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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11630 |
IFN alpha-IFNAR-IN-1 hydrochloride
|
Others; IFNAR | Immunology/Inflammation; Others |
IFN alpha-IFNAR-IN-1 hydrochloride 是 IFN-α 和 IFNAR 相互作用的抑制剂。 IFN alpha-IFNAR-IN-1 hydrochloride 抑制 BM-pDCs 的 MVA 诱导的 IFN-α 反应,IC50 为 2-8 μM。 | |||
T11630L |
IFN alpha-IFNAR-IN-1
|
Others | Others |
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM). | |||
T12933 |
SM-276001
|
TLR; COX | Immunology/Inflammation; Neuroscience |
SM-276001 是可口服的干扰素诱导剂,是选择性TLR7激动剂,可以诱导抗肿瘤免疫反应。 | |||
T81259 |
Rontalizumab
RhuMab IFNalpha,Anti-Human IFN alpha Recombinant Antibody |
||
Rontalizumab为针对IFN-α的人源化IgG1型单克隆抗体,适用于系统性红斑狼疮研究领域。 | |||
TP1117 |
IFN-α Receptor Recognition Peptide 1
IRRP1 |
||
IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions. | |||
T16169 |
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride |
Others; Proteasome; COX | Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome; Ubiquitination |
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) 是胰蛋白酶样蛋白酶的抑制剂。 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 对 IFN-γ 活性具有抑制作用。 | |||
T76853 | Ropeginterferon alfa-2b | ||
Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) 为单聚乙二醇化IFN-α类化合物,主要应用于骨髓增性肿瘤研究领域。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4334 |
Isotaxiresinol
|
TNF | Apoptosis |
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00746 |
IFN-alpha 2b/IFNA2 Protein, Human, Recombinant
干扰素,IFNA2,Interferon α-2,Interferon α-A,Interferon ... |
Human | E. coli |
At least 23 different variants of IFN-α are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-α subtypes differ in their sequences by only one or two positions. Naturally occurring variants also include proteins that are truncated by 10 amino acids at the ca... | |||
TMPJ-00745 |
IFN-alpha 2a/IFNA2 Protein, Human, Recombinant
Interferon α-2,IFNA2,干扰素,IFN α2a,IFN |
Human | E. coli |
At least 23 different variants of IFN-α are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-α subtypes only differ in their sequences by one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-ter... | |||
TMPY-04578 |
Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His)
Interferon α1,IFN-alphaD,IFN-αD,<... |
Human | P. pastoris (Yeast) |
Interferon alpha 1/IFNA1 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 20.8 kDa and the accession number is L0N195. | |||
TMPY-00638 |
Interferon alpha B/IFNA8 Protein, Human, Recombinant (His)
IFN-αB,IFN-alphaB,interferon, α8,... |
Human | HEK293 Cells |
Interferon alpha B/IFNA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is A0A7R8C381. | |||
TMPY-04799 |
IFNAR2 Protein, Human, Recombinant (His), Biotinylated
IFN-R,interferon (α, β and Ω) receptor 2,IFN |
Human | HEK293 Cells |
IFNAR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P48551-1. | |||
TMPY-02515 |
Interferon alpha 7/IFNA7 Protein, Human, Recombinant (hFc)
IFN-alphaJ,干扰素,IFNA-J,IFN |
Human | HEK293 Cells |
Interferon alpha 7/IFNA7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P01567. | |||
TMPY-02647 |
IFNAR1 Protein, Human, Recombinant (His)
interferon (alpha, beta and omega) receptor 1,I... |
Human | HEK293 Cells |
IFNAR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.6 kDa and the accession number is P17181-1. | |||
TMPY-02566 |
Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His)
干扰素,interferon, α4,MGC142200,interferon, alpha 4,IN... |
Human | Baculovirus Insect Cells |
Interferon alpha 4/IFNA4 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is P05014. | |||
TMPY-00265 |
Interferon alpha 2/IFNA2 Protein, Human, Recombinant
IFNAB,干扰素,IFNA2B,IFN-alpha |
Human | P. pastoris (Yeast) |
Interferon alpha 2/IFNA2 Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 19.3 kDa and the accession number is P01563.1. | |||
TMPK-00075 |
IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)
IFN-α-1/13,IFN α1,IFN alpha |
Human | HEK293 Cells |
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.14 kDa and the accession number is P01562. | |||
TMPK-00074 |
IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)
IFN-α-1/13,IFN alpha1,干扰素,Interfe... |
Mouse | HEK293 Cells |
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572. | |||
TMPJ-00747 |
IFN-alpha 2/IFNA2 Protein, Mouse, Recombinant
