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Search Results for " l-tryptophan "

16

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5489	Tryptophan, N-indol-3-ylacetyl- (6CI) N-(3-吲哚乙酰基)-L-色氨酸,N-(3-Indolylacetyl)-L-tryptophan,Indole-3-acetyl-L-tryptophan	Glucosidase	Metabolism
	Tryptophan, N-indol-3-ylacetyl- (6CI) (Indole-3-acetyl-L-tryptophan) 参与调节生理和病理生理反应过程中生长素活性的调节机制。还可用于合成β-D-半乳糖苷酶和β-D-葡萄糖苷酶抑制剂。
TN7093	N-Caffeoyltryptophan trans-Caffeoyl-L-tryptophan,反式咖啡酰-L-色氨酸	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan) 是一种潜在的 Sirt 抑制剂，使用咖啡提取物进行筛选。 N-Caffeoyltryptophan 抑制 Sirt2 (IC50; 8.7 μM) 优于 Sirt1 (IC50; 34μM)。
T11449L	Golotimod SCV 07,Gamma-D-glutamyl-L-tryptophan	STAT	JAK/STAT signaling; Stem Cells
	Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.
T20540	N-Valyltryptophan 二肽-2,Val-trp,L-Valyl-L-tryptophan	Others	Others
	N-Valyltryptophan (Val-trp) 是蛋白质分解代谢或蛋白质消化的不完全分解产物。
T2038	RG108 N-Phthalyl-L-tryptophan	DNA Methyltransferase	Chromatin/Epigenetic
	RG108 (N-Phthalyl-L-tryptophan) 是一种非核苷的 DNA 甲基转移酶 (DNMTs) 抑制剂，IC50为115 nM。它阻断 DNA 甲基转移酶的活性位点，可引起抑癌基因的去甲基化和再激活。
T10142L	p-Ethynylphenylalanine hydrochloride 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)	Hydroxylase	Metabolism
	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其Ki=32.6 μM。
T3119	JNJ-63533054 JNJ 63533054	GPR	Endocrinology/Hormones; GPCR/G Protein
	JNJ-63533054 是一种选择性的，具有口服活性的GPR139激动剂，对人GPR139的EC50为 16 nM。它可穿过血脑屏障，对 GPR139 的选择性高于其他 GPCR、离子通道和转运蛋白。
T19889	L-5-BromoTryptophan L-5-溴色氨酸,5-BrW,5 BrW	Others	Others
	L-5-BromoTryptophan (5-BrW) 是色氨酸(Trp) 效应物的类似物，可抑制血红蛋白 S 的凝胶化。
T11449	Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride	STAT	JAK/STAT signaling; Stem Cells
	Golotimod (SCV 07) hydrochloride 是一种免疫调节肽，具抗菌活性，能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能，展现其生物调节能力。此外，Golotimod hydrochloride 通过抑制STAT3信号传导，有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。
T11449L2	Golotimod (TFA) (229305-39-9 free base) SCV 07 (TFA),Gamma-D-glutamyl-L-tryptophan (TFA),Golotimod (TFA)	STAT	JAK/STAT signaling; Stem Cells
	Golotimod TFA (SCV 07 TFA) 一种免疫调节肽，具有抗菌作用，能够明显增加抗结核研究的效果，刺激胸腺和脾细胞增殖，改善巨噬细胞功能。Golotimod TFA 能够抑制 STAT3 信号传导，调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod TFA 具有潜力进复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 的研究。
T29842	Alclofenac W 7320,烯氯苯乙酸,MY 101,BRN 2116510,W-7320,W7320	Others	Others
	Alclofenac (W-7320) 对急性期蛋白反应和L-色氨酸与血浆蛋白结合程度有显著影响，可用于慢性风湿病患者的治疗。
T10142	p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine	Others; Hydroxylase	Metabolism; Others
	p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种色氨酸羟化酶(TPH)抑制剂，具有竞争性、有效性、选择性和可逆性，Ki 为32.6 μM。
T19258	DL-3-Indolylglycine D,L-3-吲哚甘氨酸,α-Amino-1H-indole-3-acetic acid,D,L-3-Indolylglycine	Others	Others
	D, L-3-indolylglycine is an unnatural amino acid very similar to tryptophan, and its indole portion is directly connected to the α-position. Target: D, L-3-indolyl glycine can be used for functional protein design. One study described the inclusion of sim
T78228	4-Chloro-L-phenylalanine L-4-Chlorophenylalanine,L-PCPA	5-HT Receptor	GPCR/G Protein; Neuroscience
	4-Chloro-L-phenylalanine (L-PCPA) 是一种 5-HT 生物合成抑制剂。4-Chloro-L-phenylalanine 也是色氨酸羟化酶(TPH1 和 TPH2)的非特异性拮抗剂。
T71180	Oglufanide disodium
	Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections. Check for active clinical trials or closed clinical trials u...
T68182	3-Hydroxykynurenamine
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...

