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Search Results for " jh "

Targets Recommended: LRRK2

41

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7155	JH-II-127	LRRK2	Autophagy
	JH-II-127是一种高选择性的脑渗透性 LRRK2 抑制剂，抑制野生型 LRRK2、G2019S LRRK2和 A2016T LRRK2，IC50 值分别为6.6 nM、2.2 nM 和 47.7 nM。
T15611	JH-RE-06	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	JH-RE-06是一种REV1-REV7互作抑制剂，IC50为0.78 μM，Kd 为0.42 μM。它靶向与 POLζ 的 REV7 亚基相互作用的 REV1，可改善化疗效果。它通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成。
T15612	JH-VIII-157-02	Microtubule Associated; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	JH-VIII-157-02 是一种 ALK 抑制剂，可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK)，对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。
T9203	JH-X-119-01	IRAK	Immunology/Inflammation; NF-κB
	JH-X-119-01 是白介素 1 受体相关激酶 1 的选择性抑制剂。它能够改善 LPS 诱导的小鼠败血症。它可以抑制 IRAK1(IC50:9 nM)，在浓度达到 10 μM 时，也不会对 IRAK4 产生抑制作用。
T32288	JH-IX-179 JH-IX179,JH-IX 179
	JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autoph
T40280	JH-XVI-178
	JH-XVI-178 is a highly potent and selective CDK8/19 inhibitor with favorable pharmacokinetic attributes, including low clearance and moderate oral bioavailability.
T24200	JH-VIII-49 JH-VIII49,JH-VIII 49,JHVIII-49,JHVIII 49,JHVIII49
	JH-VIII-49 is an effective and selective inhibitor of CDK8.
T40225	JH-X-119-01 hydrochloride
	JH-X-119-01 hydrochloride is a potent and selective inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). It effectively alleviates lipopolysaccharide (LPS)-induced sepsis in mice.
T71548	JH-I-25
	JH-I-25 is an IRAK1 kinase inhibitor.
T11715	JH-LPH-28	Others	Others
	JH-LPH-28, a sulfonyl piperazine analog, is a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH, exhibiting exceptional antibiotic activity with a minimum inhibitory concentration (MIC) value of 0.83 μg/mL.
T11716	JH-LPH-33	Others	Others
	JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. It exhibits remarkable antibiotic activity, reflected by a minimal inhibitory concentration (MIC) value of 0.66 μg/mL.
T13743	JH-XI-10-02	EGFR; PROTACs	Angiogenesis; JAK/STAT signaling; PROTAC; Tyrosine Kinase/Adaptors
	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
T38710	JH295
	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
T31138	Cyclopren JH-149,JH149,JH 149
	Cyclopren can be used as a juvenile hormone.
T63050	JH-XVII-10
	JH-XVII-10 是一种具有选择性的、口服具有活力的、有效的 DYRK1A (IC50: 3 nM) 和 DYRK1B (IC50: 5 nM) 抑制剂。JH-XVII-10 在颈部鳞状细胞癌 (HNSCC) 细胞系中表现出抗肿瘤效果。
T79351	JH-XII-03-02	PROTACs	PROTAC
	JH-XII-03-02为高效的选择性LRRK2 PROTAC降解剂，适用于帕金森病相关研究。
T62790	JH-XIV-68-3
	JH-XIV-68-3 是一种选择性的 DYRK1A/B 大环抑制剂。JH-XIV-68-3 在生化和细胞测定中能够选择性作用于 DYRK1A 和近亲 DYRK1B。JH-XIV-68-3 在头颈部鳞状细胞癌 (HNSCC) 细胞系中具有抗肿瘤作用。
T82007	JH-131e-153
	JH-131e-153, 作为一种二酰基甘油(DAG)内酯，具有激活 Munc13-1 的功能，靶向其 C1 结构域。JH-131e-153 对 Munc13-1 激活效率表现为 WT>I590≈R592A≈W588A。值得注意的是，Munc13-1 的 C1 结构域与蛋白激酶 C (PKC) 在序列和结构上具有同源性。对于 Munc13-1 和 PKC 的激活效率，JH-131e-153 的效果排序为 PKCα>Munc13-1>PKCε。该化合物通过调节 Munc13-1，对神经元过程产生影响，因此可用于神经退行性疾病的相关研究。
T71547	MDL-25637
	MDL-25637 is a glucosidase inhibitor.
T61061	JH295 hydrate
