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Search Results for " pci "

Targets Recommended: Others BCRP BTK

29

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4337	PCI 29732 PCI29732,PCI-29732	Others; BCRP; BTK	Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors
	PCI 29732 是一种有效的可逆BTK 抑制剂，对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。
T6325	PCI-34051 N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI 34051	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	PCI-34051 是一种有效的选择性的HDAC8抑制剂，IC50为 10 nM。
T3469	PCI-27483 PCI27483	Others	Others
	PCI-27483 是一种FVIIa/tissue factor 抑制剂，具有抗肿瘤的作用。
T0431	Abexinostat CRA 24781,阿贝司他,PCI24781,PCI-24781,PCI 24781,CRA 024781	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Abexinostat (PCI24781) 是一种新型的泛HDAC 抑制剂，对HDAC1的Ki 值为7 nM。
T10883	CRA-026440 PCI-34051	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CRA-026440(PCI-34051) 是一种高效的 HDAC 抑制剂，对 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10 具有抑制作用， Ki 值分别为 4，14，11，15，7 和 20 nM。CRA-026440 具有抗肿瘤和抗血管生成活性，可用于研究结肠癌。
T1835	Ibrutinib 伊布替尼,依鲁替尼,PCI-32765	Tyrosine Kinases; Src; BTK; Ligands for Target Protein for PROTAC	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	Ibrutinib (PCI-32765) 是一种不可逆的、选择性的 Btk 抑制剂，IC50=0.5 nM，它是一种 Btk 配体，用于合成一系列 PROTAC 分子，如 P13I。P13I 作用于人 Burkitt’s 淋巴瘤 RAMOS 细胞，浓度为 10 和 100 nM 时，分别降解 73% 和 89% Btk。
T16441	PCI-33380	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.
T16440	Ibrutinib Racemate PCI-32765 (Racemate)	Others	Others
	Ibrutinib is a selective, irreversible Btk inhibitor (IC50: 0.5 nM). Ibrutinib Racemate is the racemate of Ibrutinib.
T33487	Motexafin gadolinium PCI0120,Gd texaphyrin,PCI-0120,PCI 0120,Gd-Texgadolinium,API-GP 3
	Motexafin gadolinium, also known as PCI 0120, is a synthetic metallotexaphyrin with radiosensitizing and chemosensitizing properties. Motexafin gadolinium accumulates in tumor cells preferentially due to their increased rates of metabolism, generating rea
T11601	Ibrutinib-d5 PCI-32765 D5,Ibrutinib D5	Others	Others
	Ibrutinib D5 is a deuterium-labeled Ibrutinib. Ibrutinib is an irreversible Btk inhibitor.
T36429	Dihydrodiol-Ibrutinib
	PCI 45227 is an active metabolite of the Bruton's tyrosine kinase inhibitor ibrutinib .1PCI 45227 is formed from ibrutinib by the cytochrome P450 (CYP) isoform CYP3A. 1.Veeraraghavan, S., Viswanadha, S., Thappali, S., et al.Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic studyJ. Pharm. Biomed. Anal.107151-158(2015)
T61144	Hepcidin antagonist-1	Others	Others
	Hepcidin antagonist-1 是一种铁调素拮抗剂。Hepcidin antagonist-1 可用于研究像缺铁疾病和贫血类的代谢紊乱。
T64339	Apcin A HCL	APC	Cell Cycle/Checkpoint
	Apcin A HCL 是 Apcin 衍生物。它是一种后期促进复合物 (APC) 抑制剂。它与 Cdc20 强烈相互作用，并抑制 Cdc20 底物的泛素化。它可用于合成 PROTAC CP5V。
T76828	Sonepcizumab LT 1009	LPL Receptor	GPCR/G Protein
	Sonepcizumab (LT 1009) 是一种完全人源化的抗 S1P 单克隆抗体。Sonepcizumab 具有抗癌活性，可用于研究转移性肾细胞癌 (mRCC) ，可预防青光眼滤过手术后的眼部瘢痕形成。
T8561	Apcin	APC	Cell Cycle/Checkpoint
	Apcin 是后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂，可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC/C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋，并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。
T80341	Seabream hepcidin
	Seabream hepcidin是一种抗菌肽，具有针对细菌(V.anguillarum)、真菌(S.cerevisiae)以及病毒性出血性败血症病毒的活性。
T80108	Hepcidin-1 (mouse)
	Hepcidin-1 (mouse) 是调控铁平衡的内源性多肽激素，通过上调TRAP、组织蛋白酶K和MMP-9的mRNA水平及增强TRAP-5b蛋白的分泌作用。此外，Hepcidin-1 (mouse) 降低FPN1蛋白水平并提升细胞内铁含量，且促进破骨细胞的分化。
T76585	Hepcidin-20 (human)
	Hepcidin-20 (human) 是一种β-折叠结构肽，含有组氨酸和丰富的半胱氨酸，具备抗真菌活性，并能抑制多糖细胞间粘附素 (PIA) 阳性及阴性菌株的生物膜形成及细菌细胞代谢[3]。
T10345	Apcin-A	Others	Others
	Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.
T82888	Bibapcitide
	Bibapcitide为含26个氨基酸残基的多肽，表现出抗凝血功能。
T78037	Hepcidin-1 (mouse) TFA
	Hepcidin-1 (mouse) TFA是调控铁代谢平衡的肽类激素。该化合物通过提高TRAP、组织蛋白酶K及MMP-9的mRNA水平并促进TRAP-5b蛋白的分泌，同时降低FPN1蛋白表达，导致细胞内铁含量上升。此外，Hepcidin-1 (mouse) TFA还有助于破骨细胞的分化。
T76271	Hepcidin-25 (human)
	Hepcidin-25 (human) 是调节铁代谢的化合物，具有调控铁介导的氧化损伤功能，并表现出抗炎和抗菌活性。
T80082	Hepcidin-25 (human) (acetate)	Endogenous Metabolite	Metabolism
	Hepcidin-25 (human) acetate 作为铁代谢调节剂，表现出抗炎和抗菌活性，其作用机制涉及调节铁介导的氧化剂损伤。
T80413	Bass hepcidin
	Bass hepcidin是一种具有针对大肠埃希菌活性的抗菌肽。
T25298	Dealanylalahopcin
	Dealanylalahopcin is a procollagen prolyl-4-hydroxylase inhibitor.
T24495	MPCI
	MPCI is a selective melanocortin-4 receptor antagonist.
T25022	Alahopcin Nourseimycin,Antibiotic B 52653,B-52653,Antibiotic T 804A
	Alahopcin is a new dipeptide antibiotic generated by Streptomyces albulus subsp. ochragerus subsp. nov.
T22323	Enoxaparin sodium	Thrombin	Proteases/Proteasome
	Enoxaparin sodium 是一种低分子量肝素 (LMWH)，已获得美国 FDA 批准，可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用，并抑制凝血因子 XIa、IXa、Xa 和 IIa（凝血酶），从而防止血栓形成。
T31793	Fimaporfin TPCS2a,Disulfonated tetraphenyl chlorin
	Fimaporfin, also known as TPCS2a, is a potent chlorin-based photosensitizer, Fimaporfin is consisted of a mixture of three isomers A, B and C (25%,50%,25%). Fimaporfin has been developed by di-imide reduction of disulfonated tetraphenyl porphine (TPPS(2a)

