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信号通路 血管生成 凋亡 自噬 细胞周期 表观遗传 细胞骨架
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代谢 微生物学 神经科学 NF-κB信号通路 氧化还原 PI3K/Akt/mTOR信号通路 蛋白酶体
干细胞 蛋白酪氨酸激酶 泛素化 PROTAC 其他
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类药性化合物库 多样性核心库Part2 多样性核心库Part1 药物靶点库 多样性核心预制库 Golden骨架库 Mini骨架库 化合物库深度定制
TargetMol Compound Library
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基于表型筛选实体化合物活性筛选 细胞增殖检测 细胞周期检测 细胞凋亡检测 药代动力学研究
药物设计和结构优化 化合物定制合成 分子砌块 网络药理学平台 软件平台
细胞因子和生长因子 •   细胞因子 •   生长因子 受体蛋白 •   Fc 受体 •   细胞因子和生长因子受体
CD 蛋白 •   T 细胞 CD 蛋白 •   B 细胞 CD 蛋白 免疫检查点蛋白 •   抑制性免疫检查点蛋白 •   刺激性免疫检查点蛋白
CAR-T 细胞治疗靶点蛋白 •   血液恶性肿瘤靶点蛋白 •   实体瘤靶点蛋白 酶 •   氧化还原酶 •   转移酶
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搜索结果

Search Results for " igf‑i "
Targets Recommended: Others

17

抑制剂 & 化合物

17

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
TP1122L IGF-I 30-41 acetate(82177-09-1 free base)

Insulin-like Growth Factor I (30-41) acetate

 Others Others
IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) 是胰岛素样生长因子 I (IGF-I) 的氨基酸 30 至 41 片段。
TP1122 IGF-I (30-41)

Insulin-like Growth Factor I (30-41),IGF-I 30-41
IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).
TP1124 IGF-I (24-41)

Insulin-like Growth Factor I (24-41),IGF-I 24-41
IGF-I (24-41) is a 24-41 amino acid fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective
TP1123 IGF-I (24-41) TFA (135861-49-3 free base)

Insulin-like Growth Factor I (24-41) (TFA),IGF-I (24-41) TFA
IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).IGF-I (24-41) (TFA) is amino acids 24 to 41 fragment of Insulin-like Growth
TP1121 IGF-I (30-41) TFA(82177-09-1,FREE)

Insulin-like Growth Factor I (30-41) (TFA)
IGF-I (30-41) (TFA) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).
T76012 IGF-I (30-41) (TFA)

IGF-I (30-41) (TFA) 是类胰岛素生长因子I 30 至 41 的氨基酸片段。IGF-I 对生长激素的活性有着重要的作用，但是IGF-I 本身也具有一些自身的特性，如合成代谢、抗氧化、抗炎和细胞保护作用。
T76014 IGF-I (24-41) (TFA)

IGF-I (24-41) TFA（Insulin-like Growth Factor I (24-41) TFA）是类胰岛素生长因子I的一个氨基酸片段，覆盖24至41位点。作为一种70个氨基酸组成的多肽激素，IGF-I TFA对神经元和神经胶质细胞具有营养作用，而且在调节全身生长激素（GH）活性中扮演关键角色。它还具备合成代谢、抗氧化、抗炎及细胞保护功能，对躯体生长及行为发育调节作用显著。
T11593 I-OMe-Tyrphostin AG 538

I-OMe-AG 538

 IGF-1R; PI3K PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
I-OMe-Tyrphostin AG 538是一种特异性 IGF-1R 抑制剂和 PI5P4Kα的 ATP 竞争性抑制剂（IC50：1 µM）。I-OMe-Tyrphostin AG 538可抑制 IGF-1R 介导的信号传导，并对营养缺乏的 PANC1细胞具有优先细胞毒性。
T2085 PQ401

IGF-1R Inhibitor II

 Apoptosis; IGF-1R Apoptosis; Tyrosine Kinase/Adaptors
PQ401 (IGF-1R Inhibitor II) 是一种IGF-IR 抑制剂。在 MCF-7 细胞中，它抑制 IGF-I 刺激的 IGF-IR 自磷酸化，可有效抑制 IGF-I 刺激的 MCF-7 细胞生长。它诱导 caspase 介导的细胞凋亡，有用于乳腺癌和其他对 IGF-I 敏感的癌症的研究潜力。
T2160 Suramin Sodium Salt

苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

 Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
TP2207 Pasireotide Acetate

Somatostatin GPCR/G Protein
Pasireotide acetate 是长效的环己肽生长激素抑制素类似物，具有抗分泌、抗增殖和促凋亡活性。它可抑制 GH、IGF-I 和 ACTH 的分泌，可用于研究肢端肥大症和库欣病。它还可以提高生长抑素受体的激动剂活性，对sst1、2、3、4、5的pKi 分别为 8.2、9.0、9.1、小于7.0 和 9.9。
T70568 H-1356

