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Search Results for " vinblastine "

14

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6721	Vinblastine	Microtubule Associated; AChR	Cytoskeletal Signaling; Neuroscience
	Vinblastine 抑制微管形成并抑制 nAChR 活性，IC50 为 8.9 μM，用于治疗某些类型的癌症。
T18330	MC-Val-Cit-PAB-vinblastine	Others	Others
	MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADC linker.
T29434	4-Desacetylvinblastine hydrazide DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide
	Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.
T10772	Cevipabulin TTI-237	Microtubule Associated	Cytoskeletal Signaling
	Cevipabulin (TTI-237) 是一种微管活性的、口服有效的抗肿瘤化合物，可抑制 [3H] 长春碱与微管蛋白的结合，对人癌细胞的 IC50 值为 18-40 nM。
T10772L	Cevipabulin fumarate TTI-237 fumarate	Others	Others
	Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).
T17727	CCK2R Ligand-Linker Conjugates 1	Others	Others
	CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1].
T13672	EC0489	Others	Others
	EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor.
T26413	A 30312 A-30312,A30312
	A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells.
T21317	Avanbulin BAL27862,BAL-27862,BAL 27862
	Avanbulin is a potent inhibitor of tubulin polymerization with antitumor activity. It elicits a unique microtubule (MT) phenotype, distinct from colchicine, paclitaxel, and vinblastine has broad in vitro anti-proliferative activity against a diverse range
T36856	UA 62784
	Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity. Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID:21609844 \|Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cauti...
T25025	ALB-109564 dihydrochloride
	ALB-109564 dihydrochloride 是长春碱生物碱的半合成衍生物，是一种微管蛋白抑制剂和抗肿瘤药物。它与微管蛋白单体结合并抑制微管的形成，导致有丝分裂纺锤体组装的破坏和肿瘤细胞停滞在细胞周期的G2/M 期。
T35616	Migrastatin
	Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mam...
T38011	C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)
	C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. It inhibits Vero toxin binding to globotriaosylceramide in an ELISA assay when used at a concentration of 10 μM. AdaGb3 decreases cell surface expression of P-glycoprotein (P-gp) and reduces efflux of rhodamine 123 in MDCK cells. It also increases apical-to-basal transport of vinblastine in human intestinal ...
T71252	PC-046
	PC-046 is a potent tubulin-binding agent, which was originally identified for development based on selective activity in deleted in pancreas cancer locus 4 (DPC4/SMAD4) deficient tumors. PC-046 has growth inhibitory activity in a variety of tumor types in vitro, and efficacy in SCID mice was shown in human tumor xenografts of MV-4-11 acute myeloid leukemia, MM.1S multiple myeloma, and DU-145 prostate cancer. Pharmacokinetic studies demonstrated relatively high oral bioavailability (71 %) with di...

化合物

Cat.No: T6721

Target: Microtubule Associated, AChR

MC-Val-Cit-PAB-vinblastine

Cat.No: T18330

Target: Others

4-Desacetylvinblastine hydrazide

Cat.No: T29434

Synonym: DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide

Cat.No: T10772

Synonym: TTI-237

Target: Microtubule Associated

Cevipabulin fumarate

Cat.No: T10772L

Synonym: TTI-237 fumarate

Target: Others

CCK2R Ligand-Linker Conjugates 1

Cat.No: T17727

Target: Others

Cat.No: T13672

Target: Others

Cat.No: T26413

Synonym: A-30312,A30312

Cat.No: T21317

Synonym: BAL27862,BAL-27862,BAL 27862

Cat.No: T36856

ALB-109564 dihydrochloride

Cat.No: T25025

Cat.No: T35616

C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)

Cat.No: T38011

Cat.No: T71252

Cat. No.	Product Name	Target	Signaling Pathways
T1668	Vinblastine sulfate 硫酸长春碱,NSC49842,Vincaleukoblastine sulfate salt	Microtubule Associated; AChR; Autophagy	Autophagy; Cytoskeletal Signaling; Neuroscience
	Vinblastine sulfate (Vincaleukoblastine sulfate salt) 是对各种癌症类型有细胞毒性的生物碱。它可以抑制微管的形成，也可以抑制 nAChR，IC50值为8.9 μM。
T22455	Vindesine sulfate DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS	Others	Others
	Vindesine sulfate (Desacetyl Vinblastine amide) 是一种长春花生物碱，它是长春碱的合成衍生物，与有丝分裂纺锤体的微管蛋白结合，导致微管结晶和有丝分裂停滞或细胞死亡。
T12540	Pristinamycin IA Mikamycin IA,普利霉素IA,Mikamycin B	Others; Antibiotic; P-gp	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Pristinamycin IA (Mikamycin B) 是 P-糖蛋白的底物，也是一种环肽类大环内酯抗生素。
T3022	Anhydrovinblastine 脱水长春碱,3',4'-Anhydrovinblastine	Others	Others
	3',4'-Anhydrovinblastine (3',4'-Anhydrovinblastine) 是一种提取自Catharanthus roseus 叶片的单萜吲哚生物碱。
TN4695	Odorine	Others	Others
	Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine.
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Vinblastine sulfate

Cat.No: T1668

Synonym: 硫酸长春碱,NSC49842,Vincaleukoblastine sulfate salt

Target: Microtubule Associated, AChR, Autophagy

Vindesine sulfate

Cat.No: T22455

Synonym: DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS

Target: Others

Pristinamycin IA

Cat.No: T12540

Synonym: Mikamycin IA,普利霉素IA,Mikamycin B

Target: Others, Antibiotic, P-gp

Anhydrovinblastine

Cat.No: T3022

Synonym: 脱水长春碱,3',4'-Anhydrovinblastine

Target: Others

Cat.No: TN4695

Target: Others

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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