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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6761 |
Ossirene
AS101 |
IL Receptor; Caspase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Ossirene (AS101) 是一种免疫调节抑制剂,是一种新型 IL-1beta 转化酶抑制剂,可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化,有效抑制Caspase-1。 | |||
T81895 |
Lysophosphatidylcholine C19:0
1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine |
||
Lysophosphatidylcholine C19:0 (1-Nonadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine)为具有C19:0酰基链的脂质。该化合物能促进IL-1beta的分泌。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5660 |
Menthone
|
IL Receptor; TNF; NF-κB; Parasite | Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Menthone 是一种从植物和薄荷油中提取的单萜,是精油的主要挥发性成分,具有抗炎和抗氧化特性。 | |||
T5758 |
sphondin
6-甲氧基当归素,牛防风素,牛防风素 |
COX; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Sphondin 具有抗惊厥、抗炎和抗增殖活性,对 IL-1beta 诱导的 A549 细胞中 COX-2 蛋白水平和 PGE(2) 释放的增加具有抑制作用。 | |||
TN2539 |
1beta-Hydroxyalantolactone
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
1beta-Hydroxyalantolactone 是从药用植物大英花的花头中分离出的小分子化合物,可抑制细胞中TNF-α、IL-17、IFN-γ的表达,促进TNF-α、IFN-γ、IL-17的分泌,可防治类风湿性关节炎。 | |||
T4S0795 |
Berberrubine chloride
9-Berberoline Chloride,Beroline,Beroline Chloride,小檗红碱,Berberrubine,9-Berberoline |
IL Receptor | Immunology/Inflammation |
Berberrubine chloride (9-Berberoline Chloride) 是一种黄连素的有效代谢物,能够改善动物模型中溃疡性结肠炎的症状。 | |||
T2758 |
Madecassic acid
6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose |
Others; TNF; COX; NO Synthase; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience; Others |
Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物,抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6,可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。 | |||
T2795 |
Amygdalin
苦杏仁苷,Laetrile |
Others | Others |
Amygdalin (Laetrile) 是一种植物葡萄糖苷,分离自蔷薇果实的果核中,如杏,桃,杏仁,樱桃和李子。 | |||
T6S0077 |
Byakangelicol
|
COX | Immunology/Inflammation; Neuroscience |
Byakangelicol 是一种分离自白芷的白三醇,能够抑制环加氧酶-2的表达及活性,从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。 | |||
TN1458 |
Buddlejasaponin IV
|
PARP; Akt; Chk | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation. | |||
TN2243 |
Sugiol
10-Deoxoxanthoperol |
IL Receptor; TNF; ROS | Apoptosis; Immunology/Inflammation |
Sugiol (10-Deoxoxanthoperol) 是一种枞烷二萜,可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性,可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02134 |
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
Il-1b,IL-1beta,... |
Mouse | E. coli |
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P10749. | |||
TMPK-00162 |
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated
IL-1 β,IL-1β,IL... |
Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with C... | |||
TMPK-00515 |
IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)
Interleukin-1 β,IL-1 beta |
Cynomolgus | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The p... | |||
TMPK-00161 |
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)
Interleukin-1 beta,IL-1 ... |
Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. ... | |||
TMPY-01033 |
IL-32 Protein, Human, Recombinant (isoform alpha, His)
IL-32δ,IL-32beta,IL32,TA... |
Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,... |