化合物

Tryptophan, N-indol-3-ylacetyl- (6CI)

Cat.No: T5489

Synonym: N-(3-吲哚乙酰基)-L-色氨酸,N-(3-Indolylacetyl)-L-tryptophan,Indole-3-acetyl-L-tryptophan

Target: Glucosidase

N-Caffeoyltryptophan

Cat.No: TN7093

Synonym: trans-Caffeoyl-L-tryptophan,反式咖啡酰-L-色氨酸

Target: Sirtuin

Cat.No: T11449L

Synonym: SCV 07,Gamma-D-glutamyl-L-tryptophan

Target: STAT

N-Valyltryptophan

Cat.No: T20540

Synonym: 二肽-2,Val-trp,L-Valyl-L-tryptophan

Target: Others

Cat.No: T2038

Synonym: N-Phthalyl-L-tryptophan

Target: DNA Methyltransferase

p-Ethynylphenylalanine hydrochloride

Cat.No: T10142L

Synonym: 4-Ethynyl-L-phenylalanine HCL,p-Ethynylphenylalanine hydrochloride(278605-15-5 free base)

Target: Hydroxylase

Cat.No: T3119

Synonym: JNJ 63533054

Target: GPR

L-5-BromoTryptophan

Cat.No: T19889

Synonym: L-5-溴色氨酸,5-BrW,5 BrW

Target: Others

Golotimod hydrochloride (229305-39-9 free base)

Cat.No: T11449

Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

Target: STAT

Golotimod (TFA) (229305-39-9 free base)

Cat.No: T11449L2

Synonym: SCV 07 (TFA),Gamma-D-glutamyl-L-tryptophan (TFA),Golotimod (TFA)

Target: STAT

Cat.No: T29842

Synonym: W 7320,烯氯苯乙酸,MY 101,BRN 2116510,W-7320,W7320

Target: Others

p-Ethynylphenylalanine

Cat.No: T10142

Synonym: 4-Ethynyl-L-phenylalanine

Target: Others, Hydroxylase

DL-3-Indolylglycine

Cat.No: T19258

Synonym: D,L-3-吲哚甘氨酸,α-Amino-1H-indole-3-acetic acid,D,L-3-Indolylglycine

Target: Others

4-Chloro-L-phenylalanine

Cat.No: T78228

Synonym: L-4-Chlorophenylalanine,L-PCPA

Target: 5-HT Receptor

Oglufanide disodium

Cat.No: T71180

3-Hydroxykynurenamine

Cat.No: T68182

Cat. No.	Product Name	Target	Signaling Pathways
T0439	L-Tryptophan (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	L-Tryptophan (Tryptophane) 是一种必需氨基酸，是褪黑素、血清素和维生素B3的前体。
T8789	N-Acetyl-L-tryptophan N-acetyltryptophan,N-乙酰-L-色氨酸	Endogenous Metabolite; Neurokinin receptor	GPCR/G Protein; Metabolism; Neuroscience
	N-Acetyl-L-tryptophan (N-acetyltryptophan) 是内源性代谢产物的一种。
T5718	L-(+)-Abrine L-(+)-红豆碱,L-N-Methyltryptophan,N-α-Methyl-L-tryptophan,L-ABRINE	Others	Others
	L-(+)-Abrine (L-N-Methyltryptophan) 是一种致命白蛋白，发现于在 Abrus precatorius 种子中，是一种急性毒性生物碱，可用作化学标记物。
T7203	Oglufanide 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH	VEGFR; HCV Protease; Endogenous Metabolite	Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂，可抑制血管内皮生长因子，可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T20585	3-Acetylindole 3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole	Others	Others
	3-Acetylindole (3-Acetyl-1H-indole) 可用作取代基和 Sudlow 位点 II 的 L-色氨酸的探针。
TJO2729	L-Alanine L-2-Aminopropionic acid,alanine,丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	L-Alanine (L-2-Aminopropionic acid) 是一种非必需氨基酸，可参与糖和酸的代谢，为肌肉组织、大脑和中枢神经系统提供能量，并增强免疫力。
T4096	Quinolinic acid 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Quinolinic acid (QUIN) 是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂，由 L-色氨酸通过犬尿氨酸途径合成，具有调节 NMDA 神经元损伤和功能障碍的潜力。
T1379	L-5-Hydroxytryptophan 5-羟基色氨酸,L-oxitriptan,Oxitriptan,L-5-HTP	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	L-5-Hydroxytryptophan (L-5-HTP) 是一种天然氨基酸和膳食补充剂，可以用作抗抑郁剂、食欲抑制剂和睡眠辅助剂，是神经递质血清素的前体，是利血平(reserpine) 的拮抗剂。它能够用于肌阵挛、纤维肌痛症、偏头痛和小脑共济失调的研究。
T4928	L-Kynurenine L-犬尿氨酸,(S)-Kynurenine	AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物，是芳香烃受体激动剂，可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。
T4707	3-Hydroxyanthranilic acid 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID) 是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现，并且在多种生物体液中也已检测到，例如尿液和血液。在细胞内，它主要位于细胞质中。它存在于从酵母到人类的所有真核生物中。

天然产物

Cat.No: T0439

Synonym: (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸

Target: Amino Acids and Derivatives, Endogenous Metabolite

N-Acetyl-L-tryptophan

Cat.No: T8789

Synonym: N-acetyltryptophan,N-乙酰-L-色氨酸

Target: Endogenous Metabolite, Neurokinin receptor

Cat.No: T5718

Synonym: L-(+)-红豆碱,L-N-Methyltryptophan,N-α-Methyl-L-tryptophan,L-ABRINE

Target: Others

Cat.No: T7203

Synonym: 奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH

Target: VEGFR, HCV Protease, Endogenous Metabolite

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T20585

Synonym: 3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole

Target: Others

Cat.No: TJO2729

Synonym: L-2-Aminopropionic acid,alanine,丙氨酸

Target: Others, Endogenous Metabolite

Quinolinic acid

Cat.No: T4096

Synonym: 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN

Target: Endogenous Metabolite, NMDAR, iGluR

L-5-Hydroxytryptophan

Cat.No: T1379

Synonym: 5-羟基色氨酸,L-oxitriptan,Oxitriptan,L-5-HTP

Target: Amino Acids and Derivatives, Endogenous Metabolite

Cat.No: T4928

Synonym: L-犬尿氨酸,(S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

3-Hydroxyanthranilic acid

Cat.No: T4707

Synonym: 3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸

Target: Others, Endogenous Metabolite

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