store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aminaftone 是 4-氨基苯甲酸的衍生物,可抑制内皮素-1 (ET-1) 的产生,可用于研究高血压和系统硬化症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 7,000 | 现货 | ||
10 mg | ¥ 8,550 | 现货 | ||
25 mg | ¥ 11,240 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 |
产品描述 | Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis. |
体外活性 | In cell cultures, Aminaftone inhibits the production of Endothelin-1 (ET-1) by interfering with the transcription of the pre-pro-endothelin-1 (PPET-1) gene. Concentrations of ET-1 and PPET-1 relative gene expression increase upon incubation with IL-1beta. Aminaftone, when incubated in a concentration-dependent manner, significantly reduces the production of ET-1. A strong direct correlation is observed between ET-1 concentrations and PPET-1 relative gene expression. It is noteworthy that Aminaftone does not influence the activity of endothelin-converting enzyme (ECE)[2]. |
体内活性 | After 5 weeks, rats are randomly assigned to the following experimental groups: Control; Monocrotaline; Aminaftone 30 mg/kg/day; Aminaftone 150 mg/kg/day. In animals treated with Aminaftone at both doses, mortality is significantly lower compared to those treated with Monocrotaline alone. Aminaftone, especially at the highest dose, reduces the plasma concentration of ET-1 and appears to decrease right heart hypertrophy and the wall thickness of the pulmonary arteries. At the end of the experiment, no rats die in the control and Aminaftone 150 groups, while mortality is 38% in the Monocrotaline group and 13% in the Aminaftone 30 group. Overall, rats treated with Aminaftone show a significantly lower mortality compared to rats in the Monocrotaline group (P=0.044)[1]. |
别名 | Aminaphthone |
分子量 | 309.32 |
分子式 | C18H15NO4 |
CAS No. | 14748-94-8 |
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (193.97 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.2329 mL | 16.1645 mL | 32.329 mL | 80.8224 mL |
5 mM | 0.6466 mL | 3.2329 mL | 6.4658 mL | 16.1645 mL | |
10 mM | 0.3233 mL | 1.6164 mL | 3.2329 mL | 8.0822 mL | |
20 mM | 0.1616 mL | 0.8082 mL | 1.6164 mL | 4.0411 mL | |
50 mM | 0.0647 mL | 0.3233 mL | 0.6466 mL | 1.6164 mL | |
100 mM | 0.0323 mL | 0.1616 mL | 0.3233 mL | 0.8082 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Aminaftone 14748-94-8 GPCR/G Protein Endothelin Receptor Aminaphthone Inhibitor inhibitor inhibit