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49

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T60073	Antimycobacterial agent-4 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide	Antibacterial	Microbiology/Virology
	Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) 对结核分枝杆菌具有抗菌活性。
T63865	Antimycobacterial agent-3
	Antimycobacterial agent-3 是一种抗分枝杆菌 (antimycobacterial) 剂，细胞毒性较低。Antimycobacterial agent-3 能够有效作用于药敏的 MTB 菌株 H37Rv 和耐药的临床分离株 (MIC< 0.029-0.110 μM)。
T63420	Antimycobacterial agent-2
	Antimycobacterial agent-2 是有效的抗分枝杆菌剂，对结核分枝杆菌 (M.tb) H37Rv 的MIC99为 0.8 μM。Antimycobacterial agent-2 具有出细胞毒作用，能够作用于 CHO 细胞 (IC50: 48.1 μM)。
T79281	Antimycobacterial agent-6
	Antimycobacterial agent-6 (compound 25) 是抗结核药物，针对野生型及氟喹诺酮耐药的结核分枝杆菌 (Mtb) 株有效。此化合物对 Mtb DprE1-C387S 突变具有抑制作用，其最小抑菌浓度（MIC90）对 H37Rv 和 MoxR 株均为 0.9 μM，对 DprE1-P116S 株为 0.5 μM。
T61853	Antimycobacterial agent-1
	Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg/ml. Notably, antimycobacterial agent-1 exhibits low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells [1].
T0891	Dapsone DDS,4,4‘-Sulfonyldianiline,氨苯砜,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone	Reactive Oxygen Species; Antibacterial; Antibiotic; Parasite	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Dapsone (Sulphadione) 是具有口服活性和血脑渗透通透性的磺酰类抗生素，具有抑菌、抗细菌和抗原虫活性。它有抗麻风活性，抑制麻风杆菌细胞提取物中叶酸的合成。它可研究皮肤病。
T6425	BTZ043 Racemate BTZ044,BTZ10526038,Benzothiazinone 10526038	Antibacterial; DprE1	Microbiology/Virology; Others
	BTZ043 Racemate (Benzothiazinone 10526038) 是一种癸二烯基磷酰-β-D-核糖 2'-差向异构酶(DprE1) 抑制剂，用作新的抗分枝杆菌剂。
T7342	BM212	Antibacterial	Microbiology/Virology
	BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌，抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。
T19794	Temafloxacin 替马沙星,Omniflox	Antibiotic	Microbiology/Virology
	Temafloxacin (Omniflox) 是一种喹诺酮类广谱抗菌剂，对革兰氏阳性菌、革兰氏阴性菌和厌氧菌均有效。
T1501	Rifabutin LM-427,Ansamycin,利福布汀,利福布丁	HSP; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Rifabutin (LM-427) 是半合成的安莎霉素抗生素，抑制 DNA 依赖性 RNA 聚合酶，有抗分枝杆菌作用。
T11594	I2906	Others	Others
	I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.
T25462	Griselimycin RP-11072-B,RP11072-B,RP 11072-B,Grisellimycin B
	Griselimycin is a natural antimycobacterial product that is currently being pursued as a therapy for tuberculosis.
T62086	Tuberculosis inhibitor 5
	Tuberculosis inhibitor 5 (Compound 11i) 是一种有效的抗结核剂，无明显细胞毒性。Tuberculosis inhibitor 5 是一种抗分枝杆菌 (antimycobacterial) 联苯类似物。
T25565	Kahalalide A
	Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens.
T35872	BRD-8000.3
	BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent known for its specific inhibition of EfpA. It exhibits potent activity against wild-type strains and proves to be a valuable tool in tuberculosis research[1].
T80927	Tuberculosis inhibitor 10
	Tuberculosis inhibitor 10 对 MSMEG_6649 的酶活性呈现中等抑制效果，并增强了 PAS 对分枝杆菌的抑制作用。
T62087	Tuberculosis inhibitor 4
	Tuberculosis inhibitor 4 (compound 16) 是基于扁桃酸的螺噻唑烷酮，表现出有效的抗分枝杆菌 (antimycobacterial) 作用。Tuberculosis inhibitor 4 的浓度低于 6.25 μg/mL 时，能够抑制 98% 的结核分枝杆菌菌株 H37Rv。
T61192	CBR-6672
	CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1].
T60465	Anti-infective agent 2
	Anti-infective agent 2 (化合物 3k) 是一种抗原生动物和抗分枝杆菌剂。Anti-infective agent 2对P. falciparum 和T. brucei rhodesiense 显示出抗寄生虫活性，IC50值分别为 0.07 和 2.20 μM。Anti-infective agent 2 对耻垢分枝杆菌显示出抗分支杆菌活性，其MIC 为 32 μg/mL。
T80926	Tuberculosis inhibitor 11
	Tuberculosis inhibitor 11 (Compound 14) 是一种增强抗结核药物针对分枝杆菌活性的化学化合物。
T61984	MtMetAP1-IN-1
	MtMetAP1-IN-1 是一种蛋氨酸氨基肽酶1(MetAP1) 的抑制剂。MtMetAP1-IN-1 显示出抗分枝杆菌活性。
T7062	Ethambutol
	Ethambutol 是一种抗分枝杆菌化合物，通过抑制阿拉伯糖基转移酶活性阻止细胞壁的形成。
T79029	IpOHA
	IpOHA是一种高效的KARI抑制剂，同时具备抗结核分枝杆菌的药理活性，针对Mycobacterium tuberculosis (Mt)的Ki值达到97.7 nM。
T60468	Anti-infective agent 3
	Anti-infective agent 3 是一种抗原生动物和抗分枝杆菌剂。Anti-infective agent 3 (compound 3l) 对 P. falciparum 和 T. brucei rhodesiense 显示出抗寄生虫活性，IC50值分别为 0.47 和 0.13 μM。Anti-infective agent 3 对耻垢分枝杆菌显示出抗分支杆菌活性，MIC 值为 4 μg/mL。
T38355	Lariatin A
	Lariatin A is an antimycobacterial lasso peptide originally isolated from R. jostii. It is active against M. tuberculosis and M. smegmatis in vitro (MICs = 0.39 and 0.1 μg/ml, respectively). Lariatin A increases survival in a silkworm model of M. smegmatis infection (ED50 = 0.5 μg/g).
T37541	Amycolatopsin C
	Amycolatopsin C is a polyketide macrolide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 2.7 and 5.7 μM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC50s = >30 μM for all). Amycolatopsin C is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 10 and 5.9 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial ...
T60315	Anti-infective agent 1
	Anti-infective agent 1 (化合物 3a) 是一种有效的、选择性的抗原生动物和抗结核分枝杆菌剂。Anti-infective agent 1 对P. falciparum 和T. brucei rhodesiense 具有抗寄生虫活性，IC50分别为 10.95 和 0.06 μM。Anti-infective agent 1 显示出对耻垢分枝杆菌的抗分支杆菌活性，MIC 为 8 μg/mL。
T60716	Antitubercular agent-28
	Antitubercular agent-28 (compound 2) 对结核分枝杆菌 H37Rv 的耐药分离株具有抗分枝杆菌活性。Antitubercular agent-28 是有效的抗结核药剂，MICb 值为 4.5 μM，IC50值为 1.5 μM，IC90值为 2.5 μM。Antitubercular agent-28 显示出有效的细胞内抗分枝杆菌活性，并且细胞毒性低。
T63286	Antituberculosis agent-3
	Antituberculosis agent-3 是一种具有抗霉菌作用的抗结核剂，对结核杆菌 H37Rv 株的生长具有抑制作用，其 MIC 值为 12.5 μg/mL。
T72262	Antituberculosis agent-6
	Antituberculosis agent-6 是一种有效的抗结核分枝杆菌 (antimycobacterial) 剂。Antituberculosis agent-6 对M. tuberculosis 显示出显著的抑制活性，MIC 为 3.49 μM。Antituberculosis agent-6 还对A. niger 表现出良好的抗真菌 (antifungal) 活性，MIC 为 62.50 μM。 Antituberculosis agent-6 表现出高胃肠道吸收。
T37539	Amycolatopsin A
	Amycolatopsin A is a macrolide polyketide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.1It is active againstM. bovisandM. tuberculosis(IC50s = 0.4 and 4.4 μM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC50s = >30 μM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacteria...
T37070	Pyridomycin
	Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).
T61665	Antibacterial agent 118
	Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The minimum inhibitory concentration (MIC) values for Antibacterial agent 118 against these strains are 40.7 μM, 10.2 μM, 163.0 μM, 62.5 μM, and 62.5 μM, respectively. This compound holds potential for tuberculosis research [1].
