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Cat. No. | Product Name | Target | Signaling Pathways |
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T40248 |
JNK3 inhibitor-1
JNK3 inhibitor-1 |
||
JNK3 inhibitor-1 is a highly potent and selective compound that specifically inhibits JNK3 with an impressive IC50 value of 0.005 μM. In addition to its remarkable inhibitory effects, JNK3 inhibitor-1 possesses excellent oral bioavailability and the ability to efficiently penetrate the brain. | |||
T72715 |
JNK3 inhibitor-4
|
||
JNK3inhibitor-4 是一种强效的JNK3抑制剂(IC50=1.0 nM),属于2-芳基-1-嘧啶基-1H-咪唑-5-基乙腈衍生物。该化合物对JNK3表现出高度专一性,对比JNK1(IC50=143.9 nM)和JNK2(IC50=298.2 nM)的选择性显著。此外,JNK3inhibitor-4还具备神经保护特性及良好的血脑屏障透过性预期。 | |||
T72714 |
JNK3 inhibitor-3
|
JNK | MAPK |
JNK3inhibitor-3(compound 15g)是一种选择性的c-Jun N-terminal kinase3(JNK3)抑制剂,具有良好的血脑屏障穿透性和口服生物利用度。其对JNK1、JNK2和JNK3的IC50分别为147.8 nM、44.0 nM和4.1 nM。在小鼠痴呆模型中,JNK3inhibitor-3能显著改善记忆功能,因此有望作为阿尔茨海默病研究的工具化合物。 | |||
T74818 | JNK3 inhibitor-8 | ||
JNK3inhibitor-8是一种高效、选择性且具口服活性的JNK3抑制剂,能穿透血脑屏障。其对JNK3、JNK2、JNK1的IC50值依次为21, 2203, >10000 nM。JNK3inhibitor-8展现出显著的神经保护性能,并具备研究阿尔茨海默病(AD)的可能性。 | |||
T60805 | JNK3 inhibitor-2 | ||
JNK3 inhibitor-2 是一种有效的选择性JNK3抑制剂。JNK3 inhibitor-2 对 JNK1、JNK2、 JNK3的IC50值分别为 >100, >100, 0.25 μM。JNK3 inhibitor-2也抑制 DDR1 和 EGFR (T790M, L858R)。 | |||
T74817 | JNK3 inhibitor-7 | ||
JNK3inhibitor-7 是一种有效的口服活性JNK3抑制剂,能穿过血脑屏障,其对JNK3、JNK2、JNK1的IC50值分别为53、973、1039 nM。该化合物表现出显著的神经保护作用,并具备研究阿尔茨海默病(AD)潜力。 | |||
T4646 |
TA-02
|
p38 MAPK; Autophagy | Autophagy; MAPK |
TA02 是一种Adezmapimod 类似物,是p38 MAPK 的抑制剂,其IC50值为 20 nM。它和Adezmapimod、SB 202190 具有相似的心源活性,可抑制 TGFBR-2。 | |||
T2234 |
TCS JNK 5a
N-(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)-1-萘甲酰胺,SC202671,SC 202671,N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide,JNK Inhibitor IX,SC-202671 |
Apoptosis; JNK | Apoptosis; MAPK |
TCS JNK 5a (SC202671) 是一种 JNK2和 JNK3的有效抑制剂,pIC50分别为 6.5和 6.7。 | |||
T8477 |
IQ-3
|
JNK | MAPK |
IQ3 是c-JNK 家族选择性抑制剂,对JNK3 的选择性更好。它对JNK1、JNK2 和 JNK3 的Kd 值分别为0.24 μM、0.29 μM 和 0.066 μM。 | |||
T3109 |
SP600125
1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone |
Apoptosis; Ferroptosis; Trk receptor; JNK; Aurora Kinase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors |
SP600125 (JNK Inhibitor II) 是一种 JNK 抑制剂,抑制 JNK1、JNK2 和 JNK3 (IC50=40/40/90 nM),具有口服有效性、可逆性和 ATP 竞争性。SP600125 是一种有效的铁死亡抑制剂,可以抑制自噬,诱导凋亡。 | |||
T2675 |
Bentamapimod
AS 602801 |
JNK | MAPK |
Bentamapimod (AS 602801) 是一种ATP 竞争性的JNK 抑制剂,对JNK1、JNK2和JNK3的IC50分别为 80、90 和 230 nM。 | |||
T60534 |
JNK-IN-11
|
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JNK-IN-11 (compound 1) 是一种有效的 JNK 抑制剂,具有用于阿尔茨海默病和帕金森病研究的潜力。JNK-IN-11对 JNK1、JNK2、JNK3 的IC50值分别为 1.8、21.4、2.2 μM 。 | |||
T1828 |
TTP 22
|
Casein Kinase | Metabolism; Stem Cells |
TTP 22 是一种高亲和力、ATP 竞争性酪蛋白激酶 2 抑制剂,IC50和 Ki 值分别为 0.1 uM 和 40 nM。 | |||
T3598 |
JNK-IN-7
JNK inhibitor |
JNK | MAPK |
JNK-IN-7 (JNK inhibitor) 是 JNK 抑制剂,抑制 JNK1、JNK2和 JNK3,IC50分别为 1.5、2 和 0.7 nM。 | |||
T38260 |
SP 600125, negative control
JNK Inhibitor II, negative control |
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SP 600125, negative control 是 SP 600125 的甲基化类似物,可用作SP 600125的阴性对照,对 DTP3和GADD45β/MKK7(生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7)具有抑制作用,能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。 | |||
