首页工具

登录

搜索结果

Search Results for " hdac-in-2 "

39

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T3661	Citarinostat ACY241,HDAC-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤活性，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。
T39567	HDAC1/2-IN-3 HDAC1/2-IN-3
	HDAC1/2-IN-3 is an inhibitor of both HDAC1 and HDAC2, demonstrating IC50 values of 0-5 nM and 5-10 nM, respectively.
T63664	CDK/HDAC-IN-2
	CDK/HDAC-IN-2 是有效的 HDAC/CDK 双重抑制剂，能够作用于 HDAC1 (IC50: 6.4 nM)、HDAC2 (IC50: 0.25 nM)、HDAC3 (IC50: 45 nM)、HDAC6,8 (IC50>1000 nM)、CDK1 (IC50: 8.63 nM)、CDK2 (IC50: 0.30 nM)、CDK4,6,7 (IC50>1000 nM)。CDK/HDAC-IN-2 能够将细胞周期停滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。CDK/HDAC-IN-2 具有优异的抗增殖效果，显示出显著的抗肿瘤作用。
T64025	Top/HDAC-IN-2
	Top/HDAC-IN-2 (45b) 是 Top 和 HDAC 的双重抑制剂，能够诱导细胞凋亡，表现出显著的抗肿瘤作用。
T78708	JAK/HDAC-IN-2	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK/HDAC-IN-2 是一款高效的 JAK/HDAC 双靶点抑制剂，能在纳摩尔浓度范围内有效抑制 HDAC3/6 与 JAK1/2。此化合物不仅促进细胞凋亡，还能抑制组蛋白去乙酰化和 STAT3 磷酸化，对血液肿瘤和实体肿瘤细胞展现出了显著的抗增殖效果。
T79452	Tubulin/HDAC-IN-2
	Tubulin/HDAC-IN-2 (Compound II-19k) 为Tubulin和HDAC的双重抑制剂，IC50分别对HDAC1、HDAC2、HDAC3和HDAC6为0.403 μM、0.591μM、3.552μM和0.459μM。该化合物能够导致细胞周期在G2期的阻滞及诱导细胞凋亡。Tubulin/HDAC-IN-2 有效抑制血肿和实体瘤细胞增殖，降低肿瘤转移，并在肝肿瘤同种异体移植的小鼠模型中抑制肿瘤生长。
T62717	A2AAR/HDAC-IN-2
	A2AAR/HDAC-IN-2 是一种有效的 A2AAR/HDAC 双重抑制剂。A2AAR/HDAC-IN-2 对 A2AAR 表现出良好的亲和力 (Ki:10.3 nM), 能够良好的抑制 HDAC1 (IC50:18.5 nM). A2AAR/HDAC-IN-2 能够用于研究抗肿瘤。
T62912	PI3K/HDAC-IN-2
	PI3K/HDAC-IN-2 是一种有效的 PI3K/HDAC 双重抑制剂，能够作用于 PI3Kα (IC50: 226 nM)、PI3Kβ (IC50: 279 nM)、PI3Kγ (IC50: 467 nM)、PI3Kδ (IC50: 29 nM)、HDAC1 (IC50: 1.3 nM)、HDAC2 (IC50: 3.4 nM)、HDC4 (IC50: 973 nM)、HDAC6 (IC50: 17 nM)、HDAC8 (IC50: 12 nM)。PI3K/HDAC-IN-2 具有 PI3Kδ 和 I 类和 IIb 类 HDAC 选择性，并表现出显着的抗癌作用。
T72759	c-Met/HDAC-IN-2
	c-Met/HDAC-IN-2 是一种高效的c-Met 和HDAC 双重抑制剂，对HDAC1与c-Met 的IC50分别为 18.49 nM 和 5.40 nM。c-Met/HDAC-IN-2 对几种癌细胞具有抗增殖活性。c-Met/HDAC-IN-2 能将 HCT-116 细胞周期阻滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。c-Met/HDAC-IN-2 可用于抗癌耐药研究。
T2025	HDAC-IN-7 HBI-8000,西达本胺杂质,CS055,Chidamide impurity	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-7 (HBI-8000) 是 Chidamide 的一种杂质。Chidamide 是一种可口服的 HDAC 酶 I 类 HDAC1/2/3 和 IIb 类 HDAC10 抑制剂。
T2294	BG45	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	BG45是一个 HDAC I 型抑制剂，选择性抑制 HDAC3，IC50为289 nM。它抑制 HDAC1/2/6的效力大大降低，IC50分别为2、2.2和>20μM。
T5631	SIS17	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIS17 是一种有效的选择性 HDAC 11 抑制剂，IC50 值为 0.83 μM。它可抑制 HDAC11 底物丝氨酸羟甲基转移酶 2 的去肉豆蔻酰化。
T6865	Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。
T62920	HDAC-IN-38
	HDAC-IN-38 是一种 HDAC 的有效抑制剂。HDAC-IN-38 对 HDAC1、2、3、5、6 和 8 具有类似的微摩尔抑制作用，也可以提高组蛋白乙酰化水平 (H3K14 或 H4K5)。HDAC-IN-38 能够提高脑血流量 (CBF)，减轻认知障碍，改善海马萎缩。
T61916	HDAC-IN-35
	HDAC-IN-35 (Compound 14) 是有效的、选择性的VEGFR-2和HDAC 抑制剂，对VEGFR-2和HDAC6的IC50值分别为13.2和0.166 μM。
T62072	HDAC-IN-47
	HDAC-IN-47 是一种口服具有活力的组蛋白去乙酰化酶 (HDAC) 的抑制剂，对 HDAC1、HDAC2、HDAC3、HDAC6、HDAC8 的 IC50 值分别为 19.75 nM、57.8 nM、40.27 nM、5.63 nM、302.73 nM。HDAC-IN-47 可以将细胞周期阻滞在 G2/M 期，抑制细胞自噬，能够利用 Bax/Bcl-2 和 caspase-3 通路诱导凋亡，在体内具有抗癌活性。
T63142	AChE/HDAC-IN-1
	COX-2-IN-23 (compound A10) 是一种有效的 AChE (IC50: 0.12 nM) 和 HDAC (IC50: 0.23 nM) 抑制剂。COX-2-IN-23 表现出抗氧化作用和金属螯合特性。COX-2-IN-23 能够用于研究阿尔兹海默病。
T80873	VEGFR2/HDAC1-IN-1	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	VEGFR2/HDAC1-IN-1（compound 13）是一款有效的VEGFR-2和HDAC双重抑制剂，其IC50值分别为57.83 nM 和9.82 nM 。该化合物能够阻滞细胞周期于S期及G2期，并能诱导HeLa细胞发生凋亡，同时具有抗血管生成的特性。
T71110	Nanatinostat TFA
	Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor...
T81974	KPZ560	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	KPZ560作为HDAC1和HDAC2的有效抑制剂，在IC50数值上分别达到12 nM 和68 nM 。此化合物能提升小鼠颗粒神经元树突的棘密度，同时也能抑制MCF乳腺癌细胞系的生长。
TP1836	BMf-BH3
	BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetylation and acetylation.
T74456	JPS036