T78918	Antitubercular agent-37
	Antitubercular agent-37为具备显著抗分枝杆菌活性之抗菌剂，其最小抑菌浓度(MIC)为0.16 μg/mL，适用于结核病相关研究。
T78714	PptT-IN-4	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	PptT-IN-4 (Compound 3a) 为PptT抑制剂，IC50为0.71 μM。其对MtbH37Rv的MIC值为42 μM，并且还能抑制hERG、hCav1.2和hNav1.5通道，对应IC50s分别为11 μM、8.1 μM、6.9 μM。
T83222	AB131
	AB131，作为MSMEG 6649和Rv2172c的抑制剂，显示出低微摩尔级别的抑制常数 (Ki值分别为0.16和0.02 μM)。该化合物能够提升抗结核药物对分枝杆菌属的抗菌效力。
T75019	Antituberculosis agent-7
	Antituberculosis agent-7 是一种氧杂环丁基喹啉衍生物，对P. mirabilis 具有良好的抗菌活性，MIC 为 31.25 μM。Antituberculosis agent-7 对A. niger 显示出良好的抗真菌活性，MIC 为 62.5 μM。Antituberculosis agent-7 显示出优异的抗分枝杆菌活性，对结核分枝杆菌 H37Rv 的 MIC 为 3.41 μM。
T79440	DprE1-IN-5
	DprE1-IN-5（Compound 10）为一种DprE1抑制剂，对Mtb H37Rv菌株表现出抗结核活性（MIC: 4 μM），并对耐药菌株具有抗分枝杆菌效果，同时展现出较高的微粒体稳定性。
T61142	Antitubercular agent-17
	Antitubercular agent-17 (Compound 8a) 是一种抗结核剂，对 M. tuberculosisH37Rv、Spec. 192、Spec 210 和 Spec. 800 的 MIC 值分别为 2、2、2 和 128 μg/ml。Antitubercular agent-17 表现出高选择性的抗分支杆菌效果。
T61141	Antitubercular agent-27
	Antitubercular agent-27 (compound 1) 是一种有效的抗结核药剂，IC50值为 3.2 μM，MICb> 值为 7.8 μM，IC90值为 7.0 μM。Antitubercular agent-27 对结核分枝杆菌 H37Rv 的耐药分离株显示出抗分枝杆菌活性。Antitubercular agent-27 显示出有效的细胞内抗分枝杆菌活性和低细胞毒性。
T61143	Antitubercular agent-18
	Antitubercular agent-18 (Compound 9a) 为抗结核剂，对M. tuberculosisH37Rv、Spec. 192、Spec 210 及 Spec. 800 的最小抑制浓度(MIC)值依次为2、2、2 及128 μg/ml，展现出对分支杆菌的高选择性抗菌活性。
T78746	Mtb-IN-3
	Mtb-IN-3（化合物10c）是针对结核分枝杆菌（Mtb）的选择性抑制剂。该化合物具有有效的体外抗Mtb活性，并且不表现出细胞毒性。在小鼠结核病模型中，Mtb-IN-3可抑制脾脏的集落形成。
T79442	DprE1-IN-7
	DprE1-IN-7 (Compound 64) 是一款具有抗结核活性的DprE1抑制剂，对Mtb H37Rv菌株表现出明显的功效（MIC: 4 μM），并对耐药分枝杆菌株也显示出活性。此化合物在微粒体中稳定性强，并具有中等的清除速率。
T78883	DprE1-IN-9
	DprE1-IN-9（compound B18）是一款高效的可逆DprE1抑制剂，能够结合至DprE1的受体腔。该化合物对分枝杆菌表现出显著的抗菌活性，作用于非致病性菌株H37Ra（MIC=0.18 µg/mL）及致病性H37Rv菌株，并对多重耐药（MDR）和极度耐药（XDR）的临床分离株同样有效。
T38073	Thiocarlide Isoxyl
	Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 &#181g/ml. [1] [2] At concentrations of 10 &#181M, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drug...
T60570	Anti-inflammatory agent 11
	Anti-inflammatory agent 11 (化合物 16) 是有效的抗结核分枝杆菌剂，可用于结核病(TB)的研究。Anti-inflammatory agent 11 抑制Mtb H37Rv 和M299的生长，MIC50分别为 1.3 和 6.9 μM。Anti-inflammatory agent 11 也是一种抗炎剂，通过抑制 iNOS 的表达抑制NO，同时抑制 TNF-α 和 IL-1β 的产生。
T60560	Anti-inflammatory agent 15
	Anti-inflammatory agent 15 (化合物 29) 是有效的抗结核分枝杆菌剂，可用于结核病(TB)的研究。Anti-inflammatory agent 15 抑制 Mtb H37Rv 和 M299生长，MIC50分别为 2.3 和 7.8 μM。Anti-inflammatory agent 15也是一种抗炎剂，通过抑制 iNOS 的表达来抑制 NO，同时也抑制 TNF-α 和 IL-1β 的产生。
T35706	25-Desacetyl Rifampicin
	25-Desacetyl rifampicin is a major active metabolite of the rifamycin antibiotic rifampicin .125-Desacetyl rifampicin is active againstM. smegmatis(MIC99= 2.66 μM). 1.Kigondu, E.M., Njoroge, M., Singh, K., et al.Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolitesMed. Chem. Commun.5502-506(2014)
T37540	Amycolatopsin B
	Amycolatopsin B is a bacterial metabolite originally isolated fromAmycolatopsisthat has anticancer activity.1It is cytotoxic to NCI H460 lung and SW620 colon cancer cells (IC50s = 0.28 and 0.14 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)

