、抗病毒和镇痛的活性。此外，alpha-Cobratoxin 对急性及慢性多发性硬化症表现出免疫抑制作用，目前正在被进一步研究其在肾上腺脊髓神经病方面的潜在应用。
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T60599	CD73-IN-7
	CD73-IN-7 是一种有效的CD73抑制剂，可用于制备治疗肿瘤相关疾病的药物。CD73 催化细胞外5'-磷酸腺苷 (5'-AMP) 产生腺苷，从而诱导免疫抑制作用并促进肿瘤增殖和/或转移。
T73516	EVT801
	EVT801 是一种口服有效、选择性的 VEGFR-3抑制剂 (IC50=11 nM)，具有抗肿瘤作用。EVT801 不仅抑制VEGF-C 诱导的人内皮细胞增殖，还抑制肿瘤小鼠模型中的肿瘤 (淋巴) 血管生成。EVT801 能够减少肿瘤缺氧，减少免疫抑制细胞因子 (CCL4、CCL5) 和髓系衍生抑制细胞 (MDSC) 产生。EVT801 与免疫检查点疗法 (ICT) 组有协同作用，它提高 ICT 应答率，对癌小鼠模型的抑制效果更好。
TP1978L1	11R-VIVIT TFA (592517-80-1 Free base)
	11R-VIVIT TFA (592517-80-1 Free base) 是一种 NFAT 抑制剂。 11R-VIVIT TFA 抑制 LPS 或 LPS 加 IFN-γ 诱导的骨髓源性巨噬细胞 (BMDM) 分泌 IL-12 p40、IL-12 p70、IL-23 和 TNF。 11R-VIVIT TFA 减弱 LPS 刺激的 BMDM 中 NO 的产生和 Nos2 mRNA 的表达。 11R-VIVIT TFA 改善结肠炎小鼠模型的症状。 11R-VIVIT TFA 表现出免疫抑制作用并提高小鼠移植物的存活率。 11R-VIVIT TFA 具有细胞渗透性。

化合物

Cat.No: T9744

Target: Phosphatase

Aurothiomalate sodium

Cat.No: T20168

Synonym: 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Target: Others, PKC

trans-Urocanic Acid

Cat.No: T37547

Cat.No: T41303

Synonym: Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone

Target: Others

Cat.No: T2548

Target: Glucocorticoid Receptor

Cat.No: T34952

Synonym: Akd1D,Akd 1D,Akd-1D

Armepavine hydrochloride, (+/-)-

Cat.No: T30136

Synonym: DL-Armepavine hydrochloride

Paramethasone Acetate

Cat.No: T33883

Synonym: NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP

Target: Others

Cat.No: T13734

Target: Others

Mycophenolic acid sodium

Cat.No: T61099

Cat.No: T11701

Target: Caspase

Cat.No: T82142

Cat.No: T78304

Synonym: BAY-1905254

Cat.No: T61090

Immunosuppressant-1

Cat.No: T79791

Target: Apoptosis

Cat.No: T63856

Cat.No: T60844

alpha-Cobratoxin

Cat.No: T83136

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

Cat.No: T60599

Cat.No: T73516

11R-VIVIT TFA (592517-80-1 Free base)

Cat.No: TP1978L1

Cat. No.	Product Name	Target	Signaling Pathways
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
TN1507	Clematichinenoside AR	TNF; Autophagy	Apoptosis; Autophagy
	Clematichinenoside AR 是从中药威灵仙中提取的一种天然产物，具有抗炎和免疫抑制特性，对 PI3K/Akt 信号通路和与胶原诱导的关节炎相关的 TNF-α± 具有抗关节炎作用。
T2996	Tetrandrine NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱，可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T5S2357	Acetylcorynoline (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵	Antifungal	Microbiology/Virology
	Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分，具有抗炎活性。
TN4841	Ptaquiloside
	Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium.
TN4778	Physalin H	gp120/CD4; Antifection; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both
T80777	Withaphysalin R
	Withaphysalin R (化合物 5)，一种可从茄科植物中提取的睡茄内酯 (Withanolide)，具有麦角固醇框架的甾体内酯。其活性包括细胞毒性、免疫抑制、抗肿瘤、抗炎、抗惊厥及抗氧化等显著生物活性。

天然产物

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Clematichinenoside AR

Cat.No: TN1507

Target: TNF, Autophagy

Cat.No: T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素

Target: Potassium Channel, Calcium Channel

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Acetylcorynoline

Cat.No: T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Target: Antifungal

Cat.No: TN4841

Cat.No: TN4778

Target: gp120/CD4, Antifection, Autophagy

Withaphysalin R

Cat.No: T80777

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