	JPS036 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS036 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS036 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T74454	JPS016
	JPS016 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS016 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS016 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T77938	JPS016 TFA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JPS016 TFA是一种苯甲酰胺基Von Hippel-Lindau (VHL) E3连接酶蛋白水解靶向嵌合体(PROTAC)。该化合物能够降解I类组蛋白脱乙酰酶(HDAC)，特别是有效地降解HDAC1/2。在HCT116细胞中，JPS016 TFA与大量差异基因表达增加及细胞凋亡(apoptosis)激活相关。
T74453	JPS014
	JPS014, 基于苯甲酰胺的Von Hippel-Lindau (VHL) E3-连接酶蛋白水解靶向嵌合体 (PROTAC)，有效降解I 类组蛋白脱乙酰酶 (HDAC)。它作为HDAC1/2的强效降解剂，与HCT116细胞中的总差异表达基因更大和增强的细胞凋亡 (apoptosis) 密切相关。
T36110	L-Pyrohomoglutamic Acid
	L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors...
T38711	YF-2 hydrochloride
	YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.
T36102	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is a building block and synthetic intermediate.1,2,3,4,5It has been used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer compounds.1,2,3It is also a synthetic intermediate in the synthesis of EGFR inhibitors, including erlotinib , with antiproliferative activity.4,5
T77937	JPS014 TFA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JPS014 TFA是一种VHL E3连接酶蛋白水解靶向嵌合体(PROTAC)，以苯甲酰胺为基础，专门降解I类组蛋白脱乙酰酶(HDAC)。作为一种高效的HDAC1/2降解剂，JPS014 TFA与HCT116细胞中广泛的基因表达差异及促进细胞凋亡(apoptosis)密切相关。
T79683	HDAC/CD13-IN-1	Others	Others
	HDAC/CD13-IN-1 (Compound 12) 作为HDAC/CD13抑制剂, 对hCD13的IC50为0.34 μM, 猪CD13为0.53 μM, 对HDAC1/2/3的IC50分别为0.03、0.06、0.02 μM。此化合物有效抑制MV4-11、K562、Jeko-1 和 HL60细胞增殖, IC50范围为0.25-2.04 μM，并诱导癌细胞凋亡。同时表现出抗转移和抗侵袭的特性。
T21898	MI-192
	MI-192 是一种选择性 HDAC2和 HDAC3抑制剂，IC50分别为 30 nM 和 16 nM。MI-192 比其他 HDAC 异构体对 HDAC2/3 具有更高选择性。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。
T74455	JPS035
	JPS035 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS035 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS035 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T21719	CBHA
	m-Carboxycinnamic acid bishydroxamide 是一种有效的HDAC 抑制剂，在体外对 HDAC1 和 HDAC3 的ID50值分别为 10 nM 和 70 nM。m-Carboxycinnamic acid bishydroxamide 也可诱导细胞凋亡并且抑制肿瘤生长。
T70962	MHY219
	MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. M...
T64152	Purinostat mesylate
	Purinostat mesylate 是一种选择性的 HDAC 抑制剂。Purinostat mesylate 能够抑制 I 型和 IIb 型 HDACs (IC50: 0.81-11.5 nM)。Purinostat mesylate 能够影响LAMA84 和 188 BL-2 细胞的细胞周期，并诱导其凋亡，在体内显示出较强的抗白血病效果。Purinostat mesylate 能够用于研究淋巴细胞白血病。
T36421	Immuno-Oncology Screening Library
	The Immuno-Oncology Screening Library consists of 2 plates and contains more than 90 cancer and immunology-associated compounds in a 96-well Matrix tube rack format as 10 mM stock solutions in DMSO. This library includes a variety of immuno-oncology target modulators, including but not limited to, adenosine, CCR, CXCR, and TLR agonists and antagonists, BTK, PI3K, VEGFR, and BRAF inhibitors, PD-1/PDL-1 interaction inhibitors, and HDAC inhibitors. Please review the product insert for a full list ...
T61753	MPT0G211 mesylate
	MPT0G211 mesylate is a powerful and selective HDAC6 inhibitor (IC50 = 0.291 nM), with high oral bioavailability. It exhibits remarkable selectivity for HDAC6 over other HDAC isoforms (>1000-fold selectivity). Additionally, MPT0G211 mesylate can effectively cross the blood-brain barrier. In preclinical studies using an Alzheimer's disease model, MPT0G211 mesylate has shown promising results in reducing tau phosphorylation and cognitive deficits. Furthermore, this compound exhibits anti-metastatic...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T36103	TW9 TW9
	TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica...

