42
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9127 |
MYLS22
|
Others | Others |
MYLS22 是视神经萎缩 1 的选择性抑制剂。它通过影响 NFkB 活性和血管生成基因表达抑制血管生成,靶向作用于内皮细胞 OPA1 ,减少肿瘤的生长。 | |||
T1536 |
Promestriene
3-propyl ethyl,舒经劳,17B-methyl estradiol,Promestriano |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Promestriene (3-propyl ethyl) 是局部有效的雌激素,是合成的雌二醇二乙醚。它对阴道萎缩有作用,但吸收量小。 | |||
T4641 |
Branaplam
LMI 070,NVS-SM1 |
Others; Potassium Channel; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Others |
Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂,对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期,也抑制 hERG,IC50为 6.3 μM。 | |||
T16545 |
Pivanex
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis; HDAC; Bcr-Abl | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。 | |||
TP2373L |
Biotinoyl tripeptide-1 Acetate
Biotinoyl tripeptide-1 Acetate(299157-54-3 Free base) |
Others | Others |
Biotinoyl tripeptide-1 Acetate 可通过促进头皮微循环产生毛囊,减少毛囊萎缩和衰老。 | |||
T20802 |
Flumethasone pivalate
Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten |
Others | Others |
Flumethasone pivalate (Locorten) 具有止痒、抗炎和血管收缩的特性,可用于肾上腺皮质抑制、皮肤萎缩、血浆转皮质素结合和毛细血管扩张的研究。 | |||
T27322 |
Fispemifene
HM-101,HM 101,HM101 |
Others | Others |
Fispemifene (HM-101) 是一种雌激素受体调节剂(SERM),可用于治疗泌尿生殖系统综合征和阴道萎缩。 | |||
T3336 |
Rg3039
PF-06687859 |
Others | Others |
Rg3039 (PF-06687859) 是一种具有口服活性、能够透过血脑屏障的DcpS 抑制剂,其IC50=0.069 nM。 | |||
T12718L |
RG7800
RO6885247 |
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
RG7800 (RO6885247) 是一种 SMN2 拼接修饰剂,有用于治疗脊髓性肌萎缩的研究潜力。 | |||
T12935 |
SMN-C3
MV8T2MCK57 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SMN-C3 (MV8T2MCK57) 是口服有效的 SMN2 剪接调节剂。SMN-C3可用于脊椎肌肉萎缩 (SMA) 的研究。 | |||
T6620 |
Ospemifene
FC-1271a,欧司哌米,奥培米芬 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Ospemifene (FC-1271a) 是非雌激素的选择性雌激素受体调节剂,能够作用于雌激素受体α (Kis:380 nM)和 Erβ (Kis:410 nM)。它可用于研究阴道萎缩乳腺癌。 | |||
T28273L |
OT-551 HCl
OT-551 HCl(627085-11-4 Free base) |
NF-κB | NF-κB |
OT-551 HCl 是一种 NF-Κb 抑制剂,是一种具有抗氧化特性的二取代羟胺可用于治疗白内障和老年性黄斑变性和地域性萎缩 (GA)。 | |||
T77445 |
Apitegromab
SRK-015 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Apitegromab (SRK-015) 是一种新型肌肉生长抑制素抑制剂,是一种靶向肌肉生长抑制素前体的抗体,可用于研究脊髓性肌萎缩症在内的神经肌肉疾病。 | |||
T73475 |
SMN-C2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SMN-C2 是一种选择性的 SMN2 基因剪接调节剂,是risdiplam类似物,是调节前 mRNA 剪接的选择性 RNA 结合配体,通过结合 SMN2 pre-mRNA 来发挥作用。SMN-C2 具有研究脊髓性肌萎缩症 (SMA) 的潜力。 | |||
T31168 |
D153249
D 153249,D-153249 |
||
D153249 is a promoter of spinal muscular atrophy (SMA). | |||
