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Search Results for " pkr "

Targets Recommended: PKM

21

抑制剂 & 化合物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12499	PKR-IN-2	PKM	Metabolism
	PKR-IN-2 是丙酮酸激酶PKR 亚型的激活剂，可用于 PKR 功能相关疾病的研究，包括癌症、糖尿病、肥胖、自身免疫性疾病、良性前列腺增生等。
T16550	PKR-IN-C16	Others	Others
	PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化，解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。
T24647	PKR-IN-C51 PKRINC51,PKR IN C51,PKR-inhibitor-C51,PKR inhibitor C51
	PKR-IN-C51 is an inhibitor of protein kinase R. It acts by correcting the aberrant splicing of MBNL1-dependent pre-mRNAs in DM1 cells without affecting the splicing pattern in normal non-DM1 cells.
T4223	Mitapivat PKR-IN-1	PKM	Metabolism
	Mitapivat (PKR-IN-1) 是口服具有活性的变构丙酮酸激酶 (pyruvate kinase) 激活剂，其AC50=20 nM。它在广泛的 PKLR 基因型中增加酶活性、蛋白质稳定性和 ATP 水平。它有潜在的恢复 PK 缺乏的糖酵解途径活性的作用。
T12498	PKR activator 2	Others	Others
	PKR activator 2 is a potent activator of pyruvate kinase-R (PKR).
T12497	PKR activator 1	Others	Others
	PKR activator 1 is a potent activator of pyruvate kinase-R (PKR).
T75132	PKR activator 4
	PKR activator 4 (example 7A) 是一种高效的丙酮酸激酶 R (pyruvate kinase R (PKR)) 激活剂，展现出研究血液疾病的潜力。
T2654	GSK2656157	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	GSK2656157 是一种ATP 竞争性的PERK 选择性抑制剂，IC50值为 0.9 nM。
T2614	GSK2606414	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	GSK2606414 是可渗透细胞且有口服活性的蛋白激酶 R 样内质网激酶抑制剂，IC50值为 0.4 nM。
T21976	ONO-8130	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-8130 是前列腺素 EP1 受体选择性拮抗剂，口服有活力，能够阻断 L6 脊髓中ERK 的磷酸化。它可缓解环磷酰胺致膀胱炎小鼠的膀胱疼痛，可用于研究间质性膀胱炎。
T22436	Takeda-6d	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Takeda-6d 是一种新型、有效的 DFG-out RAF/血管内皮生长因子受体 2 (VEGFR2) 抑制剂，IC50 分别为 7.0 nM 和 2.2 nM。
T6183	ISRIB (trans-isomer) ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer)是一种 PERK 的高效抑制剂，可有效逆转 eIF2α 磷酸化的作用，IC50值为 5 nM。
T63446	PKRA83
	PKRA83 是一种能够透过血脑屏障的 potent prokineticin (PK2) 拮抗剂，可竞争 PK2 与其受体 PKR1 和 PKR2 的结合。PKRA83 能够有效抑制 PK2 受体，可作用于 PKR1 (IC50: 5.0 nM) 和 PKR2 (IC50: 8.2 nM)。PKRA83 表现出抗癌和抗血管生成作用。
T81445	PKRA83 hydrochloride hydrate PKRA7 hydrochloride hydrate
	PKRA83 hydrochloride hydrate是一种高效的促动力拮抗剂，与PK2及其受体PKR1和PKR2进行竞争性结合。该化合物在抑制PK2受体方面表现出色，其对PKR1和PKR2的IC50值分别为5.0 nM和8.2 nM。此外，PKRA83 hydrochloride hydrate还具备抗癌、抗关节炎以及抗血管生成的活性，并能够穿透血脑屏障。
T7214	TEPP-46 ML265	PKM	Metabolism
	TEPP-46 (ML265) 是选择性的丙酮酸激酶 M2 (pyruvate kinase M2; PKM2) 激活剂，AC50=92 nM，对 PKM1，PKL 和 PKR 作用较小或没有作用。
T19836	2-Aminopurine	DNA/RNA Synthesis; PKA	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	2-Aminopurine 是一种鸟苷和腺苷的荧光类似物，是基于荧光衰变的 DNA 结构探针。当它插入寡核苷酸后，其荧光会通过与天然碱基堆积而被高度淬灭。它可用于核酸的结构和动力学的探测。
T26398	7DG 7-DG
	7DG is a selective inhibitor of protein kinase R (PKR).
T71825	BEPP monohydrochloride
	BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator.
T23813	Bozepinib
	Bozepinib is an antitumor compound that acts by inducing PKR-mediated apoptosis and synergizing with IFN.
T39753	Etavopivat FT-4202
	Etavopivat is a powerful, specific, orally bioavailable activator of pyruvate kinase (PKR) in red blood cells (RBCs). It exhibits potent properties against sickling.
T72663	(Rac)-Etavopivat (Rac)-FT-4202
	(Rac)-Etavopivat((Rac)-FT-4202) 是Etavopivat 异构体。Etavopivat 是一种具有口服活性的的红细胞丙酮酸激酶-R (PKR) 激活剂，可以用于镰状细胞病和其他血红蛋白疾病研究。

