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Search Results for " endothelin "

120

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1174	Endothelin-2 (49-69), human Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2	Others	Others
	Endothelin-2 (49-69), human (Human endothelin-2) 是一种由 21 个氨基酸组成的血管活性肽。它可与 G 蛋白连接的跨膜受体，ET-RA 和ET-RB 结合。
T19309L1	Endothelin 1 (swine, human) acetate Endothelin 1 (swine, human) acetate(117399-94-7 free base)	Endothelin Receptor	GPCR/G Protein
	Endothelin 1 (swine, human) acetate(117399-94-7 free base) 是一种合成肽，其序列为人和猪内皮素 1。它是一种有效的内源性血管收缩剂，通过两种类型的受体 ETA 和 ETB 起作用。
T22540L	Ac-Endothelin-1 (16-21), human acetate	Others	Others
	Ac-Endothelin-1 (16-21), human acetate 是内皮素家族的主要肽，已被证明在血管和非血管组织中具有多种生物活性。 C-末端片段是 ET 家族肽中高度保守的序列，已显示可区分称为 ETA 和 ETB 的两种 ET 受体亚型，因为它仅激活后者。
TP1175	Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)
	Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor.
TP2143	Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA	Others	Others
	Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.
TP1173	Endothelin 3 (Rat,Human) (TFA) Endothelin-3, human, mouse, rabbit, rat TFA
	Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that specifically interacts with G-protein-linked transmembrane receptors, ET-RA and ET-RB.
TP2099	[Ala1,3,11,15]-Endothelin
	Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).
T36480	Big Endothelin-1 (1-39), porcine
	The big endothelins comprise residues 53-90 (human big ET-1) and 53-91 (porcine big ET-1) of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (ET-1), both peptides show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-54-8.
T19309	Endothelin 1 (swine, human)	Others	Others
	Endothelin 1 (swine, human), a synthetic peptide mirroring the sequence of both human and swine Endothelin 1, functions as a robust endogenous vasoconstrictor by interacting with two receptor types, ETA and ETB.
TP1512	[Ala1,3,11,15]-Endothelin TFA
	[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,3,11,15]-Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ET
T22540	Ac-Endothelin-1 (16-21), human	Others	Others
	ENDOTHELIN-1 (ET-1), the principal peptide of the endothelin family, has been shown to have a variety of biological activities in both vascular and nonvascular tissues. The C-terminal fragment, which is a highly conserved sequence in the peptides of t
TP2246	Endothelin-1 (1-15), amide, human	Others	Others
	Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC.
T36479	Big Endothelin-1 (1-38), human
	Human Big ET-1 comprises residues 53-90 of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (hET-1), the peptide show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-53-7.
T15232	TBC3711 Endothelin Mordulator 1	Others	Others
	TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders.
T76305	[Ala2] Endothelin-3, human
	[Ala2] Endothelin-3, human 为ET-3的线性类似物，其结构中的Cys残基被Ala所替代。ET-3是由人体横纹肌肉瘤细胞系产生，且仅在此细胞系中表达的一种具有血管活性的肽。在非肌肉来源的肉瘤细胞系中不表达。该肽能够作为旁分泌因子，促进内皮细胞迁移。