T33433 |
MK-3984
MK3984 |
||
Mk-3984 is a selective androgen receptor modulator, which can be used to prevent and treat cancer-related muscle atrophy. | |||
T19737 | Perthane | ||
Perthane is the diethyl derivative of common pesticide DDD. It may cause adrenocortical atrophy in humans,and also prevent the formation of spontaneous mammary carcinoma. | |||
TP2373 |
Biotinoyl tripeptide-1
Biotin GHK,BiotinGHK,Biotin-GHK |
||
Biotinoyl tripeptide-1 can produce hair follicles by promoting scalp micro-circulation and reduce follicle atrophy and aging. | |||
T34664 |
SMN2-Stablizer-27
SMN2-Stablizer 27,SMN2 Stablizer-27 |
||
SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA). | |||
T78236 |
MuRF1-IN-2
|
Others | Others |
MuRF1-IN-2(实施例3),这种化合物是MuRF1抑制剂,主要应用于肌肉消耗状况、骨骼肌或心肌萎缩的研究。 | |||
T33663 |
Nicotinamide Riboside Triflate
SRT 647 Triflate,SRT 647,Nicotinamide Riboside,Nicotinamide Ribose,SRT-647,SRT647,SRT647 Triflate,SRT-647 Triflate |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Nicotinamide Riboside Triflate (SRT647 Triflate) 是一种天然NAD前体,可增加NAD水平,可增强氧化代谢并防止高脂肪饮食引起的肥胖,KE 激活SIRT3可防止噪音引起的听力损失,可用于研究肌肉萎缩。 | |||
T76725 | Tilavonemab | ||
Tilavonemab (ABBV-8E12) 是一种人源化抗 tau 抗体,结合 tau 蛋白 N 端附近的 25-30 位氨基酸。Tilavonemab 阻断人和小鼠神经元摄取 tau 聚集体的能力,并能减少脑萎缩。Tilavonemab 可用于阿尔兹海默症的研究。 | |||
T78046 |
RG7800 tetrahydrochloride
RO6885247 tetrahydrochloride |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RG7800 hydrochloride为一可口服SMN2剪接调节剂,其对SMN2剪接及SMN蛋白的EC1.5x值分别为23 nM及87 nM。 | |||
T60042 | NPT200-11 | Others | Others |
NPT200-11 是一种口服生物利用度和脑穿透性 ASYN 错误折叠和聚集抑制剂。 NPT200-11 可用于突触核蛋白病的潜在病理学研究,包括帕金森病 (PD)、路易体痴呆 (DLB) 和多系统萎缩 (MSA)。 | |||
T74683 | IONIS-FB-LRx | ||
IONIS-FB-LRx 是一种靶向补体因子 B (CFB) 的特殊反义寡核苷酸(ASO)。IONIS-FB-LRx 能有效降低 CFB 的循环水平。IONIS-FB-LRx 可用于地理萎缩 (GA) 研究。 | |||
T78197 |
5-Fluoromethylornithine dihydrochloride
5-FMOrn dihydrochloride |
||
5-Fluoromethylornithine (5-FMOrn) dihydrochloride 是一种特异性且不可逆的 L-Ornithine:2-oxoacid aminotransferase (OAT) 抑制剂,常用于探索回旋状脉络膜视网膜萎缩。 | |||
T70941 |
CLR01 sodium
|
||
CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. | |||
T83173 | Activated T Subunit | ||
Activated T Subunit 用于合成可诱导外显子51跳跃的外显子跳跃寡聚物偶联物。该寡聚物偶联物与人类抗肌萎缩蛋白基因中选定靶位点互补,适用于肌肉萎缩症研究。 | |||
T81693 |
NCP2 Anchor
|
||
NCP2 Anchor用于合成外显子跳跃寡聚物偶联物。它的偶联物与人抗肌萎缩蛋白基因特定靶位点配对互补,从而诱导外显子52的跳跃。该偶联物常应用于肌肉萎缩症的科学研究。 | |||
T83175 |
Activated DPG Subunit
|
||
Activated DPG Subunit 用于合成可诱导外显子 51 跳跃的外显子跳跃寡聚物偶联物。这些偶联物与人抗肌萎缩蛋白基因中选定的靶位点互补,有助于肌肉萎缩症的研究。 | |||
