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Search Results for " dismutase "

37

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78346	Superoxide dismutase SOD
	超氧化物歧化酶(SOD)是能清除超氧阴离子的抗氧化酶，它将自由基转化为氧气和过氧化氢，防止过氧亚硝酸盐的形成和进一步损伤。该酶在抗炎、抗肿瘤、辐射防护及抗衰老领域有着广泛应用和研究。
T40612	Manganese(salen) chloride EUK-8	Others	Others
	Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。
T6495	EUK-134 EUK 134,乙基双亚氨基甲基愈创木酚锰氯化物	Beta Amyloid	Neuroscience
	EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。
T19668	Tiomolibdate diammonium Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa	Others	Others
	Tiomolibdate diammonium (NSC-286644) 是超氧化物歧化酶 1 (SOD1) 的抑制剂，具有抗血管生成和抗肿瘤活性。 Tiomolibdate diammonium 抑制铜酶的活性，包括 SOD1 和 COX。
T14133	AEOL-10150 pentachloride	Others	Others
	AEOL-10150 pentachloride 是一种超氧化物歧化酶模拟物，也是一种金属卟啉催化抗氧剂，可保护肺免受辐射损伤。
T19428	Mito-TEMPO	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Mito-TEMPO 是一种线粒体靶向超氧化物歧化酶的模拟物。Mito-TEMPO 可以清除超氧化物和烷基自由基，防止线粒体的氧化、坏死和凋亡。
T14341	ATN-224 四硫钼酸二胆碱,Bis(choline)tetrathiomolybdate	Others	Others
	ATN-224 (Bis(choline)tetrathiomolybdate) 抑制内皮细胞中的 SOD1 活性，这种作用呈剂量依赖性，IC50 为 17.5±3.7 nM。 ATN-224 是一种口服 Cu2+/Zn2+-超氧化物歧化酶 1 (SOD1) 抑制剂。
T20067	WST-1 WST 1
	WST-1 是一种具有细胞毒性的水溶性四唑盐，诱导细胞内线粒体脱氢酶进行 NADH 依赖性酶解反应，释放出水溶性甲基苯产物。WST-1 可通过检测吸收值来检测细胞增殖和细胞活性，可用于WST-1平板测定法测定超氧化物歧化酶活性。
T39965	NF-κΒ activator 1	NF-κB	NF-κB
	NF-κΒ activator 1 可激活NF-κΒ基因，EC50 为 0.9 μM。NF-κB 作为一种调控细胞增殖和细胞存活的基因被真核细胞广泛应用。NF-κΒ activator 1 可诱导超氧化物歧化酶 (SOD)2 mRNA 表达。
T75342	MitoSOX Red	Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	MitoSOX Red 是一种具有特异性和细胞膜渗透性且靶向活细胞线粒体的新型荧光探针。MitoSOX Red 进入线粒体后会被超氧化物氧化，而不会被其他 ROS 或 RNS 生成系统氧化。MitoSOX Red 随后与线粒体内核酸结合，产生强红色荧光。MitoSOX Red 可以作为荧光指示剂，特异性检测超氧化物。超氧化物歧化酶 (Superoxide dismutase，SOD) 能够预防 MitoSOX Red 氧化。
T40795	BNTA	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BNTA 是一种有效的细胞外基质 (ECM) 调节剂。在大鼠关节炎模型中，BNTA 通过诱导超氧化物歧化酶 3 (SOD3) 促进软骨细胞上软骨结构分子的合成和超氧阴离子消除调节软骨生成从而调节关节炎。
T38164	MnTBAP chloride Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
T20094	Adrenochrome Adraxone	Antioxidant	oxidation-reduction
	Adrenochrome (Adraxone) 是一种细胞毒性分子，可用于杀死细菌。Adrenochrome 是 Epinephrine 的氧化产物。Adrenochrome 是一种可作用于大鼠心脏的冠状动脉收缩化合物，与心脏毒性有关，可用于确定超氧化物歧化酶的活性。Adrenochrome 与可用于神经系统疾病研究，是拟精神病的潜在药物。
T34556	SC 55858 SC-55858,SC55858
	SC 55858 is a superoxide dismutase mimetic.
T23810	BMX-001 MnTnBuOE-3-PyP 5+,manganese butoxyethyl pyridyl porphyrin,BMX001,manganese (III) ortho N-butoxyethylpyridylporphyrin
	BMX-001 is a third-generation, cationic, lipophilic, manganese (Mn), and porphyrin-based mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD). It also has antioxidant and potential chemoprotective activities.
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T24817	Otaplimastat J3.046.690J,SP8203,SP-8203,SP 8203
	SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.
T25118	Avasopasem manganese
	Avasopasem manganese is a drug candidate of superoxide dismutase mimetic.
T71957	Cupferron
	Cupferron is a superoxide dismutase inhibitor.
T39763	Rucosopasem manganese GC4711
	Rucosopasem manganese (GC4711) is a potent, selective superoxide dismutase (SOD) mimetic capable of efficiently converting superoxide to hydrogen peroxide. This compound, specifically designed for research purposes, holds promise in cancer-related studies.
