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Search Results for " vn "

Targets Recommended: P450 Androgen Receptor

26

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6509	Galeterone VN-124-1,TOK-001,VN/124-1,VN 124	P450; Androgen Receptor	Endocrinology/Hormones; Metabolism
	Galeterone (VN 124) 是CYP17抑制剂，能够多功能的抗雄激素，在去势抵抗性前列腺癌中，其IC50值为 47 nM。
T126173	Gypenoside VN3
	Gypenoside VN3 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126173，CAS号为 1235721-51-3。
T9787	suvn-911	AChR	Neuroscience
	SUVN-911 是高选择性的，大脑通透性的和口服有效的神经元烟碱乙酰胆碱 α4β2 受体拮抗剂，Ki 为 1.5 nM。SUVN-911显示出抗抑郁作用。
T1979	AVN-944 VX-944	Dehydrogenase	Metabolism
	AVN-944 (VX-944) 是一种选择性的、非竞争性 IMPDH 抑制剂，对IMPDH1和IMPDH2的Ki=为6-10nM。
T9346	CVN424	GPR	Endocrinology/Hormones; GPCR/G Protein
	CVN424 是一种有效的、具有口服活性的、选择性的GPR6反向激动剂，其EC50=9.4 nM，EC50=38 nM。它可以透过血脑屏障，对帕金森病具有潜在的研究价值。
T5179	AVN-492 AVN492	5-HT Receptor	GPCR/G Protein; Neuroscience
	AVN-492 是一种有效的选择性 5-HT6R 拮抗剂，Ki 为 91 pM。
T26690	AVN-101	5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	AVN-101 是一种非常有效的 5-HT7 受体拮抗剂 (Ki = 153 pM)。 AVN-101 还对组胺 H1 (Ki = 0.58 nM) 和肾上腺素能 α2A、α2B 和 α2C (Ki = 0.41-3.6 nM) 受体表现出相当高的亲和力。 AVN-101在中枢神经系统疾病动物模型中显示出良好的口服生物利用度和促进脑血屏障通透性、低毒性和合理的疗效。
T80529	VnP-16	Integrin	Cytoskeletal Signaling
	VnP-16 通过直接作用于β1整合素 (β1 integrin)，激活FAK，促进成骨细胞分化和活性，加速骨形成。
T78090	CVN636
	CVN636，作为口服有效的选择性mGluR7变构激动剂，其对humGluR7的EC50为7 nM，并显示出良好的中枢神经系统（CNS）通透性。
T81836	Mca-SEVNLDAEFK(Dnp)-NH2
	Mca-SEVNLDAEFK(Dnp)-NH2具备一个7-甲氧基香豆素（Mca）荧光基团，由于其与2,4-二硝基苯基（Dnp）间的共振能量转移作用，荧光得到有效猝灭。该化合物主要应用于检测切割Mca与Dnp之间酰胺键的肽酶活性，如BACE-1，其活性导致荧光增强。
T78827	CVN417
	CVN417，一种含 α6 亚基的口服nAChR拮抗剂，通过脉冲依赖的方式调控多巴胺能神经传递，并对nAChR亚基介导的Ca(2+)流出显示出抑制效应，其IC50s为0.086 μM (α6)，2.56 μM (α3)，以及0.657 μM (α4)。在啮齿类动物模型之研究中，CVN417减缓静息震颤，并展现对帕金森病等运动功能障碍改善的可能性。
T84317	AVN 322 free base

T17251	VNA-932 WAY-VNA 932	Others	Others
	VNA-932 is an agonist of the vasopressin V2-receptor (IC50: 80.3 nM and 778 nM in human-V2 binding and V1a binding assay).
T39218	(S)-CVN424 (S)-CVN424
	(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease.
T78007	Vasonatrin Peptide (VNP) TFA
	Vasonatrin Peptide (VNP) TFA 是一种由心钠素 (ANP) 和C型利钠肽 (CNP) 嵌合而成的肽类化合物。它整合了CNP的静脉扩张功能、ANP的利尿效果，并展现出与ANP或CNP无关的特有动脉扩张特性。Vasonatrin Peptide TFA 透过cGMP-PKG信号途径发挥其对内质网应激介导的糖尿病心脏缺血再灌注损害的保护作用。
T26691	AVN-322 AVN 322
	AVN-322 is a 5-HT6 receptor antagonist. 5-HT6R antagonists improves cognition in animal models of cognitive impairment.
TP1872	Vasonatrin Peptide (VNP) Vasonatrin Peptide VNP
	Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activity.
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。
T28008	MDVN1003 MDVN 1003,MDVN-1003
	MDVN1003 is a potent inhibitor of BTK amd PI3Kδ, two proteins regulated by the B cell receptor (BCR) that drive the growth of many NHLs. MDVN1003 induces cell death in a B cell lymphoma cell line but not in an irrelevant erythroblast cell line.
T24942	VNRX-5133 VNRX 5133
	VNRX-5133 is an injectable broad-spectrum β-lactamase inhibitor. VNRX-5133 is a novel β-lactamase inhibitor with potent and selective direct inhibitory activity against both serines- and Metallo-β-lactamases.
T71593	AVN-101 free base
	AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
TP1505	MCA-SEVNLDAEFR-K(Dnp)-RR, amide
	MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.
T30230	AVN-211 CD-008-0173,AVN 211
	AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist for the treatment of Alzheimer's disease.
T83686	Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
	Mca-SEVNLDAEFR-K(Dnp)-RR-NH2是β-分泌酶(BACE)的荧光底物。当BACE切割该底物时，7-甲氧基香豆素-4-乙酰基(Mca)会被释放出来，其荧光可用于定量BACE活性。Mca的激发/发射最大值分别为328/420 nm。
T80128	RE(EDANS)EVNLDAEFK(DABCYL)R	Beta-Secretase	Neuroscience
	RE(EDANS)EVNLDAEFK(DABCYL)R为具有EDANS和DABCYL双标记的肽，作为BACE1的荧光底物（Em=360nm，Ex=528nM）。该化合物主要用于评估BACE1酶活性，其活性水平正相关于荧光产生的强度。
T76562	VLVNTFCDSCIPKTYWNLGY TFA
	VLVNTFCDSCIPKTYWNLGY TFA，作为M3毒蕈碱受体（M3R）的抗原肽，适用于ELISA实验。

