首页工具

登录

搜索结果

Search Results for " tamoxifen "

30

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T6906	Tamoxifen ICI 46474,他莫昔芬,Z-Tamoxifen,trans-Tamoxifen,ICI47699	Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	Tamoxifen (ICI47699) 是一种雌激素受体调节剂 (SERM)，具有选择性和口服有效性。Tamoxifen 对雌激素具有抑制活性 (如乳腺细胞) 和激活活性 (如骨、肝和子宫细胞)。
T13076	Tamoxifen-d5 ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5	HSP	Cytoskeletal Signaling; Metabolism
	Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.
T28919	Tamoxifen analog II Tamoxifen analog III
	Tamoxifen analog II is a potent growth inhibitor. Tamoxifen analog II displays activity against various cancer cell lines.
T0835	Tamoxifen Citrate Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐	Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	Tamoxifen Citrate 是一种口服有效的，选择性雌激素受体调节剂，可阻断乳腺细胞中的雌激素作用，并可激活如骨骼、肝脏和子宫细胞中的雌激素活性。它是 Hsp90激活剂，可增强 Hsp90 分子伴侣 ATPase 的活性，可激活自噬和诱导凋亡。
T22512	4’-hydroxy Tamoxifen	Others	Others
	It is a metabolite of tamoxifen and an estrogen receptor modulator.
T4281	Endoxifen (E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen	Estrogen Receptor/ERR; Aromatase; Estrogen/progestogen Receptor; Parasite; Drug Metabolite	Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Endoxifen ((E/Z)-Endoxifen) 是 Tamoxifen 的关键活性代谢物，能抑制芳香酶的活性，与雌激素受体有较高的亲和力和特异性。它有潜力研究乳腺癌。
T4420	4-Hydroxytamoxifen ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	4-Hydroxytamoxifen (ICI 79280) 是 Tamoxifen 的活性代谢产物，是一种雌激素受体调节剂 (SERM)，具有选择性和口服有效性。4-Hydroxytamoxifen 具有抗肿瘤活性，可用于乳腺癌的研究。
T31262	Deamino-hydroxytamoxifen Tamoxifen-ol,Tamoxifen metabolite Y
	Tamoxifen is a medication that is used to prevent breast cancer patients.
T19192	α-Hydroxytamoxifen α-OHTAM,(E)-α-Hydroxy tamoxifen	Others	Others
	α-Hydroxytamoxifen is a metabolite of tamoxifen. It reacts with DNA and causes the formation of DNA adducts.
T8984	FLTX1	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus.
T12148	N-Desmethyltamoxifen hydrochloride	Estrogen Receptor/ERR; Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂，也是人体 AML 细胞神经酰胺代谢的有效调节因子，可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
T6743	(E/Z)-4-Hydroxytamoxifen 4-羟基他莫昔芬,(E/Z)-4-羟基他莫昔芬,Afimoxifene,4-Hydroxytamoxifen	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	(E/Z)-4-Hydroxytamoxifen (Afimoxifene) 是 tamoxifen 的活性代谢物和选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。
T12148L	N-Desmethyltamoxifen	Others	Others
	N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Although it demonstrates weak antiestrogenic properties, it acts as a protein kinase C (PKC) inhibitor with a potency ten times greater than that of tamoxifen.
T15186	(E)-4-Hydroxytamoxifen	Others	Others
	(E)-4-Hydroxytamoxifen is a less active isomer of (Z)-4-hydroxytamoxifen and also is an estrogen receptor modulator.
