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DNA损伤和修复 内分泌与激素 G蛋白偶联受体 免疫与炎症 JAK/STAT信号通路 MAPK信号通路 离子通道
代谢 微生物学 神经科学 NF-κB信号通路 氧化还原 PI3K/Akt/mTOR信号通路 蛋白酶体
干细胞 蛋白酪氨酸激酶 泛素化 PROTAC 其他
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类药性化合物库 多样性核心库Part2 多样性核心库Part1 药物靶点库 多样性核心预制库 Golden骨架库 Mini骨架库 化合物库深度定制
TargetMol Compound Library
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结构类型 萜类 类固醇 类黄酮 醌类 香豆素 木脂素 多糖和糖苷
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基于表型筛选实体化合物活性筛选 细胞增殖检测 细胞周期检测 细胞凋亡检测 药代动力学研究
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细胞因子和生长因子 •   细胞因子 •   生长因子 受体蛋白 •   Fc 受体 •   细胞因子和生长因子受体
CD 蛋白 •   T 细胞 CD 蛋白 •   B 细胞 CD 蛋白 免疫检查点蛋白 •   抑制性免疫检查点蛋白 •   刺激性免疫检查点蛋白
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Cat. No. Product Name
L4710 非甾体类抗炎化合物库

530 compounds
530 种非甾体类的抗炎相关化合物，可用于高通量和高内涵筛选；

化合物库

非甾体类抗炎化合物库
Cat.No: L4710
Compounds: 530
Cat. No. Product Name Target Signaling Pathways
T15549 Icosabutate

NST-4016,PRC-4016

 Others Others
Icosabutate (NST-4016) 是一种具有口服活性的二十碳五烯酸的衍生物，可抑制 NASH 的肝脏炎症和纤维化，可改善他汀类药物治疗的残留高甘油三酯血症患者的心血管风险状况，降低甘油三脂，可用于研究肝纤维化和动脉粥样硬化。
T71812 Protonstatin-1

Protonstatin-1可用作降糖剂和治疗阿尔茨海默病的化合物，可抑制IGFIR 激酶的活性，可用于研究癌症。
T15271 Denifanstat

FASN-IN-2,TVB2640,TVB-2640

 Fatty Acid Synthase Metabolism
Denifanstat (FASN-IN-2) 是一种口服具有活性的选择性 FASN 抑制剂，IC50=0.052 μM，EC50=0.072 μM。它有用于脂肪肝和癌症的研究潜力。
T8883 Pizuglanstat

Others; Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation; Others
Pizuglanstat 是一种前列腺素 D 合酶抑制剂，对人造血前列腺素 D 合酶的IC50为 76 nM，可用于肌再生性疾病研究。
T38889 Thailanstatin A

Thailanstatin A 是真核 RNA 剪接抑制剂，IC50为650 nM，通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用。Thailanstatin A 对多种癌细胞系的抑制显示 nM 级别的 IC50。它与 Trastuzumab 上的赖氨酸结合，可产生“无连接子” ADC。
T27643 Izonsteride

LY-320236,LY320236,UNII-A5E8C36F34

 Reductase Endocrinology/Hormones; Metabolism
Izonsteride (LY320236) 是一种选择性强效 5α 还原酶抑制剂，对酶的 I 型和 II 型同工酶具有双重作用。Izonsteride 可用于治疗肿瘤和泌尿生殖系统疾病，可用于研究前列腺癌。
T26955 Cavosonstat

N91115,N 91115,N-91115

 GSNOR; CFTR Membrane transporter/Ion channel; Metabolism
Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂，可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
T61444 Nonsteroidal aromatase inhibitor 1

Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for research in the field of breast cancer [1].
T70660 Azalanstat HCl

Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered l...
T82465 Enlonstobart

Enlonstobart为一种人源化免疫球蛋白G4-kappa类抗PDCD1单克隆抗体，兼具免疫刺激剂与抗肿瘤药物的双重功能。
T32310 Johnstonol

Johnstonol is an specifically halogenated epoxide obtained from the red alga.
T78064 Synstatin (92-119)