T39498	Tofersen BIIB067,ISIS-SOD1Rx
	Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research.
T60386	LCS-1
	LCS-1, a superoxide dismutase 1 (SOD1) inhibitor, effectively inhibits the enzymatic activity of SOD1 with an IC50 value of 1.07 μM. Additionally, LCS-1 triggers both early and late-stage apoptosis in multiple myeloma (MM.1S) cells [1] [2] [3].
T75496	19-epi-Scholaricine
	19-epi-Scholaricine为一种口服活性吲哚生物碱，具备下调胶原纤维表达和增加超氧化物歧化酶（SOD）活性的特性。
T75028	TMV-IN-4
	TMV-IN-4（compound 3）是一种针对烟草花叶病毒（TMV）的抑制剂。该化合物通过与TMV解旋酶交互作用，能够诱导植物产生抗性并提高对TMV感染的耐受性。TMV-IN-4还可增强过氧化物酶和超氧化物歧化酶活性，从而提升烟草的TMV抗性。
T72959	NUCC-0000323
	NUCC-0000323 是一种针对超氧化物歧化酶 1 (SOD1) 的有效抑制剂，能够抑制 SOD1 的表达。该化合物在肌萎缩侧索硬化症 (ALS) 研究中有潜在应用。
T82704	CMB-087229
	CMB-087229为一种针对突变SOD1蛋白的聚集阻断剂，具有IC50值为67 nM，主要用于肌萎缩侧索硬化症的研究。
T61312	Antioxidant agent-3
	Antioxidant agent-3 (Compound 14q) 是一种抗氧化剂，具有有效的DPPH 自由基清除活性和ABTS+清除活性，IC50分别为 26.58 和 30.31 μM。Antioxidant agent-3 作用于 H2O2处理的 HepG2 细胞，可增加活性氧 (ROS)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH)，并减少乳酸脱氢酶(LDH)。
T35965	MitoTEMPOL
	MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.
T70941	CLR01 sodium
	CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
T35964	MitoTEMPO hydrate
	MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from...
T35778	Ochratoxin A-13C20 Ochratoxin A-13C20
	Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
T35966	Mn(III)TMPyP
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1, re...
T36610	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde ...
T38218	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
	1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 是一种在生物膜中的磷脂，在 sn-1 和 sn-2 位置分别含有硬脂酸和二十二碳六烯酸。它已被用于研究脂膜的组织和动力学。在超氧化物歧化酶 1 突变体转基因小鼠肌萎缩性脊髓侧索硬化症（ALS）模型中1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 的水平在疾病晚期会在 L5 前角下降。1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC 可用于研究生物膜。
T36499	CuATSM
	The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding and aggregation, have been linked to familial amyotrophic lateral sclerosis (ALS). Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that has traditionally been used in cellular imaging experiments to selectively label hypoxic tissue via its susceptibility ...
T36057	Diallyl Tetrasulfide ICD-1585
	Diallyl tetrasulfide is an organosulfur compound that has been found in A. sativum and has diverse biological activities, including antimicrobial, antioxidant, and anticancer properties.[1],[2],[3],[4] It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MICs = 0.5 and 2 mg/L, respectively), as well as the fungi C. albicans, C. krusei, C. glabrata, A. niger, A. flavus, and A. fumigatus (MICs = 0.5, 4, 2, 1, 2, and 4 mg/L, respectively).[1] It reduces cadmium-ind...
T83682	Tat-Gap 19 TFA
	Tat-Gap 19是一种针对连接蛋白43 (Cx43) 半通道的肽抑制剂，由HIV-1 Tat蛋白传导域与对应于Cx43第128-136残基的九氨基酸肽连接而成。Tat-Gap 19 (10 µM) 能够抑制初级大鼠肝细胞中由谷氨酸引发的ATP释放，这是Cx43半通道活性的标志。在通过中脑动脉堵塞(MCAO)诱导的小鼠脑缺血再灌注损伤模型中，以25 mg/kg的剂量进行给药，可减少梗死体积。腹腔内注射Tat-Gap 19 (1 mg/kg 每天) 能够减少硫代乙酰胺引起的小鼠肝损伤模型中的纤维化病灶面积及表达α-平滑肌肌动蛋白 (α-SMA) 的肝星状细胞（成纤维细胞的前体）面积，并提高同种小鼠分离的肝细胞中超氧化物歧化酶 (SOD) 活性。

