20
2
10
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9039 |
HIV-1 Nef-IN-1
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 Nef-IN-1 是 HIV-1 Nef 蛋白的抑制剂。 它有效地竞争 Nef-SH3Hck 相互作用,Kd 值为 6.7 μM。 | |||
T11538 |
Hck-IN-1
|
HIV Protease; Src; Hck | Angiogenesis; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Hck-IN-1 是二苯基吡唑啉化合物,选择性的 Nef 依赖性 Hck 抑制剂。它是广泛的 HIV-1 Nef 直接拮抗剂,对于野生型 HIV-1 复制的IC50为 100-300 nM。它结合口袋残基 Asn126,具有抗逆转录病毒活性。 | |||
T16886 |
Sinefungin
Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP |
Others; Histone Methyltransferase; Antibiotic; Antifungal | Chromatin/Epigenetic; Microbiology/Virology; Others |
Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9,通过抑制H3K4甲基化来改善肾纤维化。 | |||
T3275 |
Nefazodone hydrochloride
Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐 |
5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Nefazodone hydrochloride (Serzone) 是一种强效和选择性的5HT2A 拮抗剂,Ki 为5.8 nM,对 5-HT 和去甲肾上腺素摄取具有中度抑制作用,IC50分别为 290 和 300 nM。它是一种苯哌嗪类抗抑郁药,具有微弱的 α-肾上腺素阻断活性,用于治疗抑郁症、攻击性行为和恐慌症。 | |||
T0169 |
Nefiracetam
DM9384,奈非西坦,DZL-221 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Nefiracetam (DM9384) 是一种 GABA 能、胆碱能和单胺能神经元系统增强剂,用于治疗 Ro 5-4864 引起的抽搐。 | |||
T6089 |
Neflamapimod
VX-745 |
p38 MAPK; Autophagy | Autophagy; MAPK |
Neflamapimod (VX-745) 是一种可穿过血脑屏障的,高选择性的p38α抑制剂,对 p38α 的IC50值为 10 nM,p38β 的IC50值为 220 nM。它对 p38β 的特异性高 22 倍,具有抗炎活性。 | |||
T0470 |
Nefopam hydrochloride
盐酸奈福泮,Fenazoxine hydrochloride,Nefopam HCl |
Wnt/beta-catenin; Sodium Channel | Cytoskeletal Signaling; Membrane transporter/Ion channel; Stem Cells |
Nefopam hydrochloride (Nefopam HCl) 作用于体外和体内间充质细胞β-连环蛋白水平,是一种中枢性但非阿片类缓解中度和重度疼痛。 | |||
T19454 |
N-Desmethylnefopam
|
Others | Others |
N-Desmethylnefopam is the main Nefopam metabolite . | |||
T71821 |
Norfenefrine HCl
|
||
Norfenefrine is an Adrenergic Agonist. It is used in the treatment of female stress incontinence. | |||
T67197 |
9-methylidenefluorene
|
||
Fluorenylidenemethane is an analogue of a 1,1-Diphenylethylene. Polymerization of Fluorenylidenemethane produces a π-stacked polymer. | |||
T21451 |
Nefazodone
Nefadar,Dutonin,Serzone |
||
Nefazodone is an antidepressant. It has low affinity for the serotonin (200 nM), dopamine (360 nM), and norepinephrine (360 nM) transporters, and therefore acts as a weak serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). | |||
T126388 | 9-Oxotournefortiolide, Tourneforin | ||
9-Oxotournefortiolide, Tourneforin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126388,CAS号为 111420-61-2。 | |||
T19453 |
N-Desmethylnefopam D5 hydrochloride
|
Others | Others |
N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride. | |||
T12788 |
R(+)-IAA-94
R(+)-Methylindazone |
Chloride channel | Membrane transporter/Ion channel |
R(+)-IAA-94 (R(+)-Methylindazone) 是一种有效的氯离子 (chloride channels) 通道阻滞剂。R(+)-IAA-94 抑制 Nef-sdAb19 相互作用,并与 Nef 结合。 | |||
T61793 |
HIV-IN-6
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-IN-6 是一种 HIV 病毒抑制剂,可抑制HIV 病毒的复制。HIV-IN-6 具有抗HIV 病毒的活性,通过靶向与病毒 Nef 蛋白相互作用的 Src 家族激酶 (SFK) (如 Hck) 而起作用。 | |||
T29217 |
ZINC04177596
|
||
ZINC04177596 is a novel Nef Protein Inhibitor with anti-HIV activity. | |||
T68637 |
NSC13987
|
||
NSC13987 is an inhibitor of Nef-calnexin interaction. | |||
T24017 |
DQBS
|
||
DQBS is an HIV-1 Nef function antagonist. | |||
T29222 |
ZINC36617540
|
||
ZINC36617540 is a novel Nef Protein Inhibitor with anti-HIV activity. | |||
T31545 |
DLC27-14
DLC-2714,DLC 2714,DLC2714 |
||
DLC27-14 is an HIV-1 Nef specific protein disorder catalyzer. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1097 |
Neferine
(R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱 |
Apoptosis; NF-κB; Autophagy | Apoptosis; Autophagy; NF-κB |
Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱,可强效抑制NF-κB 激活,具有抗肿瘤活性。 | |||
TN2482 |
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid
|
Others | Others |
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2482,CAS号为 69251-99-6。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02531 |
S100B Protein, Human, Recombinant (His)
S100β,S100-B,S100beta,S100 calcium binding protein B,S100, |
Human | E. coli |
S100B Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12 kDa and the accession number is A0A0S2Z4C5. | |||
TMPY-00913 |
S100B Protein, Human, Recombinant (hFc)
NEF,S100 calcium binding protein B,S100beta,S100-B,... |
Human | HEK293 Cells |
S100B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A0S2Z4C5. | |||
TMPK-01369 |
S100B Protein, Canine, Recombinant (hFc)
S100 calcium-binding,S100-B,100β,100beta,NEF,Protei... |
Canine | HEK293 Cells |
S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions.The intracellular, and extracellular, roles of S100B are attractive therapeutic targets for the treatment of both cardiac and vascular disease. | |||
TMPH-03340 |
NEFH Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NEF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFH Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The pre... | |||
TMPH-01758 |
NEFL Protein, Human, Recombinant
|
Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFL Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 61.5 kDa and the accession number is P07196. | |||
TMPH-01757 |
NEFH Protein, Human, Recombinant (His & Myc & SUMO)
|
Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFH Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc... | |||
TMPH-02805 |
NEFL Protein, Mouse, Recombinant (His)
|
Mouse | P. pastoris (Yeast) |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFL Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63.4 kDa and the accession number is P08551. | |||
TMPH-01760 |
NEFM Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFM Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.8 kDa and the accession number is P07197. | |||
TMPH-01759 |
NEFL Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks. NEFL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with C-6xHis-SUMO tag. The predicted molecular weight is 52.4 kDa and the accession number is P07196. | |||
TMPY-00587 |
GABARAP Protein, Human, Recombinant (His & MBP)
GABARAP-a,GABA(A) receptor-associated protein,ATG8A,MM46 |
Human | E. coli |
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in vivo by delaying cell death and its associated immune-related response. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. GABARAPs as the first known direct interaction partners of Nef that are essential... |