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23

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6516	Golgicide A	Others; Virus Protease	Microbiology/Virology; Others
	Golgicide A 可抑制柯萨奇病毒 B3 和其他人类肠道病毒的复制。它是一种高度特异性可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子抑制剂。
T4061	LY2334737	Nucleoside Antimetabolite/Analog; Others; Virus Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	LY2334737 是一种具有口服活性的 Gemcitabine 的前药，也是核苷类似物。它抑制肠道病毒 A71 感染，有抗病毒和抗癌活性。
T2432	PD 169316	Virus Protease; p38 MAPK; Autophagy	Autophagy; MAPK; Microbiology/Virology
	PD 169316 是一种细胞渗透性 p38 MAP 激酶抑制剂，IC50值为 89 nM。它可选择性地抑制磷酸化 p38 的激酶活性。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
T1750	Pirodavir R77975,吡罗达韦	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pirodavir (R77975) 是一种广谱抗小核糖核酸病毒抑制剂，有效抑制人鼻病毒衣壳的结合。
T18928	Brilliant Black BN 亮黑1,E 151	Others; Virus Protease	Microbiology/Virology; Others
	Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用，是一种很有前途的抗 EV71 感染的抗病毒药物。
T4536	Pleconaril VP 63843,Win 63843,Picovir,普可那利	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pleconaril (VP 63843) 是一种有潜力研究肠病毒的衣壳抑制剂,，它可有效抑制复制, IC50值为 50 nM。
T4492	pocapavir SCH-48973,V-073	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	Pocapavir (SCH-48973) 是一种具有口服活性的研究性肠道病毒衣壳抑制剂，可防止病毒粒子进入细胞后脱壳。
T0188	Fluticasone (propionate) 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate	Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂，是一种局部抗炎激素，亲和力KD 为 0.5 nM。具有抗病毒活性。
T61652	WIN 54954
	WIN 54954 is a potent, orally active, broad-spectrum antipicornavirus agent with demonstrated efficacy against human rhinovirus, echovirus 9, and enterovirus infections [1] [2].
T61334	DMA-135 hydrochloride DMA-135 HCl	Virus Protease	Microbiology/Virology
	DMA-135 hydrochloride (DMA-135 HCl) 靶向 RNA 的抗病毒活性化合物，抑制肠道病毒 71 型 (EV71)IRES依赖的翻译和复制。DMA-135 hydrochloride 可用于研究肠道病毒感染。
T27126	DC07090 Dihydrochloride
	DC07090 Dihydrochloride is a potent inhibitor of human enterovirus 71 3C protease.
T24234	JX040 JX 040,JX-040
	JX040 is an enterovirus replication inhibitor. JX040 has strong antiviral activity against non-polio enteroviruses and it has weak antiviral activity against polioviruses.
T13284	Vapendavir diphosphate BTA798 diphosphate	Others	Others
	Vapendavir diphosphate is a potent enteroviral capsid binder (CB) and has a potent antiviral activity for enterovirus 71 (EV71) replication (EC50: 0.5-1.4 μM in different EV71 strains).
T13284L	Vapendavir BTA798	Others	Others
	Vapendavir is a potent enteroviral capsid binder. Vapendavir has an effective antiviral activity for enterovirus 71 replication (EC50: 0.5-1.4 μM in different EV71 strains).
T38374	2-hydroxy Myristic Acid
	2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax. It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively). 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation ...
T31530	Disoxaril BRN 3626820,WIN51711,WIN-51711,BRN-3626820,WIN 51711,WIN-51,711
	Disoxaril (BRN 3626820, WIN 51711) is an anti-picornavirus agent that inhibits enterovirus replication by binding to a hydrophobic bag within the VP1 coat protein, thereby stabilizing virions and preventing their uncoating. When used in combination with A
T36174	Methyl 3,4-Dihydroxyphenylacetate
	Methyl 3,4-dihydroxyphenylacetate is a polyphenol that has been found inI. aquifoliumseeds and has antioxidant and antiviral activities.1,2It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50= 0.0025 mg/ml).1Methyl 3,4-dihydroxyphenylacetate (0.01 μg/ml) inhibits enterovirus 71 replication in rhabdomyosarcoma cells.2 1.Nahar, L., Russell, W.R., Middleton, M., et al.Antioxidant phenylacetic acid derivatives from the seeds of Ilex aquifoliumActa Pharm.55(2)187-193(2005) 2...
T71856	FA-613
	FA-613 is a pyrimidine synthesis inhibitor which exhibits low micromolar antiviral activity against various influenza A and B virus strains, including the highly pathogenic influenza A strains H5N1 and H7N9, enterovirus A71, respiratory syncytial virus, human rhinovirus A, SARS- and MERS-coronavirus.
T72562	Antiviral agent 23
	Antiviral agent 23 是肠病毒 71 (EV71) 的抗病毒剂，EC50值为 94 nM。Antiviral agent 23 有效抑制 METTL3/METTL14 的活性。Antiviral agent 23 可用于感染的研究。
T61462	EV-A71-IN-1
	EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1].
T60880	Viral 2C protein inhibitor 1
	Viral 2C protein inhibitor 1 (compound 6aw) 是广谱抗肠病毒剂，可抑制病毒 2C 蛋白。Viral 2C protein inhibitor 1 具有相对较低的细胞毒性和较高的选择性指数。Viral 2C protein inhibitor 1 可抑制 EV-D68、EV-A71 和 CVB3 等多种菌株，EC50值为 0.1~3.6 μM。
T70174	Pirlindole-d4 HCl
	Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru...

