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Cat. No. | Product Name | Target | Signaling Pathways |
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T24168 |
Insulin B (20-30)
Insulin (B20-B30) |
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Insulin B (20-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into la | |||
T24169 |
Insulin B (22-30)
Insulin (B22-B30) |
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Insulin B (22-30) is a peptide hormone produced by beta cells of the pancreatic islets, and it is considered to be the main anabolic hormone of the body. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into la | |||
T7814 |
Alloxan monohydrate
|
Proteasome | Proteases/Proteasome; Ubiquitination |
Alloxan Monohydrate 是一种能够引起糖尿病的致糖尿病药物。它作为蛋白酶体抑制剂,破坏胰腺中能够分泌胰岛素的B 细胞,导致实验动物患糖尿病。 | |||
T26324 |
VU0071063
VU 0071063,VU-0071063 |
Potassium Channel | Membrane transporter/Ion channel |
VU0071063 是特异的Kir6.2/SUR1开启剂 (EC50=7.44 μM),可用于研究Kir6.2 /SUR1在大脑和胰腺中的表达。它可以诱导 β 细胞膜电位的超极化从而抑制胰岛素的分泌。 | |||
T14327 |
AS1949490
|
Phosphatase | Metabolism |
AS1949490 是选择性SHIP-2抑制剂,其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。 | |||
TP1126 |
InsB 9-23
Insulin B chain (9-23) |
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InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7. | |||
T40132 |
Insulin β Chain Peptide (15-23)
|
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Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice. | |||
T30579 |
BRD4097
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶(HDAC3)抑制剂,可用于保护b 细胞和改善胰岛素抵抗,有助于促进认知功能和增强学习和记忆的形成。 | |||
TP1664 |
Proinsulin C-Peptide (55-89), human
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Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-peptide. | |||
TP1361 |
S961 TFA (1083433-49-1 free base)
S961 TFA |
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S961 TFA is A high affinity insulin receptor (IR) antagonist with IC50 for hir-a, hir-b and human insulin-like growth factor I receptor (higf-ir) at 0.048, 0.027 and 630 nM, respectively. | |||
T76043L |
S961 acetate
|
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S961 acetate 是一种高亲和力的胰岛素受体 (insulin receptor, IR) 拮抗剂,对 HIR-A,HIR-B 和人胰岛素样生长因子 I 受体 (HIGF-IR) 的 IC50分别为 0.048,0.027 和 630 nM。 | |||
T76043 |
S961 TFA
|
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S961 TFA为一种与胰岛素受体(insulin receptor, IR)高亲和力相结合的拮抗剂,其IC50值对HIR-A、HIR-B及人胰岛素样生长因子I受体(HIGF-IR)分别为0.048、0.027及630 nM。 | |||
TP1795 |
S961
|
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S961是一种高亲和力和选择性胰岛素受体(IR)拮抗剂,接近闪烁计数法试验中对HIR-A、HIR-B 和人胰岛素样生长因子I 受体(HIGF-IR)的ic50分别为0.048、0.027和630 nM。 | |||
TP1183 |
Amylin, amide, human
DAP amide, human |
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Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitu | |||
T37799 |
PF 04671536 hydrochloride
|
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Potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable. DeNinno et al (2012) Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 22... | |||
T68808 |
11-Dehydrocorticosterone
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11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydro... | |||
T35634 |
Platensimycin
|
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Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic ... | |||
T35794 |
Kisspeptin-54 (human) (trifluoroacetate salt)
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Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6670 |
Silymarin
Silybin B,水飞蓟素 |
SARS-CoV | Microbiology/Virology |
Silymarin (Silybin B) 是一种多酚类黄酮,是从水飞蓟或水飞蓟的种子中提取的一种 SARS-CoV-2 主蛋白酶抑制剂。它可降低肿瘤细胞的增殖,血管生成以及胰岛素抵抗,用于预防和治疗肝脏疾病,有潜力研究 COVID-19 。 | |||
T13475 |
β-Aminopropionitrile
3-氨基丙腈,3-Aminopropionitrile,BAPN |
Others; Endogenous Metabolite | Metabolism; Others |
β-Aminopropionitrile (3-Aminopropionitrile) 是赖氨酰氧化酶的特异性抑制剂。 | |||
TN1128 |
Bruceine E
|
Others | Others |
Bruceine E 是从 B. javanica 种子中分离得到的,具有降血糖作用。 Bruceine E 可用于作为胰岛素促分泌剂的研究。 | |||
T1507 |
Streptozocin
STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889 |
DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Streptozocin (NSC-85998) 是一种抗生素,可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性,常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定,建议现配现用。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
T20232 |
Kazinol B
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Akt; NO Synthase; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling |
Kazinol B 是一氧化氮(NO)产生的抑制剂,是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK,增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌,可用于研究糖尿病。 | |||
T83915 |
Norbixin hydrate
|
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Norbixin是一种在B. orellana中发现的类胡萝卜素,具有多样的生物活性。在无细胞测试中,它与过氧化物酶体增殖物激活受体γ (PPARγ)结合(Ki = 1.15 µM)。在心脑血管代谢综合征大鼠模型中,Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性,降低血清脂质水平及心脏中硫代巴比妥酸反应性物质(TBARS)和谷胱甘肽(GSH)的水平。在胆固醇诱导的动脉粥样硬化兔模型中,它降低氧化型LDL和主动脉蛋白氧化水平,并减少动脉粥样硬化面积。Norbixin(每天0.1和1 mg/kg)减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外,它还能预防与年龄相关的黄斑变性(AMD)Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。 |