化合物

Cat.No: T12499

Target: PKM

Cat.No: T16550

Target: Others

Cat.No: T24647

Synonym: PKRINC51,PKR IN C51,PKR-inhibitor-C51,PKR inhibitor C51

Cat.No: T4223

Synonym: PKR-IN-1

Target: PKM

PKR activator 2

Cat.No: T12498

Target: Others

PKR activator 1

Cat.No: T12497

Target: Others

PKR activator 4

Cat.No: T75132

Cat.No: T2654

Target: Apoptosis, PERK, Autophagy

Cat.No: T2614

Target: Apoptosis, PERK, Autophagy

Cat.No: T21976

Target: Prostaglandin Receptor

Cat.No: T22436

Target: VEGFR

ISRIB (trans-isomer)

Cat.No: T6183

Synonym: ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB

Target: Apoptosis, PERK, Autophagy

Cat.No: T63446

PKRA83 hydrochloride hydrate

Cat.No: T81445

Synonym: PKRA7 hydrochloride hydrate

Cat.No: T7214

Synonym: ML265

Target: PKM

Cat.No: T19836

Target: DNA/RNA Synthesis, PKA

Cat.No: T26398

Synonym: 7-DG

BEPP monohydrochloride

Cat.No: T71825

Cat.No: T23813

Cat.No: T39753

Synonym: FT-4202

(Rac)-Etavopivat

Cat.No: T72663

Synonym: (Rac)-FT-4202

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04765	PKLR Protein, Human, Recombinant (His) PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, live...	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl...
TMPH-01556	EIF2AK2 Protein, Human, Recombinant (His) EIF2AK2,PKR,eIF-2A protein kinase 2,PRKR,p68 kinase...	Human	P. pastoris (Yeast)
	EIF2AK2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is P19525.
TMPY-03656	PRKAR1A Protein, Human, Recombinant (His) PRKAR1,CAR,CNC1,PPNAD1,CNC,protein kinase, cAMP-dependent, r...	Human	HEK293 Cells
	PRKAR1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is P10644.
TMPY-02219	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) NS1 Protein	H1N1	E. coli
	The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As...
TMPH-03670	Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO)	VACV	E. coli
	Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 26.5 kDa and the accession number is P20639.
TMPH-02358	Influenza B (strain B/Lee/1940) Non-structural protein 1 (His)	Influenza B	E. coli
	Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA.
TMPH-03672	Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO)	VACV	E. coli
	Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 26.6 kDa and the accession number is P18378.
TMPH-03671	Vaccinia virus (strain Western Reserve) K3 Protein (His)	VACV	P. pastoris (Yeast)
	Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Western Reserve) K3 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 12.6 kDa and the accession number is P18378.
TMPH-03415	Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)	RVFV	E. coli
	Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation. Forms filaments in the nucleus that may sequester NSs binding partners, causing cell cycle arrest. Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc) is expressed...
TMPH-02209	TRAF5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
TMPH-03404	Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)	Reo-3	E. coli
	Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding.; The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3. Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) is expr...
TMPH-02349	Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)	H1N1	E. coli
	Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also ...
TMPH-03732	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)	ZEBOV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-03733	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)	ZEBOV	HEK293 Cells
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm...
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO) ADAR1,IFI-4,136 kDa double-stranded RNA-binding protein,Inte...	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri...

重组蛋白

PKLR Protein, Human, Recombinant (His)

Cat.No: TMPY-04765

Species: Human

Expression System: E. coli

EIF2AK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01556

Species: Human

Expression System: P. pastoris (Yeast)

PRKAR1A Protein, Human, Recombinant (His)

Cat.No: TMPY-03656

Species: Human

Expression System: HEK293 Cells

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)

Cat.No: TMPY-02219

Species: H1N1

Expression System: E. coli

Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO)

Cat.No: TMPH-03670

Species: VACV

Expression System: E. coli

Influenza B (strain B/Lee/1940) Non-structural protein 1 (His)

Cat.No: TMPH-02358

Species: Influenza B

Expression System: E. coli

Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO)

Cat.No: TMPH-03672

Species: VACV

Expression System: E. coli

Vaccinia virus (strain Western Reserve) K3 Protein (His)

Cat.No: TMPH-03671

Species: VACV

Expression System: P. pastoris (Yeast)

Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)

Cat.No: TMPH-03415

Species: RVFV

Expression System: E. coli

TRAF5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02209

Species: Human

Expression System: E. coli

Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)

Cat.No: TMPH-03404

Species: Reo-3

Expression System: E. coli

Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)

Cat.No: TMPH-02349

Species: H1N1

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)

Cat.No: TMPH-03732

Species: ZEBOV

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)

Cat.No: TMPH-03733

Species: ZEBOV

Expression System: HEK293 Cells

IRF1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

ADAR Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01248

Species: Human

Expression System: E. coli

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