T76329	[Asn18] Endothelin-1, human
	[Asn18] Endothelin-1, human 为一种多肽，属于内皮素家族中的主要亚型，关键于血管功能调节。
T75731	Endothelin 1 (swine, human) (TFA)
	Endothelin 1 (swine, human) (TFA) 是具有人和猪内皮素 1 序列的合成肽，是有效的内源性血管收缩剂。Endothelin 1 通过两种类型受体 ETA 和 ETB 发挥作用。
T5458	Darusentan Lu-135252,达卢生坦	Endothelin Receptor	GPCR/G Protein
	Darusentan (Lu-135252) 是内皮素受体 A (ET-A) 受体选择性拮抗剂，能够作用于 ET-A 受体(Ki:1.4 nM)及ET-B 受体(Ki:184 nM)，对 ETA 受体的选择性大于 ETB 受体的100以上。它在大鼠主动脉血管平滑肌细胞膜中竞争结合放射性标记的内皮素(Ki:13 nM)。
T76564	Endothelin-1 (1-31) (Human)
	Endothelin-1 (1-31) (Human) 是源于chymase对大ET-1选择性水解而来的有效血管收缩剂和血压升高剂。
T76564L	Endothelin-1 (1-31) (Human) acetate
	Endothelin-1 (1-31) (Human) acetate，源自于chymase对大ET-1的选择性水解，是一种有效的血管收缩剂和血压升高剂。
T75772	[Ala1,3,11,15]-Endothelin (53-63) (TFA)
	[Ala1,3,11,15]-Endothelin (53-63) (TFA) 是一种ETB 激动剂。[Ala1,3,11,15]-Endothelin (53-63) (TFA) 对 ETB 具有选择性，IC50值范围为 0.33 nM 至 0.61 nM。[Ala1,3,11,15]-Endothelin (53-63) (TFA) 可用于血管收缩的研究。
T2561	Macitentan 马西替坦,ACT-064992	Apoptosis; Endothelin Receptor	Apoptosis; GPCR/G Protein
	Macitentan (ACT-064992) 是一种内皮素受体拮抗剂，用于治疗肺动脉高压。
T3194	Ro 46-2005	Endothelin Receptor	GPCR/G Protein
	Ro 46-2005是新型非肽类内皮素拮抗剂，能够抑制人血管平滑肌细胞(ETA 受体)(IC50:220 nM)。
T78063	Endothelin-1 (1-31) (Human) TFA	ERK	MAPK
	Endothelin-1 (1-31) (Human) TFA 是源自chymase对大ET-1选择性水解的一种有效血管收缩剂和血压升高剂。
T82886	Big endothelin-1 (rat 1-39)
	Big endothelin-1 (rat 1-39) 是一个由39个氨基酸残基组成的多肽。它能在清醒状态的Sprague-Dawley大鼠中诱导利尿和利钠的反应，并可导致小鼠血压上升。
T0750	Sulfisoxazole NU-445,磺胺二甲异唑,Sulfafurazole,磺胺异恶唑	Endothelin Receptor; Antibacterial; Antibiotic; Autophagy	Autophagy; GPCR/G Protein; Microbiology/Virology
	Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂，是磺胺类抗生素。它靶向内皮素受体 A，抑制乳腺癌外显子释放。
T76081	Endothelin 1 (swine, human), Alexa Fluor 488-labeled
	Endothelin 1 (swine, human), Alexa Fluor 488-labeled 是标记了488 荧光的 Endothelin 1 合成肽。Endothelin 1 (swine, human) 是具有人和猪内皮素 1 序列的合成肽，是有效的内源性血管收缩剂。Endothelin 1 通过两种类型受体 ETA 和 ETB 发挥作用。
T6258	Zibotentan ZD4054	Apoptosis; Endothelin Receptor	Apoptosis; GPCR/G Protein
	Zibotentan (ZD4054) 是一种选择性的，具有口服活性的内皮素 A (ETA) 受体拮抗剂，Ki 为 13 nM。它具有抗癌作用，可研究去势抵抗性前列腺癌。
T3474	RO 46-8443	Endothelin Receptor	GPCR/G Protein
	Ro 46-844 是选择性非肽内皮素受体拮抗剂。它对ETB(IC50: 34-69 nM) 的选择性比ETA 受体 (IC50: 6800 nM) 高的100倍以上。
TQ0282	Avosentan SPP-301,Ro 67-0565,阿伏生坦	Endothelin Receptor	GPCR/G Protein
	Avosentan 是有效的内皮素受体（ETA）拮抗剂。
T6792	BQ-123 BQ123	Endothelin Receptor	GPCR/G Protein
	BQ-123 是高效的内皮素 A(ETA)受体选择性拮抗剂，其IC50=7.3 nM，Ki=25 nM。它能够降低高血压大鼠血压，抑制内皮素-1 介导的人肺动脉平滑肌细胞增殖。
T6264	Bosentan Actelion,波生坦,Ro 47-0203,Benzenesulfonamide	Endothelin Receptor	GPCR/G Protein
	Bosentan (Benzenesulfonamide) 是 endothelin-1 (ET)拮抗剂，在人的 SMC 细胞中，它能够作用于 ETA 受体(Ki:4.7 nM)和 ETB 受体(Ki:95 nM)。
T5355	Sparsentan RE-021,DARA-a	RAAS; Endothelin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Sparsentan (DARA-a) 是一种具有高度选择的血管紧张素 II (Ki:0.8 nM)和内皮素 A 受体(Ki:9.3 nM)的双重拮抗剂。
T1655	Ambrisentan BSF-208075,BSF 208075,安倍生坦,LU 208075	Endothelin Receptor	GPCR/G Protein
