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interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc)

产品编号 TMPY-00830

别名: IFN-α, INFA5, interferon, alpha 5, IFN-alphaG, 干扰素, leIF G, interferon-α, IFN-αG, RP11-380P16.5, IFN-α-5, IFN-alpha-5, IFN-alpha, interferon, α5, INA5

interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.3 kDa and the accession number is A0A7R8C382.

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interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 2,440		5日内发货

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参考文献

生物活性	Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC50 for this effect is 0.16-0.8 ng/mL.
产品描述	interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.3 kDa and the accession number is A0A7R8C382.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	A0A7R8C382
别名	IFN-α, INFA5, interferon, alpha 5, IFN-alphaG, 干扰素, leIF G, interferon-α, IFN-αG, RP11-380P16.5, IFN-α-5, IFN-alpha-5, IFN-alpha, interferon, α5, INA5
蛋白构建	The Human IFNα G (NP_002160.1) (Leu 22-Glu 189) was fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	46.3 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interferon, alpha 5 (IFNA5) belongs to the alpha/beta interferon family. IFNA5 is the only IFNA subtype detected in normal liver, while a mixture of subtypes is observed in the liver tissue of patients with chronic hepatitis C. Interferons are produced by macrophages, IFN-alpha has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.

参考文献

1. Lau JY,et al.(1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9. 2. Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205. 3. Kessler DS,et al.(1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.

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Keywords

interferon alpha 5/IFNA5 Protein, Human, Recombinant (hFc) IFN-a-5 IFN-α INFA5 interferon, alpha 5 IFN-alphaG 干扰素 leIF G interferon-α IFN-αG RP11-380P16.5 INA-5 INA 5 INFA-5 interferon, a 5 IFN-α-5 interferon, α 5 IFN-alpha-5 IFN-alpha interferon, α5 INFA 5 INA5 recombinant recombinant-proteins proteins protein

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