化合物

Cat.No: T6516

Target: Others, Virus Protease

Cat.No: T4061

Target: Nucleoside Antimetabolite/Analog, Others, Virus Protease

Cat.No: T2432

Target: Virus Protease, p38 MAPK, Autophagy

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Cat.No: T1750

Synonym: R77975,吡罗达韦

Target: Virus Protease, Antiviral

Brilliant Black BN

Cat.No: T18928

Synonym: 亮黑1,E 151

Target: Others, Virus Protease

Cat.No: T4536

Synonym: VP 63843,Win 63843,Picovir,普可那利

Target: Virus Protease, Antiviral

Cat.No: T4492

Synonym: SCH-48973,V-073

Target: Virus Protease, Antiviral

Fluticasone (propionate)

Cat.No: T0188

Synonym: 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate

Target: Glucocorticoid Receptor, Virus Protease, Estrogen/progestogen Receptor, Phospholipase, Endogenous Metabolite

Cat.No: T61652

DMA-135 hydrochloride

Cat.No: T61334

Synonym: DMA-135 HCl

Target: Virus Protease

DC07090 Dihydrochloride

Cat.No: T27126

Cat.No: T24234

Synonym: JX 040,JX-040

Vapendavir diphosphate

Cat.No: T13284

Synonym: BTA798 diphosphate

Target: Others

Cat.No: T13284L

Synonym: BTA798

Target: Others

2-hydroxy Myristic Acid

Cat.No: T38374

Cat.No: T31530

Synonym: BRN 3626820,WIN51711,WIN-51711,BRN-3626820,WIN 51711,WIN-51,711

Methyl 3,4-Dihydroxyphenylacetate

Cat.No: T36174

Cat.No: T71856

Antiviral agent 23

Cat.No: T72562

Cat.No: T61462

Viral 2C protein inhibitor 1

Cat.No: T60880

Pirlindole-d4 HCl

Cat.No: T70174

Cat. No.	Product Name	Target	Signaling Pathways
T5779	MOSLOFLAVONE	IL Receptor; Virus Protease; TNF; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Mosloflavone 从Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成，有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。
T3345	Hederasaponin B 常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B	Others; Virus Protease	Microbiology/Virology; Others
	Hederasaponin B (Hederacoside B) 是从Hedera helix 中分离的，有广谱抗病毒活性。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
T8205	Norwogonin 5,7,8-Trihydroxyflavone,去甲汉黄芩素	Virus Protease	Microbiology/Virology
	Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的，对肠道病毒 71 具有抗病毒活性，IC50为 31.83 μg/ ml。
T1670	Lanatoside C Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C	ATPase; Virus Protease; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞，可抗登革病毒感染， IC50为0.19 μM。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T8180	7-Hydroxyisoflavone	Others	Others
	7-Hydroxyisoflavone 有体外抗肠道病毒 71作用。
T21251	OSW-1 OSW1
	OSW-1 is a natural broad-range inhibitor to inhibits replication of enterovirus.

天然产物

Cat.No: T5779

Target: IL Receptor, Virus Protease, TNF, Antibacterial

Hederasaponin B

Cat.No: T3345

Synonym: 常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B

Target: Others, Virus Protease

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Cat.No: T8205

Synonym: 5,7,8-Trihydroxyflavone,去甲汉黄芩素

Target: Virus Protease

Cat.No: T1670

Synonym: Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C

Target: ATPase, Virus Protease, Autophagy

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

7-Hydroxyisoflavone

Cat.No: T8180

Target: Others

Cat.No: T21251

Synonym: OSW1

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