IFN-Alpha-2,Interferon α-A,IFN α2... |
Mouse | E. coli |
At least 23 different variants of Interferon-α are known. The individual proteins have molecular masses between 19-26 kD and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-α subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carbo... | |||
TMPJ-00780 |
IFN-alpha 6/IFNA6 Protein, Human, Recombinant (His)
Interferon α-K,Interferon α-6,IFN α6,Interferon α-5... |
Human | HEK293 Cells |
Interferon α-6 (IFN-α6) is a secreted protein which belongs to the α/β interferon family. IFN-α6 is produced by macrophages, expressed at low level, only 1.0% of the average gene in this release. IFN-α6 contains interferon alpha, beta and delta domain. IFN-α has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPY-02347 |
IFN-alpha 13/IFNA13 Protein, Mouse, Recombinant (hFc)
interferon, alpha 13,RP23-139P14.1,IFN-α 1... |
Mouse | HEK293 Cells |
IFN-alpha 13/IFNA13 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.5 kDa and the accession number is Q80SU4. | |||
TMPY-03891 |
IFN-alpha 13/IFNA13 Protein, Mouse, Recombinant (His)
IFN-α 13,干扰素,interferon, alpha 13,interfer... |
Mouse | HEK293 Cells |
IFN-alpha 13/IFNA13 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q80SU4. | |||
TMPY-03320 |
IFN-alpha 13/IFNA13 Protein, Cynomolgus, Recombinant (hFc)
IFN-α 13,干扰素,interferon, alpha 13,IFN<... |
Cynomolgus | HEK293 Cells |
IFN-alpha 13/IFNA13 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is G7NFW4. | |||
TMPY-03375 |
IFN-alpha 13/IFNA13 Protein, Cynomolgus, Recombinant (His)
IFNA13,干扰素,interferon, α13,interferon, alpha |
Cynomolgus | HEK293 Cells |
IFN-alpha 13/IFNA13 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.8 kDa and the accession number is G7NFW4. | |||
TMPK-00342 |
IFNAR1 Protein, Mouse, Recombinant (His & Avi)
IFN-α-REC,IFN-R-1,IFNAR1,IFN<... |
Mouse | HEK293 Cells |
IFNAR1 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 46.9 kDa and the accession number is P33896. | |||
TMPK-00325 |
IFNAR1 Protein, Human, Recombinant (His & Avi)
AVP,IFN-alpha-REC,IFN-α/β R1,... |
Human | HEK293 Cells |
IFNAR1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.2 kDa and the accession number is P17181-1. | |||
TMPK-00343 |
IFNAR1 Protein, Mouse, Recombinant (hFc)
AVP,IFNBR,IFN-alpha/β R1,IFN<... |
Mouse | HEK293 Cells |
IFNAR1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 72.5 kDa and the accession number is P33896. | |||
TMPK-00326 |
IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated
IFN-alpha/β R1,IFN-α/β R1,IFN... |
Human | HEK293 Cells |
IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.2 kDa and the accession number is P17181-1. | |||
TMPY-00830 |
interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc)
IFN-α,INFA5,interferon, alpha 5,IFN |
Human | HEK293 Cells |
interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.3 kDa and the accession number is A0A7R8C382. | |||
TMPY-04855 |
interferon alpha 5/IFNA5 Protein, Human, Recombinant (His)
leIF G,IFN-alpha,interferon-α,INA5,IFN... |
Human | P. pastoris (Yeast) |
interferon alpha 5/IFNA5 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 21.1 kDa and the accession number is A0A7R8C382. | |||
TMPK-00637 |
IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His)
β receptor10,IFNbR2,IFN α/β R2,IFN |
Cynomolgus | HEK293 Cells |
Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well. IFNAR2 Protein, Cynomolgus, Recombinant (aa 27-243, His) is expressed in HEK293 mammalian cells with C-... | |||
TMPK-00889 |
IFNAR2 Protein, Human, Recombinant (aa 27-243, His)
IFN-alpha/beta R2,IFNAR2,IFN<... |
Human | HEK293 Cells |
Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well. IFNAR2 Protein, Human, Recombinant (aa 27-243, His) is expressed in HEK293 mammalian cells with C-His t... | |||
TMPY-03648 |
Interferon alpha B/IFNA8 Protein, Human, Recombinant
IFN-αB,IFN-alphaB,interferon, |
Human | HEK293 Cells |
Interferon alpha B/IFNA8 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38 kDa and the accession number is A0A7R8C381. | |||
TMPY-01640 |
IFNAR2 Protein, Human, Recombinant (hFc)
interferon (α, β and ω) receptor 2,IFNABR,IFN |
Human | HEK293 Cells |
IFNAR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.8 kDa and the accession number is P48551-1. | |||
TMPY-01642 |
