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Search Results for " cftr "

62

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2355	CFTR(inh)-172 CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	CFTR(inh)-172 (CFTR Inhibitor-172) 是一种不依赖电压的选择性 CFTR 抑制剂，在2分钟内可逆地抑制CFTR 短路电流的Ki 值为300 nM。
T10776	CFTR corrector 4	CFTR	Membrane transporter/Ion channel
	CFTR corrector 4是一种高效且可口服的囊性纤维化跨膜电导调节剂 (CFTR)，是一种有效的 (R，R) 型活性对映体。CFTR corrector 4 可以增加细胞表面的 CFTR 水平，是用来研究囊性纤维化的潜在化合物。
T5312	CFTR corrector 2 FDL169	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	CFTR corrector 2 (FDL169) 是一种新型有效的囊性纤维化跨膜电导调节因子(CFTR)调节剂，用于治疗携带 F508del 突变的囊性纤维化患者。
T63806	CFTR corrector 8	CFTR	Membrane transporter/Ion channel
	CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].
T1874	PPQ-102 PPQ102,CFTR Inhibitor,PPQ 102	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂，可以完全抑制CFTR 氯化物电流，IC50为90 nM。
T60653	CFTR corrector 9	CFTR	Membrane transporter/Ion channel
	CFTR corrector 9是一种囊性纤维化跨膜传导调节蛋白 (CFTR)调节剂。CFTR corrector 9 可用于研究囊性纤维化 (CF) 和其他 CFTR 相关疾病。
T37686	CFTR corrector 6
	CFTR corrector 6 is a highly effective CFTR potentiator utilized in research on cystic fibrosis (CF) and related CFTR-associated disorders[1]. This potent compound exhibits potentiation activity on the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), rendering it beneficial for investigations in CF and other associated conditions.
T79578	CFTR corrector 12	CFTR	Membrane transporter/Ion channel
	CFTRcorrector 12（compound 17C）作为一种双噻唑衍生物，本身是CFTR校正剂。它具有校正控制氯离子跨膜运输通道的特定折叠缺陷突变的功能，并能够在带有突变的细胞中恢复α-肌聚糖（α-SG）的含量。
T2451	GlyH-101 GlyH 101	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂，Ki 为1.4 uM。
T3135	KM11060	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	KM11060 是 F508del-CFTR 运输缺陷的新型校正剂，可纠正 F508del-CFTR 运输，增加质膜上功能性 CFTR 的数量。它可用于 F508del-CFTR 加工缺陷的研究和囊性纤维化治疗剂的开发。
T1805	Ataluren PTC124	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ataluren (PTC124) 是一种可口服的 CFTR-G542X 无义等位基因抑制剂。
T14935	Elexacaftor VX-445	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运，增加细胞表面CFTR 的数量。
T16681	Nesolicaftor PTI-428	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Nesolicaftor (PTI-428) 特异性增强囊性纤维化跨膜电导调节蛋白合成。
T9499	Icenticaftor QBW251	CFTR	Membrane transporter/Ion channel
	Icenticaftor (QBW251) 是一种具有口服活性CFTR 通道增强剂，可用于慢性阻塞性肺疾病 (COPD) 和囊性纤维化研究，对F508del 和G551D CFTR 的EC50分别为 79 和 497 nM。
T7083	GLPG1837 ABBV-974	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GLPG1837 (ABBV-974) 是一种有效的 CFTR 增强剂，对其 F508del 和 G551D 的 EC50 分别为 3 nM 和 339 nM。
T2588	Ivacaftor Ivacaftor (VX-770),VX-770,依伐卡托	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ivacaftor (VX-770) 是一种 CFTR 增强剂，靶向G551D-CFTR 和F508del-CFTR 的EC50分别为100 和 25 nM。
T10591	BPO-27 racemate BPO-27 (racemate)	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	BPO-27 racemate (BPO-27(racemate)) 是一种CFTR 抑制剂，IC50为8 nM。
T2486	IOWH-032 IOWH032,IOWH 032	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	IOWH-032 (IOWH032) 是一种合成 CFTR 抑制剂，可用于研究治疗霍乱、腹泻和分泌性腹泻，在T84和CHO-CFTR 细胞实验中IC50为1.01 uM。
T2595	Lumacaftor 鲁玛卡托,VX-809,VRT 826809	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Lumacaftor (VRT 826809) 是一种 CFTR 调节剂，可纠正 CFTR 蛋白的折叠和运输。它增强了 FRT 细胞中 F508del-CFTR 蛋白的成熟，EC50为100 nM。
T1634	Glibenclamide 格列本脲,Glyburide	Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。
T2263	Tezacaftor VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Tezacaftor (VX661) 是一种小分子，可用作囊性纤维化跨膜电导调节器基因功能的校正剂。
T16516	PG01 Phenylglycine-01	CFTR	Membrane transporter/Ion channel
	PG01是一种有效的CFTR Cl-通道增效剂,PG01对 ΔF508（Ka 为 0.3 μM）有效。PG01 对 E193K，G970R 和 G551D (CFTR 突变体)也有效，Kd 值分别为 0.22 μM，0.45 μM 和 1.94 μM 。PG01在加入Forskolin 后可增加ΔF508-CFTR Cl-电流，纠正CFTR 突变体的门控缺陷。
