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Search Results for " mav "

Targets Recommended: Virus Protease CSF-1R

19

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76690	Mavrilimumab CAM 3001	Virus Protease; CSF-1R	Microbiology/Virology; Tyrosine Kinase/Adaptors
	Mavrilimumab (CAM 3001) 是一种单克隆抗体，具有抗病毒活性，对粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 受体的 α 亚基有亲和力，并阻止 GM-CSF 下游细胞内信号传导。GM-CSF 可能与呼吸衰竭和死亡相关的过度活跃炎症反应有关，可用于研究类风湿性关节炎。
T6946	Pimavanserin tartrate ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin,匹莫范色林	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pimavanserin tartrate (Nuplazid) 是一种有效的5-HT 2A 受体反向激动剂，pIC50和 pKi 值分别为8.73和9.3，用于治疗与帕金森病相关的精神病。
T6919	Omaveloxolone RTA-408	Apoptosis; Others; Nrf2; STING	Apoptosis; Immunology/Inflammation; Others
	Omaveloxolone (RTA-408) 是一种抗氧化炎症调节剂，可激活Nrf2并抑制一氧化氮。它通过抑制 STING 依赖的 NF-κb 信号通路，来抑制破骨细胞的生成。
TQ0174	Mavorixafor AMD-070	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂，对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。
T37979	N-Desmethyl Pimavanserin AC-279	5-HT Receptor	GPCR/G Protein; Neuroscience
	N-Desmethyl Pimavanserin (AC-279) 是 Pimavanserin (一种 5-HT2A 受体反向激动剂）的活性代谢物，可用于治疗失眠等睡眠障碍。
T21322	Mavelertinib PF 06747775,PFE-X775,PF-06747775,PF-7775,PF 6747775,PF6747775	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Mavelertinib (PF-06747775) 是一种可口服且具有选择性和有效性的 EGFR 酪氨酸激酶 (EGFR TKI)抑制剂，对 T790M/L858R 和 T790M/Del 具有抑制作用，可用于研究肿瘤和呼吸系统疾病。
T16014	Mavatrep JNJ-39439335	TRP/TRPV Channel	Membrane transporter/Ion channel
	Mavatrep (JNJ-39439335) 是一种特异性的 TRPV1 拮抗剂，Ki 为 6.5 nM，可用于炎症性疼痛的研究。
T2076	Pimavanserin ACP-103,匹莫范色林	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pimavanserin (ACP-103) 是特异性的 5-HT2A 受体反向激动剂，在基于细胞的功能测定中，平均 pIC50值为8.7。它是非典型抗精神病药，用于治疗帕金森病患者的幻觉和精神病。
T7134	Mavacamten MYK-461,SAR439152	Myosin	Cytoskeletal Signaling
	Mavacamten (MYK-461) 是一种可口服的心肌肌球蛋白 ATP 酶抑制剂，在牛心脏和人心脏中的IC50值分别为 490和711 nM。
T7670	Mavacoxib	COX	Immunology/Inflammation; Neuroscience
	Mavacoxib 是口服长效环氧合酶 2 选择性抑制剂，是长效的非甾体类抗炎药，用于犬退化性关节病相关的炎疼及痛症的研究。
T12527L	Mavodelpar free acid hydrochloride Mavodelpar free acid hydrochloride(942594-93-6 Free base),Pparδ agonist HCl,HPP593 free acid HCl,REN001 free acid HCl	PPAR	DNA Damage/DNA Repair; Metabolism
	Mavodelpar free acid hydrochloride (Pparδ agonist HCl) 是一种有效的 PPARδ激动剂。
TP1595	Human Papillomavirus (HPV) E7 protein (49-57) Human Papillomavirus (HPV) E7 protein 49-57
	Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted human papillomavirus (HPV) E749-57 epitope.
T10296	Mavorixafor trihydrochloride AMD-070 trihydrochloride	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
T73088	Mavodelpar HPP593,REN001,REN001 ; HPP593
	Mavodelpar (REN001) 是一种选择性的 PPARδ激动剂。Mavodelpar 抑制肾小球损伤和肾纤维化。Mavodelpar 可用于原发性线粒体肌病 (PMM) 和长链脂肪酸氧化障碍 (LC-FAOD) 的研究。
T11951	Mavoglurant racemate AFQ-056 racemate	Others	Others
	Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.
T61181	Pentagamavunon-1
	Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), which play crucial roles in mediating cell proliferation and survival. Additionally, PGV-1 possesses the ability to inhibit the activation of NF-κB, further enhancing its apoptotic effects. [1]
TP2183	Large T antigen - rhesus polyomavirus 560-568	Others	Others
	Large T antigen - rhesus polyomavirus 560-568 has a peptide sequence of Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile. T antigen is required for viral DNA replication, transcription, and virion assembly.
T81789	Miromavimab M777-16-3
	Miromavimab (M777-16-3)为针对狂犬病毒ERAGP外域表位G-II的单克隆抗体(mAb)。
TMIH-0435	Pimavanserin-d3
	Pimavanserin-d3 是 Pimavanserin 的氘代化合物。Pimavanserin 的 CAS 号为 706779-91-1。Pimavanserin 是特异性的 5-HT2A 受体反向激动剂，在基于细胞的功能测定中，平均 pIC50值为8.7。它是非典型抗精神病药，用于治疗帕金森病患者的幻觉和精神病。

