首页工具

登录

搜索结果

Search Results for " bec "

42

抑制剂 & 化合物

5

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T6779	BEC hydrochloride BEC HCl	Arginase	Immunology/Inflammation
	BEC hydrochloride (BEC HCl) 是一种缓慢结合的竞争性精氨酸酶 II 抑制剂，在 pH 7.5 时 Ki 值为 0.31 μM。它对大鼠 Arginase I 在 0.4 到 0.6 μM 之间。
T6140	SB-334867 free base SB334867A free base,SB-334867,SB 334867,SB334867	OX Receptor	GPCR/G Protein; Neuroscience
	SB-334867 free base (SB334867A free base) 是一种选择性 orexin-1(OX1) 受体拮抗剂，对 OX2有选择性，pKb 为7.4，对 5-HT2B、5-HT2C 的选择性是 100 倍，pKi 值分别为 5.4 和 5.3。它减少乙醇消耗，还抑制吗啡诱导的体内运动活动敏感性的获得。
T61151	Beclobrate
	Beclobrate (Sgd 24774), a fibric acid derivative, exhibits potent lipid-lowering efficacy in rodent models [1].
TQ0238	Lanabecestat LY3314814,AZD3293	BACE	Neuroscience
	Lanabecestat (AZD3293) 是一种具有高效性和高渗透性、口服活性且可穿过血脑屏障的 BACE1 抑制剂（Ki：0.4 nM），Lanabecestat 可用于研究像阿尔茨海默症类的神经系统疾病。
T1127	Beclometasone dipropionate Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase	Glucocorticoid Receptor	Endocrinology/Hormones
	Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素，具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物，Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
T11175	Elenbecestat E2609	Beta-Secretase; BACE	Neuroscience
	Elenbecestat (E2609) 是一种高效、有口服活性的，能透过 CNS 的 BACE-1抑制剂，它有用于阿尔茨海默病 (AD) 的研究潜力。
T1249	Beclamide N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)	Others	Others
	Beclamide (Chlorakon) 是一种抗惊厥药，具有抗惊厥作用。
T7011	Verubecestat MK-8931,维罗司他	Beta-Secretase; BACE	Neuroscience
	Verubecestat (MK-8931) 是一种高亲和力的、具有口服活性的BACE1和BACE2抑制剂，Ki 分别为 2.2 nM 和 0.38 nM。它可以有效降低 Aβ40，并具有潜力用于阿尔茨海默氏病。
T38861L	Tat-beclin 1 acetate Tat-beclin 1 acetate(1423821-88-8 free base)	HIV Protease; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Tat-beclin 1 acetate 是一种有效的自噬诱导剂，并与自噬的负调节因子 GAPR-1 相互作用。 Tat-beclin 1 acetate 减少聚谷氨酰胺扩增蛋白聚集体的积累和几种病原体（包括 HIV-1）的复制。
T67988	Embeconazole R 120758,CS 758	Antifungal	Microbiology/Virology
	Embeconazole (R 120758) 是一种三唑类抗真菌剂。Embeconazole 对念珠菌、曲霉菌、新型隐球菌等临床重要真菌具有较强的体外活性。
T10493	Beclabuvir BMS-791325	Others	Others
	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).
T13253	Umibecestat CNP520	BACE	Neuroscience
	Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂，对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM，可用于阿尔茨海默病的研究。
T72910	APOBEC3G-IN-1	Others	Others
	APOBEC3G-IN-1 (MN136.0185) 是一种靶向 APOBEC3G 抑制剂，具有抗 HIV 活性，可用于研究传染病和癌症。
T8777	Beclometasone 倍氯米松,BecloMethasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Beclometasone 是糖皮质激素受体激动剂。
T70800	Elenbecestat free base
	Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.
T69664	Umibecestat HCl
	Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP‐transgenic mice
T74146	Ecubectedin
	Ecubectedin (PM14), 作为一种海鞘素衍生物，属于四氢异喹啉类生物碱，展现出广泛的抗肿瘤及抗菌活性。
T24924	Umibecestat HCl (1387560-01-1 free base) CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520
	Umibecestat is a beta-secretase inhibitor. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies.
T14338	Atabecestat JNJ-54861911	BACE	Neuroscience
	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and