H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.
T61506 NBI-31772 hydrate

NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3].
T20534 Lanreotide

BIM 23014,Somatulin,Lanreotide Autogel,Somatuline,Ipstyl
Lanreotide, a somatostatin analogue, suppresses GH/IGF-I hypersecretion in acromegaly patients. It also used to manage neuroendocrine tumours.
T73702 Mecasermin

Mecasermin（Human IGF-I; FK 780），一种重组人胰岛素样生长因子I（IGF-I），主要用于研究因生长激素（GH）受体缺陷或GH抑制抗体导致的GH不敏感性而引起的生长障碍。
T69221 BMS-554417

BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosph...
T69682 AEW541 HCl

AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder sc...

化合物

IGF-I 30-41 acetate(82177-09-1 free base)
Cat.No: TP1122L
Synonym: Insulin-like Growth Factor I (30-41) acetate
Target: Others
IGF-I (30-41)
Cat.No: TP1122
Synonym: Insulin-like Growth Factor I (30-41),IGF-I 30-41
Target:
IGF-I (24-41)
Cat.No: TP1124
Synonym: Insulin-like Growth Factor I (24-41),IGF-I 24-41
Target:
IGF-I (24-41) TFA (135861-49-3 free base)
Cat.No: TP1123
Synonym: Insulin-like Growth Factor I (24-41) (TFA),IGF-I (24-41) TFA
Target:
IGF-I (30-41) TFA(82177-09-1,FREE)
Cat.No: TP1121
Synonym: Insulin-like Growth Factor I (30-41) (TFA)
Target:
IGF-I (30-41) (TFA)
Cat.No: T76012
Synonym:
Target:
IGF-I (24-41) (TFA)
Cat.No: T76014
Synonym:
Target:
I-OMe-Tyrphostin AG 538
Cat.No: T11593
Synonym: I-OMe-AG 538
Target: IGF-1R, PI3K
PQ401
Cat.No: T2085
Synonym: IGF-1R Inhibitor II
Target: Apoptosis, IGF-1R
Suramin Sodium Salt
Cat.No: T2160
Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060
Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite
Pasireotide Acetate
Cat.No: TP2207
Synonym:
Target: Somatostatin
H-1356
Cat.No: T70568
Synonym:
Target:
NBI-31772 hydrate
Cat.No: T61506
Synonym:
Target:
Lanreotide
Cat.No: T20534
Synonym: BIM 23014,Somatulin,Lanreotide Autogel,Somatuline,Ipstyl
Target:
Mecasermin
Cat.No: T73702
Synonym:
Target:
BMS-554417
Cat.No: T69221
Synonym:
Target:
AEW541 HCl
Cat.No: T69682
Synonym:
Target:
Species：
Human (11)
Mouse (3)
Bovine (1)
Cynomolgus (1)
Rat (1)
Expression System：
HEK293 Cells (10)
E. coli (3)
P. pastoris (Yeast) (3)
Baculovirus Insect Cells (1)
Tag：
C-His (4)
C-His-Avi (3)
Tag Free (3)
C-hFc (2)
N-hFc (2)
C-6xHis (1)
His, GST (1)
N-GST (1)
Cat. No. Product Name Species Expression System
TMPY-06982 IGF1/IGF-I Protein, Human, Recombinant

insulin-like growth factor 1,soma...

 Human E. coli
IGF1/IGF-I Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.8 KDa. and the accession number is P05019-1.
TMPY-04878 IGF1/IGF-I Protein, Mouse, Recombinant

insulin-like growth factor 1 (som...

 Mouse P. pastoris (Yeast)
IGF1/IGF-I Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 7.7 kDa and the accession number is E9PU89.
TMPK-00083 IGF1/IGF-I Protein, Human, Recombinant (hFc)

IGF1A,胰岛素样生长因子,IBP1,I

Human HEK293 Cells
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes.
TMPY-00834 IGF1R/CD221 Protein, Human, Recombinant (His)

IGF-I R,IGFR,

Human HEK293 Cells
IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
TMPY-04942 IGF1 LR3 Protein, Human, Recombinant

IGF‑I,insulin-l...

 Human P. pastoris (Yeast)
IGF1 LR3 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 9.1 kDa and the accession number is P05019-1.
TMPK-00455 IGF1R/CD221 Protein, Human, Recombinant (His & Avi)

MGC142172,IGF-I receptor,...

 Human HEK293 Cells
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells wi...
TMPK-00658 IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)

CD221,IGFR,IGF1R,MGC1421...

