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Search Results for " gastric mucosa "

14

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4579	Pentagastrin 五肽胃泌素,ICI-50123	Others; cholecystokinin	GPCR/G Protein; Others
	Pentagastrin (ICI-50123) 是一种选择性的胆囊收缩素 B(CCKB) 受体激动剂，IC50=11 nM。它能够增强胃粘膜对酸的防御机制，并保护胃粘膜免受损伤。
T24821	Spizofurone Espizofurona,AG-629	Others	Others
	Spizofurone (Espizofurona) 具有抗溃疡活性，对大鼠胃黏膜具有保护作用，可增加分离的牛蛙十二指肠粘膜中的碱性分泌。
T15005	CP-66948	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	CP-66948 是一种有效的 histamine H2 受体拮抗剂，对胃酸分泌有抑制作用，可用于保护胃黏膜和肠粘膜。
T31675	Esaprazole C/63	Others	Others
	Esaprazole (C/63) 对人胃黏膜具有剂量依赖性的细胞保护作用。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T34087	Plaunotol Kelnac,Plaunotolum
	Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.
T31958	Glycine-pentagastrin Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap
	Glycine-pentagastrin can enhance gastric mucosal defence mechanisms against acid and protect the gastric mucosa from experimental injury.
T39795	Tricarbonyldichlororuthenium(II) dimer CORM-2
	Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response.
T28335	PD 140376 PD-140376,PD140376
	PD 140376 is a highly selective antagonist radioligand for the cholecystokinin(B)-gastrin receptor in guinea pig gastric mucosa & cerebral cortex in the peripheral and central nervous systems.
TP1838	Xenin
	Xenin is a 25 amino acid peptide that has been identified in human gastric mucosa in the search for a counterpart to the amphibian octapeptide xenopsin.
T81074	Sucrose octasulfate sodium
	Sucrose octasulfate为硫糖铝组分，能直接刺激胃粘膜D细胞以促进生长抑素样免疫反应(SLI)的释放，进而发挥内源性胃生长抑素的溃疡愈合功能，适用于抗胃溃疡研究。
T71801	Arbaprostil
	Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.
T21939	ATB-337
	S-Diclofenac 的分子结构由 H2S 供体和非甾体类抗炎药双氯芬酸组合而成。S-Diclofenac 显著抑制前列腺素的合成，并且不会损伤胃粘膜。
T38045	Cholesterol β-D-Glucoside
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity...

化合物

Cat.No: T4579

Synonym: 五肽胃泌素,ICI-50123

Target: Others, cholecystokinin

Cat.No: T24821

Synonym: Espizofurona,AG-629

Target: Others

Cat.No: T15005

Target: Histamine Receptor

Cat.No: T31675

Synonym: C/63

Target: Others

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Cat.No: T34087

Synonym: Kelnac,Plaunotolum

Glycine-pentagastrin

Cat.No: T31958

Synonym: Glycine pentagastrin,Boc-gly-trp-met-asp-phe-NH2,Tbgtmap

Tricarbonyldichlororuthenium(II) dimer

Cat.No: T39795

Synonym: CORM-2

Cat.No: T28335

Synonym: PD-140376,PD140376

Cat.No: TP1838

Sucrose octasulfate sodium

Cat.No: T81074

Cat.No: T71801

Cat.No: T21939

Cholesterol β-D-Glucoside

Cat.No: T38045

Cat. No.	Product Name	Target	Signaling Pathways
TN4489	Manassantin A	ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎºB act

天然产物

Cat.No: TN4489

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

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