	JH295 hydrate 通过 Cys22 烷基化从而抑制细胞Nek2，它是有效的，不可逆和选择性的NIMA 相关激酶 2 (Nek2)抑制剂 (IC50 = 770 nM)。JH295 hydrate 对有丝分裂激酶 Cdk1，Aurora B 或 Plk1 不具有活性，不干扰双极纺锤体组件或纺锤体组件检查点。
T64227	JAK2 JH2 binder-1
	JAK2 JH2 binder-1 是一种有效的、选择性的 JAK2 JH2 结合剂 (Ki: 37.1 nM)。JAK2 JH2 binder-1 具有用于研究各种骨髓增生性肿瘤的潜力。
T9019	JHU37152 JHU 37152	AChR	Neuroscience
	JHU37152 (JHU 37152) 是一种可透过血脑屏障的DREADD 激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中，对hM3Dq 和hM4Di DREADDs 的EC50值分别为 5 和 0.5 nM。
T11717	JHU395	Apoptosis	Apoptosis
	JHU395 是一种口服生物利用度高的前药，其活性成分是亲脂性谷氨酸拮抗剂（GA，6-叠氮-5-酮-L-去亚硝基赖氨酸）。JHU395 能有效地将DON输送至恶性周围神经鞘瘤（MPNST）的体外和体内模型中，并在MPNST上显现出显著的抗肿瘤活性。此外，JHU395在血浆中表现出良好的稳定性。
T77634	JHU 75528 JHU75528,JHU-75528	Cannabinoid Receptor	GPCR/G Protein
	JHU 75528 (JHU-75528) 是一种新型 PET 示踪剂，对 CB 具有抑制作用，可用于研究精神分裂症患者大麻素系统。
T6877	LJH685	Apoptosis; S6 Kinase	Apoptosis; MAPK; PI3K/Akt/mTOR signaling
	LJH685 是一种选择性，ATP-竞争性的RSK 抑制剂, 抑制 RSK1/2/3 生物活性，IC50为 6、5、4 nM。
T9018	JHU37160 JHU 37160	AChR	Neuroscience
	JHU37160 (JHU 37160) 是一种可透过血脑屏障的 DREADD 激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中，对hM3Dq 和hM4Di DREADDs 的EC50值分别为 18.5 和 0.2 nM。
T38107	JJH260 JJH260
	JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysa...
T75175	JHDM-IN-1
	JHDM-IN-1 (Compound 1) 为含有 Jumonji C 结构域的HDMs (JHDM) 抑制剂，针对 JMJD2C、JMJD2A、JMJD2E、PHF8 及 JMJD3 的IC50 值分别为3.4、4.3、5.9、10、43 μM。
T22877	JHW 007 hydrochloride	Others	Others
	JHW 007 hydrochloride is a Dopamine uptake inhibitor.
T32289	jhu-75528c-11 JHU75528 C-11,11c-Omar,JHU 75528 C-11
	JHU-75528 C-11 can be used as a Radiotracer for PET Imaging of CB1 Cannabinoid Receptors.
T73827	NJH-2-057
	NJH-2-057 是一种去泛素酶 OTUB1共价配体连接 lumacaftor 的结合物, 在细胞中稳定突变的 CFTR 蛋白。
T19017	JAK2 JH2 Tracer	Others	Others
	JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain (Kd: 0.2 μM).
T69043	GJH-166
	GJH-166 is an analog of dopamine that has been shown to inhibit adrenergic transmission in canines.
T70340	JHU-58
	JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.
T74277	NJH-2-056	PROTACs	PROTAC
	NJH-2-056 是一种去泛素酶靶向嵌合体 (DUBTAC)，连接OTUB1的招募因子 EN523 和CFTR 伴侣蛋白 lumacaftor。NJH-2-056 可用于囊性纤维化研究。
T15613	JHU-083	Others	Others
	JHU-083 is a selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells. JHU-083 also experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals.
T78833	AJH-836	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	AJH-836为Munc13-1及PKCε/α激活剂（Kd：4.5 nM PKCα），促进Munc13-1由细胞质转位至质膜，并可应用于神经退行性疾病研究。
T61521	NJH-2-030
	NJH-2-030 is a covalent recruiting compound utilized in targeted protein degradation applications for FEM1B.
TP1605L1	Allatostatin IV TFA(123338-13-6 free base)	Others	Others
	Allatostatin IV TFA(123338-13-6 free base) 是一种八肽胺，是在昆虫中发现的抑制（allatostatins）或刺激（allatotropins）保幼激素（JH）合成的调节肽家族的成员。
T16044	Methoprene 烯虫酯,ZR-515	Others	Others
	Methoprene (ZR-515) 是一种保幼激素模拟物和一种生物杀虫剂。Methoprene 作为昆虫生长调节剂，干扰昆虫的生命周期并阻止其成熟或繁殖。
TP1605	Allatostatin IV
	Allatostatin IV, an octapeptide amine, is a member of the allatoregulatory peptide family found in insects which either inhibit (allatostatins) or stimulate (allatotropins) juvenile hormone (JH) synthesis.