化合物

Cat.No: T4337

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

Cat.No: T6325

Synonym: N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI 34051

Target: Apoptosis, HDAC

Cat.No: T3469

Synonym: PCI27483

Target: Others

Cat.No: T0431

Synonym: CRA 24781,阿贝司他,PCI24781,PCI-24781,PCI 24781,CRA 024781

Target: HDAC

Cat.No: T10883

Synonym: PCI-34051

Target: HDAC

Cat.No: T1835

Synonym: 伊布替尼,依鲁替尼,PCI-32765

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

Cat.No: T16441

Target: BTK

Ibrutinib Racemate

Cat.No: T16440

Synonym: PCI-32765 (Racemate)

Target: Others

Motexafin gadolinium

Cat.No: T33487

Synonym: PCI0120,Gd texaphyrin,PCI-0120,PCI 0120,Gd-Texgadolinium,API-GP 3

Cat.No: T11601

Synonym: PCI-32765 D5,Ibrutinib D5

Target: Others

Dihydrodiol-Ibrutinib

Cat.No: T36429

Hepcidin antagonist-1

Cat.No: T61144

Target: Others

Cat.No: T64339

Target: APC

Cat.No: T76828

Synonym: LT 1009

Target: LPL Receptor

Cat.No: T8561

Target: APC

Seabream hepcidin

Cat.No: T80341

Hepcidin-1 (mouse)

Cat.No: T80108

Hepcidin-20 (human)

Cat.No: T76585

Cat.No: T10345

Target: Others

Cat.No: T82888

Hepcidin-1 (mouse) TFA

Cat.No: T78037

Hepcidin-25 (human)

Cat.No: T76271

Hepcidin-25 (human) (acetate)

Cat.No: T80082

Target: Endogenous Metabolite

Cat.No: T80413

Dealanylalahopcin

Cat.No: T25298

Cat.No: T24495

Cat.No: T25022

Synonym: Nourseimycin,Antibiotic B 52653,B-52653,Antibiotic T 804A

Enoxaparin sodium

Cat.No: T22323

Target: Thrombin

Cat.No: T31793

Synonym: TPCS2a,Disulfonated tetraphenyl chlorin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00490	Serpin A5 Protein, Human, Recombinant (His) Plasminogen Activator Inhibitor 3,Acrosomal Serine Protease ...	Human	HEK293 Cells
	Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o...
TMPH-02389	Hepcidin Protein, Larimichthys crocea, Recombinant	Larimichthys crocea	E. coli
	Hepcidin Protein, Larimichthys crocea, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.5 kDa and the accession number is A1Z0M0.
TMPK-01170	Hepcidin/HAMP Protein, Mouse, Recombinant (GST) Hamp1,LEAP-1,PLTR,HFE2B,LEAP1,Hepc1,Hepc	Mouse	E. coli
	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.

重组蛋白

Serpin A5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00490

Species: Human

Expression System: HEK293 Cells

Hepcidin Protein, Larimichthys crocea, Recombinant

Cat.No: TMPH-02389

Species: Larimichthys crocea

Expression System: E. coli

Hepcidin/HAMP Protein, Mouse, Recombinant (GST)

Cat.No: TMPK-01170

Species: Mouse

Expression System: E. coli

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