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Search Results for " mmp2 "

Targets Recommended: MMP

47

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T61271	MMP2-IN-3	MMP	Proteases/Proteasome
	MMP2-IN-3是一种有效的基质金属蛋白酶（MMP-2）抑制剂（ IC50 值：31 μM）。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ，其 IC50 分别为 26.6 和 32 μM。
T60845	MMP2-IN-1
	MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡，在部分癌细胞中显示出显着的抗增殖活性。MMP2-IN-1 是MMP2 的中度强效抑制剂 (IC50 = 6.8 μM)。
T60551	MMP2-IN-2
	MMP2-IN-2 (化合物 42) 是一种有效且选择性的MMP-2(基质金属蛋白酶)抑制剂，其IC50值为 4.2 μM。它对MMP-13、MMP-9和MMP-8也具有抑制活性，IC50值分别为 12、23.3 和 25 μM。
T21512	MMP-2/MMP-9 Inhibitor I	MMP	Proteases/Proteasome
	MMP-2/MMP-9-IN-1 是一种有效的、具有高选择性和可口服的 IV 型胶原酶 (MMP-9和MMP-2) 抑制剂，对 MMP-9 和 MMP-2具有抑制作用， IC50分别为 0.24 和 0.3 1μM。MMP-2/MMP-9-IN-1 在肿瘤生长和转移的动物模型中展现出口服活性，可用于研究癌症。
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
TP1535L	GPLGIAGQ acetate GPLGIAGQ acetate(109053-09-0 Free base)	MMP	Proteases/Proteasome
	GPLGIAGQ acetate 是一种 MMP2 可切割的多肽。GPLGIAGQ acetate 可用作脂质体和胶束纳米载体中的刺激敏感接头，以在光动力治疗中合成独特的 MMP2 靶向光敏剂。
T9892	JAMM protein inhibitor 2 Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-	Others	Others
	JAMM protein inhibitor 2 (Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-) 是 JAMM 蛋白酶的抑制剂，可用于抗癌的研究。对thrombin、Rpn11 和 MMP2 的 IC50 分别为 10 μM、46 μM 和 89 μM。
T28145	ND-322 HCl ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl	MMP	Proteases/Proteasome
	ND-322 HCl (ND 322 Hydrochloride) 是 MT1-MMP 和 MMP2 的选择性抑制剂，可减少体外黑色素瘤细胞的生长、迁移和侵袭。
T10597	BR351	MMP	Proteases/Proteasome
	BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).
T26720	AZD-6605 AZ11920155,AZ-11920155,AZD6605
	AZD6605 is a potent, reversible inhibitor of, MMP2, MMP9, MMP12 and MMP13.
T26104	Ro 28-2653 Ro 28 2653,Ro-28-2653,Ro282653
	Ro 28-2653 is a matrix-metalloproteinases (MMPs) inhibitor with high selectivity for MMP2, MMP9 and membrane type 1-MMP.
T69460	TSRI265
	TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.
T15015	CTS-1027 RS 130830,Ro 1130830	Others	Others
	CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
T76055	GPLGIAGQ TFA
	GPLGIAGQ TFA 是一种MMP2可降解 (cleavable) 的多肽，在脂质体和胶束纳米载体中都被用作刺激敏感的连接物，用于MMP2触发的肿瘤靶向研究。GPLGIAGQ 可用于合成光动力疗法 (PDT) 中独特的MMP2靶向光敏剂。
T74714	TP0597850
	TP0597850为MMP2选择性抑制剂，展现出卓越的亲和力（IC50=0.22 nM）和较长的MMP2解离半衰期（t1/2=265 min）。
TP1624	GPLGIAGQ TFA(109053-09-0 free base) GPLGIAGQ TFA
	GPLGIAGQ TFA, is an MMP2-cleaved polypeptide that is used as a stimulus-sensitive connector in both liposomes and micelle nanoceroses for targeted therapy of tumors triggered by MMP2.
TP1535	GPLGIAGQ
	GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting.
T74632	TP0556351	MMP	Proteases/Proteasome
	TP0556351是一种高效且选择性地抑制基质金属蛋白酶2 (MMP2) 的化合物，其IC50值为0.2 nM。在Bleomycin诱导的肺纤维化小鼠模型中，该化合物能显著减少肺部胶原蛋白的含量，适用于特发性肺纤维化(IPF)的研究。
TP1741L	Histatin 5 acetate Histatin 5 acetate (115966-68-2 Free base)	MMP	Proteases/Proteasome
	Histatin 5 acetate 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性，IC50 分别为 0.57 和 0.25 μM。
T10598	BR351 precursor	Others	Others
	BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13).
T2009	SB-3CT	MMP	Proteases/Proteasome
	SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂，Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。
T35859	Aldumastat GLPG1972,S201086,G504572	Others	Others
	Aldumastat（GLPG1972）是一种具有高效性、特异性和口服活性的 ADAMTS-5抑制剂。Aldumastat 可用于研究膝骨关节炎。