SSTN92-119

 Integrin Cytoskeletal Signaling
Synstatin (92-119)为一种抗肿瘤化合物，它能够抑制血管生成与癌细胞侵袭，通过下调整合素αvβ3，降低VEGF与FGF-2的活化。
T61423 Transthyretin-IN-1

Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T70874 Vipoglanstat

Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury.
T79085 MC-VC-PAB-Cyclohexanediamine-Thailanstatin A

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
MC-VC-PAB-Cyclohexanediamine-Thailanstatin A 是一种药物-连接子偶联物，它结合了细胞毒素Thailanstatin A以及可切割的连接子(MC-vc-PAB)，用于抗体药物偶联物（ADC）的合成，属于剪接抑素类似物。
T79846 Friluglanstat

PGE Synthase Immunology/Inflammation
Friluglanstat为一种mPGES-1抑制剂，表现出抗炎作用。
T34759 Synstab A

Synstab-A
Synstab A is a microtubule stabilizer.
T69233 Ganstigmine

Ganstigmine is an acetylcholinesterase inhibitor for Alzheimer's disease.
T25127 Azalanstat

RS-21607,RS 21607,RS21607
Azalanstat is a lanosterol 14 alpha-demethylase inhibitor. The enzyme catalyzes the first step in the conversion of lanosterol to cholesterol in mammals.
T69792 Atuzaginstat

Atuzaginstat is a bacterial protease lysine gingipain inhibitor.
T31763 Fenaminstrobin

SYP 1620,SYP-1620,SYP1620
Fenaminstrobin is a biochemical.
T70661 Azalanstat mesylate

Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially...
T124035 Cajaninstilbene acid

Cajaninstilbene acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124035，CAS号为 87402-84-4。
T62174 Protein deglycase DJ-1 against-1

Protein deglycase DJ-1 against-1 是一种能够透过血脑屏障的 DJ-1 结合化合物，依赖地靶向 DJ1。Protein deglycase DJ-1 against-1 是一种神经保护剂，具有潜力进行帕金森病的研究。
T34916 Transtinib

Transtinib is an effective and irreversible EGFR tyrosine kinase inhibitor (EGFR-TKI) that is active against L858R/T790M mutated NSCLC cell lines and xenografts.
T39000 Zaloglanstat

GRC-27864,ISC-27864
Zaloglanstat (ISC-27864) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It is utilized in the research of various conditions, including asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain, and neurodegenerative diseases.
T37585 Ensartinib

Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or point mutations is tested. Ensartinib is potent in H3122 lung cancer cells harboring EML4-ALK E13;A20 (IC50: 15nM). Ensartinib is also potent in H2228 lung cancer cells harboring EML4-ALK E6a/b; A20 (IC50: 45 nM). Furthermore, X-376 is potent in SUDHL-1 lymphoma cells harboring N...

