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42

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2397	Topiroxostat 托匹司他,FYX-051	P450; ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Topiroxostat (FYX-051) 是一种有效的口服黄嘌呤氧化还原酶 (XOR) 抑制剂，IC50=5.3 nM，Ki=5.7 nM。它还表现出弱的CYP3A4抑制活性 (18.6%)。它有用于高尿酸血症的研究潜力。
TP1832	Gluten Exorphin C	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Gluten exorphin C 是来源于谷朊粉的阿片肽。在 GPI 和 MVD 检测中，抑制 μ 阿片和 δ 阿片活性，IC50值分别为 40 和13.5 μM。
T15777	Loxoribine RWJ 21757,7-Allyl-8-oxoguanosine,洛索立宾	Influenza Virus; TLR	Immunology/Inflammation; Microbiology/Virology
	Loxoribine (RWJ 21757) 是一种鸟苷类似物，是一种口服生物可利用的选择性 Toll 样受体 (TLR) 7 激动剂。具有抗病毒和抗肿瘤活性。它是一种新型的强效免疫刺激剂，具有较广谱的免疫生物学活性。
T7886	Nidufexor	FXR; Autophagy	Autophagy; Metabolism
	Nidufexor 是一种可口服的法尼醇 X 受体激动剂，可研究非酒精性脂肪性肝炎。
T77600	Methyl-4-oxoretinoate	Apoptosis	Apoptosis
	Methyl-4-oxoretinoate 是一种合成的类视黄醇化合物，具有抗癌化合物，可可以诱导癌细胞分化和凋亡。Methyl-4-oxoretinoate 可用于治疗痤疮、牛皮癣和其他皮肤病。Methyl-4-oxoretinoate 具有治疗各种眼部疾病（如年龄相关性黄斑变性）的潜力。
T7436	Cilofexor	FXR; Autophagy	Autophagy; Metabolism
	Cilofexor 是一种法尼醇 X 受体激动剂，EC50为 43 nM。它抑制合成肽的结合，具有抗炎和抗纤维化作用。它可用于原发性硬化性胆管炎和非酒精性脂肪性肝炎的研究。
T11090L1	Aldoxorubicin hydrochloride Aldoxorubicin hydrochloride (1361644-26-9 Free base）	Topoisomerase	DNA Damage/DNA Repair
	Aldoxorubicin hydrochloride 是 Doxorubicin (DNA 拓扑异构酶 II 抑制剂) 的白蛋白结合前药。Aldoxorubicin hydrochloride 在酸性条件下从白蛋白中释放出来。 Aldoxorubicin hydrochloride 显示出有效的抗肿瘤活性。
T6123	Verdinexor KPT-335	CRM1	Membrane transporter/Ion channel
	Verdinexor (KPT-335) 是一种特异性 XPO1/CRM1 抑制剂，具有口服生物利用度。
T6053	Turofexorate Isopropyl XL335,FXR-450,WAY-362450,妥芬异丙酯	FXR; Autophagy	Autophagy; Metabolism
	Turofexorate Isopropyl (XL335) 是一种口服有效的，选择性 FXR 激动剂，EC50为 4 nM。
T8471	Vonafexor EYP001,PLX007,pxl007	FXR; HBV	Metabolism; Microbiology/Virology
	Vonafexor (EYP001) 是一种法尼醇 X 受体激动剂，具有抗 HBV 作用。
T4379	Tropifexor LJN452	FXR; Autophagy	Autophagy; Metabolism
	Tropifexor (LJN452) 是一种新型的高效 FXR 激动剂，EC50 为 0.2 nM。
T6106	Selinexor (KPT-330) Selinexor,KPT-330,塞利尼索	CRM1	Membrane transporter/Ion channel
	Selinexor (KPT-330) 是一种 CRM1 的小分子抑制剂，具有选择性和口服活性。Selinexor 可以阻滞细胞周期、诱导细胞凋亡，具有抗肿瘤活性，可以用于治疗多发性骨髓瘤。
T3203	Methyl 13-cis-4-Oxoretinoate 13-cis-4-Oxo-retinoic acid Methyl Ester,4-Keto 13-cis-Retinoic Acid Methyl Ester	Others	Others
	Methyl 13-cis-4-Oxoretinoate (13-cis-4-Oxo-retinoic acid Methyl Ester) 是神经母细胞瘤中的一种视黄酸代谢物。
T11766L	Eltanexor ONO-7706,KPT-8602,ATG-016	Others	Others
	Eltanexor (ONO-7706) 是一种具有口服活性的 exportin-1 (XPO1) 抑制剂。它具有有效的抗白血病活性。 Eltanexor 通过直接靶向 XPO1 抑制 XPO1 依赖性核输出 (EC50=60.9 nM)。 Eltanexor 在一组白血病细胞系中引起半胱天冬酶依赖性细胞凋亡。
T25435	Folitixorin calcium CoFactor,ANX 510,ANX-510,ANX510
	Folitixorin calcium is an antineoplastic enhancing agent.
T82292	Gluten Exorphin A5
	Gluten Exorphin A5是一种小麦麸质的片段，它在周围神经系统和中枢神经系统中显示出具有神经保护的多样作用。
T77832	Azide-PEG4-VC-PAB-Doxorubicin
	Azide-PEG4-VC-PAB-Doxorubicin 为链接剂 Azide-PEG4-VC-PAB 与毒性分子 Doxorubicin 结合形成，适用于抗体药物偶联物（ADCs）的制备。
T29673	Doxorubicinone Adriamycinone,Adriamycin Aglycone,Doxorubicin Aglycone
	Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.
T31567	Doxorubicin-MVCP MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox
	Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
T18418	N-(Iodoacetamido)-Doxorubicin	Others	Others
	N-(Iodoacetamido)-Doxorubicin is an ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