化合物

Cat.No: T76690

Synonym: CAM 3001

Target: Virus Protease, CSF-1R

Pimavanserin tartrate

Cat.No: T6946

Synonym: ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin,匹莫范色林

Target: 5-HT Receptor

Cat.No: T6919

Synonym: RTA-408

Target: Apoptosis, Others, Nrf2, STING

Cat.No: TQ0174

Synonym: AMD-070

Target: CXCR

N-Desmethyl Pimavanserin

Cat.No: T37979

Synonym: AC-279

Target: 5-HT Receptor

Cat.No: T21322

Synonym: PF 06747775,PFE-X775,PF-06747775,PF-7775,PF 6747775,PF6747775

Target: EGFR

Cat.No: T16014

Synonym: JNJ-39439335

Target: TRP/TRPV Channel

Cat.No: T2076

Synonym: ACP-103,匹莫范色林

Target: 5-HT Receptor

Cat.No: T7134

Synonym: MYK-461,SAR439152

Target: Myosin

Cat.No: T7670

Target: COX

Mavodelpar free acid hydrochloride

Cat.No: T12527L

Synonym: Mavodelpar free acid hydrochloride(942594-93-6 Free base),Pparδ agonist HCl,HPP593 free acid HCl,REN001 free acid HCl

Target: PPAR

Human Papillomavirus (HPV) E7 protein (49-57)

Cat.No: TP1595

Synonym: Human Papillomavirus (HPV) E7 protein 49-57

Mavorixafor trihydrochloride

Cat.No: T10296

Synonym: AMD-070 trihydrochloride

Target: HIV Protease

Cat.No: T73088

Synonym: HPP593,REN001,REN001 ; HPP593

Mavoglurant racemate

Cat.No: T11951

Synonym: AFQ-056 racemate

Target: Others

Pentagamavunon-1

Cat.No: T61181

Large T antigen - rhesus polyomavirus 560-568

Cat.No: TP2183

Target: Others

Cat.No: T81789

Synonym: M777-16-3

Pimavanserin-d3

Cat.No: TMIH-0435

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03399	KLHL2 Protein, Human, Recombinant (GST) kelch like family member 2,ABP-KELCH,MAYVEN,KLHL2,MAV	Human	E. coli
	KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is widely expressed in the brain, esophagus, and other tissues. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin-binding, and protein binding. KLHL2 localizes in various compartments such as actin cytoske...
TMPH-00789	Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc)	HaPyV	E. coli
	Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with sialic acids on the cell surface to provide virion attachment to target cell. Once attached, the virion is internalized by endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby...
TMPH-02365	JC polyomavirus (JCV) Minor capsid protein VP2 (His)	JCPyV	E. coli
	Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPH-02984	Murine polyomavirus (MPyV) (strain Kilham) VP1 Protein (His)	MPyV	Baculovirus Insect Cells
	Murine polyomavirus (MPyV) (strain Kilham) VP1 Protein (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 42.5 kDa and the accession number is P24595.
TMPH-02986	Murine polyomavirus (MPyV) (strain Kilham) VP2 Protein (His)	MPyV	E. coli
	Murine polyomavirus (MPyV) (strain Kilham) VP2 Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.4 kDa and the accession number is P24596.
TMPH-00201	BK polyomavirus (BKPyV) VP2 Protein (His) Minor capsid protein VP2,Minor structural protein VP2	BKPyV	E. coli
	Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPH-02985	Murine polyomavirus (MPyV) (strain Kilham) VP1 Protein (E. coli, His)	MPyV	E. coli
	Murine polyomavirus (MPyV) (strain Kilham) VP1 Protein (E. coli, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.4 kDa and the accession number is P24595.
TMPH-00200	BK polyomavirus (BKPyV) VP1 Protein (His & Myc) Major structural protein VP1,Major capsid protein VP1	BKPyV	E. coli
	BK polyomavirus (BKPyV) VP1 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.1 kDa and the accession number is P03088.

重组蛋白

KLHL2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03399

Species: Human

Expression System: E. coli

Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc)

Cat.No: TMPH-00789

Species: HaPyV

Expression System: E. coli

JC polyomavirus (JCV) Minor capsid protein VP2 (His)

Cat.No: TMPH-02365

Species: JCPyV

Expression System: E. coli

Murine polyomavirus (MPyV) (strain Kilham) VP1 Protein (His)

Cat.No: TMPH-02984

Species: MPyV

Expression System: Baculovirus Insect Cells

Murine polyomavirus (MPyV) (strain Kilham) VP2 Protein (His)

Cat.No: TMPH-02986

Species: MPyV

Expression System: E. coli

BK polyomavirus (BKPyV) VP2 Protein (His)

Cat.No: TMPH-00201

Species: BKPyV

Expression System: E. coli

Murine polyomavirus (MPyV) (strain Kilham) VP1 Protein (E. coli, His)

Cat.No: TMPH-02985

Species: MPyV

Expression System: E. coli

BK polyomavirus (BKPyV) VP1 Protein (His & Myc)

Cat.No: TMPH-00200

Species: BKPyV

Expression System: E. coli

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