 Cynomolgus HEK293 Cells
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells wit...
TMPK-00456 IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated

CD221,MGC142172,IGFIR,I

Human HEK293 Cells
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated is expressed in ...
TMPH-03314 IGF1/IGF-I Protein, Rat, Recombinant (GST)

Rat E. coli
N/A. IGF1/IGF-I Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 34.7 kDa and the accession number is P08025.
TMPH-00273 IGF1/IGF-I Protein, Bovine, Recombinant (hFc)

Bovine P. pastoris (Yeast)
IGF1/IGF-I Protein, Bovine, Recombinant (hFc) is expressed in yeast with N-hFc tag. The predicted molecular weight is 34.3 kDa and the accession number is P07455.
TMPJ-00781 LR3-IGF-1 Protein, Mouse, Recombinant (His)

IGF1,insulin-li...

 Mouse E. coli
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IG...
TMPY-04360 IGF1R/CD221 Protein, Human, Recombinant (His & GST)

JTK13,insulin-like growth factor ...

 Human Baculovirus Insect Cells
IGF1R/CD221 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 74.6 kDa and the accession number is P08069.
TMPY-06905 IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated

CD221,insulin-like growth factor ...

 Human HEK293 Cells
IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 106.14 kDa and the accession number is NP_000866.1.
TMPK-01371 IGFBP-7 Protein, Human, Recombinant (hFc)

RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC...

 Human HEK293 Cells
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres...
TMPK-01027 IGFBP-7 Protein, Mouse, Recombinant (hFc)

TAF,RAMSVPS,IBP7,PSF,IGFBP-7,MAC2...

 Mouse HEK293 Cells
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Mouse, Recombinant (hFc) is expres...
TMPY-00894 PAPP-A2 Protein, Human, Recombinant (His)

pappalysin 2,PAPP-E,PLAC3,PAPPE,PAPP-A2

 Human HEK293 Cells
Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member. There is no homology between the prepro-peptides of PAPP-A and PAPP-A2, but 46% of the residues of mature PAPP-A are also present in mature PAPP-A2. PAPP-A specifically cleaves insulin-like growth factor-binding protein(IGFBP)-4, one of six known modulators of IGF-I and –II, whereas PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In cont...
TMPY-00471 INSL4 Protein, Human, Recombinant (His)

EPIL,insulin-like 4 (pla...

 Human HEK293 Cells
INSL4 (Insulin-Like 4) is a Protein Coding gene. An important paralog of this gene is RLN1. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains or just the A and B chains. INSL4 is a member of the insulin family, which includes insulin, IGF-I, IGF-II, relaxin, and INSL3.INSL4 distribution was tissue- and cell-specific. Indeed, INSL4 mRNA was most abundant in syncytiotrophoblas...

重组蛋白

IGF1/IGF-I Protein, Human, Recombinant
Cat.No: TMPY-06982
Species: Human
Expression System: E. coli
IGF1/IGF-I Protein, Mouse, Recombinant
Cat.No: TMPY-04878
Species: Mouse
Expression System: P. pastoris (Yeast)
IGF1/IGF-I Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00083
Species: Human
Expression System: HEK293 Cells
IGF1R/CD221 Protein, Human, Recombinant (His)
Cat.No: TMPY-00834
Species: Human
Expression System: HEK293 Cells
IGF1 LR3 Protein, Human, Recombinant
Cat.No: TMPY-04942
Species: Human
Expression System: P. pastoris (Yeast)
IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00455
Species: Human
Expression System: HEK293 Cells
IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00658
Species: Cynomolgus
Expression System: HEK293 Cells
IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
Cat.No: TMPK-00456
Species: Human
Expression System: HEK293 Cells
IGF1/IGF-I Protein, Rat, Recombinant (GST)
Cat.No: TMPH-03314
Species: Rat
Expression System: E. coli
IGF1/IGF-I Protein, Bovine, Recombinant (hFc)
Cat.No: TMPH-00273
Species: Bovine
Expression System: P. pastoris (Yeast)
LR3-IGF-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00781
Species: Mouse
Expression System: E. coli
IGF1R/CD221 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04360
Species: Human
Expression System: Baculovirus Insect Cells
IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06905
Species: Human
Expression System: HEK293 Cells
IGFBP-7 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-01371
Species: Human
Expression System: HEK293 Cells
IGFBP-7 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-01027
Species: Mouse
Expression System: HEK293 Cells
PAPP-A2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00894
Species: Human
Expression System: HEK293 Cells
INSL4 Protein, Human, Recombinant (His)
Cat.No: TMPY-00471
Species: Human
Expression System: HEK293 Cells
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