T74699 | Avacincaptad pegol | ||
Avacincaptad pegol 是核酸适配体,作为 C5 补体抑制剂,用以减轻炎症导致的视网膜色素上皮 (RPE) 损伤。该化合物可用于研究 stargardt 黄斑营养不良 (STGD1) 与地理萎缩 (GA)。 | |||
T83176 | Activated C Subunit | ||
Activated C Subunit 用于合成可诱导外显子51跳跃的外显子跳跃寡聚物偶联物。所得寡聚物偶联物与人类抗肌萎缩蛋白基因特定靶位点互补,有助于研究肌肉萎缩症。 | |||
T80951 |
Trevogrumab
REGN-1033 |
||
Trevogrumab (REGN-1033) 是针对GDF8(即生长分化因子8,亦称为肌肉生长抑制素)的单克隆抗体。该化合物目前主要用于研究包括废用性萎缩、慢性疾病以及饮食及营养摄入变化等原因引起的肌肉减少症。 | |||
T83174 | Activated EG3 Tail | ||
Activated EG3 Tail 适用于合成外显子跳跃寡聚物偶联物。该寡聚物偶联物能与人类抗肌萎缩蛋白基因特定的靶位点匹配,进而诱导外显子 51 的跳跃。此类偶联物对于肌肉萎缩症研究具有重要价值。 | |||
T83177 | Activated A Subunit | ||
Activated A Subunit 适用于合成促进外显子跳跃的寡聚物偶联体。所合成的偶联体与人类抗肌萎缩蛋白基因内特定的序列配对互补,能够有效促进外显子51的跳跃,为肌萎缩疾病研究提供了一种工具。 | |||
T38279 |
C2-8
C2-8 |
||
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2... | |||
T74881 | FITC-labeled Tominersen | ||
FITC-labeled Tominersen 是 FITC 标记的 Tominersen。Tominersen (RG6042) 是第二代 2′-O-(2-甲氧基乙基) 反义寡核苷酸,靶向亨廷蛋白 (HTT) mRNA,有效抑制 HTT 的合成。Tominersen 能在小鼠中提高存活率并减少脑萎缩。Tominersen 可用于亨廷顿病 (HD) 的研究。 | |||
T62381 | Branaplam hydrochloride | ||
Branaplam (LMI070; NVS-SM1) hydrochloride 是一种选择性的、口服具有活力的 SMN2 拼接调节剂,能够作用于 SMN (EC50: 20 nM)。Branaplam hydrochloride 能够抑制 hERG (IC50: 6.3 μM)。在严重的脊髓性肌萎缩症 (SMA) 小鼠模型中,Branaplam hydrochloride 能够增加全长 SMN 蛋白并提高其生存期。 | |||
T62920 |
HDAC-IN-38
|
||
HDAC-IN-38 是一种 HDAC 的有效抑制剂。HDAC-IN-38 对 HDAC1、2、3、5、6 和 8 具有类似的微摩尔抑制作用,也可以提高组蛋白乙酰化水平 (H3K14 或 H4K5)。HDAC-IN-38 能够提高脑血流量 (CBF),减轻认知障碍,改善海马萎缩。 | |||
T35594 |
Cuspin-1
|
||
The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Ra... | |||
T70174 |
Pirlindole-d4 HCl
|
||
Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru... | |||
T73453 |
MRS4719
|
||
MRS4719 是一种有效的P2X4受体拮抗剂,对人 P2X4 受体的IC50为 0.503 μM。MRS4719 可减少脑梗死体积,减少脑萎缩,在缺血性脑中风模型中具有神经保护和神经康复作用。MRS4719 还能减少 ATP 诱导的人单核细胞源性巨噬细胞 [Ca2+]i 内流。MRS4719 可用于研究缺血性脑中风。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8242 |
Sabinene
|
Others | Others |
Sabinene 是香料添加剂,具有成为下一代飞机燃料成分的成分。 | |||
T4592 |
TOMATIDINE HYDROCHLORIDE
Tomatidine,Tomatidine HCl,盐酸番茄碱 |
Others; NF-κB; JNK; Autophagy | Autophagy; MAPK; NF-κB; Others |
Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱,可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用,可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。 | |||
T5294 |
(S)-Leucic acid
L-alpha-羟基异己酸,L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-2-羟基-4-甲基戊酸,(S)-(−)-2-Hydroxyisocaproic acid |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Leucic acid (Hydroxyisocaproic acid) 是氨基酸代谢物。 |