86
20
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9597 |
H2S Donor 5a
N-(苯甲酰基硫基)苯甲酰胺 |
Endogenous Metabolite | Metabolism |
H2S Donor 5a 是一种稳定的、半胱氨酸活化的的 H2S 供体。它是研究 H2S 的有用工具。 | |||
T40732 |
TMPD dihydrochloride
|
||
TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。 | |||
T22830 |
GYY4137
GYY 4137 morpholine salt |
Others | Others |
GYY4137 (GYY 4137 morpholine salt) 是一种缓释H2S 供体,具有抗炎和抗癌作用,也具有血管扩张和抗高血压活性。 | |||
T125923 |
Negundonorin A
|
||
Negundonorin A 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125923,CAS号为 1401618-51-6。 | |||
T38943 | L-Azidonorleucine hydrochloride | ||
L-Azidonorleucine hydrochloride, an unnatural amino acid, serves as a surrogate for Methionine. It is utilized for labeling mammalian cell proteins and identifying a broad range of methionyl-tRNA synthetase (MetRS) mutants. | |||
T19930 |
Nitrosoglutathione
S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO |
RAAS; NO Synthase | Endocrinology/Hormones; Immunology/Inflammation |
Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体,是大鼠酒精脱氢酶III 类同工酶的底物,能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。 | |||
T9369L |
UDP-a-D-Galactose disodium salt
|
Others | Others |
UDP-a-D-Galactose disodium salt 是半乳糖基转移酶的供体底物,用于含半乳糖的寡糖的生物合成。 | |||
T12808 |
S-Nitroso-N-acetyl-DL-penicillamine
N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸,SNAP |
NO Synthase | Immunology/Inflammation |
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种稳定的血小板聚集抑制剂,是一氧化氮的供体。 | |||
TD0082 |
EDANS sodium
EDANS sodium salt,EDANS sodium salt [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid, sodium salt],5-(2-氨乙基氨)-1-萘磺酸钠盐,5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt,N-(Aminoethyl)-5-naphthylamine-1-sulfonic Acid Sodium Salt |
Others | Others |
EDANS sodium (5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt) 是开发基于 FRET 的核酸探针的供体,该探针广泛用于实时 PCR 测定。 | |||
T36033 |
DETA NONOate
NOC-18,Diethylamine NONOate |
NO Synthase | Immunology/Inflammation |
DETA NONOate (NOC 18)是外源性一氧化氮 (NO) 供体,具有血管舒张和抗抑郁活性。DETA NONOate 可用于激活神经元中的内向电流,可加速MRSA感染伤口的愈合。 | |||
T21334 |
Bucillamine
DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019 |
VEGFR; Antioxidant | Angiogenesis; oxidation-reduction; Tyrosine Kinase/Adaptors |
Bucillamine (DE019) 可防止高危器官移植中的缺血/再灌注损伤,抑制 VEGF 的产生。 Bucillamine 是一种具有抗风湿和抗血管生成特性的口服活性巯基供体和抗氧化剂。 Bucillamine 可用于脉络膜新生血管和类风湿性关节炎的研究。 | |||
T18903 |
6-ROX
6-Carboxy-X-rhodamine,6-羧基-X-罗丹明 |
Others | Others |
6-ROX (6-Carboxy-X-rhodamine) 是寡核苷酸的荧光标记物,其激发波长和发射波长均为568nm。它是耦合至5-FAM 的受体,在FRET 成像中作为供体。 | |||
T7092 |
NADPH tetrasodium salt
|
Others; Ferroptosis; Endogenous Metabolite | Apoptosis; Metabolism; Others |
NADPH tetrasodium salt 是电子受体烟酰胺腺嘌呤二核苷酸磷酸的还原形式,在各种生物反应中充当电子供体。NADPH tetrasodium salt 也是一种内源性铁死亡抑制剂。 | |||
T60247 |
Diethylamine NONOate diethylammonium salt
NOC-18 Diethylamine,DEA NONOate diethylamine |
Antibiotic | Microbiology/Virology |
Diethylamine NONOate diethylammonium salt (DEA NONOate diethylamine) 是一种一氧化氮供体,具有抗菌活性,是铜绿假单胞菌生物膜预形成生物膜的分散剂,可抑制大肠杆菌的生长。Diethylamine NONOate diethylammonium salt 可用于离体大鼠心脏的保存。 | |||
T3560 |
Desmethylanethol trithione
ADT-OH |
VEGFR; Akt | Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡,并对体内黑色素瘤的形成具有一定的抑制作用,可用于研究癌症疾病。 | |||
T16328 |
Nitroaspirin
2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物,与 Aspirin 结合可抑制环氧合酶=,可作为 COX-1 的直接和不可逆抑制剂。 它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白,显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡,具有抗血栓和抗血小板特性。 | |||
