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Search Results for " anti-invasive "

9

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9211	Mito-LND Mito-Loidamine	OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能，刺激活性氧的形成，并诱导肺癌细胞自噬细胞死亡。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T1898	RKI-1447 RKI1447	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI-1447 是一种高效的ROCK1和ROCK2的小分子抑制剂，IC50值分别为14.5和6.2 nM。
T25384	Erbulozole R-55104,R55104,R 55104	Microtubule Associated	Cytoskeletal Signaling
	Erbulozole (R 55104) 是一种有效的合成微管抑制剂，具有抗侵袭、抗肿瘤和放射增敏活性，可诱发 Wernicke 脑病样神经毒性。
T11325	Frondoside A	Others	Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
T68425	Saracatinib difumarate
	Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.
T25925	p-DDAP pDDAP,p-Dodecylaminophenol
	p-DDAP is an anti-invasive agent that acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9).
T71965	KRIBB3
	KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27.
T62090	(Rac)-Tanomastat
	Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂，能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中，Tanomastat 表现出抗侵袭和抗转移作用。

化合物

Cat.No: T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T1898

Synonym: RKI1447

Target: ROCK

Cat.No: T25384

Synonym: R-55104,R55104,R 55104

Target: Microtubule Associated

Cat.No: T11325

Target: Others

Saracatinib difumarate

Cat.No: T68425

Cat.No: T25925

Synonym: pDDAP,p-Dodecylaminophenol

Cat.No: T71965

(Rac)-Tanomastat

Cat.No: T62090

Cat. No.	Product Name	Target	Signaling Pathways
T5834	Myrcene	Others	Others
	Myrcene 是具有可挥发性的芳香族化合物，对 TNFα 诱导的 NF-κB 具有抑制作用，且具有抗侵袭的能力。
T8193	α-Thujone Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮	Apoptosis; Reactive Oxygen Species; GABA Receptor; AChR; Parasite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，它的 IC50为 21 μM。它诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。
T5S0689	Demethylwedelolactone 去甲蟛蜞菊内酯,去甲基蟛蜞内酯	Serine Protease	Proteases/Proteasome
	Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭，是一种有效的trypsin 抑制剂(IC50:3.0 μM)。
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T12403	Penitrem A	Others	Others
	Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
TN1867	Licoricidin	MMP; VEGFR; ROS	Angiogenesis; Immunology/Inflammation; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
TN1881	Lucidenic acid C 赤芝酸 C,赤芝酸C	MMP	Proteases/Proteasome
	Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells.
T16035	Meleagrin	Others	Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.

天然产物

Cat.No: T5834

Target: Others

Cat.No: T8193

Synonym: Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Demethylwedelolactone

Cat.No: T5S0689

Synonym: 去甲蟛蜞菊内酯,去甲基蟛蜞内酯

Target: Serine Protease

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T12403

Target: Others

Cat.No: TN1867

Target: MMP, VEGFR, ROS

Lucidenic acid C

Cat.No: TN1881

Synonym: 赤芝酸 C,赤芝酸C

Target: MMP

Cat.No: T16035

Target: Others

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