	Ambrisentan (BSF 208075) 是 ET A 型受体选择性拮抗剂。
T2026	CYM5442	S1P Receptor; LPL Receptor	GPCR/G Protein
	CYM5442 是高选择性和口服活性的鞘氨醇 1-磷酸受体激动剂，EC50为 1.35 nM。它激活依赖 S1P1的 p42/p44-MAPK 磷酸化，具有视网膜神经保护作用，可轻松穿过中枢神经系统。
TQ0259	Atrasentan A-147627,(+)-A 127722,阿曲生坦,ABT-627	Endothelin Receptor	GPCR/G Protein
	Atrasentan (ABT-627) 是内皮素受体 (endothelin receptor) 拮抗剂，能够抑制 ETA 的活性(IC50:0.0551 nM)。
T6265	Bosentan (hydrate) 波生坦水合物,Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203	Endothelin Receptor	GPCR/G Protein
	Bosentan hydrate (Ro 47-0203) 是endothelin-1 (ET)竞争性拮抗剂，在人SMC 细胞中，它能够作用于 ETA 受体(Ki:4.7 nM)和 ETB 受体(Ki:95 nM)。
T7817	Aprocitentan ACT-132577,N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺	Endothelin Receptor	GPCR/G Protein
	Aprocitentan (ACT-132577) 是一种 Macitentan 的主要活性代谢物。它是 ETA/ETB 的双重拮抗剂，其 pA2值分别为 6.7 和 5.5，IC50分别为 3.4 nM 和 987 nM。
T6672	Sitaxsentan sodium 西他生坦钠,TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium	Endothelin Receptor	GPCR/G Protein
	Sitaxsentan sodium (TBC11251 sodium salt) 是 endothelin A receptor 选择性拮抗剂。
TQ0270	Atrasentan hydrochloride (+)-A 127722 hydrochloride,ABT-627 hydrochloride,盐酸阿曲生坦,A-147627 hydrochloride	Endothelin Receptor	GPCR/G Protein
	Atrasentan hydrochloride (ABT-627 hydrochloride) 是内皮素 A 受体选择性拮抗剂，抑制内皮素 A 受体活性的IC50为 0.0551 nM。
T15596	IRL 2500	Endothelin Receptor	GPCR/G Protein
	IRL 2500 是内皮素受体的拮抗剂，对内皮素 A 受体和内皮素 B 受体的 IC50 分别为 1.3 和 94 nM。
T12924	Sitaxsentan TBC-11251,IPI 1040	Endothelin Receptor	GPCR/G Protein
	Sitaxsentan (TBC-11251) 是选择性内皮素A (ETA) 受体拮抗剂。内皮素是一种有效的血管收缩剂。Sitaxsentan 阻断内皮素与其受体的结合，从而消除内皮素的有害作用。
T7391	SAR407899	ROCK; Rho	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	SAR407899 是一种选择性的 ATP 竞争性ROCK 抑制剂，对ROCK-2的IC50值为 135 nM，对人和大鼠ROCK-2的Ki 值分别为 36 和 41 nM。它是 Rho 激酶抑制剂，有效抑制 endothelin-1 诱导的肾阻力动脉收缩。
T31605	Edonentan BMS207940,BMS-207940,BMS 207940	Endothelin Receptor	GPCR/G Protein
	Edonentan 是一种有效的内皮素A（ETA）受体拮抗剂，可用于研究心脏衰竭。
T36008	Nebentan potassium
	Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan . Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2]. Nebentan potassium inhibits the specific binding of [125I] endothelin-1 to endothelin ETA and ETB re...
T14219	Aminaftone Aminaphthone	Endothelin Receptor	GPCR/G Protein
	Aminaftone 是 4-氨基苯甲酸的衍生物，可抑制内皮素-1 (ET-1) 的产生，可用于研究高血压和系统硬化症。
T21790	BMS 182874 hydrochloride	Endothelin Receptor	GPCR/G Protein
	BMS 182874 hydrochloride 是一种非肽内皮素 (El) 受体拮抗剂。
TP2262L	IRL-1038 acetate IRL-1038 acetate(144602-02-8 Free base)	Endothelin Receptor	GPCR/G Protein
	IRL-1038 acetate 是一种有效的 ETB 内皮素受体拮抗剂。
TP1220L	Carperitide acetate 醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	Endothelin Receptor	GPCR/G Protein
	Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate) 是一种由 28 个氨基酸组成的激素，由心脏产生并分泌，以响应心脏损伤和机械拉伸。Carperitide acetate 抑制内皮素-1 (endothelin-1) 分泌。
T34541	SB-209670 SB 209670	Endothelin Receptor	GPCR/G Protein
	SB-209670是一种选择性内皮素受体拮抗剂，能够抑制大鼠血管内皮和血管平滑肌中ET(B)受体的活性。

