Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 2,200 | 现货 | ||
5 mg | ¥ 3,730 | 现货 | ||
25 mg | ¥ 12,800 | 现货 | ||
50 mg | ¥ 16,800 | 8-10周 | ||
100 mg | ¥ 21,500 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,120 | 现货 |
产品描述 | Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1]. |
别名 | JNJ-54861911 |
分子量 | 367.4 |
分子式 | C18H14FN5OS |
CAS No. | 1200493-78-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (680.46 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7218 mL | 13.6091 mL | 27.2183 mL | 68.0457 mL |
5 mM | 0.5444 mL | 2.7218 mL | 5.4437 mL | 13.6091 mL | |
10 mM | 0.2722 mL | 1.3609 mL | 2.7218 mL | 6.8046 mL | |
20 mM | 0.1361 mL | 0.6805 mL | 1.3609 mL | 3.4023 mL | |
50 mM | 0.0544 mL | 0.2722 mL | 0.5444 mL | 1.3609 mL | |
100 mM | 0.0272 mL | 0.1361 mL | 0.2722 mL | 0.6805 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Atabecestat 1200493-78-2 Neuroscience BACE JNJ 54861911 JNJ54861911 JNJ-54861911 Inhibitor inhibitor inhibit