化合物

Cat.No: T3661

Synonym: ACY241,HDAC-IN-2

Target: HDAC

Cat.No: T39567

Synonym: HDAC1/2-IN-3

CDK/HDAC-IN-2

Cat.No: T63664

Top/HDAC-IN-2

Cat.No: T64025

JAK/HDAC-IN-2

Cat.No: T78708

Target: JAK

Tubulin/HDAC-IN-2

Cat.No: T79452

A2AAR/HDAC-IN-2

Cat.No: T62717

PI3K/HDAC-IN-2

Cat.No: T62912

c-Met/HDAC-IN-2

Cat.No: T72759

Cat.No: T2025

Synonym: HBI-8000,西达本胺杂质,CS055,Chidamide impurity

Target: HDAC

Cat.No: T2294

Target: Apoptosis, HDAC

Cat.No: T5631

Target: HDAC

Quisinostat dihydrochloride

Cat.No: T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

Cat.No: T62920

Cat.No: T61916

Cat.No: T62072

AChE/HDAC-IN-1

Cat.No: T63142

VEGFR2/HDAC1-IN-1

Cat.No: T80873

Target: VEGFR

Nanatinostat TFA

Cat.No: T71110

Cat.No: T81974

Target: HDAC

Cat.No: TP1836

Cat.No: T74456

Cat.No: T74454

Cat.No: T77938

Target: HDAC

Cat.No: T74453

L-Pyrohomoglutamic Acid

Cat.No: T36110

YF-2 hydrochloride

Cat.No: T38711

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

Cat.No: T36102

Cat.No: T77937

Target: HDAC

HDAC/CD13-IN-1

Cat.No: T79683

Target: Others

Cat.No: T21898

Cat.No: T74455

Cat.No: T21719

Cat.No: T70962

Purinostat mesylate

Cat.No: T64152

Immuno-Oncology Screening Library

Cat.No: T36421

MPT0G211 mesylate

Cat.No: T61753

Cat.No: T36629

Cat.No: T36103

Synonym: TW9

Cat. No.	Product Name	Target	Signaling Pathways
T7064	Valproic Acid Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，可抑制 HDAC1 活性，诱导 HDAC2 降解，具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。
T36797	1-Alaninechlamydocin
	1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a concentration-dependent manner. 1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).

天然产物

Cat.No: T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

1-Alaninechlamydocin

Cat.No: T36797

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