化合物

Cat.No: T6509

Synonym: VN-124-1,TOK-001,VN/124-1,VN 124

Target: P450, Androgen Receptor

Cat.No: T126173

Cat.No: T9787

Target: AChR

Cat.No: T1979

Synonym: VX-944

Target: Dehydrogenase

Cat.No: T9346

Target: GPR

Cat.No: T5179

Synonym: AVN492

Target: 5-HT Receptor

Cat.No: T26690

Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T80529

Target: Integrin

Cat.No: T78090

Mca-SEVNLDAEFK(Dnp)-NH2

Cat.No: T81836

Cat.No: T78827

AVN 322 free base

Cat.No: T84317

Cat.No: T17251

Synonym: WAY-VNA 932

Target: Others

Cat.No: T39218

Synonym: (S)-CVN424

Vasonatrin Peptide (VNP) TFA

Cat.No: T78007

Cat.No: T26691

Synonym: AVN 322

Vasonatrin Peptide (VNP)

Cat.No: TP1872

Synonym: Vasonatrin Peptide VNP

Cat.No: T83848

Cat.No: T28008

Synonym: MDVN 1003,MDVN-1003

Cat.No: T24942

Synonym: VNRX 5133

AVN-101 free base

Cat.No: T71593

MCA-SEVNLDAEFR-K(Dnp)-RR, amide

Cat.No: TP1505

Cat.No: T30230

Synonym: CD-008-0173,AVN 211

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate

Cat.No: T83686

RE(EDANS)EVNLDAEFK(DABCYL)R

Cat.No: T80128

Target: Beta-Secretase

VLVNTFCDSCIPKTYWNLGY TFA

Cat.No: T76562

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00121	Vitronectin Protein, Human, Recombinant (His) V75,vitronectin,VN,VNT	Human	HEK293 Cells
	Vitronectin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is D9ZGG2.
TMPY-01861	Vitronectin Protein, Mouse, Recombinant (His) vitronectin,Vn,AI256434	Mouse	HEK293 Cells
	Vitronectin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.2 kDa and the accession number is P29788.
TMPJ-00472	Vitronectin Protein, Human, Recombinant (Truncated, His) Vitronectin,Complement S-protein,Serum Spreading Factor,epib...	Human	HEK293 Cells
	Vitronectin, also known as VTN, is a large glycoprotein found in blood and the extracellular matrix (ECM). Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococca...
TMPY-05937	Influenza A H1N1 (A/Sw/Bulnes/VN1401-P6SP/2018) Neuraminidase/NA Protein (His) NA Protein	H1N1	HEK293 Cells
	Influenza A H1N1 (A/Sw/Bulnes/VN1401-P6SP/2018) Neuraminidase/NA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.1 kDa and the accession number is A0A3S7XT90.
TMPY-01403	VNN1 Protein, Human, Recombinant (His) Tiff66,HDLCQ8,vanin 1	Human	HEK293 Cells
	VNN1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.7 kDa and the accession number is O95497.
TMPY-02730	VNN1 Protein, Mouse, Recombinant (hFc) V-1,vanin 1	Mouse	HEK293 Cells
	VNN1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q9Z0K8.
TMPY-02529	VNN1 Protein, Mouse, Recombinant (His) vanin 1,V-1	Mouse	HEK293 Cells
	VNN1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.4 kDa and the accession number is Q9Z0K8.
TMPY-01614	VNN2 Protein, Human, Recombinant (His) vanin 2,FOAP-4,VNN2,GPI-80	Human	HEK293 Cells
	Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-8, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein that belongs to the CN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a fe...

重组蛋白

Vitronectin Protein, Human, Recombinant (His)

Cat.No: TMPY-00121

Species: Human

Expression System: HEK293 Cells

Vitronectin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01861

Species: Mouse

Expression System: HEK293 Cells

Vitronectin Protein, Human, Recombinant (Truncated, His)

Cat.No: TMPJ-00472

Species: Human

Expression System: HEK293 Cells

Influenza A H1N1 (A/Sw/Bulnes/VN1401-P6SP/2018) Neuraminidase/NA Protein (His)

Cat.No: TMPY-05937

Species: H1N1

Expression System: HEK293 Cells

VNN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01403

Species: Human

Expression System: HEK293 Cells

VNN1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02730

Species: Mouse

Expression System: HEK293 Cells

VNN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02529

Species: Mouse

Expression System: HEK293 Cells

VNN2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01614

Species: Human

Expression System: HEK293 Cells

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