化合物

Icosabutate
Cat.No: T15549
Synonym: NST-4016,PRC-4016
Target: Others
Protonstatin-1
Cat.No: T71812
Synonym:
Target:
Denifanstat
Cat.No: T15271
Synonym: FASN-IN-2,TVB2640,TVB-2640
Target: Fatty Acid Synthase
Pizuglanstat
Cat.No: T8883
Synonym:
Target: Others, Prostaglandin Receptor
Thailanstatin A
Cat.No: T38889
Synonym:
Target:
Izonsteride
Cat.No: T27643
Synonym: LY-320236,LY320236,UNII-A5E8C36F34
Target: Reductase
Cavosonstat
Cat.No: T26955
Synonym: N91115,N 91115,N-91115
Target: GSNOR, CFTR
Nonsteroidal aromatase inhibitor 1
Cat.No: T61444
Synonym:
Target:
Azalanstat HCl
Cat.No: T70660
Synonym:
Target:
Enlonstobart
Cat.No: T82465
Synonym:
Target:
Johnstonol
Cat.No: T32310
Synonym:
Target:
Synstatin (92-119)
Cat.No: T78064
Synonym: SSTN92-119
Target: Integrin
Transthyretin-IN-1
Cat.No: T61423
Synonym:
Target:
Vipoglanstat
Cat.No: T70874
Synonym:
Target:
MC-VC-PAB-Cyclohexanediamine-Thailanstatin A
Cat.No: T79085
Synonym:
Target: DNA/RNA Synthesis
Friluglanstat
Cat.No: T79846
Synonym:
Target: PGE Synthase
Synstab A
Cat.No: T34759
Synonym: Synstab-A
Target:
Ganstigmine
Cat.No: T69233
Synonym:
Target:
Azalanstat
Cat.No: T25127
Synonym: RS-21607,RS 21607,RS21607
Target:
Atuzaginstat
Cat.No: T69792
Synonym:
Target:
Fenaminstrobin
Cat.No: T31763
Synonym: SYP 1620,SYP-1620,SYP1620
Target:
Azalanstat mesylate
Cat.No: T70661
Synonym:
Target:
Cajaninstilbene acid
Cat.No: T124035
Synonym:
Target:
Protein deglycase DJ-1 against-1
Cat.No: T62174
Synonym:
Target:
Transtinib
Cat.No: T34916
Synonym:
Target:
Zaloglanstat
Cat.No: T39000
Synonym: GRC-27864,ISC-27864
Target:
Ensartinib
Cat.No: T37585
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T8626 Transtorine

1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID,1,4-二氢-4-氧代喹啉-2-羧酸

 GluR; NMDAR Neuroscience
Transtorine (1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID) 是一种 GluR 和 NMDA 抑制剂。
T38890 Thailanstatin C

Thailanstatin C, an antiproliferative agent derived from Burkholderia thailandensis MSMB43, functions as a potent inhibitor of pre-mRNA splicing (IC50 = 6.84 μM).
T39071 Thailanstatin D

Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.

天然产物

Transtorine
Cat.No: T8626
Synonym: 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLIC ACID,1,4-二氢-4-氧代喹啉-2-羧酸
Target: GluR, NMDAR
Thailanstatin C
Cat.No: T38890
Synonym:
Target:
Thailanstatin D
Cat.No: T39071
Synonym:
Target:
Species：
Human (6)
Mouse (3)
H7N2 (2)
MeV (2)
Cynomolgus (1)
DENV (1)
Expression System：
HEK293 Cells (7)
E. coli (6)
Baculovirus Insect Cells (2)
Tag：
C-His (5)
N-10xHis (2)
N-His (2)
Tag Free (2)
C-6xHis (1)
C-FC-Myc (1)
N-6xHis (1)
N-6xHis-SUMO (1)
Cat. No. Product Name Species Expression System
TMPJ-01296 SULT4A1 Protein, Human, Recombinant

hBR-STL,SULTX3,Nervous System Sulfotransferase,SULT4A1,ST4A1...

 Human E. coli
Sulfotransferase 4A1 (ST4A1) is a member of the Sulfotransferase 1 family. ST4A1 is highly expressed in the cerebral cortex and frontal lobe, but no expression is detected in the pancreas. ST4A1 is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. ST4A1 acts on catecholamines and T4 in a manner that may not involve sulfonation. ST4A1 may have a role in the metabolism of drugs and neurotransmitters in the CNS. In addition, ST4A1 is related to schizo...
TMPY-01756 Transthyretin Protein, Human, Recombinant (His)

PALB,HEL111,CTS,transthyretin,CTS1,HsT2651,TBPA

 Human HEK293 Cells
Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36.
TMPK-01090 Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)

Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,ATTR,C...

 Cynomolgus HEK293 Cells
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
TMPY-05071 IgE Fc Protein, Human, Recombinant (Constant Domain 3 & 4, His)

Human HEK293 Cells
IgE Fc Protein, Human, Recombinant (Constant Domain 3 & 4, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is AAB59395.1.
TMPH-02115 KNSTRN Protein, Human, Recombinant (His)

Human E. coli
N/A. KNSTRN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.5 kDa and the accession number is Q9Y448?.
TMPY-03352 Influenza A H7N2 (A/ruddy turnstone/New Jersey/563/2006) Hemagglutinin/HA Protein (His)

Harvey rat sarcoma viral oncogene homolog

 H7N2 Baculovirus Insect Cells
Influenza A H7N2 (A/ruddy turnstone/New Jersey/563/2006) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is C6KLK6.
TMPJ-00824 Ig lambda constant 2 Protein, Human, Recombinant (His)

Ig λ constant 2 Protein, Human, Recombinant (His),M...