T10591L	(R)-BPO-27	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	(R)-BPO-27 是一种具有口服活性和高效性的 ATP 竞争性 CFTR 抑制剂(IC50：4 nM)，可用于研究腹泻和多囊肾。
T30293	Bamocaftor VX-659	CFTR	Membrane transporter/Ion channel
	Bamocaftor是一种CFTR通道（DeltaF508-CFTR突变）矫正器，适用于 CF 跨膜传导调节器，被设计用于恢复 F508del-CFTR 蛋白功能。联合使用 tezacaftor 和 VX-561 治疗 F508del/MF 的囊性纤维化患者。
T20341	DNDS	CFTR	Membrane transporter/Ion channel
	DNDS 是电压依赖性囊性纤维化跨膜电导调节剂 (CFTR) 的通道阻滞剂。
T29041	UCCF-853 UCCF853,UCCF 853	CFTR	Membrane transporter/Ion channel
	UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。
T29114	VRT-532 CFpot-532,CFpot-532)	CFTR	Membrane transporter/Ion channel
	VRT-532 (CFpot-532)是CFTR 的有效调节剂，常用于CFTR 缺陷引起的囊性纤维化(CF)研究。降解囊性纤维化中积累的硫酸化糖胺聚糖(gag)所必需的Arylsulfatase B (ARSB)，小分子调节剂VRT-532对CFTR 的修饰能增加ARSB 并减少4-硫酸软骨素的积累。
T26955	Cavosonstat N91115,N 91115,N-91115	GSNOR; CFTR	Membrane transporter/Ion channel; Metabolism
	Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂，可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
T31014	Corrector C4 Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a	Others	Others
	Corrector C4 是一种常用于研究囊性纤维化突变体的校正子，通过减轻CFTR跨膜结构域突变体与蛋白稳态的相互作用来发挥作用。
T77604	WAY-326766	CFTR	Membrane transporter/Ion channel
	WAY-326766通过突变型 CFTR 增加离子转运，可用于改变真核生物的寿命。WAY-326766可用于治疗囊性纤维化（CF）。
T39596	Dirocaftor PTI-808
	Dirocaftor (PTI-808) is a CFTR potentiator that augments CFTR protein function via the activation of chloride channels. Dirocaftor holds potential utility for research pertaining to cystic fibrosis (CF).
T13705	GLPG2451	Cysteine Protease	Proteases/Proteasome
	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).
T40386	CP-628006
	CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.
T36519	Posenacaftor sodium
	Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].
T35925	(R)-Posenacaftor sodium
	(R)-Posenacaftor ((R)-PTI-801) sodium, the R enantiomer of Posenacaftor, is a cystic fibrosis transmembrane regulator (CFTR) protein modulator. It corrects the folding and trafficking of the CFTR protein, and is utilized in the research of cystic fibrosis (CF)[1].
T29040	UCCF-029 UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029
	UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR).
T22252	Galicaftor	Others	Others
	ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).
T61702	SRI-37240
	SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, when combined with G418, SRI-37240 restores CFTR function in primary bronchial epithelial cells [1].
T62630	Posenacaftor
	Posenacaftor (PTI-801) 是一种囊性纤维化跨膜调节蛋白 (CFTR) 调节剂，可纠正 CFTR 蛋白的折叠和运输。Posenacaftor 能够用于研究囊性纤维化 (CF) 。
T25898	Olacaftor VX 440,VX-440,VX440
	Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).
T13742	Ivacaftor benzenesulfonate VX-770 benzenesulfonate	Others	Others
	Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.
T78240	(R)-Elexacaftor (R)-VX-445	CFTR	Membrane transporter/Ion channel
	(R)-Elexacaftor，Elexacaftor (Compound 1) 的对映异构体，为囊性纤维化跨膜电导调节因子（CFTR）校正剂，其针对CFTR dF508突变体的EC50值为0.29 uM。
T13742L	Ivacaftor hydrate VX-770 hydrate	Others	Others
	Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.
T19788	Piretanide Eurelix,Tauliz,Arelix
	Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic.
T74417	Vanzacaftor
	Vanzacaftor 是一种囊性纤维化跨膜电导调节体（CFTR）的调节剂，用于研究囊性纤维化。
T27098	Ivacaftor-D9 deutivacaftor,CTP-656
	CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T74748	Zatonacaftor
	Zatonacaftor 是囊性纤维化跨膜调节剂(CFTR)蛋白的调节剂，主要应用于囊性纤维化的研究。
T39633	Navocaftor GLPG 3067,ABBV-3067
	Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1).
T72860	(R)-Olacaftor (R)-VX-440
	(R)-Olacaftor ((R)-VX-440)，一种对囊性纤维化 (CF) 具有研究潜力的囊性纤维化跨膜调节因子 (CFTR) 调节剂。
T69658	Ethyl-3,4-dephostatin
	Ethyl-3,4-dephostatin is a novel inhibitor of the interactions of CFTR-associated ligand and PSD-95/Dlg1/ZO-1 domain.