T10014	(1α,1'S,4β)-Lanabecestat (1α,1'S,4β)-AZD3293	Others	Others
	(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively.
T22960	Macbecin I	Others	Others
	Hsp90 inhibitor
T30310	Becocalcidiol DP006,QRX101,COL121,QRX-101,COL-121,DP-006
	Becocalcidiol(QRX-101, DP-006, COL-121) is a potential vitamin D analog for the treatment of psoriasis.
T68235	Beclabuvir HCl
	Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) ...
T60993	Alpibectir
	Alpibectir 具有抗细菌活性。
T70807	Lanabecestat HCl
	Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ.
T14281	Becampanel AMP 397	Others	Others
	Becampanel (AMP397) is the first competitive AMPA antagonist. Becampanel (AMP397) also is an antiepileptic agent.
T76058	Tat-beclin 1 TFA
	Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽，有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用，具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累，并抑制HIV-1等多种病原体的复制。同时，Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。
T79756	Beclin1-ATG14L interaction inhibitor 1	Autophagy	Autophagy
	Beclin1-ATG14L interaction inhibitor 1 (com 19) 作为一种选择性抑制剂，特定抑制脂质激酶VPS34的复合物 I 中Beclin1与ATG14L的相互作用，而对Beclin 1-UVRAG作用重要的VPS34复合物 II 无影响。由此，其阻断VPS34复合物 I 形成，抑制自噬过程，但不干扰复合物 II 介导的囊泡运输。
T36485	Becatecarin
	Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
T30309	Becantal L. 1633,1633 Labaz,Becantex
	Becantal is a bioactive chemical.
T70104	Verubecestat tosylate
	Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.
T76920	Bectumomab
	Bectumomab (IMMU-LL 2) 是一种针对人CD22(抗原) 的人源化IgG2a 单抗。Bectumomab 也是一种抗淋巴瘤抗体片段。Bectumomab 可与锝 99 (Tc99m LL2 Fab) 联合用于成像。此外，Bectumomab 能够检查复发性或新诊断的非霍奇金淋巴瘤 (NHL) 的分期，并在放射免疫研究 (RIT) 前评估靶向性。
TP2361	Abecomotide Lys-thr-val-asn-glu-leu-gln-asn-leu
	Abecomotide is a bioactive chemical.
T25610	Lanabecestat camsylate LY 3314814 camsylate,LY-3314814 camsylate,LY3314814 camsylate
	Lanabecestat camsylate is used as a BACE1 Inhibitor.
T10494	Beclomethasone 17-propionate Beclomethasone-17-monopropionate,17-BMP	Others	Others
	Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppress
T32738	Libecillide
	Libecillide is a bioactive chemical.
T82902	Beclin1-Bcl-2 interaction inhibitor 1
	Beclin1-Bcl-2 interaction inhibitor 1，有效地抑制Beclin 1/Bcl-2的结合作用，适用于癌症和神经退行性疾病的研究领域。
T76959	Vibecotamab
	Vibecotamab (XmAb14045) 是一种有效的针对 CD123和 CD3的双特异性抗体，可刺激 T 细胞介导的 CD123 表达细胞的靶向杀伤。Vibecotamab 具有抗肿瘤活性，可用于急性髓系白血病研究。
T38861	Tat-beclin 1
	Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
T80574	Becotatug JMT-101	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Becotatug (JMT-101)为一种针对EGFR的IgG1类单克隆抗体，具备与Afatinib及Osimertinib偶联生成ADC(抗体偶联药物)的潜力。
T63801	Beclometasone dipropionate monohydrate
	Beclometasone dipropionate monohydrate 是一种 Beclometasone 的前体药物，是一种口服具有活力的糖皮质激素受体激动剂，能够激动糖皮质激素受体，抑制炎症和过度增殖。Beclometasone dipropionate monohydrate 能够用于研究哮喘。
T71899	Verubecestat TFA
	Verubecestat, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat is a promising novel therapeutic drug candidate in Alzheimer's disease. Verubecestat reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.

