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Search Results for " antidepressants "

12

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0084	Moclobemide 吗氯贝胺,Ro111163	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Moclobemide (Ro111163) 是可逆的、可透过血脑屏障的单胺氧化酶 (MAO-A) 抑制剂，能够抑制 hMAO-A (IC50=6.061 μM)。它上调慢性应激小鼠海马祖细胞的增殖。
T20025	Imipramine Melipramine,HSDB3100,HSDB 3100,Dimipressin,HSDB-3100
	Imipramine is an agent of tricyclic antidepressants.
T0172	Maprotiline hydrochloride Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil	5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Maprotiline hydrochloride (Psymion) 是一种桥环四环类抗抑郁药，是去甲肾上腺素重吸收抑制剂。
T0450L	Fluoxetine hydrochloride Fluoxetine HCl,盐酸氟西汀,LY-110140,Lilly110140	5-HT Receptor; Serotonin Transporter; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Fluoxetine hydrochloride (Lilly110140) 是一种高度特异性血清素摄取抑制剂。它被用作抗抑郁药，并且通常比传统的抗抑郁药具有更可接受的副作用特征。
T0943	Carbamazepine 卡马西平,NSC 169864	Mitophagy; Sodium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel
	Carbamazepine (NSC-169864) 是与三环抗抑郁药化学相关的三环化合物，具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。它通常用于治疗与三叉神经痛相关的疼痛。
T25047	Alfetamine alpha-allyl-phenethylamine
	Alfetamine is a chemical compound of the phenethylamine family. It is similar to imipramine and amitriptyline, two tricyclic antidepressants.
T23628	AD-2646 AD2646
	AD-2646 is a new quinoline derivative. It also has similar pharmacological properties to tricyclic antidepressants.
T31604	Edivoxetine LY-2216684,LY 2216684,LY2216684
	Edivoxetine( LY2216684) is a selective norepinephrine reuptake inhibitor being developed as a treatment for attention deficit hyperactivity disorder (ADHD) and antidepressants.
T68327	Dexnafenodone Free Base
	Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressants.
T37307	Nordoxepin hydrochloride
	Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.
T60265	NV-5138 hydrochloride
	NV-5138 hydrochloride 是一种亮氨酸类似物，是一个具有选择性和口服活性的脑内的mTORC1的激动剂，可与 Sestrin2 结合。NV-5138 hydrochloride 可用于抗抑郁的研究。
T69943	Citalopram oxalate
	Citalopram oxalate is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.

化合物

Cat.No: T0084

Synonym: 吗氯贝胺,Ro111163

Target: MAO, Monoamine Oxidase

Cat.No: T20025

Synonym: Melipramine,HSDB3100,HSDB 3100,Dimipressin,HSDB-3100

Maprotiline hydrochloride

Cat.No: T0172

Synonym: Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor

Fluoxetine hydrochloride

Cat.No: T0450L

Synonym: Fluoxetine HCl,盐酸氟西汀,LY-110140,Lilly110140

Target: 5-HT Receptor, Serotonin Transporter, Autophagy

Cat.No: T0943

Synonym: 卡马西平,NSC 169864

Target: Mitophagy, Sodium Channel, Autophagy

Cat.No: T25047

Synonym: alpha-allyl-phenethylamine

Cat.No: T23628

Synonym: AD2646

Cat.No: T31604

Synonym: LY-2216684,LY 2216684,LY2216684

Dexnafenodone Free Base

Cat.No: T68327

Nordoxepin hydrochloride

Cat.No: T37307

NV-5138 hydrochloride

Cat.No: T60265

Citalopram oxalate

Cat.No: T69943

Cat. No.	Product Name	Target	Signaling Pathways
T1045	Trimipramine maleate Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐	Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。
T0185	Escitalopram Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体，是一种选择性 5-羟色胺再摄取抑制剂，Ki=0.89 nM，比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性，是一种研究抑郁症的抗抑郁药。

天然产物

Trimipramine maleate

Cat.No: T1045

Synonym: Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Cat.No: T0185

Synonym: Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

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