T2668 |
JNK-IN-8
JNK Inhibitor XVI |
JNK; c-Kit | MAPK; Tyrosine Kinase/Adaptors |
JNK-IN-8 (JNK Inhibitor XVI) 是一种有效的JNK 抑制剂,抑制JNK1、JNK2和JNK3,IC50分别为 4.7、18.7 和 1 nM。 | |||
T3627 |
IQ-1S free acid
IQ-1,IQ-1S,IQ-1S (free acid) |
NF-κB; JNK | MAPK; NF-κB |
IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力 。 | |||
T23392 |
SR 3576
|
Others | Others |
JNK3 inhibitor, potent and selective | |||
T11702 | J30-8 | Others | Others |
J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases. J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivit | |||
TP2146 |
JTP10-△-TATi TFA
|
JNK | MAPK |
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3. | |||
T24829 |
SR-3737
SR3737,SR 3737 |
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SR-3737 is potent both JNK3 and p38 inhibitor. | |||
TP2145 |
JTP10-△-R9 TFA
|
JNK | MAPK |
JTP10-△-R9 TFA is a selective inhibitor of JNK2 peptide (IC50: 89 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3. | |||
T74850 | YL5084 | ||
YL5084 是一种共价 JNK 抑制剂,对 JNK2和 JNK3的选择性高于 JNK1,IC50分别为 70 nM、84 nM 和 2173 nM。YL5084 表现出不依赖JNK2的抗增殖作用,并以不依赖JNK2的方式诱导细胞凋亡。 | |||
T14895 |
Tanzisertib
CC-930 |
JNK | MAPK |
Tanzisertib (CC-930) 是有效的JNK1/2/3抑制剂,IC50分别为61、7 和 6 nM。 | |||
T63749 | JAK3-IN-13 | ||
JAK3-IN-13 是有效的、选择性的、口服具有活力的 JAK3 抑制剂,能够作用于 NK1 (IC50: 4728 nM)、JNK2 (IC50: 2039 nM)、JNK3 (IC50: 8 nM)、Tyk2 (IC50: 365 nM)。JAK3-IN-13 能够将细胞周期阻滞在 G0/G1 期,具有抗增殖效果。JAK3-IN-13 表现出抗肿瘤作用。 | |||
T2343 |
AS601245
|
JNK | MAPK |
AS601245 是 c-Jun NH2-末端激酶 (JNK) 的抑制剂,具有神经保护特性。 | |||
T79754 |
JNK-IN-14
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JNK | MAPK |
JNK-IN-14是一种激酶(JNK1/2/3)抑制剂,IC50值为1.81、12.7和10.5 nM。它能诱导早期apoptosis,并在G2/M阶段引起细胞周期阻滞。与SP600125相比,在K562白血病细胞中,JNK-IN-14更强有效地抑制了Beclin-1的表达。 | |||
T7677 |
JNK Inhibitor VIII
TCS JNK 6o |
JNK | MAPK |
JNK Inhibitor VIII (TCS JNK 6o) 是一种 c-Jun N-末端激酶(JNK-1, -2, -3)抑制剂,对 JNK-1、JNK-2 的IC50值分别是 45 nM 和 160 nM,对JNK-1、JNK-2、JNK-3 的Ki 分别为 2 nM、4 nM、52 nM。 | |||
T9138 |
Indirubin-3′-oxime
Indirubin-3'-monoxime |
GSK-3; CDK; JNK | Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂,是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长,可能在阿尔茨海默病的神经元凋亡中发挥作用。 | |||
T8661 |
AS601245.2TFA (345987-15-7 free base)
AS601245.2TFA |
JNK | MAPK |
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) 是一种可渗透细胞的 JNK 抑制剂(对 hJNK1、hJNK2 和 hJNK3 的 IC50 分别为 150、220 和 70 nM)。 | |||
T36672 |
CAY10561
|
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The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561... | |||
T10298L2 |
AMG-548 dihydrochloride (864249-60-5 free base)
AMG-548 dihydrochloride |
p38 MAPK | MAPK |
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulate | |||
T10298 |
AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride |
p38 MAPK | MAPK |
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM). | |||
T10298L |
AMG-548
|
p38 MAPK | MAPK |
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN7121 |
d-Epigalbacin
(-)-Zuonin A,表加巴辛 |
JNK | MAPK |
d-Epigalbacin ((-)-Zuonin A) 是一种天然木质素。d-Epigalbacin 是一种强效、选择性的JNKs 抑制剂,JNK1、JNK2和JNK3的IC50s 分别为1.7μM、2.9μM 和1.74μM。 |