T78181	MMP-7-IN-2	MMP; Others	Others; Proteases/Proteasome
	MMP-7-IN-2 可作为一种具有选择性和有效性的 MMP7 抑制剂，可用于研究炎症反应和与血管相关的疾病。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T6885	Marimastat BB2516,马立马司他,KB-R8898,TA2516	MMP	Proteases/Proteasome
	Marimastat (BB2516) 是一种血管生成和转移抑制剂，限制血管的生长和生成。它是一种广谱的，具有口服活性的MMPs 抑制剂，有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7，用于癌症的研究。
T6011	Batimastat 巴马司他,BB94	MMP	Proteases/Proteasome
	Batimastat (BB94) 是广谱MMP 抑制剂，能够抑制MMP-1 (IC50:3 nM)，MMP-2 (IC50:4 nM)，MMP-9 (IC50:4 nM)，MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。
T16124	MMP13-IN-3	MMP	Proteases/Proteasome
	MMP13-IN-3 是口服有效的MMP-13选择性抑制剂，IC50为 1 nM，比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。
T20563	PD-166793 PD-166793-0000,PD 166793,PD166793	MMP	Proteases/Proteasome
	PD-166793是一种具有口服活性、有效性和选择性的 MMP 抑制剂，对 MMP-2，MMP-3 和 MMP-13 具有抑制作用。PD-166793 在大鼠心力衰竭模型中改善心肌缺血和再灌注损伤。
T2743	Ilomastat Galardin,GM6001,伊洛马司他	MMP	Proteases/Proteasome
	Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂，可抑制 MMP 的活性，IC50值分别为 1.5 nM (MMP-1)，1.1 nM (MMP-2)，1.9 nM (MMP-3)，0.5 nM (MMP-9)，对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。
T69685	AGPS-IN-2i	MMP	Proteases/Proteasome
	AGPS-IN-2i 是一种高效且具有很高亲和力的烷基甘油磷酸酯合成酶抑制剂的，可控制着细胞中醚脂的利用和代谢，降低了醚类脂质水平和细胞迁移率，促进癌细胞的增殖和运动。AGPS-IN-2i 在 PC-3和 MDA-MB-231癌细胞中测试时通过调节 E-cadherin、Snail 和 MMP2的表达水平，特异性地损害了上皮向间质转化（EMT）。AGPS-IN-2i 对癌细胞增殖具有抑制作用。
TP1446	Histatin 5 (TFA)(115966-68-2,free) Histatin 5 (TFA)	MMP	Proteases/Proteasome
	Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性，IC50 分别为 0.57 和 0.25 μM。
T41079	MMP13-IN-2 MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
T28146	ND-336 ND336,ND-336 hydrochloride,ND 336
	ND-336 is a highly selective inhibitor ofMMP-2, MMP-9 and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound.
T12082	MMP3 inhibitor 1	MMP	Proteases/Proteasome
	MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM).
T38800	MMPI-1154
	MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively.
T16986	Tanomastat BAY 12-9566	MMP	Proteases/Proteasome
	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
T10461	Batimastat sodium salt BB-94 sodium salt	MMP	Proteases/Proteasome
	Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
T13357	XL-784 free base	Others	Others
	XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T13358	XL-784	MMP	Proteases/Proteasome
	XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T22685	CP-471474 CP 471474	Others	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
T17201	UK 356618	MMP	Proteases/Proteasome
	UK 356618 is a potent and selective inhibitor of matrix metalloprotease-3 (IC50: 5.9 nM).
T12539L	Prinomastat KB-R9896,普啉司他,AG3340	MMP	Proteases/Proteasome
	Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor (
T12539	Prinomastat hydrochloride KB-R9896 hydrochloride,AG3340 hydrochloride	MMP	Proteases/Proteasome
	Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.
T13249	UK-370106	MMP	Proteases/Proteasome
	UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM).
T31063	CP-544439 UNII-516DO4KL5R
	CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.
T36492	CMC2.24
	CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis throug...
T28985	TMI-1 WAY-171318	Apoptosis; MMP	Apoptosis; Proteases/Proteasome
	TMI-1 (WAY-171318) 是一种有效的抑制剂，用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。

