11
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7829 |
FK962
|
Somatostatin | GPCR/G Protein |
FK962 是抑制生长抑素释放的增强剂,具有增强认知效果。 | |||
T16816 |
S 18986
|
GluR | Neuroscience |
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine in the rat hippocampus, leading to enhanced object-recognition memory. | |||
T28655 |
Sabeluzole
R 58735,R58735,R-58735 |
Microtubule Associated | Cytoskeletal Signaling |
Sabeluzole (R-58735) 具有抗癫痫和增强认知的作用,抑制神经毒素诱导的tau表达和细胞死亡。Sabeluzole 对氯氮卓诱导的习惯障碍有保护作用,可用于研究阿尔茨海默症。 | |||
T27806 |
Lecozotan HCl
SRA-333,SRA333,SRA 333,Lecozotan hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lecozotan HCl (SRA-333) 是一种强效且具有选择性的 5-HT 拮抗剂。Lecozotan HCl能明显增强氯化钾刺激海马齿状回谷氨酸和乙酰胆碱的释放并具有增强认知能力的特性。在表明 5-HT(1A) 受体功能的行为模型中,长期服用Lecozotan HCl不会诱发 5-HT(1A) 受体耐受或脱敏。 | |||
T0869 |
Atomoxetine hydrochloride
Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,盐酸托莫西汀,LY 139603,Atomoxetine HCl,LY 139603 HCl |
Dopamine Receptor; 5-HT Receptor; Norepinephrine | GPCR/G Protein; Neuroscience |
Atomoxetine hydrochloride (LY 139603) 是苯氧基-3-丙胺衍生物和选择性非兴奋剂,是去甲肾上腺素再摄取抑制剂,具有认知增强活性。 与人 NET,SERT 和 DAT 的放射性配体结合的 Ki 分别为5,77和1451 nM。 | |||
T15758 |
Linopirdine
利诺吡啶,DuP 996 |
Potassium Channel; TRP/TRPV Channel | Membrane transporter/Ion channel |
Linopirdine (DuP 996) 是一种口服有效的,选择性 M 型 K+电流 (IM;Kv7;KCNQ Channels) 抑制剂,IC50为 2.4 μM。Linopirdine 是TRPV1激活剂。Linopirdine 是一种公认的认知增强药物,可增加大鼠脑组织中乙酰胆碱的释放。 | |||
T32191 |
Irdabisant
CEP-26401,CEP 26401,CEP26401 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中,Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。 | |||
T27326 |
FK960
FK 59960,FK-960,FK-59960,FK59960 |
||
FK962 is an enhancer of somatostatin release, which exerts cognitive-enhancing actions in rats. FK960 increases synaptic density in the hippocampal CA3 region of aged rats. | |||
T70715 |
AQW-051 fumarate
|
||
AQW-051 fumarate is an α7 nicotinic ACh receptor partial agonist that may act as a cognitive-enhancing agent. | |||
T10224 | ABT-418 hydrochloride | Others | Others |
ABT-418 hydrochloride is a selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. It activates cholinergic channel and can be used for the research of Alzheimer's disease. | |||
T27379 |
FR-194921
FR194921 |
||
FR-194921 is a potent, selective, and orally active antagonist for central adenosine A1 receptors with cognitive-enhancing and anxiolytic activity. FR194921 has same binding affinity profile among human, rat, and mouse. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3026 |
(-)-Huperzine A
HupA,石杉碱,Huperzine A,石杉碱甲 |
Apoptosis; AChR; AChE; iGluR | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱,具有神经保护活性。它是高特异性可逆的,具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂, 其IC50值为 82 nM。 它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂,可研究神经退行性疾病,如阿尔茨海默病。 | |||
T2563 |
Acetyl-L-carnitine hydrochloride
Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂,具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外,乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应,并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。 |