化合物

Cat.No: T7155

Target: LRRK2

Cat.No: T15611

Target: DNA/RNA Synthesis

Cat.No: T15612

Target: Microtubule Associated, ALK

Cat.No: T9203

Target: IRAK

Cat.No: T32288

Synonym: JH-IX179,JH-IX 179

Cat.No: T40280

Cat.No: T24200

Synonym: JH-VIII49,JH-VIII 49,JHVIII-49,JHVIII 49,JHVIII49

JH-X-119-01 hydrochloride

Cat.No: T40225

Cat.No: T71548

Cat.No: T11715

Target: Others

Cat.No: T11716

Target: Others

Cat.No: T13743

Target: EGFR, PROTACs

Cat.No: T38710

Cat.No: T31138

Synonym: JH-149,JH149,JH 149

Cat.No: T63050

Cat.No: T79351

Target: PROTACs

Cat.No: T62790

Cat.No: T82007

Cat.No: T71547

Cat.No: T61061

JAK2 JH2 binder-1

Cat.No: T64227

Cat.No: T9019

Synonym: JHU 37152

Target: AChR

Cat.No: T11717

Target: Apoptosis

Cat.No: T77634

Synonym: JHU75528,JHU-75528

Target: Cannabinoid Receptor

Cat.No: T6877

Target: Apoptosis, S6 Kinase

Cat.No: T9018

Synonym: JHU 37160

Target: AChR

Cat.No: T38107

Synonym: JJH260

Cat.No: T75175

JHW 007 hydrochloride

Cat.No: T22877

Target: Others

Cat.No: T32289

Synonym: JHU75528 C-11,11c-Omar,JHU 75528 C-11

Cat.No: T73827

JAK2 JH2 Tracer

Cat.No: T19017

Target: Others

Cat.No: T69043

Cat.No: T70340

Cat.No: T74277

Target: PROTACs

Cat.No: T15613

Target: Others

Cat.No: T78833

Target: PKC

Cat.No: T61521

Allatostatin IV TFA(123338-13-6 free base)

Cat.No: TP1605L1

Target: Others

Cat.No: T16044

Synonym: 烯虫酯,ZR-515

Target: Others

Allatostatin IV

Cat.No: TP1605

Cat. No.	Product Name	Target	Signaling Pathways
TN2610	13-Epijhanol	Others	Others
	13-Epijhanol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2610，CAS号为 133005-15-9。

天然产物

Cat.No: TN2610

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02833	Hemojuvelin Protein, Human, Recombinant (His) JH,RGMC,HJV,HFE2A,hemochromatosis type 2 (juvenile)	Human	Baculovirus Insect Cells
	Hemojuvelin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 40 kDa and the accession number is Q6ZVN8-1.
TMPK-01062	RGMC Protein, Mouse, Recombinant (His) HJV,DL-M,JH,Rgmc,RGM-C,Hemojuvelin,HFE2,HFE2AMGC239...	Mouse	HEK293 Cells
	RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system.

重组蛋白

Hemojuvelin Protein, Human, Recombinant (His)

Cat.No: TMPY-02833

Species: Human

Expression System: Baculovirus Insect Cells

RGMC Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01062

Species: Mouse

Expression System: HEK293 Cells

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