化合物

Antimycobacterial agent-4

Cat.No: T60073

Synonym: 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide

Target: Antibacterial

Antimycobacterial agent-3

Cat.No: T63865

Antimycobacterial agent-2

Cat.No: T63420

Antimycobacterial agent-6

Cat.No: T79281

Antimycobacterial agent-1

Cat.No: T61853

Cat.No: T0891

Synonym: DDS,4,4‘-Sulfonyldianiline,氨苯砜,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone

Target: Reactive Oxygen Species, Antibacterial, Antibiotic, Parasite

BTZ043 Racemate

Cat.No: T6425

Synonym: BTZ044,BTZ10526038,Benzothiazinone 10526038

Target: Antibacterial, DprE1

Cat.No: T7342

Target: Antibacterial

Cat.No: T19794

Synonym: 替马沙星,Omniflox

Target: Antibiotic

Cat.No: T1501

Synonym: LM-427,Ansamycin,利福布汀,利福布丁

Target: HSP, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T11594

Target: Others

Cat.No: T25462

Synonym: RP-11072-B,RP11072-B,RP 11072-B,Grisellimycin B

Tuberculosis inhibitor 5

Cat.No: T62086

Cat.No: T25565

Cat.No: T35872

Tuberculosis inhibitor 10

Cat.No: T80927

Tuberculosis inhibitor 4

Cat.No: T62087

Cat.No: T61192

Anti-infective agent 2

Cat.No: T60465

Tuberculosis inhibitor 11

Cat.No: T80926

Cat.No: T61984

Cat.No: T7062

Cat.No: T79029

Anti-infective agent 3

Cat.No: T60468

Cat.No: T38355

Amycolatopsin C

Cat.No: T37541

Anti-infective agent 1

Cat.No: T60315

Antitubercular agent-28

Cat.No: T60716

Antituberculosis agent-3

Cat.No: T63286

Antituberculosis agent-6

Cat.No: T72262

Amycolatopsin A

Cat.No: T37539

Cat.No: T37070

Antibacterial agent 118

Cat.No: T61665

Antitubercular agent-37

Cat.No: T78918

Cat.No: T78714

Target: Calcium Channel

Cat.No: T83222

Antituberculosis agent-7

Cat.No: T75019

Cat.No: T79440

Antitubercular agent-17

Cat.No: T61142

Antitubercular agent-27

Cat.No: T61141

Antitubercular agent-18

Cat.No: T61143

Cat.No: T78746

Cat.No: T79442

Cat.No: T78883

Cat.No: T38073

Synonym: Isoxyl

Anti-inflammatory agent 11

Cat.No: T60570

Anti-inflammatory agent 15

Cat.No: T60560

25-Desacetyl Rifampicin

Cat.No: T35706

Amycolatopsin B

Cat.No: T37540

Cat. No.	Product Name	Target	Signaling Pathways
TN1121	Evocarpine	Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial	Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。
TN6729	Azadiradione AZD	Others	Others
	Azadiradione (AZD) 是 HSF1的一种，是由印楝树中提取得到，具有一定生物活性的柠檬苦素。
TN1926	Methyl caffeate Methyl caffeate acid,金银花,咖啡酸甲酯	Others; Antibacterial	Microbiology/Virology; Others
	Methyl caffeate (Methyl caffeate acid) acid 是一种抗微生物剂，有抗菌和抗分枝杆菌活性。它还抑制 α-葡萄糖苷酶，有氧化应激抑制活性，抗血小板活性，子宫颈癌的抗增殖活性以及肺和白细胞的抗癌活性。
TN2101	Primin	Antifection	Microbiology/Virology
	Primin 是存在于 Primula obconica 叶和茎毛状体中的天然产物，显示出抗菌和抗癌活性。
T0810	Ethambutol dihydrochloride Ethambutol 2HCl,盐酸乙胺丁醇,Emb dihydrochloride,CL40881	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Ethambutol dihydrochloride (CL40881) 能抗分枝杆菌，可抑制阿拉伯糖基转移酶活性来阻止细胞壁形成。
T1426	Pyrazinamide Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺	Antibacterial; Antibiotic; Autophagy; Fatty Acid Synthase	Autophagy; Metabolism; Microbiology/Virology
	Pyrazinamide (Pyrazinecarboxamide) 是一种口服抗结核类抗生素。它是一种前药，通过结核分枝杆菌pncA 基因编码的 PZase/烟酰胺酶转化为活性吡嗪酸形式。
