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Search Results for " anti-arrhythmic "

19

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22236	Alprenolol hydrochloride 阿普洛尔盐酸盐,盐酸阿普洛尔	5-HT Receptor	GPCR/G Protein; Neuroscience
	Alprenolol hydrochloride 是一种非选择性β受体阻滞剂，也是5-HT1A 受体拮抗剂。
T0862	Diphenidol hydrochloride Diphenidol HCl,盐酸地芬尼多,Difenidol hydrochloride	Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Diphenidol hydrochloride (Difenidol hydrochloride) 是一种非选择性的毒蕈碱 M1-M4 受体拮抗剂，具有抗心律失常活性，用作抗眩晕药和止吐药。它也是神经细胞电压门控离子通道的有效非特异性阻滞剂。
T7198	E-4031 (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇	EGFR; Potassium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	E-4031是甲磺酰苯胺III 类抗心律失常药，选择性地阻断hERG 钾通道。
T11097	Drobuline hydrochloride	Others	Others
	Drobuline hydrochloride 是一种抗心律失常剂。
T3575	Acecainide hydrochloride ASL 601,NAPA	Others	Others
	Acecainide hydrochloride (NAPA) 是 PROCAINAMIDE 的主要代谢物。其抗心律失常作用可能导致肾衰竭时的心脏毒性。
T30251	AZD-1305 UNII-CZO834LXQM,AZD 1305	Others	Others
	AZD-1305是一种新型抗心律失常化合物，主要阻断哺乳动物细胞和心室心肌细胞中 IKr 的快速组分、l 型钙电流和病房内钠电流，可用于研究逆转心律失常。
T1320	Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平	Potassium Channel; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流，延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
T22594	Azimilide	Others	Others
	class III anti-arrhythmic drug
T25344	Disobutamide
	Disobutamide is used as a Cardiac Depressant (Anti-Arrhythmic).
T11036	Diacetolol D7	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Diacetolol D7 is deuterium-labeled diacetone Roller. Diacetol is the main metabolite of Acetolol. Diacetololβ-adrenoceptor shielding and anti-arrhythmic agent.
T12548	Propafenone D7 hydrochloride 盐酸普罗帕酮 D7,SA-79 (D7 hydrochloride)	Others	Others
	Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.
T30233	AWD-G256
	AWD-G256 是一种抗心律失常物质，AWD-G256 对卒中量、肺压和全身血压没有显著影响。
T21427	Mexiletine Mexitil,Mexiletene,KO-1173,KO1173,KO 1173
	Mexiletine is a non-selective voltage-gated sodium channel blocker. It is a medicine in the class of IB anti-arrhythmic. Mexiletine may also be used in patients experiencing refractory pain and is effective to treat muscle stiffness resulting from myotonic dystrophy or non-dystrophic myotonias.
T5391L	Bepridil free base CERM1978,CERM 1978,Bepadin,CERM-1978,Angopril
	Bepridil is a class IV anti-arrhythmic agent and calcium antagonist. Bepridil hydrochloride blocks calcium entry through membranous calcium channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arter
T21424	Disopyramide phosphate SC13957,SC 13957,SC-13957
	Disopyramide, a sodium channel blocker in the Class of 1a anti-arrhythmic agent, is used in the treatment of Ventricular Tachycardia. Disopyramide has a negative inotropic effect on the ventricular myocardium, resulting in a significant decrease in contra
T6955	Propafenone hydrochloride Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol	Sodium Channel	Membrane transporter/Ion channel
	Propafenone hydrochloride (Arythmol8) 具有抗心律不齐的功效，可用于心房和心室性心律不齐。
T61231	DDO-02005 free base
	DDO-02005 (free base) 是一种针对Kv1.5 钙离子通道的高效抑制剂，其IC50 值为0.72 μM。在CaCl2-ACh诱导的房颤大鼠模型中，DDO-02005 (free base) 显示出显著的抗房颤效果，并能有效对抗乌头碱所致的心律失常。
T64286	Quinidine polygalacturonate
	Quinidine polygalacturonate 是一种有效的、选择性的、口服具有活力的细胞色素 P450db (cytochrome P450db) 抑制剂，也是一种有效的 K+通道 (K+channel) 阻断剂，其 IC50值为 19.9 μM，也能够诱导凋亡。Quinidine polygalacturonate 是一种抗心律失常剂，也能够用于研究疟疾。
T69119	Disopyramide HCl
	Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intrave...

