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Search Results for " igf1r "

12

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1967	AZD-3463 ALK/IGF1R inhibitor	Apoptosis; IGF-1R; ALK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors
	AZD-3463 (ALK/IGF1R inhibitor) 是一种具有口服活性的ALK/IGF1R 抑制剂，对 ALK 作用的Ki 值为 0.75 nM。它可诱导神经母细胞瘤细胞凋亡和自噬。
T38502	IGF-1R inhibitor-2
	IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R). By downregulating the IGF-1R, it has the potential to reverse the transformed phenotype of tumor cells and make them more susceptible to apoptosis.
T2693	AG1024 Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	AG1024 (Tyrphostin) 是一种可逆的，竞争性和选择性的胰岛素样生长因子-1 受体抑制剂，IC50为 7 μM。它抑制胰岛素受体的磷酸化，IC50值为 57 μM。它诱导细胞凋亡并具有抗癌活性。
T76810	Ganitumab AMG 479	IGF-1R	Tyrosine Kinase/Adaptors
	Ganitumab (AMG 479) 是一种高效的1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 在低浓度下识别与 IGF1R 结合，KD 值为0.22 nM，Ganitumab 对小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用有抑制作用。Ganitumab 可用于研究癌症。
T13564	AZ7550	MLK; FAK; EGFR; FLT; Tyrosine Kinases; PYK2; MNK; IGF-1R; ACK; BTK; ALK; Drug Metabolite	Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Metabolism; Tyrosine Kinase/Adaptors
	AZ7550 是 AZD9291 的活性代谢物，可抑制 IGF1R 活性，IC50为 1.6 μM。
T13564L	AZ7550 hydrochloride AZ7550 hydrochloride (1421373-99-0 free base)	EGFR; IGF-1R	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AZ7550 hydrochloride (AZ7550 hydrochloride ) 是 AZD9291 的活性代谢物，可抑制 IGF1R 活性，IC50为 1.6 μM。
T13564L2	AZ7550 trimesylate salt AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)	MLK	MAPK
	AZ7550 trimesylate salt (AZ7550 Mesylate) 是奥希替尼的活性代谢产物，AZ7550 trimesylate salt 抑制 IGF1R 活性，可用于研究非小细胞肺癌。
T11654	Indirubin Derivative E804	Others	Others
	Indirubin Derivative E804 is an effective inhibitor of IGF1R, which has an IC50 value of 0.65.
T76746	Figitumumab
	Figitumumab (CP-751871) 为一种高效对抗胰岛素样生长因子 1 受体 (IGF1R) 的全人单克隆抗体。通过阻断 IGF1 与 IGF1R 的结合，其 IC50 值达到 1.8 nM。
T80871	Veligrotug	IGF-1R	Tyrosine Kinase/Adaptors
	Veligrotug为IgG1-kappa型抗IGF1R（胰岛素样生长因子1受体，CD221）嵌合单克隆抗体。
T38584	ALK-IN-12
	ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like growth factor 1 receptor (IGF1R) and insulin receptor (InsR), with IC50 values of 20.3 nM and 90.6 nM, respectively. Notably, its antitumor effects have been observed, making it a promising compound for targeted cancer therapy.
T69221	BMS-554417
	BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). BMS-554417 treatment inhibited IGF-IR and insulin receptor signaling through extracellular signal-related kinase as well as the phosphoinositide 3-kinase/Akt pathway, as evidenced by decreased Akt phosph...

化合物

Cat.No: T1967

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

IGF-1R inhibitor-2

Cat.No: T38502

Cat.No: T2693

Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200

Target: Apoptosis, IGF-1R

Cat.No: T76810

Synonym: AMG 479

Target: IGF-1R

Cat.No: T13564

Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite

AZ7550 hydrochloride

Cat.No: T13564L

Synonym: AZ7550 hydrochloride (1421373-99-0 free base)

Target: EGFR, IGF-1R

AZ7550 trimesylate salt

Cat.No: T13564L2

Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)

Target: MLK

Indirubin Derivative E804

Cat.No: T11654

Target: Others

Cat.No: T76746

Cat.No: T80871

Target: IGF-1R

Cat.No: T38584

Cat.No: T69221

Cat. No.	Product Name	Target	Signaling Pathways
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。
T6943	Picropodophyllin AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂，IC50为1 nM。

天然产物

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Picropodophyllin

Cat.No: T6943

Synonym: AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素

Target: Apoptosis, IGF-1R

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