TN5503	Linaroside	Antibacterial	Microbiology/Virology
	Linaroside 在 6.25 microg mL(-1) 浓度下对结核分枝杆菌、菌株 H(37)Rv 的抗分枝杆菌活性表现出 30%的抑制作用。
T5747	ISOBERGAPTEN	Others	Others
	Isobergapten 是一种化感抑制剂，分离自Hevacleum laciniatum 种子。
TN2755	2-Desoxy-4-epi-pulchellin	Anti-infection	Microbiology/Virology
	2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
TN5684	5,6-Desmethylenedioxy-5-methoxyaglalactone
	5,6-Desmethylenedioxy-5-methoxyaglalactone is cytotoxic to small cell lung cancer (NCI-H187) cell line. It has antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra.
TN5657	Goniotriol
	Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H
T11274	Ferulenol	Others	Others
	Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition.
TN5581	Rediocide C
	Rediocide C exhibits antimycobacterial activity, with the MIC value of 3.84 uM; it also exhibits potent activity against D. pteronyssinus with respective LC50 values of 5.59 microg/cm2.
T38295	Calpinactam
	Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 μg/larva).
TN5134	Tetrahydroxysqualene	Antifection	Microbiology/Virology
	Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.
TN3560	Cabralealactone	Antifection	Microbiology/Virology
	Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line.
TN3559	Cabraleahydroxylactone	HSV	Microbiology/Virology
	Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL).
TN3557	Cabraleadiol	ATPase; Antifection	Membrane transporter/Ion channel; Microbiology/Virology
	Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi
TN3924	Eichlerialactone	Others	Others
	Eichlerialactone and ethyl eichlerianoate show antimycobacterial activity against mycobacterium tuberculosis H37Ra, with minimum inhibitory concentration in the range of 25-50ug/mL; eichlerialactone exhibits good antibacterial activity against both the Gr
T75631	Ganorbiformin B
	Ganorbiformin B是一种具有与灵芝酸相同羊毛甾烷骨架的羊毛甾烷三萜类化合物。其C-3差向异构体灵芝酸T对结核分枝杆菌H37Ra显示出强抗分枝杆菌活性。

天然产物

Cat.No: TN1121

Target: Apoptosis, cAMP, Anti-infection, Calcium Channel, Antibacterial

Cat.No: TN6729

Synonym: AZD

Target: Others

Methyl caffeate

Cat.No: TN1926

Synonym: Methyl caffeate acid,金银花,咖啡酸甲酯

Target: Others, Antibacterial

Cat.No: TN2101

Target: Antifection

Ethambutol dihydrochloride

Cat.No: T0810

Synonym: Ethambutol 2HCl,盐酸乙胺丁醇,Emb dihydrochloride,CL40881

Target: Antibacterial, Antibiotic, Antifungal

Cat.No: T1426

Synonym: Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺

Target: Antibacterial, Antibiotic, Autophagy, Fatty Acid Synthase

Cat.No: TN5503

Target: Antibacterial

Cat.No: T5747

Target: Others

2-Desoxy-4-epi-pulchellin

Cat.No: TN2755

Target: Anti-infection

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

5,6-Desmethylenedioxy-5-methoxyaglalactone

Cat.No: TN5684

Cat.No: TN5657

Cat.No: T11274

Target: Others

Cat.No: TN5581

Cat.No: T38295

Tetrahydroxysqualene

Cat.No: TN5134

Target: Antifection

Cabralealactone

Cat.No: TN3560

Target: Antifection

Cabraleahydroxylactone

Cat.No: TN3559

Target: HSV

Cat.No: TN3557

Target: ATPase, Antifection

Eichlerialactone

Cat.No: TN3924

Target: Others

Ganorbiformin B

Cat.No: T75631

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