T31840	Folitixorin calcium, (6R)-
	Folitixorin calcium, (6R)- is the calcium salt of Folitixorin, a substrate used by the enzyme methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate.
T25349	Doxorubicinol RP-27706,Antibiotic 27706RP,13-Dihydrodoxorubicin,Adriamycinol,RP 27706
	Doxorubicinol is the major circulating metabolite of doxorubicin with antineoplastic acitivity.
T35185L	Xorphanol mesylate TR 5379M,TR5379M,TR-5379M
	Xorphanol mesylate is a biochemical.
T31841	Folitixorin calcium, (6S)-
	Folitixorin calcium, (6S)- is the calcium salt of the substrate to generate 5-methyltetrahydrofolate.
T63818	Omesdafexor
	Omesdafexor 是 FXR 激动剂，能够用于研究肝病或代谢性炎症引起的疾病。
T70775	Zoptarelin doxorubicin
	Zoptarelin doxorubicin, also known as AEZS-108, is an LHRH agonist. Zoptarelin doxorubicin is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates in...
T81721	N,N-Dimethyldoxorubicin
	N,N-Dimethyldoxorubicin为一Doxorubicin类似物，表现出对多种肿瘤细胞系的显著细胞毒性，其半数抑制浓度(IC50s)均小于0.3 μM。
T26654	Arfolitixorin
	Arfolitixorin is an antifolate modulator.
T35185	Xorphanol TR-5379,TR5379,TR 5379
	Xorphanol is a biochemical.
T69724	Cilofexor tromethamine
	Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.
T21315	Folitixorin ANX-510
	ANX-510 is a folate-based biomodulator. It stabilizes the covalent binding of the fluorouracil metabolite FdUMP to thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituen
T11766	Eltanexor Z-isomer KPT-8602 (Z-isomer)	Others	Others
	Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.
T31839	Folitixorin sodium
	Folitixorin sodium is the sodium salt of the substrate used by the enzyme methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate.
T40736	Doxorubicinol hydrochloride 13-Dihydroadriamycin hydrochloride
	Doxorubicinol hydrochloride, also known as 13-Dihydroadriamycin hydrochloride, is a secondary alcohol metabolite derived from Doxorubicin.
TP1815	Gluten Exorphin B5
	Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.
T15161	Doxorubicin-SMCC	Others	Others
	Doxorubicin-SMCC is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T11090L	Aldoxorubicin DOXO-EMCH,INNO-206	Topoisomerase	DNA Damage/DNA Repair
	Aldoxorubicin has effective antitumor activities in various cancer cell lines and in murine tumor models. Aldoxorubicin is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitors).
T72078	Xanthine oxidoreductase-IN-4	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-4 是一种具有有口服活性黄嘌呤氧化还原酶 (XOR) 抑制剂，对 XOR 具有抑制作用，IC50 值为 29.3 nM。Xanthine oxidoreductase-IN-4 可用于研究高尿酸血症。
T72165	Xanthine oxidoreductase-IN-3	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-3 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂（IC50 ： 26.3 nM）。Xanthine oxidoreductase-IN-3 可用急性高尿酸血症的研究。
T72166	Xanthine oxidoreductase-IN-5	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-5 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂（IC50 ： 55 nM）。Xanthine oxidoreductase-IN-5 可用于急性高尿酸血症的研究。
T60890	Xanthine oxidoreductase-IN-1
	Xanthine oxidoreductase-IN-1 是黄嘌呤氧化还原酶（XOR）的抑制剂，IC50值为7.0 nM。
T61162	Xanthine oxidoreductase-IN-2
	Xanthine oxidoreductase-IN-2 (Compound IVa) is a potent inhibitor of xanthine oxidoreductase (XOR) with an IC50 value of 7.2 nM. Notably, Xanthine oxidoreductase-IN-2 demonstrates hypouricemic effects in mice, as evidenced by [1].

