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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T80671 |
ACHE-IN-38
5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one |
Antifungal | Microbiology/Virology |
ACHE-IN-38 是一种有效的Acetylcholinesterase 抑制剂,可用于合成具有抗炎、抗肿瘤和抗菌活性的化合物。 | |||
T14194 |
β-NETA
α-NETA |
AChE | Neuroscience |
β-NETA(α-NETA) 是胆碱乙酰转移酶(ChA;IC50=76 μM) 和胆碱酯酶 (ChE;IC50=40 µM)的非竞争性抑制剂,对乙酰胆碱酯的作用微弱 (AChE;IC50=1 mM)。 | |||
T61603 | H3R antagonist 2 | ||
H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist. It exhibits inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. With a Ki of 170 nM for hH3R, H3R antagonist 2 demonstrates favorable anti-neuropathic pain and memory-enhancing effects. Additionally, it can cross the blood-brain barrier (BBB) [1]. | |||
T79621 |
TZ4M
|
||
TZ4M 是一种含 2,4-噻唑烷二酮 (TZD) 的抗阿尔茨海默病试剂,可提供神经保护。在人类血浆中,TZ4M 可抑制 AChE。此外,TZ4M 能在东莨菪碱诱导的阿尔茨海默病动物模型中改善成年大鼠的记忆与认知功能。 | |||
T72804 |
Isograndifoliol
|
||
Isograndifoliol 是一种选择性丁酰胆碱酯酶 (BChE) 抑制剂,IC50值为 0.9 μM。Isograndifoliol 对乙酰胆碱酯酶 (AChE) 有一定的抑制作用,IC50值为 342.9 μM。Isograndifoliol 还具有血管松弛作用和抗肿瘤作用。Isograndifoliol 可用于研究神经退行性疾病引起的痴呆。 | |||
T72247 |
Ladostigil hydrochloride
TV-3326 hydrochloride |
||
Ladostigil (TV-3326) hydrochloride 是一种口服有效的胆碱酯酶(cholinesterase)和脑选择性单胺氧化酶(MAO)的双重抑制剂,抑制MAO-B 和AChE 的IC50值分别为 37.1 和 31.8 μM。Ladostigil hydrochloride 具有神经保护,抗氧化和抗炎的作用,可用于抑郁症和阿尔茨海默症的研究。 | |||
T61454 |
α-NETA
|
||
α-NETA是一种有效的胆碱乙酰转移酶(ChA)非竞争性抑制剂,IC50值为9μM。同时,它也是ALDH1A1(IC50=0.04μM)和趋化因子样受体1(CMKLR1)的有效拮抗剂。此外,α-NETA对胆碱酯酶(ChE; IC50=84μM)和乙酰胆碱酯酶(AChE; IC50=300μM)的抑制作用较弱。α-NETA亦显示出抗癌活性。 | |||
T82243 | hAChE-IN-5 | GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
hAChE-IN-5(化合物49)是一种同时针对hAChE和hBuChE的有效抑制剂,其IC50值均为0.17 μM。此外,hAChE-IN-5对GSK3β同样展现出良好的抑制活性,IC50值为0.21 μM。作为tau蛋白聚集和Aβ1-42自聚集的抑制剂,hAChE-IN-5能够结合PAS,进而阻止Aβ依赖的神经毒性。其能穿透血脑屏障(BBB),显示出成为多靶点抗阿尔茨海默病药物研究的潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2298 |
Vincosamide
喜果苷 |
AChE | Neuroscience |
Vincosamide 是一种来自Psychotria leiocarpa 提取物的生物碱,具有抑制乙酰胆碱酯酶 (AChE) 作用,具有抗炎活性。 | |||
T2S1200 |
Sinapine
|
Antioxidant; P-gp; AChE | Membrane transporter/Ion channel; Neuroscience; oxidation-reduction |
Sinapine 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
T3392 |
Sinapine thiocyanate
|
P-gp; AChE | Membrane transporter/Ion channel; Neuroscience |
Sinapine thiocyanate 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
TN6786 |
O-Desmethyl Galanthamine
Sanguinine,O-去甲基加兰他敏 |
AChE | Neuroscience |
O-Desmethyl Galanthamine (Sanguinine) 是一种加兰他敏型生物碱,是一种乙酰胆碱酯酶 (AChE) 抑制剂,其IC50=1.83 μM。 | |||
T2846 |
Isoimperatorin
|