化合物

Superoxide dismutase

Cat.No: T78346

Synonym: SOD

Manganese(salen) chloride

Cat.No: T40612

Synonym: EUK-8

Target: Others

Cat.No: T6495

Synonym: EUK 134,乙基双亚氨基甲基愈创木酚锰氯化物

Target: Beta Amyloid

Tiomolibdate diammonium

Cat.No: T19668

Synonym: Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa

Target: Others

AEOL-10150 pentachloride

Cat.No: T14133

Target: Others

Cat.No: T19428

Target: Reactive Oxygen Species, Mitochondrial Metabolism

Cat.No: T14341

Synonym: 四硫钼酸二胆碱,Bis(choline)tetrathiomolybdate

Target: Others

Cat.No: T20067

Synonym: WST 1

NF-κΒ activator 1

Cat.No: T39965

Target: NF-κB

Cat.No: T75342

Target: Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat.No: T40795

Target: Reactive Oxygen Species

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

Cat.No: T20094

Synonym: Adraxone

Target: Antioxidant

Cat.No: T34556

Synonym: SC-55858,SC55858

Cat.No: T23810

Synonym: MnTnBuOE-3-PyP 5+,manganese butoxyethyl pyridyl porphyrin,BMX001,manganese (III) ortho N-butoxyethylpyridylporphyrin

MTP 131 acetate

Cat.No: T35689

Target: Others

Cat.No: T24817

Synonym: J3.046.690J,SP8203,SP-8203,SP 8203

Avasopasem manganese

Cat.No: T25118

Cat.No: T71957

Rucosopasem manganese

Cat.No: T39763

Synonym: GC4711

Cat.No: T39498

Synonym: BIIB067,ISIS-SOD1Rx

Cat.No: T60386

19-epi-Scholaricine

Cat.No: T75496

Cat.No: T75028

Cat.No: T72959

Cat.No: T82704

Antioxidant agent-3

Cat.No: T61312

Cat.No: T35965

Cat.No: T70941

MitoTEMPO hydrate

Cat.No: T35964

Ochratoxin A-13C20

Cat.No: T35778

Synonym: Ochratoxin A-13C20

Cat.No: T35966

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

Cat.No: T36610

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC

Cat.No: T38218

Cat.No: T36499

Diallyl Tetrasulfide

Cat.No: T36057

Synonym: ICD-1585

Cat.No: T83682

Cat. No.	Product Name	Target	Signaling Pathways
TJS1382	Taraxerone 蒲公英赛酮	Dehydrogenase	Metabolism
	Taraxerone 是分离自景天的天然产物。它可以增强乙醇脱氢酶和乙醛脱氢酶活性，EC50分别为 512.42 μM 和 500.16 μM。
T5543	TriacetonaMine 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others	Others
	TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品，使用丙酮和氢氧化铵，或在分离过程的不同步骤中天然出现铵盐。
T8280	Deacetylasperulosidic Acid 去乙酰基车叶草苷酸,去乙酰车叶草苷酸,Desacetyl asperulosidic acid	IL Receptor; Interleukin	Immunology/Inflammation
	Deacetylasperulosidic Acid 是海巴戟果实的主要植物化学成分。它能够防止体外 4-硝基喹啉1-氧化物诱导的 DNA 损伤，抑制 IL-2的产生以及自然杀伤细胞的活化。它具有抗原活性，抑制仓鼠卵巢细胞和小鼠中染色体畸变的诱导。它可增加超氧化物歧化酶活性，从而具有抗氧化活性。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
TN3735	Cycloart-23-ene-3,25-diol	Antifection	Microbiology/Virology
	Cycloart-23-ene-3,25-diol has anti-inflammatory activity, it has protective activity against streptozotocin induced toxicity. Cycloart-23-ene-3,25-diol treatment can decrease liver malondialdehyde but increase superoxidase dismutase and reduced glutathion

天然产物

Cat.No: TJS1382

Synonym: 蒲公英赛酮

Target: Dehydrogenase

Cat.No: T5543

Synonym: 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Target: Others

Deacetylasperulosidic Acid

Cat.No: T8280

Synonym: 去乙酰基车叶草苷酸,去乙酰车叶草苷酸,Desacetyl asperulosidic acid

Target: IL Receptor, Interleukin

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Cycloart-23-ene-3,25-diol

Cat.No: TN3735

Target: Antifection

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