化合物

CFTR(inh)-172

Cat.No: T2355

Synonym: CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172

Target: CFTR, Autophagy

CFTR corrector 4

Cat.No: T10776

Target: CFTR

CFTR corrector 2

Cat.No: T5312

Synonym: FDL169

Target: CFTR, Autophagy

CFTR corrector 8

Cat.No: T63806

Target: CFTR

Cat.No: T1874

Synonym: PPQ102,CFTR Inhibitor,PPQ 102

Target: CFTR, Autophagy

CFTR corrector 9

Cat.No: T60653

Target: CFTR

CFTR corrector 6

Cat.No: T37686

CFTR corrector 12

Cat.No: T79578

Target: CFTR

Cat.No: T2451

Synonym: GlyH 101

Target: CFTR, Autophagy

Cat.No: T3135

Target: CFTR, Autophagy

Cat.No: T1805

Synonym: PTC124

Target: CFTR, Autophagy

Cat.No: T14935

Synonym: VX-445

Target: CFTR, Autophagy

Cat.No: T16681

Synonym: PTI-428

Target: CFTR, Autophagy

Cat.No: T9499

Synonym: QBW251

Target: CFTR

Cat.No: T7083

Synonym: ABBV-974

Target: CFTR, Autophagy

Cat.No: T2588

Synonym: Ivacaftor (VX-770),VX-770,依伐卡托

Target: CFTR, Autophagy

BPO-27 racemate

Cat.No: T10591

Synonym: BPO-27 (racemate)

Target: CFTR, Autophagy

Cat.No: T2486

Synonym: IOWH032,IOWH 032

Target: CFTR, Autophagy

Cat.No: T2595

Synonym: 鲁玛卡托,VX-809,VRT 826809

Target: CFTR, Autophagy

Cat.No: T1634

Synonym: 格列本脲,Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Cat.No: T2263

Synonym: VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺

Target: CFTR, Autophagy

Cat.No: T16516

Synonym: Phenylglycine-01

Target: CFTR

Cat.No: T10591L

Target: CFTR, Autophagy

Cat.No: T30293

Synonym: VX-659

Target: CFTR

Cat.No: T20341

Target: CFTR

Cat.No: T29041

Synonym: UCCF853,UCCF 853

Target: CFTR

Cat.No: T29114

Synonym: CFpot-532,CFpot-532)

Target: CFTR

Cat.No: T26955

Synonym: N91115,N 91115,N-91115

Target: GSNOR, CFTR

Cat.No: T31014

Synonym: Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a

Target: Others

Cat.No: T77604

Target: CFTR

Cat.No: T39596

Synonym: PTI-808

Cat.No: T13705

Target: Cysteine Protease

Cat.No: T40386

Posenacaftor sodium

Cat.No: T36519

(R)-Posenacaftor sodium

Cat.No: T35925

Cat.No: T29040

Synonym: UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029

Cat.No: T22252

Target: Others

Cat.No: T61702

Cat.No: T62630

Cat.No: T25898

Synonym: VX 440,VX-440,VX440

Ivacaftor benzenesulfonate

Cat.No: T13742

Synonym: VX-770 benzenesulfonate

Target: Others

(R)-Elexacaftor

Cat.No: T78240

Synonym: (R)-VX-445

Target: CFTR

Ivacaftor hydrate

Cat.No: T13742L

Synonym: VX-770 hydrate

Target: Others

Cat.No: T19788

Synonym: Eurelix,Tauliz,Arelix

Cat.No: T74417

Cat.No: T27098

Synonym: deutivacaftor,CTP-656

Cat.No: T74748

Cat.No: T39633

Synonym: GLPG 3067,ABBV-3067

Cat.No: T72860

Synonym: (R)-VX-440

Ethyl-3,4-dephostatin

Cat.No: T69658

Cat. No.	Product Name	Target	Signaling Pathways
T2S1837	Steviol 甜菊醇,NSC 226902,Hydroxydehydrostevic acid	Others	Others
	Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。
TN1834	Kobusin 去甲槟郎碱,自旋七叶素	Others; NOS; NF-κB	Immunology/Inflammation; NF-κB; Others
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-express...

天然产物

Cat.No: T2S1837

Synonym: 甜菊醇,NSC 226902,Hydroxydehydrostevic acid

Target: Others

Cat.No: TN1834

Synonym: 去甲槟郎碱,自旋七叶素

Target: Others, NOS, NF-κB

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