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Cat. No.	Product Name	Target	Signaling Pathways
T11284	FIDAS-3	Others; Wnt/beta-catenin; Methionine Adenosyltransferase (MAT)	Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Stem Cells
	FIDAS-3 是一种强效Wnt 抑制剂，也是一种二苯乙烯衍生物，对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合，并具有抗癌作用。
T11285	FIDAS-5	Others	Others
	FIDAS-5 是甲硫氨酸腺苷转移酶 2A 抑制剂(IC50:2.1 μM)，具有口服活性。它能够与 S-腺苷甲硫氨酸有效竞争 MAT2A 结合，并具有抗癌作用。
T8445	PU02 PU-02,6-[(1-Naphthalenylmethyl)thio]-9H-purine	Apoptosis; 5-HT Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) 是5-HT3受体的负变构调节剂，是 6-MP 的一个衍生物。它在 HEK293 细胞测得的转染 5-HT3A 和 5-HT3AB 受体后的 IC50值分别为 0.36 和 0.73 μM。
T11345L	Lerociclib dihydrochloride G1T38 dihydrochloride	CDK	Cell Cycle/Checkpoint
	Lerociclib dihydrochloride (G1T38 dihydrochloride) 是一种有效的选择性CDK4/CDK6抑制剂，抑制CDK6/CyclinD3和CDK4/CyclinD1，IC50值分别为 2 nM 和 1 nM。
T11345	Lerociclib G1T38	CDK	Cell Cycle/Checkpoint
	Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
T22590	AT7519 TFA AT7519 trifluoroacetate	Others	Others
	AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).
T15335	FN-1501	FLT; CDK	Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	FN-1501 是一种有效的 FLT3 和 CDK 抑制剂，具有抗肿瘤的活性，对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。
T13202	Trilaciclib hydrochloride G1T28 hydrochloride	CDK	Cell Cycle/Checkpoint
	Trilaciclib hydrochloride (G1T28 hydrochloride) 是一种CDK4/6的抑制剂，对 CDK4 和 CDK6 的IC50值分别为 1 nM 和 4 nM。
T39957	CDK4/6-IN-6	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-6 是CDK4/CDK6的有效抑制剂，结合CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 为 0.6 nM 和 13.9 nM。
T10898	Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) 是一种具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。它以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有抗肿瘤作用。
T6924	Riviciclib hydrochloride P276-00	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Riviciclib hydrochloride (P276-00) 是一种CDK 抑制剂，抑制CDK9-cyclinT1、CDK4-cyclin D1、CDK1-cyclinB 的IC50值分别为 20 nM、63 nM、79 nM。它对 Cisplatin 耐药性细胞具有抗肿瘤活性。
T2059	Purvalanol A NG-60	Apoptosis; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Purvalanol A (NG-60) 是一种CDK 抑制剂，对 cdc2-cyclin B、cdc2-cyclin B、cdk2-cyclin E、cdk4-cyclin D1 和 cdk5-p35 的IC50值分别为 4、70、35、850 和 75 nM。
T10096L	Voruciclib	CDK	Cell Cycle/Checkpoint
	Voruciclib 是一种具有口服活性和选择性 CDK 抑制剂，Ki 为 0.626 nM-9.1 nM。它在多种弥漫性大 B 细胞淋巴瘤模型中抑制 MCL-1 的表达。它有效阻断 MCL-1 的转录调节子 CDK9。
T6312	R547 Ro 4584820	Apoptosis; GSK-3; PKA; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	R547 (Ro 4584820) 是一种口服有效，选择性， ATP 竞争性CDK 抑制剂，对 CDK1/cyclin B、 CDK2/cyclin E 和 CDK4/cyclin D1 作用的Ki 值分别为 2 nM、3 nM、1 nM。
T1778	AT7519 Hydrochloride AT7519 HCl,AT 7519 hydrochloride salt	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	AT7519 Hydrochloride (AT7519 HCl) 是一种多CDK 抑制剂，对 CDK1、CDK2、CDK4-CDK6 以及 CDK9 的IC50值分别为 210、47、100、13、170 和 <10 nM。
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T6240	Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐	CDK	Cell Cycle/Checkpoint
	Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
T30600	BSJ-03-204 BSJ03204
	BSJ-03-204 is a selective Cdk4/6 degrader.
T23092	NSC 625987	Others	Others
	Cyclin-dependent kinase (cdk) 4 inhibitor
T13309	Voruciclib hydrochloride	CDK	Cell Cycle/Checkpoint
	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
T12737	Riviciclib P276-00 (free base)	Others	Others
	Riviciclib is a potent inhibitor of cyclin-dependent kinase (CDK)(CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively),with antitumor activity on cisplatin-resistant cells.
T72507	Palbociclib orotate PD 0332991 orotate	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) orotate 是一种口服活性的CDK4和CDK6选择性抑制剂，其IC50值分别为11 nM和16 nM。该化合物对癌细胞展示出抗增殖效果，并促使细胞周期处于阻滞状态。该药物适用于HR阳性、HER2阴性乳腺癌以及肝细胞癌的研究。
T12355	Palbociclib-d8 PD 0332991 D8,Palbociclib D8	CDK	Cell Cycle/Checkpoint
	Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).
T11653	Indirubin-5-sulfonate	Others	Others
	Indirubin-5-sulfonate shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1,

化合物

Cat.No: T11284

Target: Others, Wnt/beta-catenin, Methionine Adenosyltransferase (MAT)

Cat.No: T11285

Target: Others

Cat.No: T8445

Synonym: PU-02,6-[(1-Naphthalenylmethyl)thio]-9H-purine

Target: Apoptosis, 5-HT Receptor

Lerociclib dihydrochloride

Cat.No: T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

Cat.No: T11345

Synonym: G1T38

Target: CDK

Cat.No: T22590

Synonym: AT7519 trifluoroacetate

Target: Others

Cat.No: T15335

Target: FLT, CDK

Trilaciclib hydrochloride

Cat.No: T13202

Synonym: G1T28 hydrochloride

Target: CDK

Cat.No: T39957

Target: CDK

Samuraciclib hydrochloride

Cat.No: T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

Riviciclib hydrochloride

Cat.No: T6924

Synonym: P276-00

Target: Apoptosis, CDK

Cat.No: T2059

Synonym: NG-60

Target: Apoptosis, CDK, Autophagy

Cat.No: T10096L

Target: CDK

Cat.No: T6312

Synonym: Ro 4584820

Target: Apoptosis, GSK-3, PKA, CDK

AT7519 Hydrochloride

Cat.No: T1778

Synonym: AT7519 HCl,AT 7519 hydrochloride salt

Target: Apoptosis, GSK-3, CDK

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

Palbociclib Isethionate

Cat.No: T6240

Synonym: Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐

Target: CDK

Cat.No: T30600

Synonym: BSJ03204

Cat.No: T23092

Target: Others

Voruciclib hydrochloride

Cat.No: T13309

Target: CDK

Cat.No: T12737

Synonym: P276-00 (free base)

Target: Others

Palbociclib orotate

Cat.No: T72507

Synonym: PD 0332991 orotate

Target: CDK

Cat.No: T12355

Synonym: PD 0332991 D8,Palbociclib D8

Target: CDK

Indirubin-5-sulfonate

Cat.No: T11653

Target: Others

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