化合物

Cat.No: T2397

Synonym: 托匹司他,FYX-051

Target: P450, ROS, Xanthine Oxidase

Gluten Exorphin C

Cat.No: TP1832

Target: Opioid Receptor

Cat.No: T15777

Synonym: RWJ 21757,7-Allyl-8-oxoguanosine,洛索立宾

Target: Influenza Virus, TLR

Cat.No: T7886

Target: FXR, Autophagy

Methyl-4-oxoretinoate

Cat.No: T77600

Target: Apoptosis

Cat.No: T7436

Target: FXR, Autophagy

Aldoxorubicin hydrochloride

Cat.No: T11090L1

Synonym: Aldoxorubicin hydrochloride (1361644-26-9 Free base）

Target: Topoisomerase

Cat.No: T6123

Synonym: KPT-335

Target: CRM1

Turofexorate Isopropyl

Cat.No: T6053

Synonym: XL335,FXR-450,WAY-362450,妥芬异丙酯

Target: FXR, Autophagy

Cat.No: T8471

Synonym: EYP001,PLX007,pxl007

Target: FXR, HBV

Cat.No: T4379

Synonym: LJN452

Target: FXR, Autophagy

Selinexor (KPT-330)

Cat.No: T6106

Synonym: Selinexor,KPT-330,塞利尼索

Target: CRM1

Methyl 13-cis-4-Oxoretinoate

Cat.No: T3203

Synonym: 13-cis-4-Oxo-retinoic acid Methyl Ester,4-Keto 13-cis-Retinoic Acid Methyl Ester

Target: Others

Cat.No: T11766L

Synonym: ONO-7706,KPT-8602,ATG-016

Target: Others

Folitixorin calcium

Cat.No: T25435

Synonym: CoFactor,ANX 510,ANX-510,ANX510

Gluten Exorphin A5

Cat.No: T82292

Azide-PEG4-VC-PAB-Doxorubicin

Cat.No: T77832

Cat.No: T29673

Synonym: Adriamycinone,Adriamycin Aglycone,Doxorubicin Aglycone

Doxorubicin-MVCP

Cat.No: T31567

Synonym: MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox

N-(Iodoacetamido)-Doxorubicin

Cat.No: T18418

Target: Others

Folitixorin calcium, (6R)-

Cat.No: T31840

Cat.No: T25349

Synonym: RP-27706,Antibiotic 27706RP,13-Dihydrodoxorubicin,Adriamycinol,RP 27706

Xorphanol mesylate

Cat.No: T35185L

Synonym: TR 5379M,TR5379M,TR-5379M

Folitixorin calcium, (6S)-

Cat.No: T31841

Cat.No: T63818

Zoptarelin doxorubicin

Cat.No: T70775

N,N-Dimethyldoxorubicin

Cat.No: T81721

Cat.No: T26654

Cat.No: T35185

Synonym: TR-5379,TR5379,TR 5379

Cilofexor tromethamine

Cat.No: T69724

Cat.No: T21315

Synonym: ANX-510

Eltanexor Z-isomer

Cat.No: T11766

Synonym: KPT-8602 (Z-isomer)

Target: Others

Folitixorin sodium

Cat.No: T31839

Doxorubicinol hydrochloride

Cat.No: T40736

Synonym: 13-Dihydroadriamycin hydrochloride

Gluten Exorphin B5

Cat.No: TP1815

Doxorubicin-SMCC

Cat.No: T15161

Target: Others

Cat.No: T11090L

Synonym: DOXO-EMCH,INNO-206

Target: Topoisomerase

Xanthine oxidoreductase-IN-4

Cat.No: T72078

Target: Xanthine Oxidase

Xanthine oxidoreductase-IN-3

Cat.No: T72165

Target: Xanthine Oxidase

Xanthine oxidoreductase-IN-5

Cat.No: T72166

Target: Xanthine Oxidase

Xanthine oxidoreductase-IN-1

Cat.No: T60890

Xanthine oxidoreductase-IN-2

Cat.No: T61162

Cat. No.	Product Name	Target	Signaling Pathways
T7408	all-trans-4-Oxoretinoic acid 4-KETO全反式维甲酸,all-trans 4-Keto Retinoic Acid	Endogenous Metabolite	Metabolism
	all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) 是一种维生素A 的特性代谢物，能够通过作用核维甲酸受体(RARs) 来诱导基因转录。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
T1456	Doxorubicin Hydroxydaunorubicin,阿霉素,Adriamycin	Topoisomerase; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。

天然产物

all-trans-4-Oxoretinoic acid

Cat.No: T7408

Synonym: 4-KETO全反式维甲酸,all-trans 4-Keto Retinoic Acid

Target: Endogenous Metabolite

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

Cat.No: T1456

Synonym: Hydroxydaunorubicin,阿霉素,Adriamycin

Target: Topoisomerase, AMPK

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