化合物

BEC hydrochloride

Cat.No: T6779

Synonym: BEC HCl

Target: Arginase

SB-334867 free base

Cat.No: T6140

Synonym: SB334867A free base,SB-334867,SB 334867,SB334867

Target: OX Receptor

Cat.No: T61151

Cat.No: TQ0238

Synonym: LY3314814,AZD3293

Target: BACE

Beclometasone dipropionate

Cat.No: T1127

Synonym: Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase

Target: Glucocorticoid Receptor

Cat.No: T11175

Synonym: E2609

Target: Beta-Secretase, BACE

Cat.No: T1249

Synonym: N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)

Target: Others

Cat.No: T7011

Synonym: MK-8931,维罗司他

Target: Beta-Secretase, BACE

Tat-beclin 1 acetate

Cat.No: T38861L

Synonym: Tat-beclin 1 acetate(1423821-88-8 free base)

Target: HIV Protease, Autophagy

Cat.No: T67988

Synonym: R 120758,CS 758

Target: Antifungal

Cat.No: T10493

Synonym: BMS-791325

Target: Others

Cat.No: T13253

Synonym: CNP520

Target: BACE

Cat.No: T72910

Target: Others

Beclometasone

Cat.No: T8777

Synonym: 倍氯米松,BecloMethasone

Target: Glucocorticoid Receptor

Elenbecestat free base

Cat.No: T70800

Umibecestat HCl

Cat.No: T69664

Cat.No: T74146

Umibecestat HCl (1387560-01-1 free base)

Cat.No: T24924

Synonym: CNP 520,Umibecestat HCl,Umibecestat hydrochloride,CNP520,CNP-520

Cat.No: T14338

Synonym: JNJ-54861911

Target: BACE

(1α,1'S,4β)-Lanabecestat

Cat.No: T10014

Synonym: (1α,1'S,4β)-AZD3293

Target: Others

Cat.No: T22960

Target: Others

Becocalcidiol

Cat.No: T30310

Synonym: DP006,QRX101,COL121,QRX-101,COL-121,DP-006

Beclabuvir HCl

Cat.No: T68235

Cat.No: T60993

Lanabecestat HCl

Cat.No: T70807

Cat.No: T14281

Synonym: AMP 397

Target: Others

Tat-beclin 1 TFA

Cat.No: T76058

Beclin1-ATG14L interaction inhibitor 1

Cat.No: T79756

Target: Autophagy

Cat.No: T36485

Cat.No: T30309

Synonym: L. 1633,1633 Labaz,Becantex

Verubecestat tosylate

Cat.No: T70104

Cat.No: T76920

Cat.No: TP2361

Synonym: Lys-thr-val-asn-glu-leu-gln-asn-leu

Lanabecestat camsylate

Cat.No: T25610

Synonym: LY 3314814 camsylate,LY-3314814 camsylate,LY3314814 camsylate

Beclomethasone 17-propionate

Cat.No: T10494

Synonym: Beclomethasone-17-monopropionate,17-BMP

Target: Others

Cat.No: T32738

Beclin1-Bcl-2 interaction inhibitor 1

Cat.No: T82902

Cat.No: T76959

Cat.No: T38861

Cat.No: T80574

Synonym: JMT-101

Target: EGFR

Beclometasone dipropionate monohydrate

Cat.No: T63801

Verubecestat TFA

Cat.No: T71899

Cat. No.	Product Name	Target	Signaling Pathways
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
T38769	Quebecol
	Quebecol is a nutraceutical agent against periodontitis.
T16726	Rebeccamycin	Topoisomerase	DNA Damage/DNA Repair
	Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
T72578	Siegesbeckialide I
	Siegesbeckialide I 在 RAW264.7 细胞中通过直接结合IKKα/β有效地抑制 LPS 诱导的 NO 生成。
T83596	(+)-Osbeckic acid
	(+)-Osbeckic acid，一种Tartary Buckwheat中提取的血管松弛剂，对Sprague-Dawley大鼠胸主动脉环展现出显著的血管舒张效应，其半数有效浓度(EC50)为887 μM。

天然产物

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Cat.No: T38769

Cat.No: T16726

Target: Topoisomerase

Siegesbeckialide I

Cat.No: T72578

(+)-Osbeckic acid

Cat.No: T83596

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