T2280	Endoxifen (Z-isomer) Z-因多昔芬,Endoxifen Z-isomer,4-[(1E)-1-{4-[2-(甲基氨基)乙氧基]苯基}-2-苯基-1-丁烯-1-基]苯酚	Estrogen Receptor/ERR; EGFR; Potassium Channel; Estrogen/progestogen Receptor; HER	Angiogenesis; Endocrinology/Hormones; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Endoxifen Z-isomer (EDX)是 Tamoxifen 重要的代谢产物,在表达 ERα的乳腺癌细胞中发挥抗雌激素作用。它以浓度依赖的方式抑制 hERG, IC50值为1.6μM。
T15249	Estrogen receptor modulator 1	Estrogen Receptor/ERR	Endocrinology/Hormones
	Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM)，其 pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。
T35973	Cholesterol-5α,6α-epoxide Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) 是胆固醇氧化产生的代谢产物。在应用他莫昔芬和 PBPE 后，5α,6α-环氧胆甾烷醇通过与 LXRβ 结合诱导三酰甘油生物合成。
T6827L	Endoxifen hydrochloride
	Endoxifen hydrochloride，Tamoxifen的主要活性代谢产物，具备较高的对雌激素受体(estrogen receptor)的亲和力和特异性，并能抑制芳香酶活性。它在乳腺癌研究中表现出潜在应用价值。
T11098	Droloxifene 3-Hydroxytamoxifen	Estrogen Receptor/ERR	Endocrinology/Hormones
	Droloxifene (3-Hydroxytamoxifen)，Tamoxifen 衍生物，是一种具有口服活性和选择性的雌激素受体 (estrogen receptor) 调节剂。Droloxifene 具有抗雌激素和抗植入作用。Droloxifene 诱导 MCF-7 细胞 p53 表达及凋亡。Droloxifene 预防去卵巢大鼠骨丢失。
T29179	YM-01 Tosylate
	YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.
T34326	Ridaifen-B RidaifenB
	Ridaifen-B, a tamoxifen derivative, works by inducing independent autophagy of Bcl-2, without estrogen receptor involvement.
T33876	panomifene GYKI13504,GYKI 13504,EGIS5650,EGIS-5650,EGIS 5650,GYKI-13504
	Panomiphene (Gyki-13504, EGIS-5650) is an anti-estrogen drug that is a tamoxifen (TMX) analogue.
T6827	Endoxifen Z-isomer hydrochloride Endoxifen HCl,Z-因多昔芬盐酸盐	Estrogen Receptor/ERR; Potassium Channel; Estrogen/progestogen Receptor; HER	Angiogenesis; Endocrinology/Hormones; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Endoxifen Z-isomer hydrochloride (Endoxifen HCl) 是Tamoxifen 最重要的代谢产物, 在表达ERα的乳腺癌细胞中发挥抗雌激素作用, Endoxifen HCl 以浓度依赖的方式抑制hERG, IC50值为1.6μM。
T3645	Endoxifen E-isomer hydrochloride E-Endoxifen hydrochloride	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride) 是 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质，具有抗雌激素作用。
T71578	Endoxifen mesylate
	Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromat...
T70013	Pipendoxifene
	Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an imp...
T71010	Norendoxifen
	Norendoxifen, also known as 4-hydroxy-N, N-didesmethyltamoxifen, is a nonsteroidal aromatase inhibitor of the triphenylethylene group that was never marketed. It is an active metabolite of the selective estrogen receptor modulator tamoxifen.
T25888	NSC-670224 NSC 670224
	NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related t
T74457	EGFR-IN-42
	EGFR-IN-42 (Compound 17b) 是一种有效的 EGFR 抑制剂，具有单位数纳摩尔活性。EGFR-IN-42 通过共价键将他莫昔芬或安多昔芬与 EGFR 抑制剂吉非替尼连接起来。EGFR-IN-42 保留 ER 拮抗剂活性和 EGFR 抑制作用。EGFR-IN-42 具有优越的抗癌活性。
T74458	EGFR-IN-43
	EGFR-IN-43 (Compound 17c) 是一种有效的EGFR 抑制剂，具有单位数纳摩尔活性。EGFR-IN-43 通过共价键将他莫昔芬或安多昔芬与EGFR 抑制剂吉非替尼连接起来。EGFR-IN-43 保留 ER 拮抗剂活性和EGFR 抑制作用。EGFR-IN-43 具有优越的抗癌活性。

