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Cat. No.	Product Name	Target	Signaling Pathways
T7685	USP25/28 inhibitor AZ1 AZ1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP25/28 inhibitor AZ1 (AZ1) 是一种口服有效，选择性，非竞争性的双重泛素特异性蛋白酶 USP25/28抑制，IC50分别为 0.7 μM 和0.6 μM。它有抗炎和抗肿瘤作用。
T11876	LpxH-IN-AZ1	Antibacterial	Microbiology/Virology
	LpxH-IN-AZ1 是一种有效的 UDP-2,3-二酰基葡糖胺焦磷酸水解酶LpxH 抑制剂，也是磺酰基哌嗪化合物。LpxH-IN-AZ1 具有抗菌活性，对肺炎克雷伯菌具有抑制作用，IC50 为 0.36 μM。
T68668	AZ-1
	AZ-1 is an inducer of ABCA1 and apoE. It enhances ABCA1 activity and decreases P2X7 receptor activity. AZ-1 activates endogenous LXR signaling but shows no direct LXRα or LXRβ agonist activity.
T26701	AZ12216052 AZ 12216052,AZ-12216052
	AZ12216052 is an activator of mGluR II and III.
T14367	AZ1495	IRAK; CDK; Haspin Kinase	Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
	AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂，能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T26704	AZ13705339 AZ-13705339,AZ 13705339	PAK	Cytoskeletal Signaling
	AZ13705339 是一种有效的 PAK1 抑制剂，IC50 为 0.33 nM，Kd 为 0.28 nM。 AZ13705339 以 0.32 nM 的 Kd 结合 PAK2。 AZ13705339 可用于癌症研究。
T6257	AZ191	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	AZ191 是特异性 DYRK1B 抑制剂。它对 DYRK1B 的特异性分别是 DYRK1A 和 DYRK2 的 5 倍和 110 倍。
T9650	AZ12672857	Src; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	AZ12672857 是一种 EphB4 抑制剂，IC50 为 1.3 nM。 AZ12672857 抑制 Src 转染 3T3 细胞的细胞增殖，IC50 为 2 nM，抑制转染 CHO-K1 细胞中 EphB4 的自磷酸化，IC50 为 9 nM。
T9552	BAZ1A-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	BAZ1A-IN-1 是BAZ1A（含溴结构域蛋白）抑制剂(Kd:0.52 μM)。它对低表达BAZ1A 的癌细胞表现出弱活性或无活性，但对高表达BAZ1A 的癌细胞系显示出良好的抗生存作用。
T14366	AZ10606120 dihydrochloride	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	AZ10606120 dihydrochloride 是一种可选择的、有效的、高亲和力的受体拮抗剂，在人和大鼠 P2X 7 受体上的 K D 值分别为 1.4 和 19 nM。AZ10606120 dihydrochloride 抑制肿瘤生长，具有抗血管生成活性。AZ 10606120在与 ATP 结合位点偶联的位点结合时充当负变构调节剂。
T9461	AZ194	Sodium Channel	Membrane transporter/Ion channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194 是一流的CRMP2-Ubc9相互作用抑制剂及NaV1.7抑制剂 (IC50=1.2 μM)，口服有活性，具有抗伤害作用。AZ194 阻断 CRMP2 的 SUMOylation 以选择性地减少表面表达 NaV1.7 的量。
T72321	AZ13705339 hemihydrate
	AZ13705339 hemihydrate 是一种高效且具有选择性的 PAK1抑制剂，对PAK1和 pPAK1 的IC50分别为 0.33 nM 和 59 nM。AZ13705339 hemihydrate 对PAK1和PAK2具有结合亲和力，Kd 分别为 0.28 nM 和 0.32 nM。AZ13705339 hemihydrate 可用于癌症研究。
T68693	AZ12099548
	AZ12099548 is a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist.
T25123	AZ12253801 AZ 12253801,AZ-12253801
	AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.
T30245	AZ12441970 AZ-12441970,AZ 12441970
	AZ12441970 is an effective agonist of Toll-like receptor 7 (TLR7 agonist).
T10426	AZ12601011	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively inhibits the phosphorylation of SMAD2. Additionally, it has been shown to hinder the growth and metastasis of mammary tumors [1].
T18310	AZ1508 MC-Lys-MMETA	Others	Others
	AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment.
T26699	AZ10397767 AZ 10397767,AZ-10397767
	AZ10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). AZ10397767 significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models.
T26703	AZ13483342 AZ-13483342,AZ 13483342
	AZ13483342 is an antagonist of the melanin concentrating hormone receptor 1 (MCH1) with a potential diabetes therapeutic activity.
T63976	AZ13824374
	AZ13824374 是高效的、选择性的 ATAD2 抑制剂，对乳腺癌具有抗增殖效果。AZ13824374 在 ATAD2 FRET 和 ATAD2 NanoBRET 检测中对 ATAD2 的pIC50值分别为 8.2 和 6.2。
T26700	AZ11657312 Free Base AZ-11657312,AZ11657312,AZ 11657312
	AZ11657312 is a P2X7 receptor antagonist.
T70312	AZ1366
	AZ1366 is a potent tankyrase inhibitor that enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance. Combination AZ1366 and irinotecan achieved greater anti-tumor effects compared to monotherapy. Activity was limited to CRC explants that displayed irinotecan resistance and increased protein levels of tankyrase and NuMA.
T26702	AZ12971554 AZ 12971554,AZ-12971554
	AZ12971554 is a potent inhibitor of human thrombin. Ki = 0.3nM, Activated partial thromboplastin time (APTT) IC50 = 0.68µM, Ecarin clotting time (ECT) IC50 = 0.16µM in human plasma.
T63968	AZ14145845
	AZ14145845 是一种具有体内药效的、高度选择性的 I1/2 型 Mer/Axl 双特异性激酶抑制剂。
T73356	Ac32Az19
	Ac32Az19 是一种有效、无毒、高选择性的 BCRP 抑制剂，在BCRP 过度表达的HEK293/R2细胞中，EC50值为13 nM。
T30244	AZ12419304 GTPL7734,GTPL 7734,AZ-12419304,GTPL-7734
	AZ12419304, also known as GTPL7734, is a bioactive chemical.