化合物

Cat.No: T61271

Target: MMP

Cat.No: T60845

Cat.No: T60551

MMP-2/MMP-9 Inhibitor I

Cat.No: T21512

Target: MMP

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

GPLGIAGQ acetate

Cat.No: TP1535L

Synonym: GPLGIAGQ acetate(109053-09-0 Free base)

Target: MMP

JAMM protein inhibitor 2

Cat.No: T9892

Synonym: Acetamide, 2-(2-ethylphenoxy)-N-[2-methyl-4-(1-pyrrolidinyl)phenyl]-

Target: Others

Cat.No: T28145

Synonym: ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl

Target: MMP

Cat.No: T10597

Target: MMP

Cat.No: T26720

Synonym: AZ11920155,AZ-11920155,AZD6605

Cat.No: T26104

Synonym: Ro 28 2653,Ro-28-2653,Ro282653

Cat.No: T69460

Cat.No: T15015

Synonym: RS 130830,Ro 1130830

Target: Others

Cat.No: T76055

Cat.No: T74714

GPLGIAGQ TFA(109053-09-0 free base)

Cat.No: TP1624

Synonym: GPLGIAGQ TFA

Cat.No: TP1535

Cat.No: T74632

Target: MMP

Histatin 5 acetate

Cat.No: TP1741L

Synonym: Histatin 5 acetate (115966-68-2 Free base)

Target: MMP

BR351 precursor

Cat.No: T10598

Target: Others

Cat.No: T2009

Target: MMP

Cat.No: T35859

Synonym: GLPG1972,S201086,G504572

Target: Others

Cat.No: T78181

Target: MMP, Others

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T6885

Synonym: BB2516,马立马司他,KB-R8898,TA2516

Target: MMP

Cat.No: T6011

Synonym: 巴马司他,BB94

Target: MMP

Cat.No: T16124

Target: MMP

Cat.No: T20563

Synonym: PD-166793-0000,PD 166793,PD166793

Target: MMP

Cat.No: T2743

Synonym: Galardin,GM6001,伊洛马司他

Target: MMP

Cat.No: T69685

Target: MMP

Histatin 5 (TFA)(115966-68-2,free)

Cat.No: TP1446

Synonym: Histatin 5 (TFA)

Target: MMP

Cat.No: T41079

Synonym: MMP13-IN-2

Cat.No: T28146

Synonym: ND336,ND-336 hydrochloride,ND 336

MMP3 inhibitor 1

Cat.No: T12082

Target: MMP

Cat.No: T38800

Cat.No: T16986

Synonym: BAY 12-9566

Target: MMP

Batimastat sodium salt

Cat.No: T10461

Synonym: BB-94 sodium salt

Target: MMP

XL-784 free base

Cat.No: T13357

Target: Others

Cat.No: T13358

Target: MMP

Cat.No: T22685

Synonym: CP 471474

Target: Others

Cat.No: T17201

Target: MMP

Cat.No: T12539L

Synonym: KB-R9896,普啉司他,AG3340

Target: MMP

Prinomastat hydrochloride

Cat.No: T12539

Synonym: KB-R9896 hydrochloride,AG3340 hydrochloride

Target: MMP

Cat.No: T13249

Target: MMP

Cat.No: T31063

Synonym: UNII-516DO4KL5R

Cat.No: T36492

Cat.No: T28985

Synonym: WAY-171318

Target: Apoptosis, MMP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01477	MMP-2 Protein, Human, Recombinant TBE-1,MMP-II,matrix metallopeptidase 2,MON...	Human	HEK293 Cells
	MMP-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 72 kDa and the accession number is A0A024R6R4.
TMPY-02290	MMP-2 Protein, Mouse, Recombinant (His) GelA,Clg4a,MMP-2,matrix metallopeptidase <...	Mouse	HEK293 Cells
	MMP-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.9 kDa and the accession number is P33434-1.
TMPJ-00362	MMP-2 Protein, Human, Recombinant (His) 72 kDa Gelatinase,TBE-1,Gelatinase A,Matrix Metallo...	Human	HEK293 Cells
	72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathologic...
TMPH-00010	MMP-14 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to...
TMPJ-00433	VSIR Protein, Cynomolgus, Recombinant (His) Stress-induced secreted protein-1,Platelet receptor Gi2<...	Cynomolgus	HEK293 Cells
	platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively.
TMPJ-00561	SDC2 Protein, Human, Recombinant (His) CD362,SDC2,HSPG,HSPG1,Syndecan-2,...	Human	HEK293 Cells
	Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans have been reported and among them. Syndecan-2 plays a role in the cancer development. It can affect the basal and chemotherapy-induced apoptosis in osteosarcoma. It can also suppress MMP2 activation, suppressing metastasis.
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin domain-containing receptor...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...

重组蛋白

MMP-2 Protein, Human, Recombinant

Cat.No: TMPY-01477

Species: Human

Expression System: HEK293 Cells

MMP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02290

Species: Mouse

Expression System: HEK293 Cells

MMP-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00362

Species: Human

Expression System: HEK293 Cells

MMP-14 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00010

Species: Human

Expression System: E. coli

VSIR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00433

Species: Cynomolgus

Expression System: HEK293 Cells

SDC2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00561

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

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