化合物

Cat.No: T6906

Synonym: ICI 46474,他莫昔芬,Z-Tamoxifen,trans-Tamoxifen,ICI47699

Target: Apoptosis, Estrogen Receptor/ERR, HSP, Estrogen/progestogen Receptor, Autophagy

Cat.No: T13076

Synonym: ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5

Target: HSP

Tamoxifen analog II

Cat.No: T28919

Synonym: Tamoxifen analog III

Tamoxifen Citrate

Cat.No: T0835

Synonym: Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐

Target: Apoptosis, Estrogen Receptor/ERR, HSP, Estrogen/progestogen Receptor, Autophagy

4’-hydroxy Tamoxifen

Cat.No: T22512

Target: Others

Cat.No: T4281

Synonym: (E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen

Target: Estrogen Receptor/ERR, Aromatase, Estrogen/progestogen Receptor, Parasite, Drug Metabolite

4-Hydroxytamoxifen

Cat.No: T4420

Synonym: ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Deamino-hydroxytamoxifen

Cat.No: T31262

Synonym: Tamoxifen-ol,Tamoxifen metabolite Y

α-Hydroxytamoxifen

Cat.No: T19192

Synonym: α-OHTAM,(E)-α-Hydroxy tamoxifen

Target: Others

Cat.No: T8984

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

N-Desmethyltamoxifen hydrochloride

Cat.No: T12148

Target: Estrogen Receptor/ERR, Endogenous Metabolite, PKC

(E/Z)-4-Hydroxytamoxifen

Cat.No: T6743

Synonym: 4-羟基他莫昔芬,(E/Z)-4-羟基他莫昔芬,Afimoxifene,4-Hydroxytamoxifen

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

N-Desmethyltamoxifen

Cat.No: T12148L

Target: Others

(E)-4-Hydroxytamoxifen

Cat.No: T15186

Target: Others

Endoxifen (Z-isomer)

Cat.No: T2280

Synonym: Z-因多昔芬,Endoxifen Z-isomer,4-[(1E)-1-{4-[2-(甲基氨基)乙氧基]苯基}-2-苯基-1-丁烯-1-基]苯酚

Target: Estrogen Receptor/ERR, EGFR, Potassium Channel, Estrogen/progestogen Receptor, HER

Estrogen receptor modulator 1

Cat.No: T15249

Target: Estrogen Receptor/ERR

Cholesterol-5α,6α-epoxide

Cat.No: T35973

Synonym: Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176

Target: Others

Endoxifen hydrochloride

Cat.No: T6827L

Cat.No: T11098

Synonym: 3-Hydroxytamoxifen

Target: Estrogen Receptor/ERR

Cat.No: T29179

Cat.No: T34326

Synonym: RidaifenB

Cat.No: T33876

Synonym: GYKI13504,GYKI 13504,EGIS5650,EGIS-5650,EGIS 5650,GYKI-13504

Endoxifen Z-isomer hydrochloride

Cat.No: T6827

Synonym: Endoxifen HCl,Z-因多昔芬盐酸盐

Target: Estrogen Receptor/ERR, Potassium Channel, Estrogen/progestogen Receptor, HER

Endoxifen E-isomer hydrochloride

Cat.No: T3645

Synonym: E-Endoxifen hydrochloride

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Endoxifen mesylate

Cat.No: T71578

Cat.No: T70013

Cat.No: T71010

Cat.No: T25888

Synonym: NSC 670224

Cat.No: T74457

Cat.No: T74458

Cat. No.	Product Name	Target	Signaling Pathways
T3855	Tracheloside	Estrogen Receptor/ERR; Phosphorylase	Endocrinology/Hormones; Metabolism
	Tracheloside 是抗雌激素木质素，利用 ERK1/2 刺激促进角质形成细胞增殖，是一种良好的促进伤口愈合的药物。
TN4731	Pachyaximine A	Antifection	Microbiology/Virology
	Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS

天然产物

Cat.No: T3855

Target: Estrogen Receptor/ERR, Phosphorylase

Cat.No: TN4731

Target: Antifection

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