化合物

USP25/28 inhibitor AZ1

Cat.No: T7685

Synonym: AZ1

Target: DUB

Cat.No: T11876

Target: Antibacterial

Cat.No: T68668

Cat.No: T26701

Synonym: AZ 12216052,AZ-12216052

Cat.No: T14367

Target: IRAK, CDK, Haspin Kinase

Cat.No: T26704

Synonym: AZ-13705339,AZ 13705339

Target: PAK

Cat.No: T6257

Target: DYRK

Cat.No: T9650

Target: Src, Ephrin Receptor

Cat.No: T9552

Target: Epigenetic Reader Domain

AZ10606120 dihydrochloride

Cat.No: T14366

Target: P2X Receptor

Cat.No: T9461

Target: Sodium Channel

AZ13705339 hemihydrate

Cat.No: T72321

Cat.No: T68693

Cat.No: T25123

Synonym: AZ 12253801,AZ-12253801

Cat.No: T30245

Synonym: AZ-12441970,AZ 12441970

Cat.No: T10426

Target: ALK

Cat.No: T18310

Synonym: MC-Lys-MMETA

Target: Others

Cat.No: T26699

Synonym: AZ 10397767,AZ-10397767

Cat.No: T26703

Synonym: AZ-13483342,AZ 13483342

Cat.No: T63976

AZ11657312 Free Base

Cat.No: T26700

Synonym: AZ-11657312,AZ11657312,AZ 11657312

Cat.No: T70312

Cat.No: T26702

Synonym: AZ 12971554,AZ-12971554

Cat.No: T63968

Cat.No: T73356

Cat.No: T30244

Synonym: GTPL7734,GTPL 7734,AZ-12419304,GTPL-7734

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