T36503 |
Sodium Hydrogen Sulfide (hydrate)
|
Others | Others |
Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样,是一种重要的气体介质,对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体,常用于细胞和整个动物实验系统。例如,它被用来证明H2S 促进中性粒细胞迁移,减少气道炎症,保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。 | |||
T37807 |
JTV 519 fumarate
|
||
Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 |Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 |... | |||
T31796 |
FK409
NOR-3,NOR 3,FK 409,FK-409,NOR3 |
||
FK409 is a cell permeable NO donor which produces vasorelaxation. | |||
T24215 |
JS-K
JSK,JS K |
||
JS-K is a Nitric oxide donor. It has antiproliferative activity. | |||
T33689 |
Nitroparacetamol
NCX 701,NCX-701,NCX701 |
||
Nitroparacetamol is nitric oxide (NO) donor and may be used to treat pain. | |||
T23062 | NCX 466 | Others | Others |
cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor | |||
T32513 |
LA 419
LA419,LA-419 |
||
LA 419 is a nitric oxide donor. | |||
T34690 |
SPD-2
|
||
SPD-2 is a photocontrolled hydrogen sulfide donor for living cells. | |||
T23375 |
SNAP
|
Others | Others |
NO donor | |||
T29285 |
10-FTHF
10 FTHF,10-Formyltetrahydrofolic acid,10FTHF,10-Formyl-THF |
||
10-FTHF is a donor of formyl groups in anabolism used as a substrate in formyltransferase reactions, which is important in purine biosynthesis. | |||
T32514 | LA-810 | ||
LA-810 is a nitrous oxide donor. | |||
T31977 |
GLYN
NSC 137875,NSC137875,Glycidyl nitrate,NSC-137875 |
||
GLYN, a nitric oxide donor, acts by enhancing the therapeutic efficacy of chemotherapy and radiotherapy. | |||
T68944 |
NMI 1182
|
||
NMI 1182 is a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor. Inflammopharmacology. | |||
T37978 |
Coenzyme FO
|
||
Coenzyme FO, a deazaflavin chromophore, plays a crucial role as a hydride acceptor/donor in the central methanogenic pathway [1][2]. | |||
T38050 |
CP-609754
|
Transferase | Metabolism |
CP-609754 是高效的、可逆的法尼基转移酶抑制剂,对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。 | |||
T68464 |
PABA/NO
|
||
PABA/NO is a novel glutathione-S-transferase-p-activated nitric oxide donor, inhibiting proliferation and inducing apoptosis by targeting PI3K/AKT/mTOR and MEK/ERK pathways in hepatocellular carcinoma cells. | |||
T36066 |
NADP+ (sodium salt hydrate)
|
||
NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynth... | |||
T19505 |
PBDB-T
|
Others | Others |
PBDB-T serves as a wide-bandgap polymer donor within polymer solar cells that utilize Perylene Diimide (PDI) as the base. | |||
T32293 |
JK-2 lithium
JK-2,JK2,JK 2 |
||
JK-2 is a hydrogen sulfide (H2S) donor. At acidic pH, it shows a greatly accelerated H2S release upon protonation-induced intramolecular cyclization. | |||
T39795 |
Tricarbonyldichlororuthenium(II) dimer
CORM-2 |
||
Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response. | |||
T36510 |
V-PYRRO/NO
|
||
V-PYRRO/NO is a NO donor in vivo. Following hepatic metabolism, it spontaneously decomposes with a half-life of 3 seconds to liberate NO. | |||
T29651 |
Ademetionine, (S)-
|
||
Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA. | |||
T35767 |
SAHO2
|
||
SAHO2is a sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and is a substrate for radical SAM enzymes.1It is reductively cleaved to 5'-deoxyadenosine and 5'-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN. 1.Mandalapu, D., Ji, X., and Zhang, Q.Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymesBiochemistry58(1)36-39(2019) | |||