化合物

Endothelin-2 (49-69), human

Cat.No: TP1174

Synonym: Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2

Target: Others

Endothelin 1 (swine, human) acetate

Cat.No: T19309L1

Synonym: Endothelin 1 (swine, human) acetate(117399-94-7 free base)

Target: Endothelin Receptor

Ac-Endothelin-1 (16-21), human acetate

Cat.No: T22540L

Target: Others

Endothelin-3, human, mouse, rabbit, rat

Cat.No: TP1175

Synonym: Endothelin 3 (Rat,Human)

Endothelin-2 (49-69), human TFA

Cat.No: TP2143

Synonym: Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA

Target: Others

Endothelin 3 (Rat,Human) (TFA)

Cat.No: TP1173

Synonym: Endothelin-3, human, mouse, rabbit, rat TFA

[Ala1,3,11,15]-Endothelin

Cat.No: TP2099

Big Endothelin-1 (1-39), porcine

Cat.No: T36480

Endothelin 1 (swine, human)

Cat.No: T19309

Target: Others

[Ala1,3,11,15]-Endothelin TFA

Cat.No: TP1512

Ac-Endothelin-1 (16-21), human

Cat.No: T22540

Target: Others

Endothelin-1 (1-15), amide, human

Cat.No: TP2246

Target: Others

Big Endothelin-1 (1-38), human

Cat.No: T36479

Cat.No: T15232

Synonym: Endothelin Mordulator 1

Target: Others

[Ala2] Endothelin-3, human

Cat.No: T76305

[Asn18] Endothelin-1, human

Cat.No: T76329

Endothelin 1 (swine, human) (TFA)

Cat.No: T75731

Cat.No: T5458

Synonym: Lu-135252,达卢生坦

Target: Endothelin Receptor

Endothelin-1 (1-31) (Human)

Cat.No: T76564

Endothelin-1 (1-31) (Human) acetate

Cat.No: T76564L

[Ala1,3,11,15]-Endothelin (53-63) (TFA)

Cat.No: T75772

Cat.No: T2561

Synonym: 马西替坦,ACT-064992

Target: Apoptosis, Endothelin Receptor

Cat.No: T3194

Target: Endothelin Receptor

Endothelin-1 (1-31) (Human) TFA

Cat.No: T78063

Target: ERK

Big endothelin-1 (rat 1-39)

Cat.No: T82886

Cat.No: T0750

Synonym: NU-445,磺胺二甲异唑,Sulfafurazole,磺胺异恶唑

Target: Endothelin Receptor, Antibacterial, Antibiotic, Autophagy

Endothelin 1 (swine, human), Alexa Fluor 488-labeled

Cat.No: T76081

Cat.No: T6258

Synonym: ZD4054

Target: Apoptosis, Endothelin Receptor

Cat.No: T3474

Target: Endothelin Receptor

Cat.No: TQ0282

Synonym: SPP-301,Ro 67-0565,阿伏生坦

Target: Endothelin Receptor

Cat.No: T6792

Synonym: BQ123

Target: Endothelin Receptor

Cat.No: T6264

Synonym: Actelion,波生坦,Ro 47-0203,Benzenesulfonamide

Target: Endothelin Receptor

Cat.No: T5355

Synonym: RE-021,DARA-a

Target: RAAS, Endothelin Receptor

Cat.No: T1655

Synonym: BSF-208075,BSF 208075,安倍生坦,LU 208075

Target: Endothelin Receptor

Cat.No: T2026

Target: S1P Receptor, LPL Receptor

Cat.No: TQ0259

Synonym: A-147627,(+)-A 127722,阿曲生坦,ABT-627

Target: Endothelin Receptor

Bosentan (hydrate)

Cat.No: T6265

Synonym: 波生坦水合物,Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203

Target: Endothelin Receptor

Cat.No: T7817

Synonym: ACT-132577,N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺

Target: Endothelin Receptor

Sitaxsentan sodium

Cat.No: T6672

Synonym: 西他生坦钠,TBC11251 sodium salt,TBC11251,Thelin,Sitaxentan sodium

Target: Endothelin Receptor

Atrasentan hydrochloride

Cat.No: TQ0270

Synonym: (+)-A 127722 hydrochloride,ABT-627 hydrochloride,盐酸阿曲生坦,A-147627 hydrochloride

Target: Endothelin Receptor

Cat.No: T15596

Target: Endothelin Receptor

Cat.No: T12924

Synonym: TBC-11251,IPI 1040

Target: Endothelin Receptor

Cat.No: T7391

Target: ROCK, Rho

Cat.No: T31605

Synonym: BMS207940,BMS-207940,BMS 207940

Target: Endothelin Receptor

Nebentan potassium

Cat.No: T36008

Cat.No: T14219

Synonym: Aminaphthone

Target: Endothelin Receptor

BMS 182874 hydrochloride

Cat.No: T21790

Target: Endothelin Receptor

IRL-1038 acetate

Cat.No: TP2262L

Synonym: IRL-1038 acetate(144602-02-8 Free base)

Target: Endothelin Receptor

Carperitide acetate

Cat.No: TP1220L

Synonym: 醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Target: Endothelin Receptor

Cat.No: T34541

Synonym: SB 209670

Target: Endothelin Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T20541	Phosphoramidon
	Phosphoramidon is a membrane metallo-endopeptidase & endothelin-converting enzyme inhibitor and thermolysin inhibitor, which is obtained from culture filtrate of Streptomyces tanashiensis.

天然产物

Cat.No: T20541

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