 Human HEK293 Cells
Immunoglobulin lambda constant region is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. IGLC2 is 105 amino acids (aa) in length. I...
TMPH-02453 Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (His)

MeV Baculovirus Insect Cells
Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 46.9 kDa and the accession number is B8PZP3.
TMPY-00279 Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His)

chemokine (C-X-C motif) ligand 8

 DENV E. coli
Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35.5 kDa and the accession number is AAC59275.1.
TMPY-00422 Influenza A H7N2 (A/ruddy turnstone/New Jersey/563/2006) Hemagglutinin/HA1 Protein (His)

Harvey rat sarcoma viral oncogene homolog

 H7N2 HEK293 Cells
Influenza A H7N2 (A/ruddy turnstone/New Jersey/563/2006) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is C6KLK6.
TMPH-02242 Transthyretin Protein, Human, Recombinant (hFc & Myc)

Human HEK293 Cells
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TMPH-02454 Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (E. coli, His)

MeV E. coli
Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 49.9 kDa and the accession number is B8PZP3.
TMPH-02946 Transthyretin Protein, Mouse, Recombinant (His & SUMO)

Mouse E. coli
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.6 kDa and the accession number is P07309.
TMPY-04919 Transthyretin Protein, Mouse, Recombinant (His)

AI787086,prealbumin,D17860,AA408768,transthyretin

 Mouse HEK293 Cells
Transthyretin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P07309.
TMPH-02947 Transthyretin Protein, Mouse, Recombinant

Mouse E. coli
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.5 kDa and the accession number is P07309.

重组蛋白

SULT4A1 Protein, Human, Recombinant
Cat.No: TMPJ-01296
Species: Human
Expression System: E. coli
Transthyretin Protein, Human, Recombinant (His)
Cat.No: TMPY-01756
Species: Human
Expression System: HEK293 Cells
Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01090
Species: Cynomolgus
Expression System: HEK293 Cells
IgE Fc Protein, Human, Recombinant (Constant Domain 3 & 4, His)
Cat.No: TMPY-05071
Species: Human
Expression System: HEK293 Cells
KNSTRN Protein, Human, Recombinant (His)
Cat.No: TMPH-02115
Species: Human
Expression System: E. coli
Influenza A H7N2 (A/ruddy turnstone/New Jersey/563/2006) Hemagglutinin/HA Protein (His)
Cat.No: TMPY-03352
Species: H7N2
Expression System: Baculovirus Insect Cells
Ig lambda constant 2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00824
Species: Human
Expression System: HEK293 Cells
Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (His)
Cat.No: TMPH-02453
Species: MeV
Expression System: Baculovirus Insect Cells
Dengue virus DENV-2 (strain New Guinea C) NS5 (methyltransferase domain)/Nonstructural protein 5 Protein (His)
Cat.No: TMPY-00279
Species: DENV
Expression System: E. coli
Influenza A H7N2 (A/ruddy turnstone/New Jersey/563/2006) Hemagglutinin/HA1 Protein (His)
Cat.No: TMPY-00422
Species: H7N2
Expression System: HEK293 Cells
Transthyretin Protein, Human, Recombinant (hFc & Myc)
Cat.No: TMPH-02242
Species: Human
Expression System: HEK293 Cells
Measles virus (MeV) (strain Edmonston-Schwarz vaccine) Nucleoprotein/NP Protein (E. coli, His)
Cat.No: TMPH-02454
Species: MeV
Expression System: E. coli
Transthyretin Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02946
Species: Mouse
Expression System: E. coli
Transthyretin Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04919
Species: Mouse
Expression System: HEK293 Cells
Transthyretin Protein, Mouse, Recombinant
Cat.No: TMPH-02947
Species: Mouse
Expression System: E. coli
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