T14967 |
Cimlanod
BMS-986231,CXL-1427 |
Others | Others |
Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloo | |||
T15361 | FW1256 | Others | Others |
FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for cancer and cardiovascular disease trea | |||
T75420 | alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) | ||
alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) 存在于幽门螺杆菌中。alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) 催化岩藻糖从供体 GDP-β-l-岩藻糖转移到 GlcNAc。 | |||
T35960 |
PROLI NONOate
|
||
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound. | |||
T36177 |
Angeli’s Salt
Angeli’s Salt,Sodium α-oxyhyponitrite |
||
Angeli’s salt is regarded as a classical nitroxyl (NO-) donor, but under certain conditions evolution of NO is also observed.1 It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4) to liberate 0.54 moles of NO per mole of parent compound.[1],[2] | |||
T65212 | β-Glycerophosphate Disodium Salt Hydrate (2:1:4) | ||
β-Glycerophosphate Disodium Salt Hydrate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition and functions as an organic phosphate donor. | |||
T39441 |
L-Arginine-15N4 hydrochloride
L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride |
||
L-Arginine-15N4 ((S)-(+)-Arginine-15N4) hydrochloride, the 15N-labeled variant of L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as the nitrogen donor in the synthesis of nitric oxide. This potent vasodilator is crucial, especially during a sickle cell crisis where its levels are notably diminished. | |||
T36340 |
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)
|
||
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm; em = 420 nm). | |||
T35969 |
NOC-5
|
||
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor. It can release two equivalents of NO in solution under physiological conditions without a cofactor. [1] The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH >=10.0). [1] | |||
T36134 |
3,4,6-Tri-O-benzyl-β-D-Mannopyranose 1,2-(methyl orthoacetate)
|
||
3,4,6-Tri-O-benzyl-β-D-mannopyranose 1,2-(methyl orthoacetate) is a synthetic intermediate used in glycosylation reactions. Typically, the methyl orthoester protecting group is first removed by mild acid hydrolysis, producing a glycosyl donor. Removal of the O-benzyl protecting groups is performed late in the synthesis. | |||
T36615 |
DPTA NONOate
Dipropylenetriamine NONOate |
||
DPTA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of three hours and five hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound. [1][2] |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0928 |
L-Ascorbic acid
维生素C,Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,抗坏血酸,L-Ascorbate |
Apoptosis; Calcium Channel; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
L-Ascorbic acid (Vitamin C) 属于天然产物,是一种强效的还原剂和抗氧化剂。L-Ascorbic acid 具有抗细菌感染、解毒反应和胶原蛋白形成的作用。L-Ascorbic acid 被用于治疗坏血病。 | |||
T0670 |
L-Arginine hydrochloride
(S)-(+)-Arginine hydrochloride,左旋精氨酸单盐酸盐,L-Arginine HCl (L-Arg),L-arginine monohydrochloride |
Amino Acids and Derivatives; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine hydrochloride 为合成一氧化氮的氮供体,是血管扩张剂。 | |||
T21367 |
Tetrahydrofolic acid
