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Cat. No. | Product Name | Target | Signaling Pathways |
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T31383 |
D-Epinephrine
L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799 |
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D-Epinephrine can be used as a hormone, neurotransmitter, and medication. Epinephrine can be normally obtained from the adrenal glands and certain neurons. It involves in the fight-or-flight response by increasing blood flow to muscles, output of the hear | |||
T37906 |
Dibenamine hydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Dibenamine hydrochloride 是竞争性的、不可逆的肾上腺素能阻断剂,可以修饰肾上腺素的药理作用。它对小鼠体内肾上腺素的破坏率显著增加。 | |||
T31655 |
Epinephryl borate
Epinephrine borate,l-Epinephrinyl borate,l-Adrenaline borate,EINECS 226-961-8,Eppy/N |
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Epinephryl borate is an kind of adrenergic agent. | |||
T0103 |
Dipivefrin hydrochloride
盐酸地匹福林,Dipivefrin HCL |
Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
Dipivefrin hydrochloride (Dipivefrin HCl) 是抗青光眼前体药物,被角膜中的酯酶水解为其活性化合物肾上腺素。 | |||
T26712 |
AZD-1656
AZD 1656 |
Glucokinase | Metabolism |
AZD-1656 是口服有效的葡萄糖激酶选择性激活剂,EC50为 60 nM。AZD1656在2 型糖尿病中有研究的价值。 | |||
T15207 |
Eleclazine hydrochloride
GS 6615 hydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Eleclazine hydrochloride (GS 6615 hydrochloride) 是新型 Na+电流抑制剂,IC50是0.7 uM。 | |||
T68186 |
Aminomenthylnorepinephrine
|
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Aminomenthylnorepinephrine is a partial agonist of the beta-adrenoreceptor that causes irreversible inactivation. | |||
T82564 | Dibutepinephrine | ||
Dibutepinephrine是一种仿生拟交感神经药物,具有选择性地激活α和β肾上腺素能受体的作用。 | |||
T25398 |
Ethylnorepinephrine hydrochloride
Butanefrine hydrochloride,Bronkephrine |
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Ethylnorepinephrine hydrochloride is a unique bronchodilator. | |||
T5954 |
Methyldopa hydrate
L-甲基多巴,Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate |
Dopamine Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Methyldopa hydrate (MK-351 hydrate) 是一种前药,在中枢神经系统中被代谢成 α-Methylepinephrine。它是一种 α-肾上腺素能激动剂,对α2-adrenergic receptors 有选择性。 | |||
T20094 |
Adrenochrome
Adraxone |
Antioxidant | oxidation-reduction |
Adrenochrome (Adraxone) 是一种细胞毒性分子,可用于杀死细菌。Adrenochrome 是 Epinephrine 的氧化产物。Adrenochrome 是一种可作用于大鼠心脏的冠状动脉收缩化合物,与心脏毒性有关,可用于确定超氧化物歧化酶的活性。Adrenochrome 与可用于神经系统疾病研究,是拟精神病的潜在药物。 | |||
T21411L | Isoproterenol bitartrate | ||
Isoproterenol bitartrate is a beta-sympathomimetic and an isopropyl analog of Epinephrine, which acts on the heart, bronchi, skeletal muscle, and alimentary tract. It is used mainly as a bronchodilator and heart stimulant. | |||
T0103L |
Dipivefrin
K 30081,K-30081,Dipivefrinum,Dipivefrina,K30081 |
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Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma. | |||
T30880 |
Chir 2279
Chir2279 |
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Chir 2279 is a N-(substituted)glycine peptoid trimer with high-affinity binding for alpha 1-adrenoceptors. CHIR 2279 antagonized the epinephrine-induced increase in intraurethal pressure (pseudo pA2, 6.86) in dogs. | |||
T76184 |
Scyllatoxin
|
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Scyllatoxin (Leiurotoxin I) 为一种从(Leiurus quinquestriatus hebraeus)毒蝎毒液中分离的肽毒素,作为小电导钙激活型钾通道KCa(SK)的阻断剂,有能力增强体内去甲肾上腺素(NE)与肾上腺素(Epi)的释放。 | |||
T35037 |
Vanilmandelic acid, L-(+)-
Vanilmandelic acid L-form,(+)-Vanilmandelic acid |
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Vanilmandelic acid, L-(+)- is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine. It is produced via intermediary metabolites. | |||
T30591 |
Brofaromine Hydrochloride
CGP-11305A,Brofaromine HCl |
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Brofarromine hydrochloride, a reversible inhibitor of monoamine oxidase A, acts on epinephrine, norepinephrine, serotonin and dopamine. The compound is mainly used in the treatment of depression and anxiety. | |||
T73773 |
Metanephrine
|
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Metanephrine 是肾上腺素的 O-甲基化代谢物,可用于嗜铬细胞瘤的研究。 | |||
T21366 |
Sapropterin free base
BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin |
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Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter | |||
T35725 |
4-hydroxy Valsartan
|
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4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood. | |||
T68478 |
Arnolol
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Arnolol is a beta blocker. Beta blockers block the hormone epinephrine, also known as adrenaline. This causes the heart to beat more slowly and with less force, thereby reducing blood pressure. Beta blockers also help blood vessels open up to improve blood flow. | |||
T68825 |
Doxazosin HCl
|
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Doxazosin HCl is the salt form of Doxazosin Free Base which acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. | |||
T36072 |
Skyrin
Endothianin,Rhodophyscin |
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Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor. At 10 μM, skyrin reduces both glucagon-stimulated cAMP production and glycogenolysis. It does not interfere with epinephrine or glucagon-like peptide 1 effects on these parameters.[1] Reference:[1]. Parker, J.C., McPherson, R.K., Andrews, K.M., et al. Effects of skyrin, a receptor-selective glucagon antagonist, in r... | |||
T71870 |
CP21
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CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid, or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively. It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells... | |||
T81432 | PNMT-IN-1 | ||
PNMT-IN-1(Inhibitor 4)是一种高特异性的PNMT抑制剂,具有1.2 nM的Ki值和81 nM的IC50值。它对DNMT1和DNMT3b也表现出活性,IC50值分别为61 μM和17 μM,并且对肾上腺素具有拮抗效果。PNMT-IN-1属于第二代抑制剂。 | |||
T75389 | Catechol O-methyltransferase | ||
Catechol O-methyltransferase (COMT) 在镁的作用下,通过将 S-腺苷甲硫氨酸的甲基转移至多巴胺的羟基,生成3-甲氧基酪胺,从而参与调节大脑中肾上腺素、去甲肾上腺素和多巴胺的水平。存在于组织中的Catechol O-methyltransferase有两种形态:可溶性形式(S-COMT)和膜结合形式(MB-COMT)。 | |||
T36176 |
AMK (hydrochloride)
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AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13655 |
DL-Norepinephrine hydrochloride
去甲肾上腺素盐酸盐,Lys,DL-lysine |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
DL-Norepinephrine hydrochloride (DL-lysine) 是一种靶向α1 adrenoceptor 和β1 adrenoceptor 的神经递质,可降低心内膜下氧分压。它是一种模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 是β1选择性的肾上腺素能受体激动剂,EC50值为 5.37 μM。它可上调鼻咽癌肿瘤细胞中血管内皮生长因子、基质金属蛋白酶MMP-2和MMP-9的表达。 | |||
T1064 |
Norepinephrine bitartrate monohydrate
酒石酸去甲肾上腺素,Levophed,Noradrenaline bitartrate monohydrate,降肾上腺素 |
Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience |
Norepinephrine bitartrate monohydrate (Levophed) 是一种β1-选择性的肾上腺素能受体激动剂,EC50为 5.37 μM。 | |||
T21066 |
Norepinephrine bitartrate salt
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Norepinephrine bitartrate salt 是一种肾上腺素能神经递质。 | |||
T60245 |
Norepinephrine hydrochloride
|
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Norepinephrine hydrochloride (Levarterenol hydrochloride) 是一种β1选择性的肾上腺素受体激动剂,EC50值为 5.37 μM。 | |||
T0611 |
Vanillylmandelic acid
4-Hydroxy-3-methoxymandelic acid,3-甲氧基-4-羟基扁桃酸 |
Others | Others |
Vanillylmandelic acid (4-Hydroxy-3-methoxymandelic acid) 是儿茶酚胺、肾上腺素和去甲肾上腺素代谢的最终产物,常用于帮助诊断嗜铬细胞瘤,以及其升高与抑郁症状有关。 | |||
T4945 |
Normetanephrine hydrochloride
DL-Normetanephrine hydrochloride,DL-去甲变肾上腺素盐酸盐 |
Endogenous Metabolite | Metabolism |
Normetanephrine hydrochloride (DL-Normetanephrine hydrochloride) 是肾上腺素的代谢物。它与肾上腺素一起存在于尿液和某些组织中。 | |||
T1644 |
Dopamine hydrochloride
盐酸多巴胺,Dopamine HCl,ASL279 |
Ferroptosis; Dopamine Receptor; 5-HT Receptor; Endogenous Metabolite | Apoptosis; GPCR/G Protein; Metabolism; Neuroscience |
Dopamine hydrochloride (ASL279) 是在脑黑质、脑腹侧被盖区和下丘脑中产生的一种天然儿茶酚胺,由二羟基苯丙氨酸脱羧形成,是去甲肾上腺素和肾上腺素的前体。它通过 D2 多巴胺受体来诱导 VEGFR2 的内吞作用,有促进血管生成活性。 | |||
T20173 |
Noradrenaline tartrate
NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate |
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Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. | |||
TN4600 |
Myrianthic acid
|
PAFR; AChR | GPCR/G Protein; Neuroscience |
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoproteins at a 50 uM concentration. Myrianthic acid is equivalently inhibitive as acetylsalicylic acid (IC50: 57.0 microM) on epinephrine induced platelet aggregation. |