化合物

Alprenolol hydrochloride

Cat.No: T22236

Synonym: 阿普洛尔盐酸盐,盐酸阿普洛尔

Target: 5-HT Receptor

Diphenidol hydrochloride

Cat.No: T0862

Synonym: Diphenidol HCl,盐酸地芬尼多,Difenidol hydrochloride

Target: Sodium Channel, AChR

Cat.No: T7198

Synonym: (1S)-1,5-脱水-1-C-[4-氯-3-[[4-[2-(环丙氧基)乙氧基]苯基]甲基]苯基]-D-山梨醇

Target: EGFR, Potassium Channel

Drobuline hydrochloride

Cat.No: T11097

Target: Others

Acecainide hydrochloride

Cat.No: T3575

Synonym: ASL 601,NAPA

Target: Others

Cat.No: T30251

Synonym: UNII-CZO834LXQM,AZD 1305

Target: Others

Cat.No: T1320

Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平

Target: Potassium Channel, Sodium Channel, AChR

Cat.No: T22594

Target: Others

Cat.No: T25344

Cat.No: T11036

Target: Adrenergic Receptor

Propafenone D7 hydrochloride

Cat.No: T12548

Synonym: 盐酸普罗帕酮 D7,SA-79 (D7 hydrochloride)

Target: Others

Cat.No: T30233

Cat.No: T21427

Synonym: Mexitil,Mexiletene,KO-1173,KO1173,KO 1173

Bepridil free base

Cat.No: T5391L

Synonym: CERM1978,CERM 1978,Bepadin,CERM-1978,Angopril

Disopyramide phosphate

Cat.No: T21424

Synonym: SC13957,SC 13957,SC-13957

Propafenone hydrochloride

Cat.No: T6955

Synonym: Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol

Target: Sodium Channel

DDO-02005 free base

Cat.No: T61231

Quinidine polygalacturonate

Cat.No: T64286

Disopyramide HCl

Cat.No: T69119

Cat. No.	Product Name	Target	Signaling Pathways
T4550	Ajmaline Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline	Sodium Channel	Membrane transporter/Ion channel
	Ajmaline (Cardiorythmine) 是一种钠通道阻断剂，属于1A 类抗心律失常剂。Ajmaline 阻断 HERG 电流，在 HEK 细胞的 IC50为 1 μM，爪蟾卵母细胞的IC50为 42.3 μM。Ajmaline 在室性心动过速方面具有研究价值。
T2763	Panaxadiol 人参二醇,20(R)-Panaxadiol	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Panaxadiol (20(R)-Panaxadiol) 是从人参根中获得，具有神经保护和抗肿瘤作用，能够抑制程序性细胞死亡配体-1(PD-L1)的表达和肿瘤增殖。
T3P2904	α-Linolenic acid Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸，人体无法合成，从种子油中分离得到。它可调节 PI3K/Akt 信号传导，影响血栓形成过程。它具有抗心律失常的特性，并且与心血管疾病和癌症等有关。
TN1065	Hirsutine	Apoptosis	Apoptosis
	Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T4S1102	Liensinine diperchlorate 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate	Mitophagy; Others; Autophagy	Autophagy; Others
	Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬，具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。
T11510	Guanfu base I Acorine	Others	Others
	Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.

天然产物

Cat.No: T4550

Synonym: Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline

Target: Sodium Channel

Cat.No: T2763

Synonym: 人参二醇,20(R)-Panaxadiol

Target: Others, HIF/HIF Prolyl-Hydroxylase

α-Linolenic acid

Cat.No: T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸

Target: Akt, PI3K

Cat.No: TN1065

Target: Apoptosis

Liensinine diperchlorate

Cat.No: T4S1102

Synonym: 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Cat.No: T11510

Synonym: Acorine

Target: Others

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