Antibacterial; AChE | Microbiology/Virology; Neuroscience |
Isoimperatorin 是 Angelica dahurica 根的甲醇提取物,是一种抗炎剂,有效抑制乙酰胆碱酯酶,IC50为 74.6 μM。 | |||
T9862 |
Pseudocoptisine chloride
盐酸异黄连碱,Isocoptisine chloride |
AChE | Neuroscience |
Pseudocoptisine chloride (Isocoptisine chloride) 是从 Corydalis Tuber 中分离出来的,具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。 | |||
TN1030 |
N-p-trans-Coumaroyltyramine
N-反式对香豆酰基酪胺,N-反式-对香豆酰酪胺 |
AChE; Parasite | Microbiology/Virology; Neuroscience |
N-p-trans-Coumaroyltyramine 是从蓼属植物中分离出的肉桂酰苯乙酰胺,是一种乙酰胆碱酯酶抑制剂,IC50 为 122 μM。它具有抗锥虫活性,对T. brucei rhodesiense 作用的 IC50值为 13.3 µM。 | |||
T5S2254 |
Swertianolin
Bellidifolin-8-O-Glucoside,当药醇苷 |
Others; HBV; Antibacterial; AChE | Microbiology/Virology; Neuroscience; Others |
Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮,具有抗 HBV 和抗菌活性,可抑制乙酰胆碱酯酶。 | |||
T5S2360 |
Corydaline
Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline |
P450; Virus Protease; Opioid Receptor; AChE | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱,是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运,促进胃的调节,具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。 | |||
TN3466 |
Atherosperminine
|
cAMP; Calcium Channel; AChR; Parasite | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Atherosperminine 是一种天然生物碱,在体外表现出抗疟原虫活性,IC50为 5.80 μM。它具有DPPH 自由基清除活性,其IC50值为 29.56 µg/mL。它对气管有非特异性的弛缓作用。它是一种良好的还原剂,具有螯合金属的能力。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN6009 | Pseudopalmatine | ||
Pseudopalmatine exhibits antiplasmodial activity. It also shows anti-acetylcholinesterase (AChE) activity, with IC50 values of 1.8uM. | |||
TN1409 |
Asimilobine
|
AChR; Antifection | Microbiology/Virology; Neuroscience |
(-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Streptococcus mutans (ATCC 25175), with a minimum inhibition concentration (MIC) o | |||
T28122 |
Myrtenal
NSC-54384,NSC 54384,NSC54384,Benihinal |
||
Myrtenal is a natural monoterpene. It is found to attenuate diethylnitrosamine-induced hepatocellular carcinoma in rats by stabilizing intrinsic antioxidants and modulating apoptotic and anti-apoptotic cascades. Myrtenal also inhibits acetylcholinesterase | |||
T38606 | Sinapine hydroxide | ||
Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4]. | |||
TN4492 | Mangostanol | AChR | Neuroscience |
Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 values of 9.6 microg/ml. | |||
T81235 | S-(-)-N-trans-Feruloyl normetanephrine | ||
S-(-)-N-trans-Feruloyl normetanephrine为天然产物,呈现弱抗乙酰胆碱酯酶活性,可从Bassia indica Wight地上部分提取。 | |||
T79968 |
Coumarinic acid
|
||
Coumarinic acid为具有脑穿透性的双重功能抑制剂,能够抑制AChE和β-amyloid,适用于开发治疗阿尔茨海默病的药物研究。 |