IFNAR2 Protein, Human, Recombinant (His)
IFNARB,IFNABR,interferon (α, β and ω) rece... |
Human | HEK293 Cells |
IFNAR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P48551-1. | |||
TMPY-04841 |
Interferon alpha 7/IFNA7 Protein, Human, Recombinant (His)
interferon, alpha 7,interferon, α7,IFN-αJ,... |
Human | P. pastoris (Yeast) |
Interferon alpha 7/IFNA7 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 21 kDa and the accession number is A0A7R8C383. | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-<... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... | |||
TMPJ-00331 |
IFNAR1 Protein, Rhesus macaque, Recombinant (His)
IFN-al,CRF2-1,IFN-alpha/beta rece... |
Rhesus | HEK293 Cells |
Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory... | |||
TMPY-00829 |
Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc)
interferon, α4,IFN-α4a,干扰素,interferon, alpha |
Human | HEK293 Cells |
Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46 kDa and the accession number is P05014. | |||
TMPY-02634 |
IFNAR1 Protein, Human, Recombinant (hFc)
interferon (α, β and Ω) receptor 1,IFNBR,AVP,IF... |
Human | HEK293 Cells |
IFNAR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74 kDa and the accession number is P17181-1. | |||
TMPY-06407 |
Interferon alpha 2/IFNA2 Protein, Human, Recombinant (hFc)
IFN-αA,INFA2,干扰素,Interferon α2,IFNA2B,inte... |
Human | HEK293 Cells |
Interferon alpha 2/IFNA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.29 kDa and the accession number is P01563-1. | |||
TMPY-03758 |
Vaccinia Virus B18R/B19R Protein (His)
|
VACV | Baculovirus Insect Cells |
B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to un... | |||
TMPH-01547 |
Interferon alpha 21/IFNA21 Protein, Human, Recombinant (His)
|
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPH-01544 |
Interferon alpha 14/IFNA14 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPH-01545 |
Interferon alpha 16/IFNA16 Protein, Human, Recombinant (His)
|
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha 16/IFNA16 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.4 kDa and the accession number is P05015. | |||
TMPH-01546 |
Interferon alpha 17/IFNA17 Protein, Human, Recombinant (His)
|
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha 17/IFNA17 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.3 kDa and the accession number is P01571. | |||
TMPH-00276 |
Interferon alpha-G/IFNAG Protein, Bovine, Recombinant (His & SUMO)
|
Bovine | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha-G/IFNAG Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.2 kDa and the accession number is P49877. | |||
TMPU-00003 |
STAT2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of... | |||
TMPH-02273 |
JAK1 Protein, Human, Recombinant (His)
|
Human | P. pastoris (Yeast) |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. | |||
TMPH-02272 |
JAK1 Protein, Human, Recombinant (E. coli, His)
|
Human | E. coli |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. | |||
TMPJ-00961 |
STAT1 Protein, Human, Recombinant
Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ... |
Human | E. coli |
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul... | |||
TMPK-00317 |
IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated
IL-18 R α,IL-1 R5,IL18Ra,IL-18Ra,CD218a,IL-18 R alpha |
Human | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Pr... | |||
TMPK-00512 |
IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)
IL18R1,IL-1 Rrp,CD218a,IL18Ra,IL-18Ra,IL-18 R alpha... |
Cynomolgus | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Pr... | |||
TMPK-00316 |
IL-18R alpha Protein, Human, Recombinant (His & Avi)
CD218a,IL-18 R1,IL1RRP,IL-18Ra,IL-18 R alpha,IL-1 R... |
Human | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Pr... | |||
TMPH-02961 |
JAK1 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb... | |||
TMPJ-00930 |
VCAM-1 Protein, Mouse, Recombinant (hFc)
Vascular cell adhesion protein 1,Vcam1 |
Mouse | HEK293 Cells |
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interac... | |||
TMPJ-00344 |
IL-18RAP Protein, Human, Recombinant (hFc & His)
IL-1R accessory protein-like,Interleukin-18 receptor β,C,IL1... |
Human | HEK293 Cells |
IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease. | |||
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