Powder: -20°C for 3 years | In solvent: -80°C for 1 year
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂,其Ki=32.6 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 243 | 现货 | ||
10 mg | ¥ 348 | 现货 | ||
25 mg | ¥ 566 | 现货 | ||
50 mg | ¥ 828 | 现货 | ||
100 mg | ¥ 1,220 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 913 | 现货 |
产品描述 | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the biosynthesis of serotonin may contribute to the characterization of the role of serotonin in behavioral and physiological activities[1]. |
靶点活性 | TPH:32.6 μM |
体外活性 | p-Ethynylphenylalanine hydrochloride 已证实在体外以竞争性和可逆的方式抑制 TPH (Ki = 32.6 +/- 6.2 microM 对照色氨酸)[1]。 |
体内活性 | 给大鼠注射p-Ethynylphenylalanine hydrochloride(30 mg/kg)后,24小时后大脑匀浆中的TPH活性显著下降(95 +/- 5%),且着血清素及5-羟吲哚-3-乙酸水平的同步降低(85%)[1]。 |
别名 | 4-Ethynyl-L-phenylalanine HCL, p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) |
分子量 | 225.67 |
分子式 | C11H12ClNO2 |
CAS No. | 188640-63-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12 mg/mL (53.17 mM), Sonification is recommended.
DMSO: 99 mg/mL (438.69 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 4.4312 mL | 22.1562 mL | 44.3125 mL | 110.7812 mL |
5 mM | 0.8862 mL | 4.4312 mL | 8.8625 mL | 22.1562 mL | |
10 mM | 0.4431 mL | 2.2156 mL | 4.4312 mL | 11.0781 mL | |
20 mM | 0.2216 mL | 1.1078 mL | 2.2156 mL | 5.5391 mL | |
50 mM | 0.0886 mL | 0.4431 mL | 0.8862 mL | 2.2156 mL | |
DMSO | 100 mM | 0.0443 mL | 0.2216 mL | 0.4431 mL | 1.1078 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
p-Ethynylphenylalanine hydrochloride 188640-63-3 Metabolism Hydroxylase p-Ethynylphenylalanine p Ethynylphenylalanine hydrochloride 4-Ethynyl-L-phenylalanine HCL 5-HT inhibit 5-HIAA Tryptophan Hydroxylase hydroxylase p-Ethynylphenylalanine Hydrochloride Inhibitor tryptophan serotonin p-Ethynylphenylalanine hydrochloride(278605-15-5 free base) TPH pEthynylphenylalanine hydrochloride inhibitor