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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0386L	Ropivacaine LEA-103 HCl,罗哌卡因	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine (LEA-103 HCl) 是有效的钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine 也是一种 K2P(双孔钾通道)TREK-1的抑制剂，在 COS-7 细胞膜上的 IC50值为 402.7 μM。Ropivacaine 可以用于神经性疼痛的缓解的相关研究。
T0386	Ropivacaine hydrochloride 盐酸罗哌卡因,Ropivacaine monohydrochloride	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) 是钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine hydrochloride 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中，Ropivacaine hydrochloride 可用于神经性疼痛的缓解。
T6645	Ropivacaine hydrochloride monohydrate Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine hydrochloride monohydrate (LEA-103 HCl) 是钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine HCl monohydrate 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中，Ropivacaine HCl monohydrate 可用于神经性疼痛的缓解。
T15756	Lidorestat IDD-676	Reductase	Endocrinology/Hormones; Metabolism
	Lidorestat (IDD-676) 是一种醛糖还原酶抑制剂(IC50: 5 nM)，具有有效性，选择性和口服活性。Lidorestat 改善神经传导，减少白内障的形成。Lidorestat 可用于治疗慢性糖尿病并发症。
T0030	Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl,盐酸布比卡因	Sodium Channel	Membrane transporter/Ion channel
	Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂，可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道，还阻断SCN5A 通道，IC50为 69.5 μM。
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T6476	Dofetilide UK 68789,UK-68798,Tikosyn,多非利特	Potassium Channel	Membrane transporter/Ion channel
	Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂，作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。
T6541	Ibutilide Fumarate Corvert Fumarate,U70226E,富马酸伊布利特	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物，可作用于急性心梗阻塞。
T15257	Etripamil MSP-2017,(-)-MSP-2017	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂，可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入，显示房室结传导并延长房室结不应期
T9857	Vasopressin antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)	Endogenous Metabolite	Metabolism
	Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽，是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程，增加无溶质水从肾小管的滤液中重新吸收回循环中的量，收缩小动脉提高压强，增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质，与特定的 G 蛋白偶联受体结合发挥作用。
T68252	Mesotrin
	Mesotrin is a calcium antagonist that influences atrial and ventricular conduction, but has been linked with side effects of euphoria, ventigo and heavyheadedness.
T26230	Stilbamidine dihydrochloride NSC 35605,NCI 174
	Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection.
T31119	CVT-2759 UNII-42E8N8RC9Z,CVT2759
	CVT-2759 is A potential partial agonist for A(1)-ADORs, and it may be useful to slow atrioventricular node conduction to reduce ventricular rate without causing the atrioventricular block, bradycardia, atrial arrhythmias, or vasodilation.
T24623	PF-06807656 PF 06807656
	PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM).
T69144	Hexylcaine HCl
	Hexylcaine HCl also called cyclaine or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.
T71559	Melanotan II acetate
	Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases in sensory nerve conduction velocity. Melanotan II acetate increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol.
T61475	Ropivacaine mesylate
	Ropivacaine mesylate 是一种高效的钠通道 (sodium channel) 阻断剂，通过可逆性抑制钠离子内流 (sodium ion influx)，引致神经纤维脉冲传导阻滞。此外，Ropivacaine 还能抑制 K2P(双孔钾通道)TREK-1，其在 COS-7 细胞膜上的 IC50 值为 402.7 μM。
T82567	Di-4-ANEPPS
	Di-4-ANEPPS为膜电位电压敏感染料，时间分辨率达1 ms优于，并能够呈现每100 mV荧光变化高至10%。常用于描绘心脏电活动图，对兔离体心脏模型的自发心率和心室冲动传导显示出显著直接不可逆影响。
T71228	Adaprolol maleate
	Adaprolol maleate is a beta-blocker and opthalmic which may be used in the treatment of Glaucoma or other ailments of the eye. Adaprolol has marked electrophysiologic effects. Its major action was on sinus node; it prolonged the basic sinus cycle length and had significant effect on intrinsic automaticity as reflected by the prolonged corrected sinus node recovery time and sinuatrial conduction time. There was, also, direct effect on atrial function and AV nodal function. Adaprolol prolonged the...

化合物

Cat.No: T0386L

Synonym: LEA-103 HCl,罗哌卡因

Target: Potassium Channel, Sodium Channel

Ropivacaine hydrochloride

Cat.No: T0386

Synonym: 盐酸罗哌卡因,Ropivacaine monohydrochloride

Target: Potassium Channel, Sodium Channel

Ropivacaine hydrochloride monohydrate

Cat.No: T6645

Synonym: Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,盐酸罗哌卡因,盐酸罗哌卡因一水合物,LEA-103 HCl

Target: Potassium Channel, Sodium Channel

Cat.No: T15756

Synonym: IDD-676

Target: Reductase

Bupivacaine hydrochloride

Cat.No: T0030

Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因

Target: Sodium Channel

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

Cat.No: T6476

Synonym: UK 68789,UK-68798,Tikosyn,多非利特

Target: Potassium Channel

Ibutilide Fumarate

Cat.No: T6541

Synonym: Corvert Fumarate,U70226E,富马酸伊布利特

Target: Calcium Channel, Sodium Channel

Cat.No: T15257

Synonym: MSP-2017,(-)-MSP-2017

Target: Calcium Channel

Cat.No: T9857

Synonym: antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)

Target: Endogenous Metabolite

Cat.No: T68252

Stilbamidine dihydrochloride

Cat.No: T26230

Synonym: NSC 35605,NCI 174

Cat.No: T31119

Synonym: UNII-42E8N8RC9Z,CVT2759

Cat.No: T24623

Synonym: PF 06807656

Cat.No: T69144

Melanotan II acetate

Cat.No: T71559

Ropivacaine mesylate

Cat.No: T61475

Cat.No: T82567

Adaprolol maleate

Cat.No: T71228

Cat. No.	Product Name	Target	Signaling Pathways
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate

天然产物

N-Methyltaxol C

Cat.No: TN4616

Target: Others

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