5,6,7,8-tetrahydrofolic acid,folate-H4,Tetrahydropteroylglutamic acid,th-folate |
Endogenous Metabolite | Metabolism |
Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) 是一种维生素 B9 衍生物,是生物体常见的一碳供体,参与生物体生长代谢。 | |||
T8693 |
Diallyl Trisulfide
二烯丙基三硫化物,二烯丙基三硫醚 |
Apoptosis; Reactive Oxygen Species; Antifungal | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Diallyl Trisulfide 是一种在大蒜中发现的有机多硫化物,可作为 H2S 供体。它抑制扩张性青霉的生长,有抗癌能力。 | |||
T1039 |
Choline chloride
Biocolina,Biocoline,Hepacholine,氯化胆碱 |
AChR | Neuroscience |
Choline chloride (Biocoline) 是一种必需营养素,可激活 α7 烟碱受体,具有抗炎、镇痛的活性。对动脉粥样硬化、神经系统疾病和肝脏疾病等具有影响。 | |||
T4915 |
β-Glycerophosphate disodium salt hydrate
|
Phosphatase; Endogenous Metabolite | Metabolism |
β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂,是内源性代谢产物的一种。 | |||
T4447 |
S-(5'-Adenosyl)-L-methionine tosylate
S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt |
Others | Others |
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体,参与多种生物反应,包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。 | |||
T4920 |
2-Ketoglutaric acid Sodium
Oxoglutaric acid,AKG,2-oxoglutarate monobasic,LPHA-酮戊二酸钠,α-Ketoglutaric acid sodium salt |
Tyrosinase; Endogenous Metabolite | Metabolism; Proteases/Proteasome |
2-Ketoglutaric acid Sodium (AKG) 是一种三羧酸循环的中间产物,它可以由谷氨酸通过谷氨酸脱氢酶氧化脱氨产生,也可以作为磷酸吡哆醛依赖的转氨化反应的产物(由支链氨基酸转氨酶介导),其中谷氨酸是常见的氨基供体。 | |||
T4909 |
N-Acetyl-DL-methionine
N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-DL-methionine 是内源性代谢产物的一种。 | |||
T4826 |
L-Histidine monohydrochloride monohydrat
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一,即蛋白质的组成部分。 | |||
T20574 |
Magnesium lactate
Bis(lactato)magnesium |
||
Magnesium lactate is a magnesium donor and buffering agent. | |||
T19471 |
NCX 1000
|
Others | Others |
NCX 1000 is a liver-specific NO donor compound,NCX 1000 derived from ursodeoxycholic acid (UDCA). | |||
T4116 |
S-Adenosyl-DL-Methionine
Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE |
Others | Others |
S-Adenosyl-DL-Methionine (Ademetionine) 是一种 Ademetionine 的衍生物。其中Ademetionine 是蛋氨酸的中间代谢产物。 | |||
T10042 |
11-Oxomogroside IIa
|
Others | Others |
11-Oxomogroside IIa is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. It has inhibitory effects against the EBV-EA activation induced by TPA, shows weak inhibitory effects on activation of NOR 1, a nitric oxide (NO) donor. | |||
T74497 | S-Adenosyl-L-methionine iodide | ||
S-(5'-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) 是所有生物体中重要的甲基供体。 | |||
TN1935 |
Mogroside III A2
Mogroside III-A2,罗汉果苷IIIA2,罗汉果苷 III A2 |
Others | Others |
Mogroside III-A2 exhibits inhibitory effects with IC50 values of 346-400 mol ratio/32 pmol TPA. and shows weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor. | |||
T4922 |
Uridine 5′-triphosphate tris salt
尿苷-5′-三磷酸酯 三羟甲基氨基甲烷盐,Uridine 5'-triphosphoric acid |
Others; Endogenous Metabolite | Metabolism; Others |
Uridine 5′-triphosphate tris salt (Uridine 5'-triphosphoric acid) 是 P2Y 受体的激动剂,已用于研究细胞内 Ca2+ 的浓度,以及用于体外激酶测定的磷酸盐供体。 | |||
T73607 | UDP-xylose | ||
UDP-xylose是一种从Cryptococcus laurentii(NRRL Y-1401)提取的天然产物。它作为糖供体,在植物、脊椎动物和真菌中参与糖蛋白、多糖及多种代谢物和寡糖的合成。 | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T75566 | 11-Oxomogroside II A1 | ||
11-Oxomogroside II A1(化合物 7)是一种从罗汉果乙醇提取物中分离的氧化葫芦苷,对12-O-十四烷酰基激素-13-乙酸酯(TPA)诱导的Epstein-Barr病毒(EBV)早期抗原(EBV-EA)活化具有抑制效果,并对一氧化氮(NO)供体(+/-)-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺(NOR 1)的活化也展示出轻微的抑制作用。 |